Plasmid DNA introduced into cultured cells with diagnostic ultrasound.

abstract：:Rab is a large subfamily of small GTPases which play an important role in multiple processes relating to cellular transportation and modulation of the cytoskeleton. Novel gene Rab-like 3 (Rabl3), which we originally reported as a new member belonging to this subfamily, may participate in other processes in human cance...

journal_title：Oncology reports

authors： Li Q,Wang L,Zeng L,Zhang Y,Li K,Jin P,Su B,Wang L

更新日期：2010-08-01 00:00:00

abstract：:Given such differences as relative tumor burden, the optimal dose and schedule for postoperative adjuvant chemotherapy of microscopic disease might be expected to differ significantly from therapy of advanced higher volume disease. We investigated this hypothesis by determining the optimal dose and schedule of the 5-F...

journal_title：Oncology reports

authors： Uchida J,Okabe H,Nakano K,Fujioka A,Saito H,Sugimoto Y,Oka T,Fukushima M

更新日期：2007-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is known to play a central role in tumour angiogenesis. Up to now inconclusive data have been published on the clinical-biological significance of circulating VEGF and on the most suitable blood fraction for measuring it. The aims of this pilot study were to assess VEGF in blo...

journal_title：Oncology reports

authors： Ranieri G,Coviello M,Chiriatti A,Stea B,Montemurro S,Quaranta M,Dittadi R,Paradiso A

更新日期：2004-02-01 00:00:00

abstract：:Breast cancer is the most common cancer type and the leading cause of cancer‑associated mortality in women across the majority of countries. In general, the incidence of breast cancer has been decreasing in developed countries over the previous 20 years, while it has increased in the other areas, such as the Asian‑Pac...

journal_title：Oncology reports

authors： Han R,Zhao J,Lu L

更新日期：2020-06-01 00:00:00

abstract：:Casein kinase 2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is involved in regulating many processes such as cell proliferation, differentiation and apoptosis. CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma. In the present study, we found that...

journal_title：Oncology reports

authors： Zhu X,Ouyang Y,Zhong F,Wang Q,Ding L,Zhang P,Chen L,Liu H,He S

更新日期：2017-01-01 00:00:00

abstract：:Hyaluronan (HA), a component of the extracellular matrix, plays an important role in cell-cell adhesion and cell migration. Membrane type 1-matrix metalloproteinase (MT1‑MMP) is often expressed in invasive cancer cells. CD44, a transmembrane receptor for HA, is implicated in various adhesion-dependent cellular process...

journal_title：Oncology reports

authors： Kung CI,Chen CY,Yang CC,Lin CY,Chen TH,Wang HS

更新日期：2012-11-01 00:00:00

abstract：:Adoptive immunotherapy requires the isolation of CD8+ T cells specific for tumor-associated antigens, their expansion in vitro and their transfusion to the patient to mediate a therapeutic effect. MUC1 is an important adenocarcinoma antigen immunogenic for T cells. The MUC1-derived SAPDTRPA (MUC1-8-mer) peptide is a p...

journal_title：Oncology reports

authors： Atzin-Méndez JA,López-González JS,Báez R,Arenas-Del Angel MC,Montaño LF,Silva-Adaya D,Lascurain R,Gorocica P

更新日期：2016-01-01 00:00:00

abstract：:Cyclin D1 expression is closely related with ER status in breast cancer. We executed this study to evaluate whether therapeutic response to tamoxifen varies with levels of cyclin D1 expression in 66 ER positive breast cancer patients having solitary bone metastasis. Treatment response to tamoxifen and correlation betw...

journal_title：Oncology reports

authors： Han S,Park K,Bae BN,Kim KH,Kim HJ,Kim YD,Kim HY

更新日期：2003-01-01 00:00:00

abstract：:The metastasis-associated (MTA) gene family is a critical component of the nucleosome remodeling and histone deacetylase complex, and plays an important role in metastatic processes. We systematically evaluated dysregulation of the MTA family to clarify their clinical significance in gastric cancer (GC). One hundred a...

journal_title：Oncology reports

authors： Okugawa Y,Mohri Y,Tanaka K,Kawamura M,Saigusa S,Toiyama Y,Ohi M,Inoue Y,Miki C,Kusunoki M

更新日期：2016-10-01 00:00:00

abstract：:Dendritic cell-mediated cancer immunotherapy employs several ways to engage tumor antigens. We have demonstrated in both pre-clinical animal studies and early clinical trials that dendritomas, highly purified hybrids between dendritic cells (DC) and tumor cells, are superior activators of anti-tumor immunity. It has b...

journal_title：Oncology reports

authors： Branham-O'Connor M,Li J,Kotturi HS,Yu X,Wagner TE,Wei Y

更新日期：2010-02-01 00:00:00

abstract：:p73 is a member of p53 tumor suppressor protein family. In spite of similarities of three meaningful domains between p53 and p73, the exact function of p73 protein is not established. To approach the relevance of p73 expression to a pathological parameter in human breast cancer, the apoptotic index (AI) and the mitoti...

journal_title：Oncology reports

authors： Yamamoto T,Oda K,Kubota T,Miyazaki K,Takenouti Y,Nimura Y,Hamaguchi M,Matsuda S

更新日期：2002-07-01 00:00:00

abstract：:Multicellular tumor spheroids have been used to examine aspects of combined modality treatment since they often recreate the in vivo tumor environment much more closely than other models. The radioenhancement by gemcitabine (dFdC) on human glioma spheroids derived from cell lines (CLS) and biopsy tissue, grown as orga...

journal_title：Oncology reports

authors： Fehlauer F,Muench M,Smid EJ,Slotman B,Richter E,Van der Valk P,Sminia P

更新日期：2006-01-01 00:00:00

abstract：:No information is currently available regarding pancreatic cancer (PC) pattern of care in Italy. In the present study, a nationwide survey using a questionnaire was performed to enquire the local standards for PC diagnosis and radiotherapy treatment. Fifty-seven percent of 140 Italian centres completed questionnaire. ...

journal_title：Oncology reports

authors： Macchia G,Sainato A,Talamini R,Boz G,Bacigalupo A,Caravatta L,Fiore M,Friso ML,Fusco V,Lupattelli M,Mantello G,Mattiucci GC,Slim N,Sciacero P,Turri L,Valentini V,Morganti AG,Genovesi D

更新日期：2015-07-01 00:00:00

abstract：:Long non-coding RNA growth arrest-specific 5 (GAS5) was reported to be aberrantly expressed in various types of cancers. However, the role of GAS5 in the evolution and progression of ovarian cancer remains elusive. In the present study, we aimed to investigate the cellular function and clinical significance of GAS5 in...

journal_title：Oncology reports

authors： Li J,Huang H,Li Y,Li L,Hou W,You Z

更新日期：2016-12-01 00:00:00

abstract：:The present study aimed to examine the inhibitory effects of morusin on the human lung cancer cell line A549. Various doses of morusin were applied to A549 cells and the effects were assessed by wound‑healing and MTT assays, flow cytometry analysis of apoptosis, a mitochondrial membrane potential assay and RT‑PCR. The...

journal_title：Oncology reports

authors： Yin XL,Lv Y,Wang S,Zhang YQ

更新日期：2018-07-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes mediating cell survival, proliferation and angiogenesis and is aberrantly activated in various types of malignancies, including bladder cancer. We examined whether it could be a novel therapeutic target for bladder cancer usin...

journal_title：Oncology reports

authors： Tsujita Y,Horiguchi A,Tasaki S,Isono M,Asano T,Ito K,Asano T,Mayumi Y,Kushibiki T

更新日期：2017-10-01 00:00:00

abstract：:The aim of the present study was to investigate the efficacy of using human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) as gene delivery vectors in the treatment of ovarian cancer. Lentivectors overexpressing cytosine deaminase (CD) and herpes simplex virus thymidine kinase (HSV-tk) (pGC-FU-CD-TK) ...

journal_title：Oncology reports

authors： Jiang J,Wei D,Sun L,Wang Y,Wu X,Li Y,Fang Z,Shang H,Wei Z

更新日期：2014-02-01 00:00:00

abstract：:A small subset of cells within a malignant neoplasm, named cancer stem cells (CSCs) or tumour initiating cells, are thought to be capable of initiating the neoplasm itself, and of driving its growth and recurrence after treatment. It is unclear whether CSCs can be identified and experimentally induced within oral squa...

journal_title：Oncology reports

authors： Qiao B,Johnson NW,Chen X,Li R,Tao Q,Gao J

更新日期：2011-08-01 00:00:00

abstract：:Although radiotherapy is routinely administered to high-risk endometrial carcinoma and offer a significant disease-free survival advantage, the therapeutic effect is sometimes limited by the occurrence of radioresistance. To determine the patterns of gene expression responsible for the radioresistance and to search fo...

journal_title：Oncology reports

authors： Du XL,Jiang T,Wen ZQ,Li QS,Gao R,Wang F

更新日期：2009-03-01 00:00:00

abstract：:Heparanase is endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane. Heparanase has been thought to have an important role in the process of cancer invasion and metastasis. Recent studies have revealed that heparanase has multifunctional mo...

journal_title：Oncology reports

authors： Naomoto Y,Takaoka M,Okawa T,Nobuhisa T,Gunduz M,Tanaka N

更新日期：2005-07-01 00:00:00

abstract：:Laryngeal squamous cell carcinoma (LSCC) is a common cancer of the upper respiratory tract. The cytogenetic and molecular events involved in the pathogenesis of LSCC are not well understood. In this study, a combined strategy of conventional cytogenetics, fluorescent in situ hybridization (FISH) and microsatellite pol...

journal_title：Oncology reports

authors： Kang N,Li F,Fu W,Zhang J,Sun K

更新日期：2007-12-01 00:00:00

abstract：:The p53 tumor suppressor is a transcription factor that regulates cell cycle and apoptosis in response to a variety of environmental stress conditions. Recent studies indicated that the apoptotic protease activating factor-1 (Apaf-1) is a direct transcriptional target of p53 in DNA damage-induced apoptosis. However, t...

journal_title：Oncology reports

authors： Ho CK,Bush JA,Li G

更新日期：2003-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of important regulators in human types of cancer including non-small cell lung cancer (NSCLC). miR-616 has been found to be a novel cancer-related miRNA. However, the expression and biological function of miR-616 in NSCLC have not been investigated. In this study, qRT-PCR was performed t...

journal_title：Oncology reports

authors： Wang D,Cao Q,Qu M,Xiao Z,Zhang M,Di S

更新日期：2017-10-01 00:00:00

abstract：:We investigated a phase III randomized trial to compare efficacy and tolerance of CDDP + 5-FU to CDDP + VP16, both given intravenously in patients with unresectable advanced head and neck cancer. The 197 eligible patients were paired off successively on the basis of tumor sites and UICC stage. Comparisons were made th...

journal_title：Oncology reports

authors： Prévost A,Mérol JC,Aimé P,Moutel K,Roger-Liautaud F,Nasca S,Legros M,Coninx P

更新日期：2005-09-01 00:00:00

abstract：:SET domain bifurcated 1 (SETDB1) is a histone H3 lysine 9 methyltransferase that is highly expressed in various tumor types, including breast cancer. However, how SETDB1 functions in breast cancer is unclear. In the present study, proliferation, migration and invasion assays were performed to explore the role of SETDB...

journal_title：Oncology reports

authors： Yang W,Su Y,Hou C,Chen L,Zhou D,Ren K,Zhou Z,Zhang R,Liu X

更新日期：2019-02-01 00:00:00

abstract：:The aim of the present study was to investigate the expression, function and underlying molecular mechanism of the long non‑coding (lnc) RNA RP1‑163G9.1 in patients with gastric adenocarcinoma (GA). The expression levels of lncRNA RP1‑163G9.1 were determined in 112 paired clinical GA tissues by reverse transcription‑q...

journal_title：Oncology reports

authors： Sun B,Dang Y,Zhang F,Li K,Ouyang X,Wang K,Huang Q

更新日期：2019-06-01 00:00:00

abstract：:DNA methylation plays an important role in the genesis and progression of tumor diseases. To identify new DNA methylation markers possibly associated with the clinical characteristics of renal cell carcinoma (RCC), we investigated loci in the sarcosine dehydrogenase (SARDH) gene. SARDH is involved in the metabolism of...

journal_title：Oncology reports

authors： Mazdak M,Tezval H,Callauch JC,Dubrowinskaja N,Peters I,Bokemeyer C,Hennenlotter J,Stenzl A,Kuczyk MA,Serth J

更新日期：2019-11-01 00:00:00

abstract：:Despite improvements in immunotherapy, little is known about dendritic cell (DC) subpopulations naturally occurring in the laryngeal cancer tissue (LCT) and peripheral blood (PB) of untreated laryngeal cancer (LC) patients. The purpose of the present study was to evaluate mature, im...

journal_title：Oncology reports

authors： Klatka J,Grywalska E,Tabarkiewicz J,Polak A,Rolinski J

更新日期：2012-07-01 00:00:00

abstract：:Recent studies suggest that latexin (Lxn) expression is involved in stem cell regulation and that it plays significant roles in tumor cell migration and invasion. The clinicopathological significance of Lxn expression and its possible correlation with CD133 expression in pancreatic ductal adenocarcinoma (PDAC) is curr...

journal_title：Oncology reports

authors： Xue Z,Zhou Y,Wang C,Zheng J,Zhang P,Zhou L,Wu L,Shan Y,Ye M,He Y,Cai Z

更新日期：2016-01-01 00:00:00

abstract：:The medicinal properties of extracts from the hemp plant Cannabis sativa have been known for centuries but only in the 90s membrane receptors for the Cannabis major principle were discovered in mammalian cells. Later on the endogenous ligands for the cannabinoid receptors were identified and the term 'endocannabinoid ...

journal_title：Oncology reports

authors： Bifulco M,Laezza C,Gazzerro P,Pentimalli F

更新日期：2007-04-01 00:00:00