Abstract:
:v-ets erythroblastosis virus E26 oncogene homolog 1 (ETS-1) plays crucial roles in a spectrum of malignancies. ETS-1 has gained attention in cancer research for its importance in cell migration, invasion and proliferation. In the present study, we focused on the effect of ETS-1 on epithelial-mesenchymal transition (EMT), which is characterized by reduced E-cadherin expression and increased N-cadherin expression. We found that ETS-1 mRNA expression was positively correlated with N-cadherin and negatively correlated with E-cadherin mRNA expression in five pancreatic cancer cell lines. To elucidate the functionality of ETS-1 on EMT in pancreatic cancer cells, we constructed a green fluorescent protein (GFP)-expressing plasmid carrying ETS-1 short hairpin RNA (shRNA), and transfected Panc-1 cells with the plasmid. We detected reduced N-cadherin and vascular endothelial growth factor yet higher E-cadherin expression in the ETS-1-silenced cells compared with the control group. In addition, we observed reduced cell migration and increased adhesion in these cells. Our data showed that ETS-1 actively functioned as a regulator of EMT in Panc-1 cells, and provide additional evidence supporting a fundamental role for ETS-1 in metastatic pancreatic cancer cells. These results suggest that analysis of ETS-1 expression levels may provide an avenue for evaluating prognosis in pancreatic cancer.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Li C,Wang Z,Chen Y,Zhou M,Zhang H,Chen R,Shi F,Wang C,Rui Zdoi
10.3892/or.2014.3613subject
Has Abstractpub_date
2015-02-01 00:00:00pages
559-65issue
2eissn
1021-335Xissn
1791-2431journal_volume
33pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::The isothiocyanates (ITCs) have long been known to possess chemopreventive activities for a variety of neoplasms including breast cancer, but the molecular mechanism by which ITCs prevent breast cancer development has not been established. In this study, we investigated the effects of benzyl and phenethyl isothiocyana...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::The medicinal properties of extracts from the hemp plant Cannabis sativa have been known for centuries but only in the 90s membrane receptors for the Cannabis major principle were discovered in mammalian cells. Later on the endogenous ligands for the cannabinoid receptors were identified and the term 'endocannabinoid ...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2007-04-01 00:00:00
abstract::Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type 2 (CCR2), which is expressed in various tissues. However, the role of the CCL2/CCR2 axis in hepatocell...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6069
更新日期:2018-01-01 00:00:00
abstract::Several studies have shown that curcumin can induce apoptosis and inhibit growth in human A549 lung adenocarcinoma cells. However, the mechanism is not completely understood yet. The present study was designed to investigate the effects of curcumin on A549 cells to better understand its apoptosis and apoptosis-related...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2010-02-01 00:00:00
abstract::The objective of our study was to define a neural network for predicting recurrence and progression-free probability in patients affected by recurrent pTaG3 urothelial bladder cancer to use in everyday clinical practice. Among all patients who had undergone transurethral resection for bladder tumors, 143 were finally ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-10-01 00:00:00
abstract::Chromosomal translocations are very common in human cancer. The molecular mechanisms of chromosomal translocations are complex and are not fully understood. Recent studies showed organization of genomes is higher-order in the nucleus and every chromosome or chromatin has its preferential position and territory. These ...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2013.2677
更新日期:2013-11-01 00:00:00
abstract::Cisplatin (DDP), a cytotoxic antitumor drug, functions in a dose-dependent manner. However, the pursuit for high‑dose therapeutic effects leads to more serious side effects including kidney toxicity. Nephrotoxicity caused due to endothelial cell dysfunction and neutrophils infiltration in kidneys. Interleukin-8 (IL-8)...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3659
更新日期:2015-02-01 00:00:00
abstract::Honokiol (HNK), a potential antitumor compound, has been widely studied in recent years. It induces apoptosis and affects autophagy in cancer cells, yet the mechanism of its antitumor efficacy remains obscure. Chloroquine (CQ), an autophagy inhibitor, is often applied to sensitize antitumor drugs in clinical trials. H...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4091
更新日期:2015-09-01 00:00:00
abstract::Graft-versus-host disease (GVHD) is a devastating complication of hematopoietic stem cell transplantation (HSCT), and is characterized by systemic inflammation and tissue damage in multiple organs, such as the liver and small intestine. Interleukin-18 (IL-18), an important pro-inflammatory cytokine, is elevated during...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4176
更新日期:2015-10-01 00:00:00
abstract::Patients with autosomal recessive primary microcephaly have a small but architecturally normal brain containing a reduced number of neurons. Microcephalin and ASPM are two of the genes causing this disease. Both are centrosomal proteins involved in cell cycle regulation. Whereas microcephalin is a component of the DNA...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-08-01 00:00:00
abstract::Gallbladder cancer (GBC) is a rare disease associated with an extremely poor patient prognosis, and occasionally, aberrant expression of p53 is present. Considering that p53 is one of the most widely studied tumor‑suppressor genes, we used a cell-penetrating peptide, 11R, to enhance the transferring efficiency of the ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2511
更新日期:2013-08-01 00:00:00
abstract::Using a series of potential biomarkers relevant to mechanisms of protein synthesis, we observed that estrogen receptor (ER)-positive breast tumor cells exist in two distinct yet interconvertible phenotypic states (of roughly equal proportion) which differ in the degree of differentiation and use of IRES-mediated trans...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6332
更新日期:2018-06-01 00:00:00
abstract::Aberrant glycosylation, a common feature of malignant alteration, is partly due to changes in the expression of glycosyltransferases, including β1,3-N-acetyl-glucosaminyltrans-ferase 8 (β3Gn‑T8), which synthesizes poly-N-acetyllactosamine (poly-LacNAc) chains on β1,6 branched N‑glycans. Although the role of β3Gn‑T8 in...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4959
更新日期:2016-09-01 00:00:00
abstract::Glioma is the most frequent and aggressive primary tumor of the brain in humans. Over the last few decades, significant progress has been made in early detection and multi-mode treatments, but the prognosis of gliomas is still extremely poor. MicroRNAs are endogenously expressed non-coding, single strand and short RNA...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5320
更新日期:2017-02-01 00:00:00
abstract::Orotate phosphoribosyl transferase (OPRT) is the initial enzyme of 5-fluorouracil (5-FU) activation, in which 5-FU is converted to 5-fluorouridinemonophosphate. Dihydropyrimidine dehydrogenase (DPD) is a degrading enzyme that catabolizes 5-FU. In this study, we investigated the expression of these enzymes in normal pr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a predictor of prognosis and response to cytotoxic treatments. Its immunoexpression was assessed in 63 ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2540
更新日期:2013-09-01 00:00:00
abstract::Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human disorders such as developmental diseases. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. In the present study, we used clinical samples from gastric cancer (GC) patients to investigate poten...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7254
更新日期:2019-10-01 00:00:00
abstract::Subsequently to the publication of the above paper, the authors have drawn to our attention that, owing to errors made in the compilation of the images in Fig. 6, the images shown in Fig. 6A‑C in the article were selected incorrectly (essentially, the images shown in Fig. 6A and B were alterative presentations of the ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7903
更新日期:2020-12-16 00:00:00
abstract::Expression of miR-365 has been reported to be downregulated in hepatocellular carcinoma (HCC). However, the biological function and underlying mechanism of miR-365 in HCC growth and metastasis remain unclear. The aim of the present study was to explore the role of miR-365 in HCC progression. We found that miR-365 expr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5423
更新日期:2017-03-01 00:00:00
abstract::This study evaluates and compares the accuracy of positron emission tomography with 18F-fluoro-2-deoxyglucose (FDG-PET) and gallium-67 citrate (Ga-67) scintigraphy in identifying disease sites in patients with malignant lymphoma at initial diagnosis or relapse. Histology subgroups included low (n=5), intermediate (n=6...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Lung cancer is still the leading cause of cancer-related deaths worldwide. Identifying new oncogenic drivers and developing efficient inhibitors through molecular targeting approaches are crucial for improving therapies. The aim of this study was to investigate whether targeting fibroblast growth factor receptor 1 (FG...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2386
更新日期:2013-06-01 00:00:00
abstract::Minimal residual disease (MRD) is derived from tumor-initiating cells (TICs) and is responsible for tumor relapse. Neuroblastoma is characterized by extreme tumor heterogeneity, and more than half of high-risk patients experience tumor relapse. To overcome tumor heterogeneity and ac...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2286
更新日期:2013-04-01 00:00:00
abstract::The phosphatidylinositol 3 OH-kinase (PI3K) pathway is a key intracellular signalling cascade in cellular survival. Our previous studies indicated that specific blockade of this enzyme led to sensitisation of human breast carcinoma cells to killing by doxorubicin through induction of both G2 arrest and apoptosis in so...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-02-01 00:00:00
abstract::Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. The present study was performed to characterize the role of Fzd2 in the migration and invasion of oral squamous cell carcinomas (OSCC) in...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4285
更新日期:2015-12-01 00:00:00
abstract::Gastric cancer rich in stromal tissue, such as diffuse-type disease, carries a poor prognosis. In some cancers, expression of vimentin, a mesenchymal maker, is associated with poor survival. The expression of mesenchymal markers such as vimentin is observed after epithelial-mesenchymal transition (EMT), an important i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1185
更新日期:2011-05-01 00:00:00
abstract::In the present study, we investigated the antitumor activity of caudatin in the human hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis and metastasis. The results showed that caudatin impaired the cell viability and inhibited the growth of SMMC-7721 cells in a time- and do...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2749
更新日期:2013-12-01 00:00:00
abstract::Recent studies suggest that latexin (Lxn) expression is involved in stem cell regulation and that it plays significant roles in tumor cell migration and invasion. The clinicopathological significance of Lxn expression and its possible correlation with CD133 expression in pancreatic ductal adenocarcinoma (PDAC) is curr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4353
更新日期:2016-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of highly conserved, small endogenous single-strand non-coding RNAs. They are aberrantly expressed in the circulation and tissue of patients with cancer. Therefore, it has been suggested that they may act as key regulators of carcinogenesis. The aim of the present study was to examine th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.2971
更新日期:2014-03-01 00:00:00
abstract::To clarify hepatocarcinogenesis by the heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), we investigated the global expression of genes in rat liver. Rats were continuously fed MeIQx 100 ppm in their diet, and were sacrificed at weeks 4 and 16 for early time points, and week 104 for tumor samp...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00