Abstract:
:Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. How autophagosomal vesicle forms in a spatio-temporally regulated manner remains elusive. Our recent study revealed that small GTPase, RAB37 (RAB37, member RAS oncogene family), functions as a key organizer of autophagosomal membrane biogenesis. RAB37 interacts with ATG5 (autophagy related 5) and promotes autophagosome formation by modulating ATG12-ATG5-ATG16L1 complex assembly. These findings provide new insights into autophagy regulation.
journal_name
Autophagyjournal_title
Autophagyauthors
Song Y,Shang D,Cheng H,Zhou Rdoi
10.1080/15548627.2018.1434374subject
Has Abstractpub_date
2018-01-01 00:00:00pages
727-729issue
4eissn
1554-8627issn
1554-8635journal_volume
14pub_type
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