Dysregulation of TMPRSS3 and TNFRSF11B correlates with tumorigenesis and poor prognosis in patients with breast cancer.

Abstract:

:The present study was carried out to investigate the clinical significance of TMPRSS3 and TNFRSF11B in breast cancer. Thus, the expression levels of TMPRSS3 and TNFRSF11B and the correlation with prognosis in patients with breast cancer were analyzed in silico using gene microarray and hierarchical clustering analysis. Then, the differential expression in breast cancer vs. normal breast tissue was explored in the Oncomine platform and verified in our independent samples using IHC technique. Our results indicated that TMPRSS3 was upregulated and TNFRSF11B was downregulated in breast cancer tissues compared with the levels in the human normal breast tissues. TMPRSS3 and TNFRSF11B were confirmed to be correlated with distant organ metastasis of breast cancer. Moreover, upregulation of TMPRSS3 accompanied by downregulation of TNFRSF11B was found to be associated with a shorter median overall survival and indicated a poor prognosis. In conclusion, TMPRSS3 and TNFRSF11B may have potential prognostic value to be used as tumor biomarkers in breast cancer patients.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Luo P,Lu G,Fan LL,Zhong X,Yang H,Xie R,Lv Z,Lv QZ,Fu D,Yang LX,Ma Y

doi

10.3892/or.2017.5449

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

2057-2062

issue

4

eissn

1021-335X

issn

1791-2431

journal_volume

37

pub_type

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