Multistep regulation of TFEB by MTORC1.

abstract：:Increasing evidence suggests that misfolded proteins and intracellular aggregates contribute to cardiac disease and heart failure. We wished to determine if autophagic induction by Atg7 is sufficient to reduce misfolded protein and aggregate content in protein misfolding-stressed cardiomyocytes. We used loss- and gain...

journal_title：Autophagy

authors： Pattison JS,Robbins J

更新日期：2011-10-01 00:00:00

abstract：:Adaptive immunity, which plays an important role in the development of atherosclerosis, is mediated by major histocompatibility complex (MHC)-dependent antigen presentation. In atherosclerotic lesions, macrophages constitute an important class of antigen-presenting cells that activate adaptive immune responses to oxid...

journal_title：Autophagy

authors： Choi SH,Gonen A,Diehl CJ,Kim J,Almazan F,Witztum JL,Miller YI

更新日期：2015-01-01 00:00:00

abstract：:Apoptosis (programmed cell death type I) and autophagy (type II) are crucial mechanisms regulating cell death and homeostasis. The Bcl-2 proto-oncogene is overexpressed in 50-70% of breast cancers, potentially leading to resistance to chemotherapy, radiation and hormone therapy-induced apoptosis. Here, we investigated...

journal_title：Autophagy

authors： Akar U,Chaves-Reyez A,Barria M,Tari A,Sanguino A,Kondo Y,Kondo S,Arun B,Lopez-Berestein G,Ozpolat B

更新日期：2008-07-01 00:00:00

abstract：:It has been a longstanding problem to identify specific and efficient pharmacological modulators of autophagy. Recently, we found that depletion of acetyl-coenzyme A (AcCoA) induced autophagic flux, while manipulations designed to increase cytosolic AcCoA efficiently inhibited autophagy. Thus, the cell permeant ester ...

journal_title：Autophagy

authors： Mariño G,Pietrocola F,Kong Y,Eisenberg T,Hill JA,Madeo F,Kroemer G

更新日期：2014-05-01 00:00:00

abstract：:The uptake and degradation of cytoplasmic material by vacuolar autophagy in plants has been studied extensively by electron microscopy and shown to be involved in developmental processes such as vacuole formation, deposition of seed storage proteins and senescence, and in the response of plants to nutrient starvation ...

journal_title：Autophagy

authors： Bassham DC,Laporte M,Marty F,Moriyasu Y,Ohsumi Y,Olsen LJ,Yoshimoto K

更新日期：2006-01-01 00:00:00

abstract：:Complex membrane trafficking events are involved in the regulation of antigen processing and presentation of both endogenous and exogenous antigens. While these processes were believed to involve mainly organelles along the endo/phagocytic and the biosynthetic pathways, recent studies have shown that autophagy also pa...

journal_title：Autophagy

authors： English L,Chemali M,Desjardins M

更新日期：2009-10-01 00:00:00

abstract：:The RNA replication complexes of small positive-strand RNA viruses such as poliovirus are known to form on the surfaces of membranous vesicles in the cytoplasm of infected mammalian cells. These membranes resemble cellular autophagosomes in their double-membraned morphology, cytoplasmic lumen, lipid-rich composition a...

journal_title：Autophagy

authors： Taylor MP,Kirkegaard K

更新日期：2008-04-01 00:00:00

abstract：:Autophagy plays critical roles in plant responses to stress. In contrast to the wealth of information concerning the core process of plant autophagosome assembly, our understanding of the regulation of autophagy is limited. In this study, we demonstrated that transcription factor HsfA1a played a critical role in tomat...

journal_title：Autophagy

authors： Wang Y,Cai S,Yin L,Shi K,Xia X,Zhou Y,Yu J,Zhou J

更新日期：2015-11-02 00:00:00

abstract：:Autophagy is a conserved homeostatic process in which cytoplasmic contents are degraded and recycled. Two ubiquitin-like conjugation pathways are required for the generation of autophagosomes, and ATG5 is necessary for both of these processes. Studies of mice deficient in ATG5 reveal a key role for autophagy in T lymp...

journal_title：Autophagy

authors： Conway KL,Kuballa P,Khor B,Zhang M,Shi HN,Virgin HW,Xavier RJ

更新日期：2013-04-01 00:00:00

abstract：:The ability to respond and adapt to changes in the physical environment is a universal and essential cellular property. Here we demonstrated that cells respond to mechanical compressive stress by rapidly inducing autophagosome formation. We measured this response in both Dictyostelium and mammalian cells, indicating t...

journal_title：Autophagy

authors： King JS,Veltman DM,Insall RH

更新日期：2011-12-01 00:00:00

abstract：:During reticulocyte maturation, hematopoietic progenitors undergo numerous changes to reach the final functional stage which concludes with the release of reticulocytes and erythrocytes into circulation. During this process some proteins, which are not required in the mature stage, are sequestered in the internal vesi...

journal_title：Autophagy

authors： Fader CM,Colombo MI

更新日期：2006-04-01 00:00:00

abstract：:The critical role of the cellular autophagy pathway in viral infection and pathogenesis has become increasingly apparent. Mounting evidences suggest that viruses have developed different strategies to meticulously modulate intracellular autophagy for their own benefits, thereby either promoting efficient viral replica...

journal_title：Autophagy

authors： Liang C,E X,Jung JU

更新日期：2008-04-01 00:00:00

abstract：:Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and ...

journal_title：Autophagy

authors： Xie W,Jin S,Cui J

更新日期：2020-06-01 00:00:00

abstract：:The induction of autophagy appears to be tightly controlled in all eukaryotic cells. This highly conserved, degradative process is induced by a variety of signals, including nutrient deprivation, and is generally thought to be incompatible with rapid cell growth. Recent work in the budding yeast, Saccharomyces cerevis...

journal_title：Autophagy

authors： Stephan JS,Herman PK

更新日期：2006-04-01 00:00:00

abstract：:Selective autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. This process is a specific degradation pathway for a wide variety of substrates including unwanted cytosolic components, such as protein aggregates, damaged and/or superfluous organelles, and pathogens. Howeve...

journal_title：Autophagy

authors： Yin Z,Klionsky DJ

更新日期：2020-10-01 00:00:00

abstract：:Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD. Previous research has separately studied the effect of oxygen conc...

journal_title：Autophagy

authors： He R,Wang Z,Cui M,Liu S,Wu W,Chen M,Wu Y,Qu Y,Lin H,Chen S,Wang B,Shao Z

更新日期：2021-01-18 00:00:00

abstract：:The relationship between macroautophagy/autophagy and miRNA in regulating cancer cell motility is not clearly delineated. Here, we found that induction of BECN1-dependent or -independent autophagy decreased ubiquitin-binding proteins SQSTM1/p62 and CALCOCO2/NDP52. Downregulation of SQSTM1 (but not CALCOCO2) led to a d...

journal_title：Autophagy

authors： Liao CC,Ho MY,Liang SM,Liang CM

更新日期：2018-01-01 00:00:00

abstract：:Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell biologist and geneticist, I always find it easier to show a microscopy ...

journal_title：Autophagy

authors： Juhász G

更新日期：2019-11-01 00:00:00

abstract：:T lymphocytes, the master regulators of immunity, have an unusual lifestyle. Equipped with a clonally distributed receptor they remain resting for long periods of time but go into overdrive when encountering antigen. Antigen recognition triggers an activation program that results in massive proliferation, differentiat...

journal_title：Autophagy

authors： Yang Z,Goronzy JJ,Weyand CM

更新日期：2014-02-01 00:00:00

abstract：:Autophagy is a degradation pathway for the turnover of dysfunctional organelles or aggregated proteins in cells. Extracellular accumulation of beta-amyloid peptide has been reported to be a major cause of Alzheimer disease (AD) and large numbers of autophagic vacuoles accumulate in the brain of AD patient. However, ho...

journal_title：Autophagy

authors： Hung SY,Huang WP,Liou HC,Fu WM

更新日期：2009-05-01 00:00:00

abstract：:UVRAG is a promoter of the autophagy pathway, and its deficiency may fuel the development of cancers. Intriguingly, our recent study has demonstrated that this protein also mediates the repair of damaged DNA and patrols centrosome stability, mechanisms that commonly prevent cancer progression, in a manner independent ...

journal_title：Autophagy

authors： Zhao Z,Ni D,Ghozalli I,Pirooz SD,Ma B,Liang C

更新日期：2012-09-01 00:00:00

abstract：:We have previously shown that Kaposi sarcoma-associated herpesvirus (KSHV) impairs monocyte differentiation into dendritic cells (DCs). Macroautophagy/autophagy has been reported to be essential in such a differentiating process. Here we extended these studies and found that the impairment of DC formation by KSHV occu...

journal_title：Autophagy

authors： Santarelli R,Granato M,Pentassuglia G,Lacconi V,Gilardini Montani MS,Gonnella R,Tafani M,Torrisi MR,Faggioni A,Cirone M

更新日期：2016-12-01 00:00:00

abstract：:Oxidative stress-induced granulosa cell (GCs) death represents a common reason for follicular atresia. Follicle-stimulating hormone (FSH) has been shown to prevent GCs from oxidative injury, although the underlying mechanism remains to be elucidated. Here we first report that the suppression of autophagic cell death v...

journal_title：Autophagy

authors： Shen M,Jiang Y,Guan Z,Cao Y,Li L,Liu H,Sun SC

更新日期：2017-08-03 00:00:00

abstract：:In a recent paper we addressed the mechanism by which defective autophagy contributes to TARDBP/TDP-43-mediated neurodegenerative disorders. We demonstrated that TARDBP regulates MTORC1-TFEB signaling by targeting RPTOR/raptor, a key component and an adaptor protein of MTORC1. Loss of TARDBP decreased the mRNA stabili...

journal_title：Autophagy

authors： Ying Z,Xia Q,Hao Z,Xu D,Wang M,Wang H,Wang G

更新日期：2016-01-01 00:00:00

abstract：:Our laboratory has been investigating for some time the nature of the response of T lymphocytes in autoimmunity in the reactions against self-proteins that result in a number of diseases, such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis (RA) and others. T cells recognize peptides generated from protei...

journal_title：Autophagy

authors： Ireland JM,Unanue ER

更新日期：2012-03-01 00:00:00

abstract：:Pathological developments leading to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are associated with misbehavior of several key proteins, such as SOD1 (superoxide dismutase 1), TARDBP/TDP-43, FUS, C9orf72, and dipeptide repeat proteins generated as a result of the translation of th...

journal_title：Autophagy

authors： Uversky VN

更新日期：2017-01-01 00:00:00

abstract：:Phagocytosis plays a central role in immunity and tissue homeostasis. After internalization of cargo into single-membrane phagosomes, these compartments undergo a maturation sequences that terminates in lysosome fusion and cargo degradation. Components of the autophagy pathway have recently been linked to phagosome ma...

journal_title：Autophagy

authors： Cemma M,Grinstein S,Brumell JH

更新日期：2016-09-01 00:00:00

abstract：:Autophagy is a major pathway for the degradation of long-lived proteins and cytoplasmic organelles and an essential part of programmed cell death, as well. Our findings indicate that programmed cell death of the ovarian follicle cells in the higher Diptera species Bactrocera oleae and Ceratitis capitata manifests feat...

journal_title：Autophagy

authors： Nezis IP,Stravopodis DJ,Margaritis LH,Papassideri IS

更新日期：2006-10-01 00:00:00

abstract：:The vascular system of plants consists of two conducting tissues, xylem and phloem, which differentiate from procambium cells. Xylem serves as a transporting system for water and signaling molecules and is formed by sequential developmental processes, including cell division/expansion, secondary cell wall deposition, ...

journal_title：Autophagy

authors： Kwon SI,Cho HJ,Park OK

更新日期：2010-11-01 00:00:00

abstract：:Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75 percent of renal cell carcinoma (RCC) is associated with an inactivation of the tumor suppressor gene von Hippel-Lindau (VHL). We exploited the possibility of targeting VHL-deficient RCC through synthetic let...

journal_title：Autophagy

authors： Turcotte S,Sutphin PD,Giaccia AJ

更新日期：2008-10-01 00:00:00