Gene essentiality of Tubgcp4: dosage effect and autophagy regulation in retinal photoreceptors.

abstract：:To facilitate the purification of rat liver autophagosomes, isolated rat hepatocytes are first incubated for 2 h at 37°C with vinblastine, which induces autophagosome accumulation by blocking the fusion of these organelles with endosomes and lysosomes. The hepatocytes are then electrodisrupted and homogenized, and the...

journal_title：Autophagy

authors： Seglen PO,Brinchmann MF

更新日期：2010-05-01 00:00:00

abstract：:Protein synthesis and autophagy work as two opposing processes to control cell growth in response to nutrient supply. The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway, which acts as a master regulator to control protein synthesis, has recently been shown to inhibit autophagy by phosphorylating ...

journal_title：Autophagy

authors： Dunlop EA,Hunt DK,Acosta-Jaquez HA,Fingar DC,Tee AR

更新日期：2011-07-01 00:00:00

abstract：:The European autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14th and 15th of June 2018. This Marie Skłodowska-Curie Early Training Network was approved under the European Union's Horizon 2020 Research and Innovation Program a...

journal_title：Autophagy

authors： Kraft C,Boya P,Codogno P,Elazar Z,Eskelinen EL,Farrés J,Kirkin V,Jungbluth H,Martinez A,Pless O,Primard C,Proikas-Cezanne T,Simonsen A,Reggiori F

更新日期：2019-02-01 00:00:00

abstract：:Atg13 is an essential subunit of the Atg1 autophagy initiation complex in yeast and its mammalian counterpart, ATG13, is indispensable for autophagy induction by the ULK1 complex. The N terminus of the protein folds into a HORMA domain, an architecture that has been revealed by crystallography. 1-4 In human cells, the...

journal_title：Autophagy

authors： Popelka H,Klionsky DJ

更新日期：2017-03-04 00:00:00

abstract：:A pilot clinical trial based on nutritional modulation was designed to assess the efficacy of a one-year low-protein diet in activating autophagy in skeletal muscle of patients affected by COL6/collagen VI-related myopathies. Ullrich congenital muscular dystrophy and Bethlem myopathy are rare inherited muscle disorder...

journal_title：Autophagy

authors： Castagnaro S,Pellegrini C,Pellegrini M,Chrisam M,Sabatelli P,Toni S,Grumati P,Ripamonti C,Pratelli L,Maraldi NM,Cocchi D,Righi V,Faldini C,Sandri M,Bonaldo P,Merlini L

更新日期：2016-12-01 00:00:00

abstract：:The extensive autophagic-lysosomal pathology in Alzheimer disease (AD) brain has revealed a major defect: in the proteolytic clearance of autophagy substrates. Autophagy failure contributes on several levels to AD pathogenesis and has become an important therapeutic target for AD and other neurodegenerative diseases. ...

journal_title：Autophagy

authors： Yang DS,Stavrides P,Mohan PS,Kaushik S,Kumar A,Ohno M,Schmidt SD,Wesson DW,Bandyopadhyay U,Jiang Y,Pawlik M,Peterhoff CM,Yang AJ,Wilson DA,St George-Hyslop P,Westaway D,Mathews PM,Levy E,Cuervo AM,Nixon RA

更新日期：2011-07-01 00:00:00

abstract：:Autophagy plays critical roles in plant responses to stress. In contrast to the wealth of information concerning the core process of plant autophagosome assembly, our understanding of the regulation of autophagy is limited. In this study, we demonstrated that transcription factor HsfA1a played a critical role in tomat...

journal_title：Autophagy

authors： Wang Y,Cai S,Yin L,Shi K,Xia X,Zhou Y,Yu J,Zhou J

更新日期：2015-11-02 00:00:00

abstract：:Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell biologist and geneticist, I always find it easier to show a microscopy ...

journal_title：Autophagy

authors： Juhász G

更新日期：2019-11-01 00:00:00

abstract：:The initiation of macroautophagy/autophagy is tightly regulated by the upstream ULK1 kinase complex, which affects many downstream factors including the PtdIns3K complex. The phosphorylation of the right position at the right time on downstream molecules is governed by proper complex formation. One component of the UL...

journal_title：Autophagy

authors： Kim BW,Jin Y,Kim J,Kim JH,Jung J,Kang S,Kim IY,Kim J,Cheong H,Song HK

更新日期：2018-01-01 00:00:00

abstract：:The flank organ of the Syrian hamster, which shows a biodynamic response to androgen stimulation, is considered a good model for studying the androgen effect on sebaceous gland and hair. This organ is susceptible to programmed cell death (PCD), a prominent feature associated with sexual organ adjustment. We have recen...

journal_title：Autophagy

authors： Vega-Naredo I,Tomas-Zapico C,Coto-Montes A

更新日期：2009-02-01 00:00:00

abstract：:Neurons are highly polarized cells composed of two distinct domains, the axon and the somatodendritic domain. Although AMPA-type glutamate receptors, which mediate fast excitatory neurotransmission in the vertebrate CNS, are preferentially expressed in the somatodendritic domain, the molecular mechanisms underlying su...

journal_title：Autophagy

authors： Matsuda S,Yuzaki M

更新日期：2008-08-01 00:00:00

abstract：:The uptake and degradation of cytoplasmic material by vacuolar autophagy in plants has been studied extensively by electron microscopy and shown to be involved in developmental processes such as vacuole formation, deposition of seed storage proteins and senescence, and in the response of plants to nutrient starvation ...

journal_title：Autophagy

authors： Bassham DC,Laporte M,Marty F,Moriyasu Y,Ohsumi Y,Olsen LJ,Yoshimoto K

更新日期：2006-01-01 00:00:00

abstract：:Autophagy is a highly conserved homeostatic pathway that plays an important role in tumor development and progression by acting on cancer cells in a cell-autonomous mechanism. However, the solid tumor is not an island, but rather an ensemble performance that includes nonmalignant stromal cells, such as macrophages. A ...

journal_title：Autophagy

authors： Chen P,Cescon M,Bonaldo P

更新日期：2014-02-01 00:00:00

abstract：:Although several oncogenes enhance autophagic flux, the molecular mechanism and consequences of oncogene-induced autophagy remain to be clarified. We have recently shown that expression of oncogenic H-Ras (V12) promotes autophagy through upregulation of Beclin 1 and the BH3-only protein Noxa. H-Ras-expressing cells un...

journal_title：Autophagy

authors： Martin SJ

更新日期：2011-08-01 00:00:00

abstract：:Macroautophagy/autophagy is an intracellular degradative pathway that is often induced as a pro-survival process for cells under stress. A few recent reports establish the role of the glycogen metabolic pathway in neuronal cell survival in conditions such as oxidative stress and hypoxia, and the possible link between ...

journal_title：Autophagy

authors： Onkar A,Sheshadri D,Ganesh S

更新日期：2020-11-01 00:00:00

abstract：:Vascular endothelial cells (VECs) that form the inner wall of blood vessels can be injured by high glucose-induced autophagy and apoptosis. Although the role of long noncoding RNA in regulating cell fate has received widespread attention, long noncoding RNAs (lncRNAs) that can both regulate autophagy and apoptosis nee...

journal_title：Autophagy

authors： Zhao X,Su L,He X,Zhao B,Miao J

更新日期：2020-01-01 00:00:00

abstract：:Quercetin, a dietary antioxidant present in fruits and vegetables, is a promising cancer chemopreventive agent that inhibits tumor promotion by inducing cell cycle arrest and promoting apoptotic cell death. In this study, we examined the biological activities of quercetin against gastric cancer. Our studies demonstrat...

journal_title：Autophagy

authors： Wang K,Liu R,Li J,Mao J,Lei Y,Wu J,Zeng J,Zhang T,Wu H,Chen L,Huang C,Wei Y

更新日期：2011-09-01 00:00:00

abstract：:Ferroptosis is a form of regulated cell death caused by iron accumulation and oxidative injury. BECN1 is a key regulator of macroautophagy/autophagy, a catabolic process of degradation induced by starvation or other stressors. Our recent findings reveal a novel alternative mechanism by which BECN1 can promote ferropto...

journal_title：Autophagy

authors： Kang R,Zhu S,Zeh HJ,Klionsky DJ,Tang D

更新日期：2018-01-01 00:00:00

abstract：:Ridding neurons of toxic misfolded proteins is a critical feature of many neurodegenerative diseases. We have recently reported that lack of access of nuclear polyglutamine-expanded androgen receptor (AR) to the autophagic degradation pathway is a critical point in pathogenesis. When mutant AR is contained within the ...

journal_title：Autophagy

authors： Montie HL,Merry DE

更新日期：2009-11-01 00:00:00

abstract：:SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, the mechanism by which SPHK1 signaling promotes invasion and metastasis in HCC remains to be clarified. Here, we repor...

journal_title：Autophagy

authors： Liu H,Ma Y,He HW,Zhao WL,Shao RG

更新日期：2017-05-04 00:00:00

abstract：:Autophagy as a natural part of cellular homeostasis usually takes place unnoticed by neighboring cells. However, its co-occurrence with cell death may contribute to the clearance of these dying cells by recruited phagocytes. Autophagy associated with programmed cell death has recently been reported to be essential for...

journal_title：Autophagy

authors： Petrovski G,Zahuczky G,Májai G,Fésüs L

更新日期：2007-09-01 00:00:00

abstract：:The N-terminal amino acid of a protein is an essential determinant of ubiquitination and subsequent proteasomal degradation in the N-end rule pathway. Using para-chloroamphetamine (PCA), a specific inhibitor of the arginylation branch of the pathway (Arg/N-end rule pathway), we identified that blocking the Arg/N-end r...

journal_title：Autophagy

authors： Jiang Y,Lee J,Lee JH,Lee JW,Kim JH,Choi WH,Yoo YD,Cha-Molstad H,Kim BY,Kwon YT,Noh SA,Kim KP,Lee MJ

更新日期：2016-11-01 00:00:00

abstract：:The elimination of tumor cells by apoptosis is the main mechanism of action of chemotherapeutic drugs used in current treatment protocols of acute lymphoblastic leukemia (ALL). Despite the rapid cytoreduction achieved, serious acute and late complications are frequent, and resistance to chemotherapy develops. During t...

journal_title：Autophagy

authors： Crazzolara R,Bradstock KF,Bendall LJ

更新日期：2009-07-01 00:00:00

abstract：:ISG15 (ISG15 ubiquitin-like modifier), a ubiquitin-like protein, is one of the major type I IFN (interferon) effector systems. ISG15 can be conjugated to target proteins (ISGylation) via the stepwise action of E1, E2, and E3 enzymes. Conjugated ISG15 can be removed (deISGylated) from target proteins by USP18 (ubiquiti...

journal_title：Autophagy

authors： Xu D,Zhang T,Xiao J,Zhu K,Wei R,Wu Z,Meng H,Li Y,Yuan J

更新日期：2015-04-03 00:00:00

abstract：:The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in β-cells and increased β-cell apoptosis attributable at least in part to intracellular toxic oligomers of IAPP (islet amyloid polypeptide). β-cells of individuals with T2DM are also characterized by accumulation of polyubiquitinated proteins ...

journal_title：Autophagy

authors： Costes S,Gurlo T,Rivera JF,Butler PC

更新日期：2014-06-01 00:00:00

abstract：:Cytotoxic necrotizing factor 1 is a bacterial protein toxin from Escherichia coli that is able to activate the Rho GTPases and to hinder apoptosis and mitotic catastrophe. Upon exposure to toxin, cells undergo a complex framework of changes, including cytoskeleton remodeling and multinucleation. These cells also show ...

journal_title：Autophagy

authors： Fiorentini C,Malorni W

更新日期：2006-10-01 00:00:00

abstract：:Abnormal aggregation of SNCA/?-synuclein plays a crucial role in Parkinson disease (PD) pathogenesis. SNCA levels determine its toxicity, and its accumulation, even to a small extent, may be a risk factor for neurodegeneration. One of the main pathways for SNCA degradation is chaperone-mediated autophagy (CMA), a sele...

journal_title：Autophagy

authors： Xilouri M,Brekk OR,Kirik D,Stefanis L

更新日期：2013-12-01 00:00:00

abstract：:Some key questions being examined in the field of autophagy concern the origin of the membrane that forms the sequestering vesicle, the function of the related machinery, including the identification of new components and binding partners of previously identified autophagy-related proteins and the mechanism of autopha...

journal_title：Autophagy

authors： Vellai T,Klionsky DJ

更新日期：2010-01-01 00:00:00

abstract：:Numerous studies have reported that inhibition of MTOR (mechanistic target of rapamycin kinase) clearly reduces Alzheimer disease neuropathological hallmarks in mouse models. This has resulted in calls for the use of the MTOR inhibitor rapamycin for the treatment of dementia in humans. Unfortunately, intervention with...

journal_title：Autophagy

authors： Carosi JM,Sargeant TJ

更新日期：2019-08-01 00:00:00

abstract：:In a recent paper we addressed the mechanism by which defective autophagy contributes to TARDBP/TDP-43-mediated neurodegenerative disorders. We demonstrated that TARDBP regulates MTORC1-TFEB signaling by targeting RPTOR/raptor, a key component and an adaptor protein of MTORC1. Loss of TARDBP decreased the mRNA stabili...

journal_title：Autophagy

authors： Ying Z,Xia Q,Hao Z,Xu D,Wang M,Wang H,Wang G

更新日期：2016-01-01 00:00:00