Abstract:
:Ovarian cancer is the leading cause of death among malignancies of the female reproductive system. The 5-year survival rates of ovarian cancer (OC) patients are very poor as a result of recurrent disease and emergence of drug resistance; thus, studies to find predictive markers and factors for drug resistance are ongoing. In the present study, based on the microarrays from The Cancer Genome Atlas (TCGA), and the Gene Expression Omnibus (GEO) profiles covering 1648 OC patients, 11 out of 136 genes that were found to be significantly dysregulated in OC were associated with overall survival (OS) in 489 OC patients of the TCGA cohort. Of these genes, CRISP3, LYVE1, OVGP1 and BCHE were identified as independent prognostic factors, with decreased expression of the first three genes predicting shorter OS, and decreased BCHE predicting longer OS. OVGP1, BCHE and further two genes, CKAP2 and CLDN10, were consistently and remarkably associated with OS when the number of patients increased from 489 to 1583, with increased CKAP2 and decreased CLDN10 predicted shorter OS; combining the four genes provided better predictions. Associations among the four genes with OS in subgroups of OC were further verified. Downregulation of OVGP1 was significantly associated with shorter OS in all subgroups of OC patients, including subgroups of 752 patients treated with chemotherapy regimens containing taxol, 763 with both platin and taxol, 1364 with platin, 371 patients with grade 1-2 disease, 968 with grade 3 disease, 1148 with stage III-IV disease, and 439 with TP53 mutations. In addition, CKAP2 expression was significantly associated with shorter OS in 515 OC patients who had low CA125 levels. Furthermore, comprehensive analyses that including RT-qPCR, bioinformatics analysis and clinical data revealed an association of CKAP2, BCHE, CLDN10 and OVGP1 with drug resistance in OC. The genes identified in the present study might be prognostic factors as well as potential therapeutic targets in the treatment of OC.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Gao Y,Liu X,Li T,Wei L,Yang A,Lu Y,Zhang J,Li L,Wang S,Yin Fdoi
10.3892/or.2017.5534subject
Has Abstractpub_date
2017-05-01 00:00:00pages
3084-3092issue
5eissn
1021-335Xissn
1791-2431journal_volume
37pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::p73 is a member of p53 tumor suppressor protein family. In spite of similarities of three meaningful domains between p53 and p73, the exact function of p73 protein is not established. To approach the relevance of p73 expression to a pathological parameter in human breast cancer, the apoptotic index (AI) and the mitoti...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::Progestin and adipoQ receptor family member III (PAQR3) is a regulator that negatively modulates the Ras/Raf/MEK/ERK signaling cascade and the GPCR Gβγ subunit signaling pathway. The role of PAQR3 in hepatocellular carcinoma (HCC) has not been elucidated. The present study investigated the expression of PAQR3 and its ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3532
更新日期:2014-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a leading cause of cancer‑related morbidity and mortality globally. Despite the remarkable improvements in comprehensive HCC treatment, the underlying mechanistic details of HCC remain elusive. We screened HCC patients for differentially expressed genes (DEGs) using the Gene Expressio...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7779
更新日期:2020-11-01 00:00:00
abstract::Chromosomal translocations are very common in human cancer. The molecular mechanisms of chromosomal translocations are complex and are not fully understood. Recent studies showed organization of genomes is higher-order in the nucleus and every chromosome or chromatin has its preferential position and territory. These ...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2013.2677
更新日期:2013-11-01 00:00:00
abstract::The clinicopathological significance of cell-cycle proteins has remained unclear in oral tongue squamous cell carcinomas (OTSCC). In the current study, we evaluated several cell-cycle proteins in relation to clinicopathological parameters and disease outcome for OTSCC. A total of 123 previously untreated patients with...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-10-01 00:00:00
abstract::High expression of the 110 kDa catalytic subunit of the class IA PI3K (PI3Kp110α) may play an important role in cetuximab resistance exhibited by both colorectal cancer and head and neck squamous cell carcinoma. Therefore, the present study aimed to examine the association between the expression of proteins in the PI3...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7674
更新日期:2020-09-01 00:00:00
abstract::Osteosarcoma is the most common type of malignant bone tumor in children and adolescents and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. In this study, we investigated the role of miR-34a in the invasion and metastasis of osteosarc...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2234
更新日期:2013-03-01 00:00:00
abstract::In order to erase reactive oxygen species (ROS) related with the proliferation of tumor cells by reducing activity of hydrogen, we developed functional water containing nano-bubbles (diameters: <900 nm for 71%/population) hydrogen of 1.1-1.5 ppm (the theoretical maximum: 1.6 ppm) with a reducing ability (an oxidation-...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00001006
更新日期:2010-12-01 00:00:00
abstract::MicroRNAs (miRNAs) play important roles in the the gene regulation of carcinogenesis including breast cancer. miR‑519d has been studied in various types of cancer, but its role in breast cancer remains unclear. In the present study, we investigated the expression and biological function of miR-519d in breast cancer. U...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4160
更新日期:2015-10-01 00:00:00
abstract::Serenoa repens, a palm species native to the Southeastern United States, is one of the widely used phytotherapeutic agents in benign prostatic hyperplasia. In this study, we found for the first time that Serenoa repens induced growth arrest of a variety of human leukemia cells including U266 and RPMI 8226 multiple mye...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-08-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is the predominant histologic subtype of esophageal cancer and is characterized by a high mortality rate and geographic differences in incidence. microRNAs (miRNAs) are small, non-coding RNAs that play important roles in the regulation of genes associated with cancer developme...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3389
更新日期:2014-10-01 00:00:00
abstract::Cytochalasin B (CB) is a cell-permeable mycotoxin. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments, it inhibits cell movement and induces nuclear extrusion. In the present study, we investigated the anticancer activity of CB in HeLa human cervical carcinoma cells. CB showed sig...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2617
更新日期:2013-10-01 00:00:00
abstract::Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract::The growth inhibitory effects of bufadienolide compounds were investigated in two intractable cancer cells, a human glioblastoma cell line U-87 and a pancreatic cancer cell line SW1990. Among four bufadienolide compounds, a dose-dependent cytotoxicity was observed in these cancer cells after treatment with gamabufotal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4946
更新日期:2016-09-01 00:00:00
abstract::Previous studies have suggested that certain genetic polymorphisms, specifically the Xeroderma pigmentosum group D (XPD) gene codon 751 and the X-ray repair cross-complementing group 1 (XRCC1) gene codon 399 polymorphisms, were associated with an increased risk of lung cancer, and, in some studies, with a greater risk...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000854
更新日期:2010-07-01 00:00:00
abstract::The aim of the study was to estimate the long-term results and the prognostic value of clinical and pathological factors following R0 anterior resection with total mesorectal excision (TME). Ninety-eight consecutive patients with histologically confirmed rectal cancer were studied prospectively with five-year follow-u...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
abstract::Ampelopsis sinica root (ASR) is a known hepatoprotective folk traditional Chinese medicine. The anti‑hepatoma activity of ethyl acetate extract from A. sinica root (ASRE) in vitro and in vivo and its possible mechanism were explored. This study was designed to investigate cytotoxicity by MTT assay, induction of apopto...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5504
更新日期:2017-04-01 00:00:00
abstract::Resistance to docetaxel, a chemotherapy drug for breast cancer (BC) treatment, occurs in ~50% of patients, and the underlying molecular mechanisms of drug resistance are not fully understood. Gene regulation through miR-141 has been proven to play an important role in cancer drug resistance. The present study investig...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3866
更新日期:2015-05-01 00:00:00
abstract::Human chorionic gonadotropin β (β-hCG) is a well-known and accurate marker for the diagnosis and monitoring of pregnancy, trophoblastic tumors and ovarian germ cell tumors. Recently, β-hCG has been found to be closely related to poor prognosis and metastasis in various other malignant tumors, while its role and mechan...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5818
更新日期:2017-09-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are n...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7140
更新日期:2019-07-01 00:00:00
abstract::Multidrug resistance (MDR) to chemotherapeutic drugs is the main cause of chemotherapy failure in cancer treatment, and it generally results from expression of ATP-dependent efflux pump P-glycoprotein (P-gp). MDR reversal agents typically act by inhibiting the drug efflux activity of P-gp, thereby increasing intracell...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3326
更新日期:2014-09-01 00:00:00
abstract::The present study aimed to explore the relationship between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKIs) and the expression of the cancer stem cell (CSC)‑related markers. Specimens of 72 cases of lung adenocarcinoma with significantly different therapeutic effects of the firs...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7454
更新日期:2020-02-01 00:00:00
abstract::A patient who had undergone radical gastrectomy for synchronous gastric cancer (T(1)N(0)M(0), stage I) and duodenal cancer (Tis, stage 0) in November 1987 was found to have esophageal cancer in November 1994, and underwent radical thoracolaparotomy at our hospital (T(1)N(0)M(0), stage I). After follow-up for about 3.5...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are reported to be involved in renal hypoxia/reoxygenation (H/R) damage. To investigate this further, human kidney (HK‑2) cells were cultured, subjected to H/R and the function of miR‑30a‑5p and glutamate dehydrogenase 1 (GLUD1) was evaluated. The results showed that, miR‑30‑5p was downregulated and...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7718
更新日期:2020-10-01 00:00:00
abstract::Histone deacetylase (HDAC) inhibitors exert potent inhibitory effects on various types of human cancer. The pioneer drug suberoylanilide hydroxamic acid (SAHA) is currently used in the clinic for cancer treatment. However, the effect of SAHA on tumor lymphangiogenesis is unclear. We recently showed that SAHA suppresse...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2523
更新日期:2013-08-01 00:00:00
abstract::The present study determined the anticancer activity and its mechanism of microRNA‑133b on cell proliferation of cisplatin-induced non-small cell lung cancer cells. The expression of microRNA-133b cisplatin‑induced non-small cell lung cancer (NSCLC) tissue was lower than that of para-carcinoma tissue in patients. Over...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6215
更新日期:2018-03-01 00:00:00
abstract::A phase I study of S-1 and biweekly docetaxel (DOC) combination therapy was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic parameters. Fourteen patients with advanced or recurrent gastric cancer were analyzed. The treatment consisted of S-1 [body surface area (BSA) <1.25 m2:80 mg/day, 1.25...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
abstract::Predicting the tumor response to radiotherapy is one of the major goals of human cancer treatment. Identification of the genes that are differentially expressed between radiosensitive and radioresistant cancers by global gene analysis may provide new insights into the mechanisms underlying clinical radioresistance and...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2007-11-01 00:00:00
abstract::The blood‑brain barrier (BBB) constitutes an efficient organization of tight junctions that limits the delivery of tumor to the brain. The principal tight junction protein in BBB is claudin‑5 (CLDN5), but its mechanism of action remains largely unknown. Long non‑coding RNAs (lncRNAs) are aberrantly expressed in many c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6208
更新日期:2018-03-01 00:00:00
abstract::5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is a new ablation treatment for tumors, while its function mechanism in cervical cancer has not been elucidated. In this study, we investigated the effects of ALA-PDT on the cervical cancer cell line Me180, to search for optimal parameters of PDT. ALA-PDT o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000295
更新日期:2009-04-01 00:00:00