Abstract:
:Oxymatrine, a traditional Chinese herb extracted from Sophora flavescens Ait., displays strong anti-inflammatory and anticancer activities, but how oxymatrine exhibits anticarcinogenic effects in human colorectal cancer (CRC) remains uncertain. The present study aimed to elucidate the exact mechanism by which oxymatrine exhibits anticarcinogenic effects in CRC using the human colon cancer RKO cell line as the experimental model. CRC cells were treated with oxymatrine, and cell proliferation, migration and invasion were examined by colorimetric MTT, Transwell chamber and wound healing assays, respectively. In addition, epithelial-mesenchymal transition (EMT) markers and p65 were assessed by western blot analysis. Our study demonstrated that oxymatrine hindered the proliferation, migration and invasion of the CRC cells. Mechanistically, we found that oxymatrine modulated the expression of EMT markers including E-cadherin, Snail and N-cadherin, and reduced expression of p65 which is crucial to NF-κB activation. In conclusion, our results indicate that oxymatrine reduces the activation of the NF-κB signaling pathway and inhibits CRC invasion by modulating EMT.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Liang L,Huang Jdoi
10.3892/or.2016.4927subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1333-8issue
3eissn
1021-335Xissn
1791-2431journal_volume
36pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::The growth inhibitory effects of bufadienolide compounds were investigated in two intractable cancer cells, a human glioblastoma cell line U-87 and a pancreatic cancer cell line SW1990. Among four bufadienolide compounds, a dose-dependent cytotoxicity was observed in these cancer cells after treatment with gamabufotal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4946
更新日期:2016-09-01 00:00:00
abstract::Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend on different cellular mechanisms ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6242
更新日期:2018-04-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) patients with epithelial growth factor receptor (EGFR) mutations and bone metastases are often concurrently administered tyrosine kinase inhibitors (TKIs) and bisphosphonates. Yet, the effects and mechanisms of these agents are unclear. In the present study, we aimed to ascertain whe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4741
更新日期:2016-06-01 00:00:00
abstract::Regulatory T cells (Tregs) play an important role in maintaining immunological tolerance. However, this mechanism is one of the major obstacles to overcome when attempting to improve antitumor immunity. Protein-bound polysaccharide‑K (PSK) has been used clinically as an antitumor drug, and one of its antitumor mechani...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2834
更新日期:2014-01-01 00:00:00
abstract::Although many studies have been conducted on the role of alternative medicine in the treatment of cancer, only a few reports have been published regarding the total regression of malignant tumors. At the PBH Research Foundation (PBHRF), two of the authors have used homoeopathic therapy to treat many patients with vari...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract::To evaluate the efficacy of long-term postoperative adjuvant chemotherapy with low-dose cisplatin (CDDP) plus 5-fluorouracil (5-FU) (CDDP/5-FU), we retrospectively examined 167 patients with squamous cell carcinoma of the esophagus who received the treatment after curative surgery (R0 resection). We classified the pat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract::Somatic inactivation of the von Hippel-Lindau (VHL) gene is the most frequent genetic event observed in clear cell renal cell carcinoma (CC-RCC). However, the prognostic relevance of somatic VHL alteration and its target, hypoxia inducible factor (HIF)-1alpha has not been defined. We investigated the genetic changes i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::We have recently shown that covalent attachment of the nitric oxide (NO) moiety to the HIV protease inhibitor Saquinavir (Saq) produced a qualitatively new chemical entity, named Saquinavir-NO (Saq-NO), with enhanced anticancer properties and reduced toxicity both in vitro and in vi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1840
更新日期:2012-08-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are associated with invasion and metastasis of several human malignant tumors. Especially so MMP-7, as it is mainly produced by the actual cancer cells. However, the expression of MMP-7 in transitional cell carcinoma (TCC) of the urinary bladder has not been previously investigated. We...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::WNT/planar cell polarity (PCP) signaling pathway controls tissue polarity and cell movement through the activation of RHOA, c-Jun N-terminal kinase (JNK), and nemo-like kinase (NLK) signaling cascades. PCP is induced in Drosophila by the asymmetrical localization of Frizzled-Dishevelled-Diego-Starry night (Flamingo) c...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2005-12-01 00:00:00
abstract::Cetuximab, an IgG1 monoclonal antibody against the epidermal growth factor receptor (EGFR), is widely used for the treatment of metastatic colorectal cancer (mCRC). One of the mechanisms of action is considered to be antibody-dependent cell-mediated cytotoxicity (ADCC) triggered by Fcγ-R on natural killer cells. Howev...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3077
更新日期:2014-05-01 00:00:00
abstract::The present study aimed to investigate the effects of cold atmospheric plasma (CAP)‑activated Ringer's solution on osteosarcoma cell lines MG63 and U2OS, and to identify the molecular mechanism underlying these effects. CAP‑activated Ringer's solution was used to treat osteosarcoma cell lines MG63 and U2OS for 30 min....
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7518
更新日期:2020-05-01 00:00:00
abstract::More than 80% of hepatocellular carcinoma (HCC) arises in HBV based liver cirrhotic patients, suggesting that patients with cirrhosis form the main risk group of HCC. α fetoprotein (AFP) has poor sensitivity for the detection of AFP-negative and/or small tumors in HCC patients. Screening serum markers, along with HCC ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000982
更新日期:2010-11-01 00:00:00
abstract::Honokiol (HNK), a potential antitumor compound, has been widely studied in recent years. It induces apoptosis and affects autophagy in cancer cells, yet the mechanism of its antitumor efficacy remains obscure. Chloroquine (CQ), an autophagy inhibitor, is often applied to sensitize antitumor drugs in clinical trials. H...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4091
更新日期:2015-09-01 00:00:00
abstract::Thymidine kinase-1 (TK-1) and thymidylate synthase (TS) are key enzymes for salvage and de novo pyrimidine synthesis, respectively. Numerous studies have suggested that increased TS levels are associated closely with resistance to fluoropyrimidine-based chemotherapy. TAS-102 is a novel drug containing trifluorothymidi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000770
更新日期:2010-05-01 00:00:00
abstract::SRY-box containing gene 17 (Sox17), a transcription factor, is considered as an antagonist to canonical Wnt/β‑catenin signaling in several types of malignant tumors. As the influence of Sox17 in the pathogenesis of human melanoma is still unknown, the investigation of Sox17 expression in melanoma is warranted and its ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3534
更新日期:2014-12-01 00:00:00
abstract::Mast cell-derived chymase promotes inflammatory responses and tissue fibrosis. Although previous studies have reported changes in the number of mucosal mast cells in inflammatory bowel disease (IBD), the behaviour of chymase immunopositive mast cells has not been studied. In this study, we immunohistochemically invest...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNAs that are involved in tumor initiation and development by suppressing target gene expression. miRNA-154 has been shown to be important in tumorigenesis in many types of cancers. However, its role in osteosarcoma (OS) remains unknown. In the present study, we focused on the r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4495
更新日期:2016-03-01 00:00:00
abstract::B-cell‑specific Moloney murine leukaemia virus integration site-1 (BMI-1) contributes to the growth of tumour cells post-irradiation (IR). The aim of the present study was to characterize the effects of BMI-1 on cell viability, radiosensitivity and its mechanisms of action in oesophageal squamous cell cancer (ESCC). W...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6136
更新日期:2018-02-01 00:00:00
abstract::Thymidylate synthase (TS) is the rate-limiting enzyme in the synthesis of pyrimidine nucleotides, required for DNA synthesis, and is also a critical target for fluoropyrimidines, which are widely used in the treatment of gastrointestinal tumours. We examined TS expression in tumours from 86 patients with advanced colo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.14.3.657
更新日期:2005-09-01 00:00:00
abstract::Expression of miR-365 has been reported to be downregulated in hepatocellular carcinoma (HCC). However, the biological function and underlying mechanism of miR-365 in HCC growth and metastasis remain unclear. The aim of the present study was to explore the role of miR-365 in HCC progression. We found that miR-365 expr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5423
更新日期:2017-03-01 00:00:00
abstract::Human colon cancer cells were implanted subcutaneously into nude mice. After 12 days, the animals were divided into two groups. The first group received 40 microg/kg body weight of octreotide, galanin and serotonin via an intraperitoneally implanted pump. The second group received sterile saline only. Treatment lasted...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Prostate specific antigen (PSA) is still the best available tumour marker in prostate cancer (PCa), but presents some limits. Therefore, there is a need for novel markers in the detection and management of PCa. The 80-kDa soluble form of E-cadherin (sE-cad) and the cytokine IL-6 are being discussed as supplemental ser...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1785
更新日期:2012-07-01 00:00:00
abstract::Hepatocyte growth factor (HGF) was suggested to play an important role in the regulation of mitogenesis, motogenesis, angiogenesis, migration and invasion for various types of cells, and acts through a specific membrane receptor encoded by c-met proto-oncogene. However, the mechanism of the effect of HGF on tumor inva...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::Casticin, one of the main components from Fructus Viticis, has been reported to inhibit the growth of various cancer cells, including the human cervical cancer cell line HeLa. The purpose of this study was to examine the apoptotic activity and molecular mechanism of casticin action on human cervical cancer cells. The ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1367
更新日期:2011-11-01 00:00:00
abstract::Mammary stem cells (MSCs) are the progenitor population for human breast epithelia. MSCs give rise during mammary gland development to estrogen receptor (ER)-negative basal cells and the ER- luminal progenitor (LP) population which maintains ER+ and ER- luminal cells. The MSC population is expanded and tumorigenic in ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4003
更新日期:2015-07-01 00:00:00
abstract::Semaphorin 3A (SEMA3A), a secretory protein, is a founding member of the semaphorin family and functions in both the biological behavior of tumor cells and the modulation of tumor-associated macrophages. However, the role of SEMA3A in hepatocellular carcinoma (HCC) is still not well established. In the present study, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5616
更新日期:2017-06-01 00:00:00
abstract::Gallbladder cancer (GBC) is a rare disease associated with an extremely poor patient prognosis, and occasionally, aberrant expression of p53 is present. Considering that p53 is one of the most widely studied tumor‑suppressor genes, we used a cell-penetrating peptide, 11R, to enhance the transferring efficiency of the ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2511
更新日期:2013-08-01 00:00:00
abstract::The aim of the present study was to investigate the expression, function and underlying molecular mechanism of the long non‑coding (lnc) RNA RP1‑163G9.1 in patients with gastric adenocarcinoma (GA). The expression levels of lncRNA RP1‑163G9.1 were determined in 112 paired clinical GA tissues by reverse transcription‑q...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7127
更新日期:2019-06-01 00:00:00
abstract::Activation of ras genes and human papilloma virus (HPV) infection have been extensively described in cervical carcinomas while information concerning their implication in premalignant lesions of the cervix is limited. We investigated the incidence of K-ras codon 12 point mutations and HPV infection in cases of cervici...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00