Inhibition of cell growth and induction of apoptosis in human prostate cancer cell lines by 6-aminoquinolone WM13.

abstract：:It is known that the TGF-β superfamily receptors act as master regulators of cancer progression. However, alteration and role of type III TGF-β receptor (TβRIII, or betaglycan) as the most abundant of the TGF-β receptor has not been explored in salivary gland adenoid cystic carcinoma (ACC). Here, we reported that tumo...

journal_title：Oncology reports

authors： Xu D,Li D,Lu Z,Dong X,Wang X

更新日期：2016-01-01 00:00:00

abstract：:Cell cycle control is a promising target in cancer treatments, and some small-molecule cyclin-dependent kinase (CDK) inhibitors have exhibited clinical effectiveness. However, no biomarkers predictive of efficacy have been developed. Recent studies have revealed that CDK inhibitor (CKI) proteins, such as p27 and p16, ...

journal_title：Oncology reports

authors： Okada Y,Kato S,Sakamoto Y,Oishi T,Ishioka C

更新日期：2017-07-01 00:00:00

abstract：:Neoadjuvant chemotherapy is often used in the treatment of advanced esophageal cancer. In this study, we determined the impact of chemotherapy on microRNA (miRNA) expression in esophageal cancer cells, and whether identified changes might have biological relevance. Two esophageal carcinoma cell lines (one adenocarcino...

journal_title：Oncology reports

authors： Hummel R,Wang T,Watson DI,Michael MZ,Van der Hoek M,Haier J,Hussey DJ

更新日期：2011-10-01 00:00:00

abstract：:Lapatinib, an inhibitor of human epidermal growth factor receptor 2 (HER2) phosphorylation, has been reported to inhibit several types of tumors such as HER2-overexpressing breast cancer. However, the effect of lapatinib on the malignant phenotype of human osteosarcoma (OS) cells and the potential molecular mechanisms...

journal_title：Oncology reports

authors： Long XH,Zhang GM,Peng AF,Luo QF,Zhang L,Wen HC,Zhou RP,Gao S,Zhou Y,Liu ZL

更新日期：2014-01-01 00:00:00

abstract：:Recently, overexpression of EphA2, a member of the Eph family of receptor tyrosine kinases, has been reported in several cancers. Reduced expression of E-cadherin, an intercellular adhesion molecule of epithelial cells, has been reported to be associated with aggressive clinicopathological phenotypes in various cancer...

journal_title：Oncology reports

authors： Saito T,Masuda N,Miyazaki T,Kanoh K,Suzuki H,Shimura T,Asao T,Kuwano H

更新日期：2004-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs of 20-25 nucleotides in length that are capable of modulating gene expression post-transcriptionally. The potential roles of miRNAs in the tumorigenesis of glioblastoma (GBM) have been under intensive studies in the past few years. In the present study, we found a positive ...

journal_title：Oncology reports

authors： Jiang H,Hua D,Zhang J,Lan Q,Huang Q,Yoon JG,Han X,Li L,Foltz G,Zheng S,Lin B

更新日期：2014-05-01 00:00:00

abstract：:The present study determined the anticancer activity and its mechanism of microRNA‑133b on cell proliferation of cisplatin-induced non-small cell lung cancer cells. The expression of microRNA-133b cisplatin‑induced non-small cell lung cancer (NSCLC) tissue was lower than that of para-carcinoma tissue in patients. Over...

journal_title：Oncology reports

authors： Li B,Ding CM,Li YX,Peng JC,Geng N,Qin WW

更新日期：2018-03-01 00:00:00

abstract：:Acquired chemoresistance refers to tumor cells gradually losing their sensitivity to anticancer drugs during the course of treatment, resulting in tumor progression or recurrence. This phenomenon, which has deleterious outcomes for the patient, has long been observed in patients with glioblastoma receiving temozolomid...

journal_title：Oncology reports

authors： Lin J,Zuo J,Cui Y,Song C,Wu X,Feng H,Li J,Li S,Xu Q,Wei W,Qiu G,He H

更新日期：2018-05-01 00:00:00

abstract：:We investigated cell susceptibility to hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines (RYSTs) and attempted to correlate this with the known potentially relevant molecular determinants of apoptosis, p53 protein status, Bcl-2 family of proteins and heat shock proteins (Hsp). Parent cell line, NMT-1...

journal_title：Oncology reports

authors： Islam MS,Mitsuhashi N,Akimoto T,Sakurai H,Hasegawa M,Ishikawa H,Niibe H

更新日期：2001-05-01 00:00:00

abstract：:In a screen for thoracic malignancy-associated markers, thyroid stimulating hormone receptor (TSHR) was identified as a candidate as it binds to the previously-characterized lung cancer marker NKX2-1. We screened for mutations in all coding regions of the TSHR gene in 96 lung adenoc...

journal_title：Oncology reports

authors： Kim JW,Lee S,Lui N,Choi H,Mulvihill M,Fang LT,Kang HC,Kwon YW,Jablons D,Kim IJ

更新日期：2012-10-01 00:00:00

abstract：:We established a new cell line (ACCNS) from human adenoid cystic carcinoma (AdCC) of the maxilla, using tissue culture techniques and it has been successfully subcultured for more than 100 passages during 2 years. The population doubling time was approximately 39.2 h on a plastic dish. In type I collagen gel culture, ...

journal_title：Oncology reports

authors： Tanaka N,Urabe K,Hashitani S,Sakurai K,Urade M

更新日期：2007-02-01 00:00:00

abstract：:Four tumour suppressor genes (Chk1, Chk2, Apaf1 and Rb1) in nine human malignant melanoma cell lines were screened for a loss of gene expression, point mutations and small deletions/insertions by cDNA-based DGGE/SCCP analysis. In two cell lines alterations of the investigated genes could be demonstrated. This result c...

journal_title：Oncology reports

authors： Papp T,Niemetz A,Dosdahl N,Kumar K,Schiffmann D

更新日期：2007-01-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) caused by NF1 gene mutation is a commonly inherited autosomal dominant disorder. Malignant peripheral nerve sheath tumors (MPNSTs), a type of aggressive sarcoma, are a major cause of mortality in NF1 patients. The malignant transformation of benign plexiform neurofibromas (PNs) to MPNSTs...

journal_title：Oncology reports

authors： Park GH,Lee SJ,Yim H,Han JH,Kim HJ,Sohn YB,Ko JM,Jeong SY

更新日期：2014-10-01 00:00:00

abstract：:nm23-H1, a nucleoside diphosphate kinase (NDPK), enhances drug sensitivity and has antimetastatic activity, whereas focal adhesion kinase (FAK) is closely associated with cell migration and tumour spreading. The relationship between these two proteins, however, is not well elucidated. In this study, we investigate the...

journal_title：Oncology reports

authors： Hsu NY,Chen CY,Hsu CP,Lin TY,Chou MC,Chiou SH,Chow KC

更新日期：2007-07-01 00:00:00

abstract：:microRNAs (miRNAs), a class of small non-coding RNA molecules, can regulate gene expression by interacting with the 3'-untranslated regions (3'UTR) of target genes and influence various biological processes. We investigated the potential role of miR-24-3p in the development of bladder cancer by regulating DEDD, a memb...

journal_title：Oncology reports

authors： Yu G,Jia Z,Dou Z

更新日期：2017-02-01 00:00:00

abstract：:In the present study, we investigated the antitumor activity of caudatin in the human hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis and metastasis. The results showed that caudatin impaired the cell viability and inhibited the growth of SMMC-7721 cells in a time- and do...

journal_title：Oncology reports

authors： Luo Y,Sun Z,Li Y,Liu L,Cai X,Li Z

更新日期：2013-12-01 00:00:00

abstract：:Apoptosis repressor with caspase recruitment domain (ARC), an inhibitor of apoptosis, is primarily expressed in terminally differentiated tissues. Recent studies have revealed that ARC is highly expressed in a variety of human cancer cell lines and epithelial-derived cancers, which suggests that ARC plays an important...

journal_title：Oncology reports

authors： Wu P,Tang Y,He J,Qi L,Jiang W,Zhao S

更新日期：2013-10-01 00:00:00

abstract：:The incidence of malignant melanoma has increased greatly in recent decades presenting a high mortality rate despite intensive efforts in this area of research. Recent studies indicate that the chemokine receptor 4 (CXCR4) plays a critical role in cancer. Thus, it has been reported that CXCL12 binding to CXCR4 initiat...

journal_title：Oncology reports

authors： André ND,Silva VA,Watanabe MA,De Lucca FL

更新日期：2016-04-01 00:00:00

abstract：:To study the role of the chemokine receptor CCR7 in the metastatic process, a murine CCR7 gene was transduced in two mammary cancer cell lines with different origins and molecular features; TS/A, derived from a spontaneous mammary cancer of BALB/c strain, and N202.1A, derived from a HER-2/neu transgenic mammary cancer...

journal_title：Oncology reports

authors： Croci S,Nicoletti G,Landuzzi L,Palladini A,Chiarini F,Nanni P,Lollini PL,De Giovanni C

更新日期：2007-08-01 00:00:00

abstract：:We have previously demonstrated that gastric and intestinal endocrine cell (End-cell) marker expression is important for assessment of the histogenesis of endocrine cell tumors. However, the End-cell phenotypes of carcinoid tumors in the rectum remain largely unclear. We therefore examined marker expression of rectal ...

journal_title：Oncology reports

authors： Hirata Y,Mizoshita T,Mizushima T,Shimura T,Mori Y,Kubota E,Wada T,Ogasawara N,Tanida S,Kataoka H,Sasaki M,Kamiya T,Tsukamoto T,Tatematsu M,Joh T

更新日期：2009-01-01 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is involved in malignant transformation and the biological aggressiveness of several human malignancies. Growing evidence indicates that EZH2 may be an appropriate therapeutic target for malignancies, including cholangiocarcinoma. Recently, an S-adenosyl-L-homocysteine hydrolase inhi...

journal_title：Oncology reports

authors： Nakagawa S,Sakamoto Y,Okabe H,Hayashi H,Hashimoto D,Yokoyama N,Tokunaga R,Sakamoto K,Kuroki H,Mima K,Beppu T,Baba H

更新日期：2014-02-01 00:00:00

abstract：:Breast cancer is the worldwide leading cause of cancer incidence among women. Night shift work exposure has been recently considered one of the significant breast cancer risk factors in industrialized countries. The mechanisms by which this work exposure may be responsible for cance...

journal_title：Oncology reports

authors： Leonardi GC,Rapisarda V,Marconi A,Scalisi A,Catalano F,Proietti L,Travali S,Libra M,Fenga C

更新日期：2012-08-01 00:00:00

abstract：:The purpose of this study was to examine the effects of irradiation by 125I seeds in human lung cancer xenograft model and to determine the underlying mechanisms involved, with a focus on angiogenesis. A group of 40 mice bearing A549 lung adenocarcinoma xenografts was randomly separated into 4 groups: control group (n...

journal_title：Oncology reports

authors： Xiang GL,Zhu XH,Lin CZ,Wang LJ,Sun Y,Cao YW,Wang FF

更新日期：2017-05-01 00:00:00

abstract：:Osteosarcoma (OS) is a common primary malignancy in children and adolescents with relative high survival rate after chemotherapy. While the toxicity of chemotherapy and personalized different response to chemotherapy makes it difficult for the selection of therapeutics and improvement of diagnosis. In this study, we c...

journal_title：Oncology reports

authors： Zhang W,Han S,Sun K

更新日期：2017-02-01 00:00:00

abstract：:Pentoxifylline (PTX) is commonly used in peripheral blood vessel diseases, however it has also been found to decrease the level of proinflammatory cytokines such as IL-12, TNF-alpha and IFN-gamma. Moreover, some authors reported that PTX suppresses spontaneous cytotoxicity of peripheral blood mononuclear cells (PBMC) ...

journal_title：Oncology reports

authors： Lazarczyk M,Grzela T,Korczak-Kowalska G,Niderla J,Oldak M,Jozwiak J,Skopinski P

更新日期：2002-03-01 00:00:00

abstract：:v-ets erythroblastosis virus E26 oncogene homolog 1 (ETS-1) plays crucial roles in a spectrum of malignancies. ETS-1 has gained attention in cancer research for its importance in cell migration, invasion and proliferation. In the present study, we focused on the effect of ETS-1 on epithelial-mesenchymal transition (EM...

journal_title：Oncology reports

authors： Li C,Wang Z,Chen Y,Zhou M,Zhang H,Chen R,Shi F,Wang C,Rui Z

更新日期：2015-02-01 00:00:00

abstract：:Multidrug resistance (MDR) to chemotherapeutic drugs is the main cause of chemotherapy failure in cancer treatment, and it generally results from expression of ATP-dependent efflux pump P-glycoprotein (P-gp). MDR reversal agents typically act by inhibiting the drug efflux activity of P-gp, thereby increasing intracell...

journal_title：Oncology reports

authors： Cao Z,Wright M,Cheng J,Huang X,Liu L,Wu L,Yang P

更新日期：2014-09-01 00:00:00

abstract：:High-density single nucleotide polymorphism (SNP) array is a recently introduced technology that genotypes more than 10,000 human SNPs on a single array. It has been shown that SNP arrays can be used to determine not only SNP genotype calls, but also DNA copy number (DCN) aberrations, which are common in solid tumors....

journal_title：Oncology reports

authors： Wang Y,Makedon F,Pearlman J

更新日期：2006-01-01 00:00:00

abstract：:No information is currently available regarding pancreatic cancer (PC) pattern of care in Italy. In the present study, a nationwide survey using a questionnaire was performed to enquire the local standards for PC diagnosis and radiotherapy treatment. Fifty-seven percent of 140 Italian centres completed questionnaire. ...

journal_title：Oncology reports

authors： Macchia G,Sainato A,Talamini R,Boz G,Bacigalupo A,Caravatta L,Fiore M,Friso ML,Fusco V,Lupattelli M,Mantello G,Mattiucci GC,Slim N,Sciacero P,Turri L,Valentini V,Morganti AG,Genovesi D

更新日期：2015-07-01 00:00:00

abstract：:Breast cancer is one of the major health issues confronting women; however, treatment with conventional chemotherapeutic drugs is limited. Currently, paclitaxel is used as a therapeutic clinical agent to treat breast cancer that exerts antitumor activity in numerous types of cancer cell. Curcumin (diferuloylmethane), ...

journal_title：Oncology reports

authors： Calaf GM,Ponce-Cusi R,Carrión F

更新日期：2018-10-01 00:00:00