Metastasin leads to poor prognosis of hepatocellular carcinoma through partly inducing EMT.

abstract：:Platinum compounds and vinorelbine (VNB) are active in the treatment of non-small cell lung cancer (NSCLC), but moderate toxicity has been reported. The aims of the present study were to assess activity and tolerability of low dose carboplatin (CBDCA): 4.5 AUC according to Calvert formula on day 1, combined with vinor...

journal_title：Oncology reports

authors： Bretti S,Manzin E,Celano A,Ritorto G,Loddo C,Berruti A

更新日期：2001-03-01 00:00:00

abstract：:The aim of this study was to better understand the mechanisms of tumor development and disease progression in human epithelial ovarian cancer. Fifty genes were screened for gene signature; 20 expressed genes were assessed in tumor and normal samples of EOC patients by RT-PCR. Expres...

journal_title：Oncology reports

authors： Guo Y,Fu P,Zhu H,Reed E,Remick SC,Petros W,Mueller MD,Yu JJ

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to look for a new medicine in diagnosing and treating of glioblastoma. Radioiodine-labeled anti-epidermal growth factor receptor (EGFR) binding nanoparticles were constructed. In vitro cell-binding assays were confirmed by confocal microscopy and flow cytometry. Cell cytotoxicity assays were ...

journal_title：Oncology reports

authors： Li C,Tan J,Chang J,Li W,Liu Z,Li N,Ji Y

更新日期：2017-11-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin lymphoma. A20 and mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) are known to be related to DLBCL pathogenesis and progression. This study aimed to assess the effects of phorbol myristate acetate/ionomycin (PMA/IONO) on the growth a...

journal_title：Oncology reports

authors： Yang W,Li Y,Li P,Wang L

更新日期：2016-08-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT) is an attractive target for cancer gene therapy. However, the poor inhibition of telomerase and a time lag between the inhibition and arrest of cell proliferation limits its use in cancer gene therapy. RNA interference (RNAi) has been proposed as a potential technique for...

journal_title：Oncology reports

authors： Qian X,Cheng J,Chen A,Wang Y,Tao Y,Cao J,Feng Z

更新日期：2008-02-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors of HBV, HBV X protein (HBx) is attracting increased attention. Although it is documented that HBx is a multifunctional regulator that modulates cell inflammation and apoptosis, the exact mechanism r...

journal_title：Oncology reports

authors： Gao WY,Li D,Cai DE,Huang XY,Zheng BY,Huang YH,Chen ZX,Wang XZ

更新日期：2017-01-01 00:00:00

abstract：:Activating mutations of Ras gene families have been found in a variety of human malignancies, including lung cancer, suggesting their dominant role in tumorigenesis. Many studies have showed that the Kras gene is activated by point mutations in approximately 15-20% of non-small cell lung cancers (NSCLCs), however, the...

journal_title：Oncology reports

authors： Sasaki H,Okuda K,Kawano O,Endo K,Yukiue H,Yokoyama T,Yano M,Fujii Y

更新日期：2007-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common form of adult liver cancer and accounts for approximately 90% of all cases of primary liver cancer annually. Rhotekin (RTKN), which functions as a cancer promoter, can be frequently detected in many human cancers, including gastric cancer, colorectal carcinoma and blad...

journal_title：Oncology reports

authors： Zhou J,Zhang Y,Qi Y,Yu D,Shao Q,Liang J

更新日期：2017-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) play crucial roles in the initiation and progression of various cancers, including melanoma. Recently, the genetic variants and deregulation of miR-605 have been reported to participate in carcinogenesis. However, the expression status of the miR-605 in melanoma tissues and its role in melanoma prog...

journal_title：Oncology reports

authors： Chen L,Cao Y,Rong D,Wang Y,Cao Y

更新日期：2017-08-01 00:00:00

abstract：:The aim of this study was to define the clinical implications of semi-quantitative telomerase activity in gynecological tumors by comparing the telomerase activity of cancerous lesion and the adjacent non-cancerous lesion. In 118 cases of gynecologic tumors, including 41 uterine cervical tumors, 43 uterine body tumors...

journal_title：Oncology reports

authors： Sakamoto M,Toyoizumi T,Kikuchi Y,Okamoto A,Nakayama H,Aoki D,Yamamoto K,Hata H,Sugishita T,Tenjin Y

更新日期：2000-09-01 00:00:00

abstract：:The drug sensitivity of tumor cells is one of key issues to explore individualized therapy for cancer patients. One of such methods is in vitro anticancer drug sensitivity test which is generally based on one drug concentration and contact time. In this study, 5-fluorouracil (5-FU) sensitivity of cancer cells from col...

journal_title：Oncology reports

authors： Ochiai T,Nishimura K,Noguchi H,Kitajima M,Tsuruoka Y,Takahashi Y

更新日期：2005-07-01 00:00:00

abstract：:In this work we studied the effect of v-raf and different form RAF on up regulation of VEGF gene expression and angiogenesis. In the experiments the truncated forms of RAF1 gene were transfected into the cells of the established human urothelial line HCV-29, otherwise non-angiogenic. The plasmids coding for mitochondr...

journal_title：Oncology reports

authors： Malecki M,Seneta M,Miloszewska J,Trembacz H,Przybyszewska M,Janik P

更新日期：2004-01-01 00:00:00

abstract：:Cytochalasin B (CB) is a cell-permeable mycotoxin. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments, it inhibits cell movement and induces nuclear extrusion. In the present study, we investigated the anticancer activity of CB in HeLa human cervical carcinoma cells. CB showed sig...

journal_title：Oncology reports

authors： Hwang J,Yi M,Zhang X,Xu Y,Jung JH,Kim DK

更新日期：2013-10-01 00:00:00

abstract：:It has been shown that deguelin, one of the compounds of rotenoids from flavonoid family, induced cytotoxic effects through induction of cell cycle arrest and apoptosis in many types of human cancer cell lines, but deguelin-affected DNA damage and repair gene expression (mRNA) are not clarified yet. We investigated th...

journal_title：Oncology reports

authors： Ji BC,Yu CC,Yang ST,Hsia TC,Yang JS,Lai KC,Ko YC,Lin JJ,Lai TY,Chung JG

更新日期：2012-04-01 00:00:00

abstract：:Endometrial cancer is a common gynecological malignancy with a good prognosis in early stages of the disease. The CpG island in the promoter region of tumor-suppressor genes are frequently methylated in various types of human cancers. In the present study, we examined the methylation status of the GSTP1, CDH1 and RASS...

journal_title：Oncology reports

authors： Fiolka R,Zubor P,Janusicova V,Visnovsky J,Mendelova A,Kajo K,Lasabova Z,Plank L,Danko J

更新日期：2013-12-01 00:00:00

abstract：:Melanoma is the most aggressive cutaneous cancer due to its propensity to metastasise and proliferate. Melanoma accounts for 80‑90% of skin‑cancer related deaths worldwide. Alhough numerous published studies have attempted to define the markers of diagnosis and prognosis of melanoma, a sensitive and specific biomarker...

journal_title：Oncology reports

authors： Wei C,Lu N,Wang L,Zhang Y,Feng Z,Yang Y,Qi F,Gu J

更新日期：2018-06-01 00:00:00

abstract：:An arsenical compound, As2O3 has been reported to be effective for treating acute leukemia and induce apoptosis in many different tumor cell types. In this study we designed a novel arsenical compound, As4O6, and compared its ability to induce cell growth inhibition as well as gene expression profiles along with As2O3...

journal_title：Oncology reports

authors： Ahn WS,Bae SM,Lee KH,Kim YW,Lee JM,Namkoong SE,Lee IP,Kim CK,Seo JS,Sin JI,Kim YW

更新日期：2004-09-01 00:00:00

abstract：:Cancer cells in ascites are usually exposed to a hypoxia tumor microenvironment and utilize enhanced glycolysis which produces energy and metabolizes nutrients to support proliferation. Vesicular stomatitis virus (VSV) is an oncolytic virus that relies on the host cellular metabolism for replication. We tested the eff...

journal_title：Oncology reports

authors： Zhou Y,Wen F,Zhang P,Tang R,Li Q

更新日期：2016-03-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is a malignant hematological disease. Tanshinone IIA (Tan IIA) has antitumor activity in vitro and in vivo. The aim of the present study was to investigate the effects of Tan IIA in combination with imatinib (IM) on the proliferation, apoptosis, migration and invasion of acute T lymp...

journal_title：Oncology reports

authors： Teng Z,Xu S,Lei Q

更新日期：2020-02-01 00:00:00

abstract：:A patient who had undergone radical gastrectomy for synchronous gastric cancer (T(1)N(0)M(0), stage I) and duodenal cancer (Tis, stage 0) in November 1987 was found to have esophageal cancer in November 1994, and underwent radical thoracolaparotomy at our hospital (T(1)N(0)M(0), stage I). After follow-up for about 3.5...

journal_title：Oncology reports

authors： Mukai M,Makuuchi H,Mukohyama S,Oida Y,Himeno S,Nishi T,Nakazaki H,Satoh S

更新日期：2001-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs of 20-25 nucleotides in length that are capable of modulating gene expression post-transcriptionally. The potential roles of miRNAs in the tumorigenesis of glioblastoma (GBM) have been under intensive studies in the past few years. In the present study, we found a positive ...

journal_title：Oncology reports

authors： Jiang H,Hua D,Zhang J,Lan Q,Huang Q,Yoon JG,Han X,Li L,Foltz G,Zheng S,Lin B

更新日期：2014-05-01 00:00:00

abstract：:Livistona chinensis seeds have been used for centuries to clinically treat various types of cancer. Our published data suggest that Livistona chinensis seeds are able to inhibit hepatocellular carcinoma (HCC) growth in vitro and in vivo via promotion of mitochondrial-dependent apoptosis. To further elucidate the molec...

journal_title：Oncology reports

authors： Lin W,Zhao J,Cao Z,Zhuang Q,Zheng L,Zeng J,Hong Z,Peng J

更新日期：2014-04-01 00:00:00

abstract：:The TP53 mutation (R175H) is one of the most common mutations in human cancer. It is a highly attractive strategy for cancer therapy to find the genes that lead the R175H-expressing cancer cells. The aim of this study was to identify the synthetic sick/lethal gene interacting with R175H. Using lentiviral bar-coded com...

journal_title：Oncology reports

authors： Imai H,Kato S,Sakamoto Y,Kakudo Y,Shimodaira H,Ishioka C

更新日期：2014-03-01 00:00:00

abstract：:To estimate the incidence of Epstein-Barr virus-associated gastric carcinoma (EBV-GC) in Colombia and to clarify its clinicopathological features, we examined 178 consecutive gastric carcinoma cases, diagnosed during the period from 1996 to 1998, at Hospital Universitario del Valle in Cali, Colombia. The mean age of t...

journal_title：Oncology reports

authors： Carrascal E,Koriyama C,Akiba S,Tamayo O,Itoh T,Eizuru Y,Garcia F,Sera M,Carrasquilla G,Piazuelo MB,Florez L,Bravo JC

更新日期：2003-07-01 00:00:00

abstract：:IFN-alpha regulates tumor cell growth at least through induction of apoptosis. We have recently demonstrated that IFN-alpha causes apoptosis through upregulation of TNF-related apoptosis-inducing ligand (TRAIL) in Daudi B lymphoma and U266 myeloma cells. However, other cell lines such as Ramos and RPMI 8226 underwent ...

journal_title：Oncology reports

authors： Yanase N,Kanetaka Y,Mizuguchi J

更新日期：2007-10-01 00:00:00

abstract：:microRNAs (miRNAs) are known to be involved in the pathogenesis of hepatocellular carcinoma (HCC). miR-128-3p was recently reported to be deregulated in several types of cancer. However, the biological function and potential mechanisms of miR-128-3p in HCC remain unknown. In the present study, we found that miR-128-3p...

journal_title：Oncology reports

authors： Huang CY,Huang XP,Zhu JY,Chen ZG,Li XJ,Zhang XH,Huang S,He JB,Lian F,Zhao YN,Wu GB

更新日期：2015-06-01 00:00:00

abstract：:The tumour suppressor protein p53 (wild-type = wt-p53) is of major importance in the genetic integrity of the cell. Mutations of the p53-gene (mt-p53) are the most frequent genetic aberrations identified in different tumour entities. As analyzed in a wide variety of human malignomas, mt-p53 evokes a specific immune re...

journal_title：Oncology reports

authors： Cordes C,Von Lingen J,Görögh T,Ambrosch P,Gottschlich S,Hoffmann M

更新日期：2009-12-01 00:00:00

abstract：:Emodin (EMO) has been shown to possess pleiotropic anticancer capabilities in many types of cancer, including epithelial ovarian cancer (EOC). Inhibitory efficacy of EMO on EOC invasion and migration was previously observed, however, the underlying mechanisms have not been completely elucidated. The present study is a...

journal_title：Oncology reports

authors： Hu C,Dong T,Li R,Lu J,Wei X,Liu P

更新日期：2016-04-01 00:00:00

abstract：:Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend on different cellular mechanisms ...

journal_title：Oncology reports

authors： Zhou J,Hu Q,Zhang X,Zheng J,Xie B,Xu Z,Zhang W

更新日期：2018-04-01 00:00:00

abstract：:Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a long non‑coding RNA (lncRNA) that has an oncogenic role in some types of cancers, uncluding breast cancer (BC). To investigate the role of MALAT1 in human BC progression, we detected MALAT1 expression levels based on tissue samples from 20 BC cases a...

journal_title：Oncology reports

authors： Huang XJ,Xia Y,He GF,Zheng LL,Cai YP,Yin Y,Wu Q

更新日期：2018-11-01 00:00:00