Abstract:
:In the use of the case-study or problem-solving method of teaching epidemiology, the technique of the 'blind' problem, namely the withholding of the diagnosis of the disease until the end, presents many advantages. The student is forced to confront the purely epidemiological data without being prejudiced by his preconceived notions about the disease in question. In the study of an individual clinical case the objective is to make a diagnosis so that an accurate prognosis and specific treatment may be determined. So, in the study of an epidemic or outbreak (an epidemiological case) the objective is to establish a source of infection, a mode of spread or an aetiological factor, in order to predict a future trend and institute specific control measures. The 'blind' problem creates suspense, enhances the intellectual challenge, and permits the student and discussion leader to test a variety of hypotheses purely on the basis of the epidemiological evidence presented. An example of a localized epidemic is presented to illustrate these points.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Langmuir ADdoi
10.1093/ije/4.4.253subject
Has Abstractpub_date
1975-12-01 00:00:00pages
253-6issue
4eissn
0300-5771issn
1464-3685journal_volume
4pub_type
杂志文章abstract:BACKGROUND:The effect of antioxidant vitamin and mineral supplementation on health is one of the most controversial issues in human nutrition. Our objective was to investigate the effect of nutritional doses of a combination of antioxidant vitamins and minerals on health-related quality of life (HRQoL) in a sample of h...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyr161
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Ready-made spectacles (RMS) have advantages; however, visual performance and satisfaction has not been evaluated. METHODS:A 1-month, double-masked, randomized clinical trial comparing planned continued use and visual performance of RMS to Custom Spectacles (CS) in adults aged 18-45 years with > or =1 diopte...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyp384
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Mortality was compared in the Jewish populations of Montreal and Israel and the overall Canadian population, to investigate whether the Israeli pattern of low male mortality and relatively high female mortality is replicated among Jews living elsewhere. METHODS:In Montreal, death certificates were obtained ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.4.730
更新日期:1995-08-01 00:00:00
abstract::The total duration of 'ovulatory activity' or 'ovulatory age' has been reported to be the strongest indicator of the risk of ovarian cancer. In the case-control study examined in this paper this variable was found to be a strong correlate of the risk of ovarian cancer. However, the finding that in older women the majo...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/12.2.161
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:Mortality from smoking-related diseases in women is increasing worldwide. Studies comparing hazards associated with smoking in women and men based on a sufficient number of heavy smokers of both genders are lacking. METHODS:We used pooled data from three prospective population studies conducted in Copenhage...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.1.27
更新日期:1998-02-01 00:00:00
abstract::The reliability of casual blood pressures for reflecting blood pressure status and predicting cardiovascular sequelae of hypertension was examined in the Framingham cohort of 5209 men and women followed for 18 years. Blood pressures were more variable in persons with higher levels. After controlling for pressure level...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/5.4.327
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:A growing body of evidence supports the role of type 2 diabetes as an individual-level risk factor for tuberculosis (TB), though evidence from developing countries with the highest TB burdens is lacking. In developing countries, TB is most common among the poor, in whom diabetes may be less common. We assess...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyq238
更新日期:2011-04-01 00:00:00
abstract::The paper reports on the trends of induced abortion in Italy since its legalization in 1978. Data collected through the national surveillance system show that the abortion rates and ratios in Italy, after an initial increase, have been stable in the last four years, and are comparable to those of other European countr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/15.3.343
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:The relationship between cutaneous malignant melanoma and sunlamp use is examined in a Caucasian population in Connecticut, United States. METHODS:Cases were diagnosed between 15 January 1987 and 15 May 1987 with a first primary cutaneous melanoma. Controls were obtained from the general population, frequen...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.5.758
更新日期:1998-10-01 00:00:00
abstract::Monks in a rural community in northern Thailand were observed to conduct anti-smoking activities. To evaluate the effects of the monks' efforts on change of people's smoking behaviour and attitudes, we conducted a survey of adults > or = 15 years of age in this village (intervention village sample) and a randomly sele...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.4.660
更新日期:1993-08-01 00:00:00
abstract::Specificity of association between putative risk factor and disease under study is important to inference on causality. Nevertheless many studies investigate mortality of a single disease without comparison with a control. Age-standardized proportional mortality ratios make single disease studies into case-control stu...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.4.984
更新日期:1991-12-01 00:00:00
abstract::Occupation and industry classifications are used in epidemiological studies to classify study subjects according to their job and subsequently to study risk by job, to infer social class indicators, or to infer exposure to specific agents through job-exposure matrices. However, documentation on methodological aspects ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyg080
更新日期:2003-06-01 00:00:00
abstract:Background:Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx252
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:There is evidence that occupational factors that cause psychological strain can affect physical and mental health, but findings are not consistent. METHODS:Work satisfaction was used as a convenient global index of job-related psychological strain. Relationships with general, physical and emotional health, ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.1.98
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:To describe the seroepidemiology of Helicobacter pylori infection in a population of Egyptian children under 3 years. METHODS:A cohort of children under 36 months, residing in Abu Homos, Egypt, were visited at home twice weekly. Information regarding the child's breastfeeding status was obtained, and period...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/29.5.928
更新日期:2000-10-01 00:00:00
abstract::A review of the international epidemiological literature is undertaken with the view of identifying the main demographic and sociocultural features of MS as they apply to ethnic groups. Ethnic groups are differentiated principally in terms of three variables: race, religion, and nationality. Although MS is present in ...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/17.1.14
更新日期:1988-03-01 00:00:00
abstract::One task faced by public health surveillance practitioners is the timely identification of data patterns that might suggest the onset of an epidemic period. Many available techniques for analysis of surveillance data are based on sequential procedures, which predict expected numbers of cases and compare this estimate ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.2.408
更新日期:1994-04-01 00:00:00
abstract::The clustering of xerophthalmia in villages and in households was assessed among preschool children surveyed in the Lower Shire Valley, Malawi, and in Aceh province, Indonesia. Trachoma clustering was similarly assessed among the same children in Malawi. Trachoma clustered much more than xerophthalmia among villages a...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.4.865
更新日期:1988-12-01 00:00:00
abstract::The Birbhum HDSS was established in 2008 and covers 351 villages in four administrative blocks in rural areas of Birbhum district of West Bengal, India. The project currently follows 54 585 individuals living in 12557 households. The population being followed up is economically underprivileged and socially marginalize...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/dyu228
更新日期:2015-02-01 00:00:00
abstract::An outbreak of typhoid fever occurred in Chu-Tung township, Taiwan, with dates of onset from 6 July to 8 August, 1983. Fifty-four cases were hospitalized, of which 52 were laboratory confirmed. A chloramphenicol-resistant strain of Salmonella typhi was isolated from patients' blood samples. A community survey of 2772 ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.1.254
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Lower maternal serum vitamin B12 (B12) and folate levels have been associated with lower offspring birthweight, in observational studies. The aim of this study was to investigate whether this relationship is causal. METHODS:We performed two-sample Mendelian randomization (MR) using summary data on associati...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa256
更新日期:2020-12-21 00:00:00
abstract:BACKGROUND:The objective of this retrospective cohort study was to assess the effect of hysterectomy on subsequent risk of cancer among 25,382 hysterectomized and a similar number of non-hysterectomized control women, registered in 1963-1976 in the Mass Screening Registry (MSR). METHODS:Cancer cases were obtained from...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.3.476
更新日期:1997-06-01 00:00:00
abstract:Background:Bloodstream infections (BSI) cause considerable morbidity and mortality, and primary prevention should be a priority. Lifestyle factors are of particular interest since they represent a modifiable target. Methods:We conducted a prospective cohort study among participants in the population-based Norwegian HU...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx091
更新日期:2017-10-01 00:00:00
abstract::This paper contains part of the results of a repetitive and comprehensive analysis of accidents among bus drivers. In a series of articles different aspects of the aetiology of bus drivers' accidents will be highlighted. The results presented indicate a strong negative association of experience with accident risk, mod...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.1.35
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:Although individual studies have been inconsistent, meta-analyses of epidemiological data suggest that high folate and vitamin B12 levels may be associated with increased prostate cancer risk. METHODS:Within JANUS, a prospective cohort in Norway (n = 317 000) with baseline serum samples, we conducted a nest...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys199
更新日期:2013-02-01 00:00:00
abstract::The distribution of death certification rates from various cancers or groups of cancers in broad Italian geographical areas (north/centre/south) was analysed. In both sexes, total cancer mortality was considerably elevated in the north of the country compared to southern regions (around 70% for males and 30% for femal...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.4.538
更新日期:1985-12-01 00:00:00
abstract::Blood pressure levels were measured in 626 children (138 Japanese, 477 Bolivian and 11 of mixed blood) in a Japanese agricultural settlement in Bolivia. Systolic (SBP) and diastolic (DBP) blood pressure was higher in Japanese children than in Bolivian children at each measured age by 4.09 mmHg (P = 0.0001) and 2.25 mm...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.1.100
更新日期:1989-03-01 00:00:00
abstract::Estimating the number of people in hidden populations is needed for public health research, yet available methods produce highly variable and uncertain results. The Anchored Multiplier calculator uses a Bayesian framework to synthesize multiple population size estimates to generate a consensus estimate. Users submit p...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyz101
更新日期:2019-12-01 00:00:00
abstract::There has been a general decline in mortality from ischaemic heart disease (IHD) in Finland since the beginning of the 1970s. An intensified preventive programme was started in the province of North Karelia in 1972. Between 1974 and 1979 the decline in IHD mortality in North Karelian men was steeper than that in the r...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Computer stimulations have been used to estimate the efficiency, as measured by the statistical power, of various combinations of design and analysis strategies for case-control studies. Conditions under which the various forms of analysis yield consistent relative risk estimators are derived for the general model. Th...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/12.2.238
更新日期:1983-06-01 00:00:00