Nuclear membrane-derived autophagy, a novel process that participates in the presentation of endogenous viral antigens during HSV-1 infection.

abstract：:ULK1 and ATG13 assemble with RB1CC1/FIP200 and ATG101 to form a macroautophagy (hereafter autophagy) induction (ULK1) complex in higher eukaryotes. The yeast counterpart, the Atg1 complex, is comprised of Atg1 and Atg13 (ULK1 and ATG13 homologs), Atg17 (a proposed functional homolog of RB1CC1), and either the Atg101 s...

journal_title：Autophagy

authors： Popelka H,Klionsky DJ

更新日期：2015-11-02 00:00:00

abstract：:The molecular mechanism of macroautophagy/autophagy induction has been intensively studied, but little is known about downregulation of autophagy and how this process is restricted. In particular, how is autophagy maintained at an appropriate homeostatic level when cells are subjected to prolonged stress? In this stud...

journal_title：Autophagy

authors： Feng Y,Klionsky DJ

更新日期：2016-07-02 00:00:00

abstract：:Prion protein modulates many cellular functions including the secretion of trophic factors by astrocytes. Some of these factors are found in exosomes, which are formed within multivesicular bodies (MVBs) and secreted into the extracellular space to modulate cell-cell communication. The mechanisms underlying exosome bi...

journal_title：Autophagy

authors： Dias MV,Teixeira BL,Rodrigues BR,Sinigaglia-Coimbra R,Porto-Carreiro I,Roffé M,Hajj GN,Martins VR

更新日期：2016-11-01 00:00:00

abstract：:Increasing evidence suggests that misfolded proteins and intracellular aggregates contribute to cardiac disease and heart failure. We wished to determine if autophagic induction by Atg7 is sufficient to reduce misfolded protein and aggregate content in protein misfolding-stressed cardiomyocytes. We used loss- and gain...

journal_title：Autophagy

authors： Pattison JS,Robbins J

更新日期：2011-10-01 00:00:00

abstract：:The exploration into the roles of autophagy in tumorigenesis, either as tumor suppressor or tumor promoter, has led to a great increase in the knowledge of cancer development, progression and treatment. However, there is currently no consensus on how to manipulate autophagy to improve antitumor effects. In this study,...

journal_title：Autophagy

authors： Chang Y,Lin J,Tsung A

更新日期：2012-12-01 00:00:00

abstract：:Minocycline has been shown to alleviate several neurological disorders. Unexpectedly, we found that minocycline had opposite effects on glioma cells: minocycline induced nonapoptotic cell death in glioma cells. The glioma cell death was associated with the presence of autophagic vacuoles in the cytoplasm. Minocycline ...

journal_title：Autophagy

authors： Liu WT,Lin CH,Hsiao M,Gean PW

更新日期：2011-02-01 00:00:00

abstract：:The elimination of tumor cells by apoptosis is the main mechanism of action of chemotherapeutic drugs used in current treatment protocols of acute lymphoblastic leukemia (ALL). Despite the rapid cytoreduction achieved, serious acute and late complications are frequent, and resistance to chemotherapy develops. During t...

journal_title：Autophagy

authors： Crazzolara R,Bradstock KF,Bendall LJ

更新日期：2009-07-01 00:00:00

abstract：:Mechanisms to protect against viral infections are crucial during pregnancy as maternal-fetal transmission can have serious pathological outcomes, including fetal infection and its sequelae, such as growth restriction, birth defects, and/or fetal death. The trophoblast forms the interface between the feto-placental un...

journal_title：Autophagy

authors： Delorme-Axford E,Bayer A,Sadovsky Y,Coyne CB

更新日期：2013-12-01 00:00:00

abstract：:Macroautophagy/autophagy is an intracellular degradative pathway that is often induced as a pro-survival process for cells under stress. A few recent reports establish the role of the glycogen metabolic pathway in neuronal cell survival in conditions such as oxidative stress and hypoxia, and the possible link between ...

journal_title：Autophagy

authors： Onkar A,Sheshadri D,Ganesh S

更新日期：2020-11-01 00:00:00

abstract：:Flies expressing the most common Parkinson disease (PD)-related mutation, LRRK2-G2019S, in their dopaminergic neurons show loss of visual function and degeneration of the retina, including mitochondrial abnormalities, apoptosis and autophagy. Since the photoreceptors that degenerate are not dopaminergic, this demonstr...

journal_title：Autophagy

authors： Hindle SJ,Elliott CJ

更新日期：2013-06-01 00:00:00

abstract：:Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both...

journal_title：Autophagy

authors： Gomes LC,Scorrano L

更新日期：2011-10-01 00:00:00

abstract：:Ferroptosis is a form of regulated cell death caused by iron accumulation and oxidative injury. BECN1 is a key regulator of macroautophagy/autophagy, a catabolic process of degradation induced by starvation or other stressors. Our recent findings reveal a novel alternative mechanism by which BECN1 can promote ferropto...

journal_title：Autophagy

authors： Kang R,Zhu S,Zeh HJ,Klionsky DJ,Tang D

更新日期：2018-01-01 00:00:00

abstract：:Autophagy is a lysosome-directed membrane trafficking event for the degradation of cytoplasmic components, including organelles. The past few years have seen a great advance in our understanding of the cellular machinery of autophagosome biogenesis, the hallmark of autophagy. However, our global understanding of autop...

journal_title：Autophagy

authors： Liang C,Sir D,Lee S,Ou JH,Jung JU

更新日期：2008-08-01 00:00:00

abstract：:Although Beclin 1 and mTOR are considered to be the main molecules to modulate the autophagic process, searching for other autophagy-regulating molecules is still an ongoing challenge to scientists. Here we demonstrated that FoxO1, a forkhead O family protein, is a mediator of autophagy. Upon oxidative stress or serum...

journal_title：Autophagy

authors： Zhao Y,Wang L,Yang J,Zhang P,Ma K,Zhou J,Liao W,Zhu WG

更新日期：2010-10-01 00:00:00

abstract：:Autophagy is essential for prolonging yeast survival during nutrient deprivation; however, this report shows that some autophagy proteins may also be accelerating population death in those conditions. While leucine starvation caused YCA1-mediated apoptosis characterized by increased annexin V staining, nitrogen depriv...

journal_title：Autophagy

authors： Dziedzic SA,Caplan AB

更新日期：2012-05-01 00:00:00

abstract：:Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary tangles. Dysregulated clearance of Aβ largely contributes to its accumulation and plaque formation in the brain. Macroautophagy/autophagy is a l...

journal_title：Autophagy

authors： Wani A,Al Rihani SB,Sharma A,Weadick B,Govindarajan R,Khan SU,Sharma PR,Dogra A,Nandi U,Reddy CN,Bharate SS,Singh G,Bharate SB,Vishwakarma RA,Kaddoumi A,Kumar A

更新日期：2021-01-19 00:00:00

abstract：:Heme is an essential molecule expressed in many tissues where it plays key roles as the prosthetic group of several proteins involved in vital physiological and metabolic processes such as gas and electron transport. Structurally, heme is a tetrapyrrole ring containing an atom of iron (Fe) in its center. When released...

journal_title：Autophagy

authors： Travassos LH,Vasconcellos LR,Bozza MT,Carneiro LA

更新日期：2017-03-04 00:00:00

abstract：:Hepatic stellate cell (HSC) activation, the transition from a resident quiescent HSC to a myofibroblastic collagen-producing HSC, is a fundamental feature of liver fibrosis. Autophagy has been implicated in major liver pathologies, such as HCV infection and hepatocarcinoma. However, its role in HSC biology is largely ...

journal_title：Autophagy

authors： Thoen LF,Guimarães EL,Grunsven LA

更新日期：2012-01-01 00:00:00

abstract：:Delivery of cellular contents to yeast vacuoles/mammalian lysosomes via autophagy ensures long-term cell survival and extends life span. When cultured yeast cells are grown for a prolonged period of time to enter stationary phase, a nondividing state mimicking quiescence, vacuolar membrane proteins partition into eith...

journal_title：Autophagy

authors： Wang CW

更新日期：2014-01-01 00:00:00

abstract：:We have previously shown that Kaposi sarcoma-associated herpesvirus (KSHV) impairs monocyte differentiation into dendritic cells (DCs). Macroautophagy/autophagy has been reported to be essential in such a differentiating process. Here we extended these studies and found that the impairment of DC formation by KSHV occu...

journal_title：Autophagy

authors： Santarelli R,Granato M,Pentassuglia G,Lacconi V,Gilardini Montani MS,Gonnella R,Tafani M,Torrisi MR,Faggioni A,Cirone M

更新日期：2016-12-01 00:00:00

abstract：:Ticks are long-lived hematophagous arthropods and have tolerance to starvation. They can survive without food during the host-seeking period for several months to years. To understand how ticks obtain energy over a long period of non-feeding (starvation), we focused on autophagy, a crucial proteolysis system via the l...

journal_title：Autophagy

authors： Umemiya-Shirafuji R,Matsuo T,Liao M,Boldbaatar D,Battur B,Suzuki H,Fujisaki K

更新日期：2010-05-01 00:00:00

abstract：:The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in β-cells and increased β-cell apoptosis attributable at least in part to intracellular toxic oligomers of IAPP (islet amyloid polypeptide). β-cells of individuals with T2DM are also characterized by accumulation of polyubiquitinated proteins ...

journal_title：Autophagy

authors： Costes S,Gurlo T,Rivera JF,Butler PC

更新日期：2014-06-01 00:00:00

abstract：:Tumor-associated inflammation is predictive of poor prognosis and drives a variety of tumorigenic phenotypes, including tumor proliferation and survival, angiogenesis, invasiveness, and metastasis. Here, we review mammalian data addressing the interaction of macroautophagy/autophagy with key signaling cascades associa...

journal_title：Autophagy

authors： Monkkonen T,Debnath J

更新日期：2018-01-01 00:00:00

abstract：:Autophagy is a conserved membrane traffic pathway that equips eukaryotic cells to capture cytoplasmic components within a double-membrane vacuole, or autophagosome, for delivery to lysosomes. Although best known as a mechanism to survive starvation, autophagy is now recognized to combat infection by a variety of micro...

journal_title：Autophagy

authors： Dubuisson JF,Swanson MS

更新日期：2006-07-01 00:00:00

abstract：N:6-methyladenosine (m6A), the most abundant internal modification on mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism remains largely unclear. Here, we show that m6A plays a critical role in regulating macroautophagy/autophagy and adipogenesis through targeting Atg5 and Atg7. Mechanis...

journal_title：Autophagy

authors： Wang X,Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Shi H,Wang F,Wang Y

更新日期：2020-07-01 00:00:00

abstract：:Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on the autophagy machinery of the host. This response is studied intensively in epithelial cells, the target of Salmonella during gastrointestinal infections. However, little is known of the role that autophagy plays in macrophages,...

journal_title：Autophagy

authors： Masud S,Prajsnar TK,Torraca V,Lamers GEM,Benning M,Van Der Vaart M,Meijer AH

更新日期：2019-05-01 00:00:00

abstract：:The cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guerin (BCG/CWS) is an effective antitumor immunotherapy agent. Here, we demonstrate that BCG/CWS has a radiosensitizing effect on colon cancer cells through the induction of autophagic cell death. Exposure of HCT116 colon cancer cells to BCG/CWS before i...

journal_title：Autophagy

authors： Yuk JM,Shin DM,Song KS,Lim K,Kim KH,Lee SH,Kim JM,Lee JS,Paik TH,Kim JS,Jo EK

更新日期：2010-01-01 00:00:00

abstract：:Autophagy is a conserved homeostatic process in which cytoplasmic contents are degraded and recycled. Two ubiquitin-like conjugation pathways are required for the generation of autophagosomes, and ATG5 is necessary for both of these processes. Studies of mice deficient in ATG5 reveal a key role for autophagy in T lymp...

journal_title：Autophagy

authors： Conway KL,Kuballa P,Khor B,Zhang M,Shi HN,Virgin HW,Xavier RJ

更新日期：2013-04-01 00:00:00

abstract：:The Syrian hamster Harderian gland (HG) is a juxtaorbital organ exhibiting marked gender-associated morphological differences. Regarding contents of porphyrins, this gland is a good model for studying physiological oxidative stress effects, since both sexes present strong (in females) and moderate (in males) levels of...

journal_title：Autophagy

authors： Coto-Montes A,Tomás-Zapico C

更新日期：2006-04-01 00:00:00

abstract：:The NIH-funded center for autophagy research named Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence, located at the University of New Mexico Health Science Center is now completing its second year as a working center with a mission to promote autophagy research locally, nationally...

journal_title：Autophagy

authors： Deretic V,Prossnitz E,Burge M,Campen MJ,Cannon J,Liu KJ,Liu M,Hall P,Sklar LA,Allers L,Mariscal L,Garcia SA,Weaver J,Baehrecke EH,Behrends C,Cecconi F,Codogno P,Chen GC,Elazar Z,Eskelinen EL,Fourie B,Gozuacik D

更新日期：2019-10-01 00:00:00