Abstract:
:The aim of this study was to look for a new medicine in diagnosing and treating of glioblastoma. Radioiodine-labeled anti-epidermal growth factor receptor (EGFR) binding nanoparticles were constructed. In vitro cell-binding assays were confirmed by confocal microscopy and flow cytometry. Cell cytotoxicity assays were evaluated by MTT assay; radionuclide uptake assays were performed by γ-counter. Radioiodine-imaging studies were conducted using a xenograft nude mouse model in vivo. The results showed that EGFR significantly enhanced the uptake and accumulation of BSA-PCL in the experimental model of xenografts in nude mice, suggesting improved specific nanoparticle-based delivery. In conclusion, the data showed 131I-EGFR-BSA-PCL leading radioiodine therapy for U251 and U87 cells had a good effect in vitro and in vivo. Thus, 131I-EGFR-BSA-PCL may provide a new method for glioblastoma treatment.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Li C,Tan J,Chang J,Li W,Liu Z,Li N,Ji Ydoi
10.3892/or.2017.5937subject
Has Abstractpub_date
2017-11-01 00:00:00pages
2919-2926issue
5eissn
1021-335Xissn
1791-2431journal_volume
38pub_type
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