Abstract:
:The deficiencies of nucleotide excision repair (NER) factors are involved in rare genetic diseases such as xeroderma pigmentosum (XP) with increased risk of developing cancer on sun-exposed areas of the skin. However, the abnormality of NER factors in human sporadic carcinoma remains unclear. Loss of heterozygosity (LOH) analysis, using the microdissected tissues, for the XPA, XPB, XPC, XPD, XPE, XPF, XPG and the transcription-coupled repair factor, Cockayne syndrome B (CSB) revealed that NER factors were abnormal in 30.0% (3/10 cases) of oral squamous cell carcinomas. Furthermore, 10.0% of oral carcinomas exhibited LOH for NER factors without LOH for tumor suppressor genes such as p53, FHIT, APC, BRCA1, BRCA2 and DCC. These observations raise the possibility that alterations of NER factors may be involved in carcinogenesis in human oral squamous cell carcinoma.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Miyashita H,Mori S,Tanda N,Nakayama K,Kanzaki A,Sato A,Morikawa H,Motegi K,Takebayashi Y,Fukumoto Mdoi
10.3892/or.8.5.1133keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
1133-8issue
5eissn
1021-335Xissn
1791-2431journal_volume
8pub_type
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