Induction of human leukemia U937 cell apoptosis by an ethanol extract of Dendropanax morbifera Lev. through the caspase-dependent pathway.

Abstract:

:Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not yet been clearly elucidated. In the present study, we investigated the pro-apoptotic effects of an ethanol extract of D. morbifera stem bark (EEDM) on human leukemia U937 cells. EEDM markedly inhibited the growth of U937 cells by decreasing cell proliferation and inducing apoptosis. EEDM-induced apoptosis in U937 cells was associated with the upregulation of death receptor-related protein levels and downregulation of anti-apoptotic IAP family proteins. The increase in apoptosis was also associated with proteolytic activation of caspase-8, -9 and -3, inhibition of anti‑apoptotic Bcl-2 and Bcl-xL expression, Bid cleavage, and loss of MMP suggesting that apoptosis of U937 cells induced by EEDM was through the extrinsic and intrinsic pathways. However, a pan-caspase inhibitor, z-VED-fmk, significantly inhibited EEDM-induced U937 cell apoptosis indicating that the caspases were key regulators of apoptosis in response to EEDM in U937 cells. Our data suggest that D. morbifera may be a potential anticancer agent for cancer treatment.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Lee JW,Park C,Han MH,Hong SH,Lee TK,Lee SH,Kim GY,Choi YH

doi

10.3892/or.2013.2542

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1231-8

issue

3

eissn

1021-335X

issn

1791-2431

journal_volume

30

pub_type

杂志文章
  • Apoptosis induced by PGC-1β in breast cancer cells is mediated by the mTOR pathway.

    abstract::The peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator-1β (PGC-1β) is a well-established regulator of mitochondrial biogenesis. However, the underlying mechanism of PGC-1β action remains elusive. This study reveals that knockdown of endogenous PGC-1β by short-hairpin RNA (shRNA) leads to a decrease in t...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2628

    authors: Wang L,Liu Q,Li F,Qiu J,Fan H,Ma H,Zhu Y,Wu L,Han X,Yang Z,Jiang H,Wei J,Xia H

    更新日期:2013-10-01 00:00:00

  • Time-dependent release of extracellular vesicle subpopulations in tumor CABA I cells.

    abstract::Investigations into extracellular vesicles (EVs) have significantly increased since their role in physiological and pathological processes has become more clearly understood. Furthermore, it has become increasingly clear that several subpopulations of EVs exist, such as exosomes (EXOs) and microvesicles (MVs). Various...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4199

    authors: Giusti I,Di Francesco M,Cantone L,D'Ascenzo S,Bollati V,Carta G,Dolo V

    更新日期:2015-11-01 00:00:00

  • Thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in hepatocellular carcinoma and metastatic liver cancer.

    abstract::Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are considered to be key enzymes affecting the prognosis for patients with various cancers. We tried to prove the correlation of TP and DPD expression in hepatocellular carcinoma (HCC) and liver metastasis. We quantified TP and DPD levels by an enz...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Hotta T,Kobayashi Y,Taniguchi K,Johata K,Sahara M,Watanabe T,Ochiai M,Tanimura H,Tsubota YT

    更新日期:2004-08-01 00:00:00

  • Loss of Smad4 expression predicts liver metastasis in human colorectal cancer.

    abstract::Distant metastases represent the major cause of death after curative surgery of colorectal cancer. The aim of this study was to evaluate the role of Smad4 and KRAS genetic alterations in colorectal metastases taking into account both the site (hepatic versus extrahepatic) and the time (synchronous versus metachronous)...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Losi L,Bouzourene H,Benhattar J

    更新日期:2007-05-01 00:00:00

  • HSPA9 overexpression inhibits apoptin-induced apoptosis in the HepG2 cell line.

    abstract::Apoptin, a small protein derived from chicken anemia virus, possesses the capacity to specifically kill tumor cells while leaving normal cells intact. Previous studies have indicated that the subcellular localization of apoptin appears to be crucial for this tumor-selective activity. Apoptin resides in the cytoplasm o...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2399

    authors: Peng C,Yang P,Cui Y,He M,Liang L,Di Y

    更新日期:2013-06-01 00:00:00

  • MicroRNA-154 functions as a tumor suppressor in osteosarcoma by targeting Wnt5a.

    abstract::MicroRNAs (miRNAs) are small non-coding RNAs that are involved in tumor initiation and development by suppressing target gene expression. miRNA-154 has been shown to be important in tumorigenesis in many types of cancers. However, its role in osteosarcoma (OS) remains unknown. In the present study, we focused on the r...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4495

    authors: Zhou H,Zhang M,Yuan H,Zheng W,Meng C,Zhao D

    更新日期:2016-03-01 00:00:00

  • Human DNA topoisomerase II-alpha expression in laparoscopically treated renal cell carcinoma.

    abstract::To investigate whether the expression of Topoisomerase II-alpha (TII-alpha) can serve as a prognostic factor in renal cell carcinoma (RCC), histological sections from 27 renal tumors were stained immunohistochemically for TII-alpha expression. The percentage of positive cells in the area of greatest staining was recor...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Dekel Y,Frede T,Kugel V,Neumann G,Rassweiler J,Koren R

    更新日期:2005-07-01 00:00:00

  • Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma.

    abstract::Expression of Src homology phosphotyrosine phosphatase 2 (SHP2) has been observed in human breast cancer. SHP2 is known to promote cell migration and invasiveness. However, the pathophysiologic role of SHP2 and its relevance to tumorigenesis are still largely unknown. In the present study, we aimed to evaluate the eff...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3201

    authors: Hu Z,Fang H,Wang X,Chen D,Chen Z,Wang S

    更新日期:2014-07-01 00:00:00

  • Antitumor activity of monomethoxy poly(ethylene glycol)-poly (ε-caprolactone) micelle-encapsulated doxorubicin against mouse melanoma.

    abstract::Doxorubicin (Dox) is one of the most commonly used and highly effective antineoplastic agents, but the clinical application of this broad spectrum drug is largely hampered by its poor stability and serious toxicity to normal tissues. Hence, it is essential to improve the therapeutic effect and decrease the systematic ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1243

    authors: Zheng L,Gou M,Zhou S,Yi T,Zhong Q,Li Z,He X,Chen X,Zhou L,Wei Y,Qian Z,Zhao X

    更新日期:2011-06-01 00:00:00

  • Complementation of temperature tolerance by rat Rgl-1 recessive oncogene in the absence of Saccharomyces cerevisiae Sop genes.

    abstract::It has been demonstrated that homozygous mutations at the L(2)gl locus in Drosophila result in the development of tumor in the presumptive adult optic centers of the larval brain and of the imaginal discs. We previously cloned an L(2)gl homologue, Rgl-1, in the rat brain. In this study, we analyzed the capability of R...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Kim YK,Kim YS,Chung HM,Baek KH

    更新日期:2004-11-01 00:00:00

  • P2Y2 nucleotide receptor-mediated extracellular signal-regulated kinases and protein kinase C activation induces the invasion of highly metastatic breast cancer cells.

    abstract::Tumor metastasis is considered the main cause of mortality in cancer patients, thus it is important to investigate the differences between high- and low-metastatic cancer cells. Our previous study showed that the highly metastatic breast cancer cell line MDA-MB-231 released higher levels of ATP and exhibited higher P2...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.3972

    authors: Eun SY,Ko YS,Park SW,Chang KC,Kim HJ

    更新日期:2015-07-01 00:00:00

  • IGF expression in HPV-related and HPV-unrelated human cancer cells.

    abstract::The human Igf-1 gene not only produces insulin‑like growth factor-I (IGF-I), but also different carboxy‑terminal extensions, known as E peptides, through alternative splicing. We and others have shown that human Eb peptide (hEb) derived from Igf-1 has intrinsic biological activity and is localized to nuclei of transfe...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3329

    authors: Durzyńska J,Barton E

    更新日期:2014-09-01 00:00:00

  • TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells.

    abstract::Esophageal cancer is one of the most aggressive cancers in the world. Novel preventive and therapeutic strategies tend to target the key molecules involved in the signaling transduction pathways for cell growth. It is known that FAK and mTOR are important controllers of cell growth. TAE226, a novel small molecule comp...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Wang ZG,Fukazawa T,Nishikawa T,Watanabe N,Sakurama K,Motoki T,Takaoka M,Hatakeyama S,Omori O,Ohara T,Tanabe S,Fujiwara Y,Shirakawa Y,Yamatsuji T,Tanaka N,Naomoto Y

    更新日期:2008-12-01 00:00:00

  • Decreased expression of repulsive guidance molecule member A by DNA methylation in colorectal cancer is related to tumor progression.

    abstract::Previous studies have shown decreased expression of repulsive guidance molecule member A (RGMa) in colorectal cancer. However, the relationship between the expression levels and promoter DNA methylation status of RGMa and the clinical characteristics of colorectal cancer has not bee...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1693

    authors: Zhao ZW,Lian WJ,Chen GQ,Zhou HY,Wang GM,Cao X,Yang HJ,Hou YP

    更新日期:2012-05-01 00:00:00

  • Vesicular stomatitis virus is a potent agent for the treatment of malignant ascites.

    abstract::Cancer cells in ascites are usually exposed to a hypoxia tumor microenvironment and utilize enhanced glycolysis which produces energy and metabolizes nutrients to support proliferation. Vesicular stomatitis virus (VSV) is an oncolytic virus that relies on the host cellular metabolism for replication. We tested the eff...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4522

    authors: Zhou Y,Wen F,Zhang P,Tang R,Li Q

    更新日期:2016-03-01 00:00:00

  • Sequencing hormonal ablation and radiotherapy in prostate cancer: a molecular and therapeutic prespective (Review).

    abstract::Current therapeutic modalities for advanced prostate cancer are palliative in nature, with no effective treatment increasing survival in patients with metastatic prostate cancer. Apoptosis as a molecular process of genetically regulated cell death has a critical endpoint that coincides with the goal of successful trea...

    journal_title:Oncology reports

    pub_type: 杂志文章,评审

    doi:

    authors: Hill B,Kyprianou N

    更新日期:2002-11-01 00:00:00

  • MicroRNA-616 promotes the growth and metastasis of non-small cell lung cancer by targeting SOX7.

    abstract::MicroRNAs (miRNAs) are a group of important regulators in human types of cancer including non-small cell lung cancer (NSCLC). miR-616 has been found to be a novel cancer-related miRNA. However, the expression and biological function of miR-616 in NSCLC have not been investigated. In this study, qRT-PCR was performed t...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5854

    authors: Wang D,Cao Q,Qu M,Xiao Z,Zhang M,Di S

    更新日期:2017-10-01 00:00:00

  • MicroRNA-302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma.

    abstract::Glioma is the most frequent and aggressive primary tumor of the brain in humans. Over the last few decades, significant progress has been made in early detection and multi-mode treatments, but the prognosis of gliomas is still extremely poor. MicroRNAs are endogenously expressed non-coding, single strand and short RNA...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.5320

    authors: Ma J,Yu J,Liu J,Yang X,Lou M,Liu J,Feng F,Ji P,Wang L

    更新日期:2017-02-01 00:00:00

  • Metastasin leads to poor prognosis of hepatocellular carcinoma through partly inducing EMT.

    abstract::Hepatocellular carcinoma (HCC) is a common malignant cancer worldwide characterized by high metastatic potential and poor prognosis following radical resection. Metastasin is a Ca(2+)-binding protein associated with tumor metastasis. However, the expression and function of metastasin remain unknown. In the present stu...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2341

    authors: Zheng X,Gai X,Wu Z,Liu Q,Yao Y

    更新日期:2013-05-01 00:00:00

  • Inactivation of AKT/NF‑κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin.

    abstract::The high activation of protein kinase B (AKT)/nuclear factor‑κB (NF‑κB) signaling has often been associated with the induction of non‑small cell lung cancer (NSCLC) cell survival and resistance to cisplatin, which is one of the most widely used chemotherapeutic drugs in the treatment of NSCLC. The inhibition of AKT/NF...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2020.7710

    authors: Dukaew N,Chairatvit K,Pitchakarn P,Imsumran A,Karinchai J,Tuntiwechapikul W,Wongnoppavich A

    更新日期:2020-10-01 00:00:00

  • Overexpression of CPXM2 predicts an unfavorable prognosis and promotes the proliferation and migration of gastric cancer.

    abstract::Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human disorders such as developmental diseases. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. In the present study, we used clinical samples from gastric cancer (GC) patients to investigate poten...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2019.7254

    authors: Niu G,Yang Y,Ren J,Song T,Hu Z,Chen L,Hong R,Xia J,Ke C,Wang X

    更新日期:2019-10-01 00:00:00

  • Salinomycin induces apoptosis and differentiation in human acute promyelocytic leukemia cells.

    abstract::At present, acute promyelocytic leukemia (APL) is the most curable form of acute myeloid leukemia and can be treated using all-trans retinoic acid and arsenic trioxide. However, the current treatment of APL is associated with some issues such as drug toxicity, resistance and relapse. Therefore, other strategies are ne...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6513

    authors: Zhao Y,Zhong L,Liu L,Yao SF,Chen M,Li LW,Shan ZL,Xiao CL,Gan LG,Xu T,Liu BZ

    更新日期:2018-08-01 00:00:00

  • miRNA‑199b‑3p suppresses growth and progression of ovarian cancer via the CHK1/E‑cadherin/EMT signaling pathway by targeting ZEB1.

    abstract::Ovarian cancer is one of the most common gynecological malignancies and its pathogenesis and progression are regulated by multiple genes. MicroRNAs (miRNAs) are endogenous non‑coding RNAs that regulate body function by altering post‑transcriptional gene expression. Previous studies have suggested that miRNAs are close...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2020.7895

    authors: Wei L,He Y,Bi S,Li X,Zhang J,Zhang S

    更新日期:2020-12-11 00:00:00

  • Combretazet-3 a novel synthetic cis-stable combretastatin A-4-azetidinone hybrid with enhanced stability and therapeutic efficacy in colon cancer.

    abstract::In recent years an extensive series of synthetic combretastatin A-4 (CA-4)-azetidinone (β-lactam) hybrids were designed and synthesised with a view to improve the stability, therapeutic efficacy and aqueous solubility of CA-4. Lead compounds containing a 3,4,5-trimethoxy aromatic ring at position 1 and a variety of su...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2379

    authors: Greene LM,Wang S,O'Boyle NM,Bright SA,Reid JE,Kelly P,Meegan MJ,Zisterer DM

    更新日期:2013-06-01 00:00:00

  • Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.

    abstract::Licochalcone A (LicA) is a chalcone extracted from liquorice which has been used as a traditional Chinese medicine for many generations. Increased glucose consumption and glycolytic activity are important hallmarks of cancer cells, and hexokinase 2 (HK2) upregulation is a major contributor to the elevation of glycolys...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.6155

    authors: Wu J,Zhang X,Wang Y,Sun Q,Chen M,Liu S,Zou X

    更新日期:2018-03-01 00:00:00

  • Loss of imprinting of PEG1/MEST in lung cancer cell lines.

    abstract::Paternally expressed imprinted gene 1/mesoderm-specific transcript (PEG1/MEST) is an imprinted gene expressed from the paternal allele. Recently, frequent loss of imprinting (LOI) of PEG1/MEST has been reported in lung adenocarcinomas. It is suggested that the LOI may be involved in pathogenesis of lung adenocarcinoma...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Nakanishi H,Suda T,Katoh M,Watanabe A,Igishi T,Kodani M,Matsumoto S,Nakamoto M,Shigeoka Y,Okabe T,Oshimura M,Shimizu E

    更新日期:2004-12-01 00:00:00

  • β‑carotene reverses tobacco smoke‑induced gastric EMT via Notch pathway in vivo.

    abstract::Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid pre...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6246

    authors: Lu L,Chen J,Li M,Tang L,Wu R,Jin L,Liang Z

    更新日期:2018-04-01 00:00:00

  • Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer.

    abstract::Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in tumor invasion, but their prognostic significance is still under discussion. We set out to analyze the epithelial and stromal expression of MMP-2, MMP-7, MMP-9, MT1-MMP, TIMP-1 and TIMP-2 in advanced epithelial ovarian cancers and to ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1608

    authors: Brun JL,Cortez A,Lesieur B,Uzan S,Rouzier R,Daraï E

    更新日期:2012-04-01 00:00:00

  • Internal mammary sentinel node biopsy for breast cancer: is it practicable and relevant? (Review).

    abstract::Sentinel lymph node (SLN) biopsy is a useful way of assessing axillary nodal status and obviates unnecessary axillary lymph node dissection for patients with node-negative breast cancer. However, SLN can also be located in the internal mammary lymph node (IMN) chain or elsewhere. The practicability and relevance of in...

    journal_title:Oncology reports

    pub_type: 杂志文章,评审

    doi:

    authors: Noguchi M

    更新日期:2002-05-01 00:00:00

  • Spindle-cell ameloblastic carcinoma: A case report with immunohistochemical, ultrastructural, and comparative genomic hybridization analyses.

    abstract::Spindle-cell ameloblastic carcinoma is a classification proposed for a group of rare odontogenic carcinomas with sarcomatoid components and is distinguished from odontogenic carcinosarcoma. We report a case of spindle-cell ameloblastic carcinoma of the right mandible that occurred in a 67-year-old Japanese man. Growth...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Kawauchi S,Hayatsu Y,Takahashi M,Furuya T,Oga A,Niwa S,Sasaki K

    更新日期:2003-01-01 00:00:00