Abstract:
:Autophagy is a highly conserved intracellular degradation system, and recently was shown to display circadian rhythms in mice. The mechanisms underlying circadian regulation of autophagy, however, are still unclear. Here, we observed that numbers of autophagosomes and autolysosomes exhibit daily rhythms in the zebrafish liver, and cebpb/(c/ebpβ) and various autophagy genes are rhythmically expressed in zebrafish larvae but significantly upregulated in per1b and TALEN-generated nr1d1/rev-erbα mutant fish, indicating that both Per1b and Nr1d1 play critical roles in autophagy rhythms. Luciferase reporter and ChIP assays show that the circadian clock directly regulates autophagy genes through Nr1d1, and also regulates transcription of cebpb through Per1b. We also found that fasting leads to altered expression of both circadian clock genes and autophagy genes in zebrafish adult peripheral organs. Further, transcriptome analysis reveals multiple functions of Nr1d1 in zebrafish. Taken together, these findings provide evidence for how the circadian clock regulates autophagy, imply that nutritional signaling affects both circadian regulation and autophagy activities in peripheral organs, and shed light on how circadian gene mutations act through autophagy to contribute to common metabolic diseases such as obesity.
journal_name
Autophagyjournal_title
Autophagyauthors
Huang G,Zhang F,Ye Q,Wang Hdoi
10.1080/15548627.2016.1183843subject
Has Abstractpub_date
2016-08-02 00:00:00pages
1292-309issue
8eissn
1554-8627issn
1554-8635journal_volume
12pub_type
杂志文章相关文献
Autophagy文献大全abstract::Phagocytosis plays a central role in immunity and tissue homeostasis. After internalization of cargo into single-membrane phagosomes, these compartments undergo a maturation sequences that terminates in lysosome fusion and cargo degradation. Components of the autophagy pathway have recently been linked to phagosome ma...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1191724
更新日期:2016-09-01 00:00:00
abstract::Damaged mitochondria are turned over through a process of selective autophagy termed mitophagy. In mitophagy, unhealthy mitochondria are recognized and ubiquitinated by Parkinson disease-linked proteins PINK1 and PARK2. The subsequent recruitment of ubiquitin-binding autophagy receptors leads in turn to the sequestrat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1212788
更新日期:2016-10-02 00:00:00
abstract::Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase compl...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1581009
更新日期:2019-08-01 00:00:00
abstract::Autophagy is a catabolic process by which cells remove unwanted proteins and damaged organelles. It is important for maintaining cellular homeostasis and can also be used by cells to remove intracellular microbial pathogens. As such, some viruses such as herpes simplex virus-1 (HSV-1) have evolved mechanisms to suppre...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.4.11669
更新日期:2010-05-01 00:00:00
abstract::As a selective degradation system, chaperone-mediated autophagy (CMA) is essential for maintaining cellular homeostasis and survival under stress conditions. Increasing evidence points to an important role for the dysfunction of CMA in the pathogenesis of Parkinson disease (PD). However, the mechanisms by which CMA re...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1179401
更新日期:2016-08-02 00:00:00
abstract::Autophagy as a natural part of cellular homeostasis usually takes place unnoticed by neighboring cells. However, its co-occurrence with cell death may contribute to the clearance of these dying cells by recruited phagocytes. Autophagy associated with programmed cell death has recently been reported to be essential for...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.4731
更新日期:2007-09-01 00:00:00
abstract::(Macro)autophagy is a membrane-trafficking process that serves to sequester cellular constituents in organelles termed autophagosomes, which target their degradation in the lysosome. Autophagy operates at basal levels in all cells where it serves as a homeostatic mechanism to maintain cellular integrity. The levels an...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.11.16646
更新日期:2011-11-01 00:00:00
abstract::The European autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14th and 15th of June 2018. This Marie Skłodowska-Curie Early Training Network was approved under the European Union's Horizon 2020 Research and Innovation Program a...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1515532
更新日期:2019-02-01 00:00:00
abstract::Mitochondrial dysfunction is associated with the occurrence of a variety of neurodegenerative diseases, especially Alzheimer disease (AD). As a mitochondrial quality control process, mitophagy is greatly inhibited in AD; increasing evidence shows that the induction of mitophagy is an effective therapeutic intervention...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1860542
更新日期:2020-12-20 00:00:00
abstract::Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.10.16771
更新日期:2011-10-01 00:00:00
abstract::Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. How autophagosomal vesicle forms in a spatio-temporally regulated manner remains elusive. Our recent study revealed that small GTPase, RAB37 (RAB37, member RAS oncogene family), functions as a key organizer of autophagosomal me...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1434374
更新日期:2018-01-01 00:00:00
abstract::Loss-of-function mutations in PARK2/PARKIN and PINK1 cause early-onset autosomal recessive Parkinson disease (PD). The cytosolic E3 ubiquitin-protein ligase PARK2 cooperates with the mitochondrial kinase PINK1 to maintain mitochondrial quality. A loss of mitochondrial transmembrane potential (ΔΨ) leads to the PINK1-de...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.25884
更新日期:2013-11-01 00:00:00
abstract::Proteome profiling and global protein-interaction approaches have significantly improved our knowledge of the protein interactomes of autophagy and other cellular stress-response pathways. New discoveries regarding protein complexes, interaction partners, interaction domains, and biological roles of players that are p...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1775394
更新日期:2020-06-07 00:00:00
abstract::Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell biologist and geneticist, I always find it easier to show a microscopy ...
journal_title:Autophagy
pub_type: 评论,社论
doi:10.1080/15548627.2019.1659624
更新日期:2019-11-01 00:00:00
abstract::The 4th International Symposium on Autophagy was held in Mishima, a small town between Tokyo and Kyoto, October 1-5, 2006 (http://isa4th.umin.jp/). The meeting was organized by the group of Eiki Kominami. Approximately 150 participants took part in this well-organized meeting in the spacious and comfortable Toray Conf...
journal_title:Autophagy
pub_type:
doi:10.4161/auto.3654
更新日期:2007-03-01 00:00:00
abstract::Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary tangles. Dysregulated clearance of Aβ largely contributes to its accumulation and plaque formation in the brain. Macroautophagy/autophagy is a l...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2021.1872187
更新日期:2021-01-19 00:00:00
abstract::A pilot clinical trial based on nutritional modulation was designed to assess the efficacy of a one-year low-protein diet in activating autophagy in skeletal muscle of patients affected by COL6/collagen VI-related myopathies. Ullrich congenital muscular dystrophy and Bethlem myopathy are rare inherited muscle disorder...
journal_title:Autophagy
pub_type: 临床试验,杂志文章
doi:10.1080/15548627.2016.1231279
更新日期:2016-12-01 00:00:00
abstract::Protein misfolding is the common theme for neurodegenerative disorders including Huntington disease (HD), which is mainly caused by cytotoxicity of the mutant HTT (huntingtin) protein (mHTT). The soluble mHTT has an expanded polyglutamine (polyQ) stretch that may adopt multiple conformations, among which the one recog...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1382783
更新日期:2017-01-01 00:00:00
abstract::Autophagy is a lysosome-directed membrane trafficking event for the degradation of cytoplasmic components, including organelles. The past few years have seen a great advance in our understanding of the cellular machinery of autophagosome biogenesis, the hallmark of autophagy. However, our global understanding of autop...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6496
更新日期:2008-08-01 00:00:00
abstract::The yeast serine threonine kinase Atg1 appears to be a key regulator of autophagy and its kinase activity is crucial for autophagy induction. Recent reports have indicated that a mammalian Atg1 homolog, UNC-51-like kinase (ULK) 1, is required for autophagy. We found that ULK1 localizes to the autophagic isolation memb...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.1.7180
更新日期:2009-01-01 00:00:00
abstract::Minocycline has been shown to alleviate several neurological disorders. Unexpectedly, we found that minocycline had opposite effects on glioma cells: minocycline induced nonapoptotic cell death in glioma cells. The glioma cell death was associated with the presence of autophagic vacuoles in the cytoplasm. Minocycline ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.2.14043
更新日期:2011-02-01 00:00:00
abstract::Many recent studies indicate that dysregulation of autophagy is a common feature of many neurodegenerative diseases. The HIV-1-associated neurological disorder is an acquired cognitive and motor disease that includes a severe neurodegenerative dementia. We find that the neurodegeneration seen in the brain in HIV-1 inf...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6805
更新日期:2008-10-01 00:00:00
abstract::Quercetin, a dietary antioxidant present in fruits and vegetables, is a promising cancer chemopreventive agent that inhibits tumor promotion by inducing cell cycle arrest and promoting apoptotic cell death. In this study, we examined the biological activities of quercetin against gastric cancer. Our studies demonstrat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.9.15863
更新日期:2011-09-01 00:00:00
abstract::Macroautophagy/autophagy is an important catabolic process for maintaining cellular homeostasis by adapting to various stress conditions. Autophagy is mediated by a double-membrane autophagosome, which sequesters a portion of cytoplasmic components for delivery to the vacuole. Several autophagy-related (ATG) genes pla...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1746592
更新日期:2020-04-02 00:00:00
abstract::Cutaneous inflammation from UV radiation exposure causes epidermal damage, cellular infiltration, and secretion of pro-inflammatory mediators that exacerbate tissue destruction. Recovery is mediated chiefly by anti-inflammatory M2 macrophages that suppress inflammation and augment epidermal regeneration. Vitamin D ena...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1569298
更新日期:2019-05-01 00:00:00
abstract::Salinomycin is perhaps the first promising compound that was discovered through high throughput screening in cancer stem cells. This novel agent can selectively eliminate breast and other cancer stem cells, though the mechanism of action remains unclear. In this study, we found that salinomycin induced autophagy in hu...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.24632
更新日期:2013-07-01 00:00:00
abstract::Antagonizing the strongly activated pathway of autophagy in renal ischemic injury has been associated with poor outcome. In our recent study we used mice with a selective deletion of Atg5 in the S3 proximal tubule segment, which is most susceptible to ischemic damage. In line with the notion that autophagy is a prosur...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2015.1135284
更新日期:2016-01-01 00:00:00
abstract::Helicobacter pylori is a gram negative pathogen that infects at least half of the world's population and is associated not only with gastric cancer but also with other diseases such as gastritis and peptic ulcers. Indeed, H. pylori is considered the single most important risk factor for the development of gastric canc...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.6.1.10222
更新日期:2010-01-01 00:00:00
abstract::We demonstrated for the first time that the COP9 signalosome (COPS) controls the degradation of a surrogate and a bona fide misfolded protein in the cytosol of cardiomyocytes likely via supporting ubiquitination by CUL/cullin-RING ligases, and that Cops8 hypomorphism exacerbates cardiac proteinopathy in mice, in which...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2015.1136773
更新日期:2016-01-01 00:00:00
abstract::Heme is an essential molecule expressed in many tissues where it plays key roles as the prosthetic group of several proteins involved in vital physiological and metabolic processes such as gas and electron transport. Structurally, heme is a tetrapyrrole ring containing an atom of iron (Fe) in its center. When released...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1271515
更新日期:2017-03-04 00:00:00