PI3Kβ inhibitor AZD6482 exerts antiproliferative activity and induces apoptosis in human glioblastoma cells.

abstract：:Metastatic progression is the cause of most cancer deaths. Host tumour cell separation (fission) is accompanied by simultaneous acquisition of migrating capability of cancer cells, remodeling of cellular architecture and effective 'homing' in body host environment. Cell remodeling involves cytoskeletal protein-protein...

journal_title：Oncology reports

authors： Patra SK,Bettuzzi S

更新日期：2007-06-01 00:00:00

abstract：:Aberrantly expressed miRNAs play a crucial role in the progression of lung adenocarcinoma. However, to date, the role of miR‑888 in lung adenocarcinoma progression is unclear. In the present study, the biological function of miR‑888 and its underlying mechanism in lung adenocarcinoma progression were explored. RT‑qPCR...

journal_title：Oncology reports

authors： Cao JX

更新日期：2019-06-01 00:00:00

abstract：:Mother-to-infant transmission of hepatitis B virus (HBV) can occur as an intrauterine, intrapartum or postpartum infection. In the present study, we induced a multifunctional viral regulator of HBV gene products, HBx, and its different fragments to overexpress in a tropho-blast cell line, HTR-8/SVneo. We then identifi...

journal_title：Oncology reports

authors： Cui H,Li QL,Chen J,Na Q,Liu CX

更新日期：2015-10-01 00:00:00

abstract：:Ultraviolet (UV) radiation is the primary risk factor underlying photoaging and photocarcinogenesis. Mounting research has focused on the role of DNA damage response pathways in UV-induced double-strand break (DSB) repair. In the present study, we hypothesized that UVA-induced aberrant progerin upregulation may advers...

journal_title：Oncology reports

authors： Huang X,Pan Y,Cao D,Fang S,Huang K,Chen J,Chen A

更新日期：2017-06-01 00:00:00

abstract：:Loss of proliferative control and failure to undergo cellular differentiation are key events during carcinogenesis. We recently identified a new potential tumor suppressor gene named MTUS1 (mitochondrial tumor suppressor 1), down-regulated in undifferentiated tumor cell lines, inhibiting tumor cell proliferation after...

journal_title：Oncology reports

authors： Zuern C,Heimrich J,Kaufmann R,Richter KK,Settmacher U,Wanner C,Galle J,Seibold S

更新日期：2010-01-01 00:00:00

abstract：:Vimentin is a member of the intermediate filament family, and the NF-kappaB binding site is located in the human vimentin promoter. To gain insight into the role of NF-kappaB in the regulation of the vimentin gene during 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent differentiation of HL-60 cells, the effect of...

journal_title：Oncology reports

authors： Zheng M,Son MY,Park C,Park JI,Jo EK,Yoon WH,Park SK,Hwang BD,Lim K

更新日期：2005-09-01 00:00:00

abstract：:The goal of this study was to evaluate the effect of the Na+/H+ exchanger-1 (NHE-1) antisense gene on drug-resistant human small cell lung cancer (SCLC) cell proliferation and apoptosis. A recombinant NHE-1 antisense gene was transfected into drug-resistant human SCLC H446/CDDP cells. Intracellular pH (pHi) was measur...

journal_title：Oncology reports

authors： Li S,Bao P,Li Z,Ouyang H,Wu C,Qian G

更新日期：2009-05-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, is involved in suppressing the growth of several tumors. We showed that PPAR-gamma is expressed in Barrett's adenocarcinoma cell lines and inhibited the growth of these lines through the induction of G1...

journal_title：Oncology reports

authors： Takashima T,Fujiwara Y,Hamaguchi M,Sasaki E,Tominaga K,Watanabe T,Oshitani N,Higuchi K,Arakawa T

更新日期：2005-04-01 00:00:00

abstract：:Immature colon carcinoma transcript-1 (ICT1) is a newly identified oncogene, which regulates proliferation, cell cycle progression and apoptosis of cancer cells. However, the clinical significance, biological function and underlying mechanisms of ICT1 in hepatocellular carcinoma (HCC) remain poorly known. In the prese...

journal_title：Oncology reports

authors： Chang W,Yu Z,Tian M,Lin X

更新日期：2017-12-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a common type of esophageal cancer and is prevalent worldwide. Understanding the mechanisms underlying its formation and the search for more effective therapeutic strategies are critical due to the occurrence of chemotherapeutic drug resistance. The aim of the present study...

journal_title：Oncology reports

authors： Wang X,Cheng G,Zhang T,Deng L,Xu K,Xu X,Wang W,Zhou Z,Feng Q,Chen D,Bi N,Wang L

更新日期：2020-01-01 00:00:00

abstract：:Targeted gene therapy needs to be implemented for future therapies to ensure efficient activity at the site of patient primary tumors or metastases without causing intolerable side-effects. One of the elements of gene therapy is vector, which includes viral and non-viral vector. In the present study, we constructed a ...

journal_title：Oncology reports

authors： Zuo Y,Liao S,Xu Z,Xie J,Huang W,Yu Z

更新日期：2014-12-01 00:00:00

abstract：:Pentoxifylline (PTX) is commonly used in peripheral blood vessel diseases, however it has also been found to decrease the level of proinflammatory cytokines such as IL-12, TNF-alpha and IFN-gamma. Moreover, some authors reported that PTX suppresses spontaneous cytotoxicity of peripheral blood mononuclear cells (PBMC) ...

journal_title：Oncology reports

authors： Lazarczyk M,Grzela T,Korczak-Kowalska G,Niderla J,Oldak M,Jozwiak J,Skopinski P

更新日期：2002-03-01 00:00:00

abstract：:Overexpression or amplification of G1 cyclins has been demonstrated in various types of human cancers. Overexpression of cyclin D1, an accelerator of cell cycle, is thought to be an early event in colonic multistage carcinogenesis, but its expression at transformation from benign to neoplastic foci is not clear. We an...

journal_title：Oncology reports

authors： Izawa H,Yamamoto H,Ikeda M,Ikeda K,Fukunaga H,Yasui M,Ikenaga M,Sekimoto M,Monden T,Matsuura N,Monden M

更新日期：2002-11-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer, and numerous oncogenes are associated with this disease. Oxysterol‑binding protein‑related protein 8 (ORP8) is essential for cell growth, migration and the modulation of mitochondrial respiration and morphology. However, the underlying role of ...

journal_title：Oncology reports

authors： Li J,Cui J,Li Z,Fu X,Li J,Li H,Wang S,Zhang M

更新日期：2020-05-01 00:00:00

abstract：:Survivin, an anti-apoptotic protein, is abundantly expressed in a variety of cancer cells, including hepatoma cells, resulting in the resistance of these cells to various apoptotic stimuli. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known to induce cancer cell-specific apoptosis, but hepa...

journal_title：Oncology reports

authors： Nakao K,Hamasaki K,Ichikawa T,Arima K,Eguchi K,Ishii N

更新日期：2006-08-01 00:00:00

abstract：:Breast cancers especially in the late and metastatic stages remain refractory to treatment despite advances in surgical techniques and chemotherapy. Tumor-specific promoter-directed suicide gene therapy and adenoviral technology can be promising strategies for such advanced disease. Previous studies suggested that com...

journal_title：Oncology reports

authors： Yu B,Zhang Y,Zhan Y,Zha X,Wu Y,Zhang X,Dong Q,Kong W,Yu X

更新日期：2011-07-01 00:00:00

abstract：:Breast cancer is the most common type of cancer among women worldwide. Research using breast cancer cell lines derived from primary tumors may provide valuable additional knowledge regarding this type of cancer. Therefore, the aim of this study was to investigate the phenotypic prof...

journal_title：Oncology reports

authors： Corrêa NC,Kuasne H,Faria JA,Seixas CC,Santos IG,Abreu FB,Nonogaki S,Rocha RM,Aparecida Borges Silva G,Gobbi H,Rogatto SR,Goes AM,Gomes DA

更新日期：2013-04-01 00:00:00

abstract：:Although many studies have been conducted on the role of alternative medicine in the treatment of cancer, only a few reports have been published regarding the total regression of malignant tumors. At the PBH Research Foundation (PBHRF), two of the authors have used homoeopathic therapy to treat many patients with vari...

journal_title：Oncology reports

authors： Banerji P,Campbell DR,Banerji P

更新日期：2008-07-01 00:00:00

abstract：:Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not ...

journal_title：Oncology reports

authors： Lee JW,Park C,Han MH,Hong SH,Lee TK,Lee SH,Kim GY,Choi YH

更新日期：2013-09-01 00:00:00

abstract：:Low-intensity ultrasound (LIUS) combined with chemotherapy is an innovative modality for cancer treatment, but its effect on orthotopic carcinoma remains unknown. Our previous study revealed that LIUS enhanced the growth inhibitory effects of several chemotherapeutic drugs in nude mice with transplanted tumors. In the...

journal_title：Oncology reports

authors： Li HX,Zheng JH,Ji L,Liu GY,Lv YK,Yang D,Hu Z,Chen H,Zhang FM,Cao W

更新日期：2018-04-01 00:00:00

abstract：:We evaluated the efficacy of anti-human VEGF antibody (bevacizumab) with or without irinotecan (CPT-11) against lung metastases in which neovascularization was already induced, as a postoperative adjuvant therapy using orthotopically implanted colon cancer in rat. The high VEGF productive KM12SM human colon cancer cel...

journal_title：Oncology reports

authors： Mizobe T,Ogata Y,Murakami H,Akagi Y,Ishibashi N,Mori S,Sasatomi T,Shirouzu K

更新日期：2008-09-01 00:00:00

abstract：:Different members of the Ets-family of transcription factors are involved in TMPRSS-2-Ets translocations frequently found in human prostate cancers. We previously reported that Ets-1, which is the prototype of Ets-family members, promotes both migration and invasion of melanoma, Hela and glioma cells. Here, we examine...

journal_title：Oncology reports

authors： Shaikhibrahim Z,Langer B,Lindstrot A,Florin A,Bosserhoff A,Buettner R,Wernert N

更新日期：2011-04-01 00:00:00

abstract：:The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of r...

journal_title：Oncology reports

authors： Shoji H,Motegi M,Takakusagi Y,Asao T,Kuwano H,Takahashi T,Ogoshi K

更新日期：2017-02-01 00:00:00

abstract：:The deficiencies of nucleotide excision repair (NER) factors are involved in rare genetic diseases such as xeroderma pigmentosum (XP) with increased risk of developing cancer on sun-exposed areas of the skin. However, the abnormality of NER factors in human sporadic carcinoma remains unclear. Loss of heterozygosity (L...

journal_title：Oncology reports

authors： Miyashita H,Mori S,Tanda N,Nakayama K,Kanzaki A,Sato A,Morikawa H,Motegi K,Takebayashi Y,Fukumoto M

更新日期：2001-09-01 00:00:00

abstract：:The present study was carried out to investigate the clinical significance of TMPRSS3 and TNFRSF11B in breast cancer. Thus, the expression levels of TMPRSS3 and TNFRSF11B and the correlation with prognosis in patients with breast cancer were analyzed in silico using gene microarray and hierarchical clustering analysis...

journal_title：Oncology reports

authors： Luo P,Lu G,Fan LL,Zhong X,Yang H,Xie R,Lv Z,Lv QZ,Fu D,Yang LX,Ma Y

更新日期：2017-04-01 00:00:00

abstract：:Ovarian cancer is the leading cause of death among malignancies of the female reproductive system. The 5-year survival rates of ovarian cancer (OC) patients are very poor as a result of recurrent disease and emergence of drug resistance; thus, studies to find predictive markers and factors for drug resistance are ongo...

journal_title：Oncology reports

authors： Gao Y,Liu X,Li T,Wei L,Yang A,Lu Y,Zhang J,Li L,Wang S,Yin F

更新日期：2017-05-01 00:00:00

abstract：:Current therapeutic modalities for advanced prostate cancer are palliative in nature, with no effective treatment increasing survival in patients with metastatic prostate cancer. Apoptosis as a molecular process of genetically regulated cell death has a critical endpoint that coincides with the goal of successful trea...

journal_title：Oncology reports

authors： Hill B,Kyprianou N

更新日期：2002-11-01 00:00:00

abstract：:Casticin, one of the main components from Fructus Viticis, has been reported to inhibit the growth of various cancer cells, including the human cervical cancer cell line HeLa. The purpose of this study was to examine the apoptotic activity and molecular mechanism of casticin action on human cervical cancer cells. The ...

journal_title：Oncology reports

authors： Chen D,Cao J,Tian L,Liu F,Sheng X

更新日期：2011-11-01 00:00:00

abstract：:Nuclear factor (NF)-κB is the key transcription factor involved in the inflammatory responses, and its activation aggravates tumors. Peptidoglycan (PGN), a main cell wall component of Gram-positive bacteria, stimulates Toll-like receptor 2 (TLR-2) and activates a number of inflammat...

journal_title：Oncology reports

authors： Echigo R,Sugimoto N,Yachie A,Ohno-Shosaku T

更新日期：2012-10-01 00:00:00

abstract：:Acute pancreatitis (AP) is an inflammatory disease with high morbidity and mortality rates. Pancreatic ductal cells are the most susceptible of all cell types that are exposed to the noxious stimuli of pancreatitis. Our previous studies demonstrated that emodin, a natural product extracted from Rheum palmatum L., prot...

journal_title：Oncology reports

authors： Zhang Q,Hu F,Guo F,Zhou Q,Xiang H,Shang D

更新日期：2019-08-08 00:00:00