Abstract:
:Autophagy removes long-lived proteins and damaged organelles and is important for maintaining cellular homeostasis. It can also serve in innate immunity to remove intracellular pathogens. As such, viruses have evolved different mechanisms to subvert this innate immune response. We have recently demonstrated that hepatitis C virus (HCV) can also suppress autophagic protein degradation by suppressing the fusion between autophagosomes and lysosomes. This suppression causes the accumulation of autophagosomes and enhances HCV RNA replication.(1) Our further analysis indicated that the induction of autophagosomes by HCV is dependent on the unfolded protein response (UPR). Our studies thus delineate a molecular pathway by which HCV induces autophagosomes. The prolonged perturbation of the autophagic pathway by HCV likely plays an important role in HCV pathogenesis.
journal_name
Autophagyjournal_title
Autophagyauthors
Sir D,Liang C,Chen WL,Jung JU,Ou JHdoi
10.4161/auto.6566subject
Has Abstractpub_date
2008-08-01 00:00:00pages
830-1issue
6eissn
1554-8627issn
1554-8635pii
6566journal_volume
4pub_type
杂志文章相关文献
Autophagy文献大全abstract::The precise degradation of dysfunctional mitochondria by mitophagy is essential for maintaining neuronal homeostasis. HTT (huntingtin) can interact with numerous other proteins and thereby perform multiple biological functions within the cell. In this study, we investigated the role of HTT during mitophagy and analyze...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1728096
更新日期:2020-02-24 00:00:00
abstract::One of the major side effects of cisplatin chemotherapy is toxic acute kidney injury due to preferential accumulation of cisplatin in renal proximal tubule epithelial cells and the subsequent injury to these cells. Apoptosis is known as a major mechanism of cisplatin-induced cell death in renal tubular cells. We have ...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.6309
更新日期:2008-07-01 00:00:00
abstract::Post-translational modifications of autophagy-related (ATG) genes are necessary to modulate their functions. However, ATG protein methylation and its physiological role have not yet been elucidated. The methylation of non-histone proteins by SETD7, a SET domain-containing lysine methyltransferase, is a novel regulator...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1389357
更新日期:2018-01-01 00:00:00
abstract::Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying therapeutic mechanisms are not fully understood, especially the paradox between the low survival rate of transplanted cells and the beneficial therapeutic effects generated by t...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1717128
更新日期:2020-12-01 00:00:00
abstract::Survival of environmental stress conditions requires the maintenance of cellular homeostasis. To preserve this balance, cells utilize a degradative mechanism known as autophagy. During this process, in response to starvation or other stresses, bulk cytoplasm is non-specifically sequestered within double-membrane vesic...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.4129
更新日期:2007-09-01 00:00:00
abstract::Photodynamic therapy (PDT) is a procedure that has applications in the selective eradication of neoplasia where sites of malignant lesions are clearly delineated. It is a two-step process whereby cells are first sensitized to light and then photoirradiated. This results in the formation of singlet molecular oxygen and...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.6.1.10220
更新日期:2010-01-01 00:00:00
abstract::Autophagy is a conserved homeostatic process in which cytoplasmic contents are degraded and recycled. Two ubiquitin-like conjugation pathways are required for the generation of autophagosomes, and ATG5 is necessary for both of these processes. Studies of mice deficient in ATG5 reveal a key role for autophagy in T lymp...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.23484
更新日期:2013-04-01 00:00:00
abstract::FTY720, a sphingosine analog, is a novel immunosuppressant currently undergoing multiple clinical trials for the prevention of organ transplant rejection and treatment of various autoimmune diseases. Recent studies indicate an additional cytotoxic effect of FTY720 and its preclinical efficacy in a variety of cancer mo...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13614
更新日期:2010-11-01 00:00:00
abstract::Chronic drinking leads to myocardial contractile dysfunction where ethanol metabolism plays an essential role. Acetaldehyde, the main ethanol metabolite, mediates alcohol-induced cell injury although the underlying mechanism is still elusive. This study was designed to examine the mechanism involved in accelerated eth...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.18997
更新日期:2012-04-01 00:00:00
abstract::Complex membrane trafficking events are involved in the regulation of antigen processing and presentation of both endogenous and exogenous antigens. While these processes were believed to involve mainly organelles along the endo/phagocytic and the biosynthetic pathways, recent studies have shown that autophagy also pa...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.7.9163
更新日期:2009-10-01 00:00:00
abstract::Autophagy is a degradative pathway conserved among eukaryotes. It is a major route for degradation of long-lived proteins and entire organelles, such as peroxisomes. Atg26, a sterol glucosyltransferase, is specifically required for micro- and macropexophagy, but not for starvation-induced bulk autophagy in Pichia past...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.3371
更新日期:2007-01-01 00:00:00
abstract::Tumor hypoxia underlies treatment failure and yields more aggressive and metastatic cancer phenotypes. Although therapeutically targeting these hypoxic environments has been proposed for many years, to date no approaches have shown the therapeutic value to gain regulatory approval. Here, we demonstrated that a novel h...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.26838
更新日期:2014-01-01 00:00:00
abstract::The accumulation of ubiquitin-positive protein aggregates has been implicated in the pathogenesis of neurodegenerative diseases, heart disease and diabetes. Emerging evidence indicates that the autophagy lysosomal pathway plays a critical role in the clearance of ubiquitin aggregates, a process that is mediated by the...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.5.12189
更新日期:2010-07-01 00:00:00
abstract::A steady increase in life expectancy has resulted in an equivalent increase in elderly patients who are more susceptible to diseases than young patients. In a recent study, we found that in both in vitro and in vivo models of ischemia/reperfusion (I/R), a loss of ATG4B is causatively associated with the increased sens...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.8.1.18391
更新日期:2012-01-01 00:00:00
abstract::Our laboratory has been investigating for some time the nature of the response of T lymphocytes in autoimmunity in the reactions against self-proteins that result in a number of diseases, such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis (RA) and others. T cells recognize peptides generated from protei...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19261
更新日期:2012-03-01 00:00:00
abstract::Here, we present a summary of our recent findings on the (patho-)physiological relevance of PINK1-phosphorylated ubiquitin (p-S65-Ub). Using novel polyclonal antibodies, we find that p-S65-Ub specifically accumulates on damaged mitochondria. Phosphorylation of ubiquitin on serine 65 depends on the activity of PINK1 an...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2015.1091912
更新日期:2015-11-02 00:00:00
abstract::Several recent reports have demonstrated that autophagy is induced in response to hypoxia in cultured cells. However, the mechanism and consequence of hypoxia-induced autophagy remains unclear as there is no consensus between these studies. In our recent report we show that, in human cancer cells, hypoxia cooperates w...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.7.9821
更新日期:2009-10-01 00:00:00
abstract::Mechanisms to protect against viral infections are crucial during pregnancy as maternal-fetal transmission can have serious pathological outcomes, including fetal infection and its sequelae, such as growth restriction, birth defects, and/or fetal death. The trophoblast forms the interface between the feto-placental un...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.26558
更新日期:2013-12-01 00:00:00
abstract::Tumor-associated inflammation is predictive of poor prognosis and drives a variety of tumorigenic phenotypes, including tumor proliferation and survival, angiogenesis, invasiveness, and metastasis. Here, we review mammalian data addressing the interaction of macroautophagy/autophagy with key signaling cascades associa...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2017.1345412
更新日期:2018-01-01 00:00:00
abstract::Mitochondrial quality control is an essential process required to maintain cellular homeostasis and functions. Mutations of PINK1 and PRKN/PARK2 contribute to the risk of Parkinson disease. Our recent findings indicate that depletion of Pink1 and Prkn promotes pancreatic tumorigenesis in KRAS-driven engineered mouse m...
journal_title:Autophagy
pub_type: 评论,杂志文章
doi:10.1080/15548627.2018.1526611
更新日期:2019-01-01 00:00:00
abstract::Autophagy and microRNA (miRNA) are important regulators during cancer cell tumorigenesis. Impaired autophagy and high expression of the oncogenic microRNA MIR224 are prevalent in hepatocellular carcinoma (HCC); however, the relationship between the 2 phenomena remains elusive. In this study, we are the first to reveal...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.29959
更新日期:2014-09-01 00:00:00
abstract::Mutations in the ER-associated VAPB/ALS8 protein cause amyotrophic lateral sclerosis and spinal muscular atrophy. Previous studies have argued that ER stress may underlie the demise of neurons. We find that loss of VAP proteins (VAPs) leads to an accumulation of aberrant lysosomes and impairs lysosomal degradation. VA...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1580103
更新日期:2019-07-01 00:00:00
abstract::The cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guerin (BCG/CWS) is an effective antitumor immunotherapy agent. Here, we demonstrate that BCG/CWS has a radiosensitizing effect on colon cancer cells through the induction of autophagic cell death. Exposure of HCT116 colon cancer cells to BCG/CWS before i...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.1.10325
更新日期:2010-01-01 00:00:00
abstract::Autophagy describes the degradation of unnecessary or dysfunctional cellular components through the lysosomal machinery. Autophagy is essentially required to prevent accumulation of cellular damage and to ensure cellular homeostasis. Indeed, impaired autophagy has been implicated in a variety of different diseases. We...
journal_title:Autophagy
pub_type: 评论,杂志文章
doi:10.4161/auto.25467
更新日期:2013-08-01 00:00:00
abstract::Multiple stress pathways result in the induction of autophagy and apoptosis. Current methods (e.g., protein gel blot, microscopy) do not offer quantitative single-cell resolution, thus making it difficult to discern if these pathways are mutually exclusive or, in some situations, cooperative in executing cell death. W...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.9.16252
更新日期:2011-09-01 00:00:00
abstract::Autophagy is a highly conserved intracellular degradation system, and recently was shown to display circadian rhythms in mice. The mechanisms underlying circadian regulation of autophagy, however, are still unclear. Here, we observed that numbers of autophagosomes and autolysosomes exhibit daily rhythms in the zebrafi...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1183843
更新日期:2016-08-02 00:00:00
abstract::An increasing body of data links endoplasmic reticulum (ER) function to autophagy. Not surprisingly, then, some aberrant proteins in the ER can be destroyed either via ER associated degradation (ERAD), which is proteasome-mediated, or via autophagy. One such substrate is the "Z" variant of the alpha-1 protease inhibit...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.4906
更新日期:2007-11-01 00:00:00
abstract::Adaptive immunity, which plays an important role in the development of atherosclerosis, is mediated by major histocompatibility complex (MHC)-dependent antigen presentation. In atherosclerotic lesions, macrophages constitute an important class of antigen-presenting cells that activate adaptive immune responses to oxid...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2015.1037061
更新日期:2015-01-01 00:00:00
abstract::Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary tangles. Dysregulated clearance of Aβ largely contributes to its accumulation and plaque formation in the brain. Macroautophagy/autophagy is a l...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2021.1872187
更新日期:2021-01-19 00:00:00
abstract::The relationship between macroautophagy/autophagy and miRNA in regulating cancer cell motility is not clearly delineated. Here, we found that induction of BECN1-dependent or -independent autophagy decreased ubiquitin-binding proteins SQSTM1/p62 and CALCOCO2/NDP52. Downregulation of SQSTM1 (but not CALCOCO2) led to a d...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1501135
更新日期:2018-01-01 00:00:00