Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon.

abstract：:Autophagy is a conserved membrane trafficking pathway that mediates the delivery of cytoplasmic substrates to the lysosome for degradation. Impaired autophagic function is implicated in the pathology of various neurodegenerative diseases. We have generated transgenic C. elegans that express human beta-amyloid peptide ...

journal_title：Autophagy

authors： Florez-McClure ML,Hohsfield LA,Fonte G,Bealor MT,Link CD

更新日期：2007-11-01 00:00:00

abstract：:Numerous studies have reported that inhibition of MTOR (mechanistic target of rapamycin kinase) clearly reduces Alzheimer disease neuropathological hallmarks in mouse models. This has resulted in calls for the use of the MTOR inhibitor rapamycin for the treatment of dementia in humans. Unfortunately, intervention with...

journal_title：Autophagy

authors： Carosi JM,Sargeant TJ

更新日期：2019-08-01 00:00:00

abstract：:Macroautophagy/autophagy is a fundamental intracellular degradation process with multiple roles in immunity, including direct elimination of intracellular microorganisms via 'xenophagy.' In this review, we summarize studies from the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans that highlig...

journal_title：Autophagy

authors： Kuo CJ,Hansen M,Troemel E

更新日期：2018-01-01 00:00:00

abstract：:The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in β-cells and increased β-cell apoptosis attributable at least in part to intracellular toxic oligomers of IAPP (islet amyloid polypeptide). β-cells of individuals with T2DM are also characterized by accumulation of polyubiquitinated proteins ...

journal_title：Autophagy

authors： Costes S,Gurlo T,Rivera JF,Butler PC

更新日期：2014-06-01 00:00:00

abstract：:Mitochondrial quality control is an essential process required to maintain cellular homeostasis and functions. Mutations of PINK1 and PRKN/PARK2 contribute to the risk of Parkinson disease. Our recent findings indicate that depletion of Pink1 and Prkn promotes pancreatic tumorigenesis in KRAS-driven engineered mouse m...

journal_title：Autophagy

authors： Kang R,Xie Y,Zeh HJ,Klionsky DJ,Tang D

更新日期：2019-01-01 00:00:00

abstract：:This Editor's Corner may sound like the title of a mystery novel, but it actually reflects a question I have about the puncta articles that appear in Autophagy (or rather, the ones that do not appear). In particular, I am surprised by the number of solicitations sent out for puncta that are either ignored, or, less fr...

journal_title：Autophagy

authors： Klionsky DJ

更新日期：2017-09-02 00:00:00

abstract：:Recent studies have suggested that autophagy is involved in a neural death pathway following cerebral ischemia. In vivo detection of autophagy could be important for evaluating ischemic neural cell damage for human stroke patients. Using novel green fluorescent protein (GFP)-fused microtubule-associated protein 1 ligh...

journal_title：Autophagy

authors： Tian F,Deguchi K,Yamashita T,Ohta Y,Morimoto N,Shang J,Zhang X,Liu N,Ikeda Y,Matsuura T,Abe K

更新日期：2010-11-01 00:00:00

abstract：:The elimination of tumor cells by apoptosis is the main mechanism of action of chemotherapeutic drugs used in current treatment protocols of acute lymphoblastic leukemia (ALL). Despite the rapid cytoreduction achieved, serious acute and late complications are frequent, and resistance to chemotherapy develops. During t...

journal_title：Autophagy

authors： Crazzolara R,Bradstock KF,Bendall LJ

更新日期：2009-07-01 00:00:00

abstract：:To maintain proper cellular homeostasis, the magnitude of autophagy activity has to be finely tuned in response to environmental changes. Many aspects of autophagy regulation have been extensively studied: pathways integrating signals through the master regulators TORC1 and PKA lead to multiple post-translational modi...

journal_title：Autophagy

authors： Bernard A,Klionsky DJ

更新日期：2015-04-03 00:00:00

abstract：:Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary tangles. Dysregulated clearance of Aβ largely contributes to its accumulation and plaque formation in the brain. Macroautophagy/autophagy is a l...

journal_title：Autophagy

authors： Wani A,Al Rihani SB,Sharma A,Weadick B,Govindarajan R,Khan SU,Sharma PR,Dogra A,Nandi U,Reddy CN,Bharate SS,Singh G,Bharate SB,Vishwakarma RA,Kaddoumi A,Kumar A

更新日期：2021-01-19 00:00:00

abstract：:Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD. Previous research has separately studied the effect of oxygen conc...

journal_title：Autophagy

authors： He R,Wang Z,Cui M,Liu S,Wu W,Chen M,Wu Y,Qu Y,Lin H,Chen S,Wang B,Shao Z

更新日期：2021-01-18 00:00:00

abstract：:Combining two different treatment modalities for targeting malignancies is gaining importance, with preclinical/clinical results indicating higher success rates in eradicating tumors or having longer remission periods. A better understanding of the synergy between the treatments helps in optimizing the dose and time o...

journal_title：Autophagy

authors： Ramakrishnan R,Gabrilovich DI

更新日期：2013-04-01 00:00:00

abstract：:One of the major side effects of cisplatin chemotherapy is toxic acute kidney injury due to preferential accumulation of cisplatin in renal proximal tubule epithelial cells and the subsequent injury to these cells. Apoptosis is known as a major mechanism of cisplatin-induced cell death in renal tubular cells. We have ...

journal_title：Autophagy

authors： Kaushal GP,Kaushal V,Herzog C,Yang C

更新日期：2008-07-01 00:00:00

abstract：:Recent evidence has indicated that the lysosome is able to act as a signaling organelle that senses nutrient availability and generates an adaptive response that is important for cellular homeostasis. We recently discovered another example of lysosomal signaling where lysosomal calcium release activates the master aut...

journal_title：Autophagy

authors： Medina DL,Ballabio A

更新日期：2015-01-01 00:00:00

abstract：:The PIK3C3/VPS34-containing phosphatidylinositol 3-kinase (PtdIns3K) initiation complex (complex I) is necessary for macroautophagy/autophagy initiation and is comprised of PIK3R4/VPS15-PIK3C3/VPS34-BECN1-ATG14, while the endosomal trafficking complex (complex II) is necessary for vesicle trafficking and is comprised ...

journal_title：Autophagy

authors： Pavlinov I,Salkovski M,Aldrich LN

更新日期：2020-08-01 00:00:00

abstract：:Accumulating evidence has demonstrated that macroautophagy/autophagy plays an essential role in self-renewal and differentiation in embryonic hematopoiesis. Here, according to the RNA sequencing data sets of 5 population cells related to hematopoietic stem cell (HSC) formation during mouse embryogenesis (endothelial c...

journal_title：Autophagy

authors： Hu Y,Huang Y,Yi Y,Wang H,Liu B,Yu J,Wang D

更新日期：2017-04-03 00:00:00

abstract：:The cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guerin (BCG/CWS) is an effective antitumor immunotherapy agent. Here, we demonstrate that BCG/CWS has a radiosensitizing effect on colon cancer cells through the induction of autophagic cell death. Exposure of HCT116 colon cancer cells to BCG/CWS before i...

journal_title：Autophagy

authors： Yuk JM,Shin DM,Song KS,Lim K,Kim KH,Lee SH,Kim JM,Lee JS,Paik TH,Kim JS,Jo EK

更新日期：2010-01-01 00:00:00

abstract：:Upon completion of cytokinesis, the midbody ring is transported asymmetrically into one of the two daughter cells where it becomes a midbody ring derivative that is degraded by autophagy. In this study we showed that the ubiquitin-binding autophagy receptor SQSTM1/p62 and the interacting adaptor protein WDFY3/ALFY for...

journal_title：Autophagy

authors： Isakson P,Lystad AH,Breen K,Koster G,Stenmark H,Simonsen A

更新日期：2013-12-01 00:00:00

abstract：:Loss-of-function mutations in PARK2/PARKIN and PINK1 cause early-onset autosomal recessive Parkinson disease (PD). The cytosolic E3 ubiquitin-protein ligase PARK2 cooperates with the mitochondrial kinase PINK1 to maintain mitochondrial quality. A loss of mitochondrial transmembrane potential (ΔΨ) leads to the PINK1-de...

journal_title：Autophagy

authors： Bertolin G,Ferrando-Miguel R,Jacoupy M,Traver S,Grenier K,Greene AW,Dauphin A,Waharte F,Bayot A,Salamero J,Lombès A,Bulteau AL,Fon EA,Brice A,Corti O

更新日期：2013-11-01 00:00:00

abstract：:In a recent paper we addressed the mechanism by which defective autophagy contributes to TARDBP/TDP-43-mediated neurodegenerative disorders. We demonstrated that TARDBP regulates MTORC1-TFEB signaling by targeting RPTOR/raptor, a key component and an adaptor protein of MTORC1. Loss of TARDBP decreased the mRNA stabili...

journal_title：Autophagy

authors： Ying Z,Xia Q,Hao Z,Xu D,Wang M,Wang H,Wang G

更新日期：2016-01-01 00:00:00

abstract：:Although Beclin 1 and mTOR are considered to be the main molecules to modulate the autophagic process, searching for other autophagy-regulating molecules is still an ongoing challenge to scientists. Here we demonstrated that FoxO1, a forkhead O family protein, is a mediator of autophagy. Upon oxidative stress or serum...

journal_title：Autophagy

authors： Zhao Y,Wang L,Yang J,Zhang P,Ma K,Zhou J,Liao W,Zhu WG

更新日期：2010-10-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a complex, degenerative and progressive eye disease that usually does not lead to complete blindness, but can result in severe loss of central vision. Risk factors for AMD include age, genetics, diet, smoking, oxidative stress and many cardiovascular-associated risk factors. A...

journal_title：Autophagy

authors： Kaarniranta K,Sinha D,Blasiak J,Kauppinen A,Veréb Z,Salminen A,Boulton ME,Petrovski G

更新日期：2013-07-01 00:00:00

abstract：:Quercetin, a dietary antioxidant present in fruits and vegetables, is a promising cancer chemopreventive agent that inhibits tumor promotion by inducing cell cycle arrest and promoting apoptotic cell death. In this study, we examined the biological activities of quercetin against gastric cancer. Our studies demonstrat...

journal_title：Autophagy

authors： Wang K,Liu R,Li J,Mao J,Lei Y,Wu J,Zeng J,Zhang T,Wu H,Chen L,Huang C,Wei Y

更新日期：2011-09-01 00:00:00

abstract：:Protein misfolding is the common theme for neurodegenerative disorders including Huntington disease (HD), which is mainly caused by cytotoxicity of the mutant HTT (huntingtin) protein (mHTT). The soluble mHTT has an expanded polyglutamine (polyQ) stretch that may adopt multiple conformations, among which the one recog...

journal_title：Autophagy

authors： Sun X,Fu Y,Pan Y,Lu B

更新日期：2017-01-01 00:00:00

abstract：:Macroautophagy/autophagy is an intracellular stress survival and recycling system whereas phagocytosis internalizes material from the extracellular milieu; yet, both pathways utilize lysosomes for cargo degradation. Whereas autophagy occurs in all cells, phagocytosis is performed by cell types such as macrophages and ...

journal_title：Autophagy

authors： Muniz-Feliciano L,Doggett TA,Zhou Z,Ferguson TA

更新日期：2017-01-01 00:00:00

abstract：:Neuroblastoma is the most common extracranial solid tumor in childhood. Despite intense multimodal therapy and many improvements through basic scientific and clinical research, the successful response of advanced-stage patients to chemotherapy remains poor. Autophagy is a cytoprotective mechanism that may help advance...

journal_title：Autophagy

authors： Oehme I,Lodrini M,Brady NR,Witt O

更新日期：2013-12-01 00:00:00

abstract：:Photoreceptor degeneration and damages often lead to blindness, and the underlying molecular mechanisms are largely unknown. There is also a lot of missing information for establishing the role of macroautophagy/autophagy in the retinopathy. We recently generated knockout mouse lines of the essential gene Tubgcp4 (tub...

journal_title：Autophagy

authors： Xu X,Shang D,Cheng H,Klionsky DJ,Zhou R

更新日期：2019-10-01 00:00:00

abstract：:Accumulation of mutant TP53 proteins in cancer cells has been recognized as an important factor that promotes cancer progression and metastasis. Thus, strategies that promote the degradation of mutant TP53 might be beneficial for the treatment of cancers. In a recent issue of Genes & Development, we demonstrated that ...

journal_title：Autophagy

authors： Vakifahmetoglu-Norberg H,Yuan J

更新日期：2013-12-01 00:00:00

abstract：:Cigarette smoke (CS)-induced mitochondrial damage with increased reactive oxygen species (ROS) production has been implicated in COPD pathogenesis by accelerating senescence. Mitophagy may play a pivotal role for removal of CS-induced damaged mitochondria, and the PINK1 (PTEN-induced putative kinase 1)-PARK2 pathway h...

journal_title：Autophagy

authors： Ito S,Araya J,Kurita Y,Kobayashi K,Takasaka N,Yoshida M,Hara H,Minagawa S,Wakui H,Fujii S,Kojima J,Shimizu K,Numata T,Kawaishi M,Odaka M,Morikawa T,Harada T,Nishimura SL,Kaneko Y,Nakayama K,Kuwano K

更新日期：2015-01-01 00:00:00

abstract：:The highly invasive and chemoresistant phenotype of pancreatic cancer highlights the urgency to identify prognostic biomarkers and novel therapeutic targets. Recently, we observed a significant correlation between shorter survival and loss of the cytoband 18q22.3. Here we investigated genes encoded by this cytoband, a...

journal_title：Autophagy

authors： Giovannetti E,Giaccone G

更新日期：2014-04-01 00:00:00