Overexpression of orotate phosphoribosyl transferase in hormone-refractory prostate cancer.

abstract：:It has been reported that cimetidine, a histamine type-2 receptor (H2R) antagonist, inhibits the growth of glandular tumors such as colorectal cancer. However, its effects against salivary gland tumors are still unknown. We demonstrated previously that human salivary gland tumor (HSG) cells spontaneously express the n...

journal_title：Oncology reports

authors： Fukuda M,Tanaka S,Suzuki S,Kusama K,Kaneko T,Sakashita H

更新日期：2007-03-01 00:00:00

abstract：:Acquired chemoresistance refers to tumor cells gradually losing their sensitivity to anticancer drugs during the course of treatment, resulting in tumor progression or recurrence. This phenomenon, which has deleterious outcomes for the patient, has long been observed in patients with glioblastoma receiving temozolomid...

journal_title：Oncology reports

authors： Lin J,Zuo J,Cui Y,Song C,Wu X,Feng H,Li J,Li S,Xu Q,Wei W,Qiu G,He H

更新日期：2018-05-01 00:00:00

abstract：:The usefulness of diagnostic ultrasound in gene transfer was investigated. The hepatocellular carcinoma cell lines PRL/PRF/5 and Hep3B, and the pancreatic carcinoma Panc-1 cells were transfected with lipofectin or irradiated with a linear probe with a frequency of 8 MHz at a mechani...

journal_title：Oncology reports

authors： Tomizawa M,Shinozaki F,Sugiyama T,Yamamoto S,Sueishi M,Yoshida T

更新日期：2012-05-01 00:00:00

abstract：:Cisplatin (DDP), a cytotoxic antitumor drug, functions in a dose-dependent manner. However, the pursuit for high‑dose therapeutic effects leads to more serious side effects including kidney toxicity. Nephrotoxicity caused due to endothelial cell dysfunction and neutrophils infiltration in kidneys. Interleukin-8 (IL-8)...

journal_title：Oncology reports

authors： Li L,Khan MN,Li Q,Chen X,Wei J,Wang B,Cheng JW,Gordon JR,Li F

更新日期：2015-02-01 00:00:00

abstract：:The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutat...

journal_title：Oncology reports

authors： Park YK,Chi SG,Unni KK

更新日期：2001-11-01 00:00:00

abstract：:The growth of supportive tissue during the progression of solid tumors is an absolute requirement for the nourishment of the tumor. The blockade of this proliferative response of normal tissues to the growing tumor should hence inhibit tumor progression. We have shown earlier, that the heparinoid pentosan polysulfate ...

journal_title：Oncology reports

authors： Yunmbam MK,Wellstein A

更新日期：2001-01-01 00:00:00

abstract：:The aim of the present study was to uncover potential prognostic microRNA (miRNA) markers in head and neck squamous cell carcinoma (HNSCC). miRNA expression profile and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. Survival analysis was conducted by Kaplan-Meier method. Then, candidate prog...

journal_title：Oncology reports

authors： Hui L,Wu H,Yang N,Guo X,Jang X

更新日期：2016-06-01 00:00:00

abstract：:Homeobox containing 1 (HMBOX1) is a novel transcription repressor that is significantly downregulated in human liver cancer tissues and cell lines, but the exact biological function of HMBOX1 in liver cancer is still unknown. We observed a negative association between HMBOX1 expression level and the clinical stages of...

journal_title：Oncology reports

authors： Zhao H,Jia H,Han Q,Zhang J

更新日期：2018-09-01 00:00:00

abstract：:Intratumoral regions of low extracellular pH and low nutrition are common features of solid tumors. Although cancer cells normally die when they are removed from their environment, a small population of cells survive. In the present study, the subline LNCaP-F10, of the prostate canc...

journal_title：Oncology reports

authors： Iguchi K,Hayakawa Y,Ishii K,Matsumoto K,Usui S,Sugimura Y,Hirano K

更新日期：2012-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous pathogen that was first identified as a human cancer virus. Many human cancers are associated with EBV, and we demonstrated that EBV infects macrophages. Macrophages infected with EBV show a close correlation with many human cancers, and thus more attention must be given to the...

journal_title：Oncology reports

authors： Shimakage M

更新日期：2014-11-01 00:00:00

abstract：:Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation and histone modification markers. Changes in the epigenome significantly contribute to the initiation and progression of cancer. The goal of the present s...

journal_title：Oncology reports

authors： Kamińska K,Białkowska A,Kowalewski J,Huang S,Lewandowska MA

更新日期：2019-07-01 00:00:00

abstract：:The gene Nm23, which encodes for a nucleoside diphosphate kinase, has been defined as a metastasis-suppressor gene because of the inverse correlation between its expression and the metastatic capacity of the tumor cells. For colorectal cancer, however, the findings are equivocal. The aim of our study was to assess, in...

journal_title：Oncology reports

authors： Dusonchet L,Corsale S,Migliavacca M,Calò V,Bazan V,Amato A,Cammareri P,Totaro MS,Agnese V,Cascio S,La Rocca G,Sisto PS,Dardanoni G,Valerio MR,Grassi N,Latteri S,Cajozzo M,Buscemi M,Castorina S,Morello V,Tomasino R

更新日期：2003-09-01 00:00:00

abstract：:Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis is particularly complicated. Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic ...

journal_title：Oncology reports

authors： Xu PF,Yang JA,Liu JH,Yang X,Liao JM,Yuan FE,Liu BH,Chen QX

更新日期：2019-01-01 00:00:00

abstract：:Colon cancer is the main cause of cancer mortality worldwide. Its poor prognosis is mainly ascribed to high recurrence rates. Identifying novel prognostic biomarkers and therapeutic key points for management is crucial and important. Long non-coding RNAs (lncRNAs) are a class of RNAs, which have various roles in carci...

journal_title：Oncology reports

authors： Yang H,Wang S,Kang YJ,Wang C,Xu Y,Zhang Y,Jiang Z

更新日期：2018-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers worldwide. Long non-coding RNAs (lncRNAs) have been confirmed to play a critical regulatory role in various biological processes including carcinogenesis, which indicates that lncRNAs are valuable biomarkers and therapeutic targets. The novel lncRNA prostate ca...

journal_title：Oncology reports

authors： Yang L,Qiu M,Xu Y,Wang J,Zheng Y,Li M,Xu L,Yin R

更新日期：2016-01-01 00:00:00

abstract：:A growing body of evidence suggests that microRNA-365 (miR-365) played crucial role in the initiation and development of many types of cancers. However, the biological role of miR-365 in human glioma remains unclear. Herein, the aims of this study were to investigate the role and underlying mechanisms of miR-365 in gl...

journal_title：Oncology reports

authors： Zhu Y,Zhao H,Rao M,Xu S

更新日期：2017-04-01 00:00:00

abstract：:Male breast cancer (MBC) is extremely rare, with an incidence in the general US population of <1%. It tends to be diagnosed at later stages than breast cancer in females, likely because of low awareness on the part of the patient and low suspicion by the physician. Risk factors include genetic predisposition, alterati...

journal_title：Oncology reports

authors： Johansen Taber KA,Morisy LR,Osbahr AJ 3rd,Dickinson BD

更新日期：2010-11-01 00:00:00

abstract：:Glutamine RF‑amide peptide (QRFP) belongs to the RFamide neuropeptide family, which is involved in a wide spectrum of biological activities, ranging from food intake and cardiovascular functioning to analgesia, aldosterone secretion, locomotor activity and reproduction. Recently, QRFP has been demonstrated to exert it...

journal_title：Oncology reports

authors： Kawan MA,Kyrou I,Ramanjaneya M,Williams K,Jeyaneethi J,Randeva HS,Karteris E

更新日期：2019-02-01 00:00:00

abstract：:The present study investigated the effect of macrophage colony-stimulating factor (M-CSF) on the immune functions and blood cell counts of patients with ovarian carcinoma receiving cytotoxic chemotherapy (CTX). Seventy-five consecutive patients with white blood cell counts less than 3,000/microl after CTX were randoml...

journal_title：Oncology reports

authors： Shimizu Y,Utsugi K,Umezawa S,Shimizu K,Hasumi K,Suzuki M,Takaku F

更新日期：2001-07-01 00:00:00

abstract：:Ribonucleotide reductase M2 subunit (RRM2) is one of the two subunits of human ribonucleotide reductase which plays a critical role in tumor progression. The aim of the present study was to analyze its expression, clinical significance and biological functions in gastric adenocarcinoma. We observed the upregulation of...

journal_title：Oncology reports

authors： Kang W,Tong JH,Chan AW,Zhao J,Wang S,Dong Y,Sin FM,Yeung S,Cheng AS,Yu J,To K

更新日期：2014-06-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the function and mechanism of lncRNA NEAT1 in oral squamous cell carcinoma (OSCC) are unclear. In the present study, NEAT1 was significantly upregulated in OSCC cells and tissues. High expression of NEAT1 was correlated w...

journal_title：Oncology reports

authors： Huang G,He X,Wei XL

更新日期：2018-04-01 00:00:00

abstract：:Bufalin, a major digoxin-like immunoreactive component of the Chinese medicine Chansu, is prepared from toad venom. This compound has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro. However, the detailed molecular mechanisms ...

journal_title：Oncology reports

authors： Hong SH,Choi YH

更新日期：2012-01-01 00:00:00

abstract：:The present study investigated the expression and potential influence of SHC SH2 domain‑binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell proliferation and cell cycle progression, but its role in GC remains unclear. The TCGA database revealed that SHCBP1 is highly expressed in ...

journal_title：Oncology reports

authors： Dong YD,Yuan YL,Yu HB,Tian GJ,Li DY

更新日期：2019-03-01 00:00:00

abstract：:Epigenetic anticancer drugs such as histone deacetylase (HDAC) inhibitors have been combined with existing anticancer drugs for synergistic or additive effects. In the present study, we found that a very low concentration of depsipeptide, an HDAC inhibitor, potentiated the antitumor activity of 5-fluorouracil (5-FU) i...

journal_title：Oncology reports

authors： Okada K,Hakata S,Terashima J,Gamou T,Habano W,Ozawa S

更新日期：2016-10-01 00:00:00

abstract：:nm23-H1, a nucleoside diphosphate kinase (NDPK), enhances drug sensitivity and has antimetastatic activity, whereas focal adhesion kinase (FAK) is closely associated with cell migration and tumour spreading. The relationship between these two proteins, however, is not well elucidated. In this study, we investigate the...

journal_title：Oncology reports

authors： Hsu NY,Chen CY,Hsu CP,Lin TY,Chou MC,Chiou SH,Chow KC

更新日期：2007-07-01 00:00:00

abstract：:It has been revealed by our previous proteomic study that the expression profile is different between well‑differentiated and poorly differentiated hepatocellular carcinoma (HCC). Among those differently expressed proteins, peroxiredoxin2 (PRDX2) was our protein of interest. The present study aimed to further investig...

journal_title：Oncology reports

authors： Bai B,Lin Y,Hu J,Wang H,Li L,Zhao S,Zhang J,Meng W,Yue P,Bai Z,Li X

更新日期：2019-03-01 00:00:00

abstract：:Ulcerative colitis (UC) is an important risk factor for colorectal cancer (CRC). Histone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC. At present, there are no studies comparing histone modification patterns of UC and CRC in the literature. Therefore the aim o...

journal_title：Oncology reports

authors： Gerçeker E,Boyacıoglu SO,Kasap E,Baykan A,Yuceyar H,Yıldırım H,Ayhan S,Ellidokuz E,Korkmaz M

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to discover the signaling pathways associated with 2-(3-hydroxy-5-methoxy-phenyl)-6,7-methylenedioxyquinolin-4-one (YYK1)-induced apoptosis in HL-60 human leukemia cells. YYK1 induced cytotoxic effects, cell morphological changes, decreased the cell ...

journal_title：Oncology reports

authors： Cheng YY,Yang JS,Tsai SC,Liaw CC,Chung JG,Huang LJ,Lee KH,Lu CC,Chien HC,Tsuzuki M,Kuo SC

更新日期：2012-10-01 00:00:00

abstract：:Angiogenesis is a key factor in the growth and dissemination of malignant diseases, including breast cancer, with significant implications for its clinical management. It is known that microRNAs (miRNAs) play important roles in regulating tumor properties in cancers. However, whether miR-497 contributes to breast canc...

journal_title：Oncology reports

authors： Wu Z,Cai X,Huang C,Xu J,Liu A

更新日期：2016-03-01 00:00:00

abstract：:Extracellular matrix remodeling crucial to tumorigenesis involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs). MMP production is stimulated by multiple factors, including the extracellular matrix metallo-proteinase inducer EMMPRIN/CD147. Overexpression of EMMPRIN...

journal_title：Oncology reports

authors： Takahashi M,Suzuki S,Ishikawa K

更新日期：2012-01-01 00:00:00