Disclosure of a stem cell phenotype in an oral squamous cell carcinoma cell line induced by BMP-4 via an epithelial-mesenchymal transition.

abstract：:Luteolin was recently demonstrated to suppress tumor growth by interfering with nuclear factor (NF)‑κB activation. As the NF‑κB pathway plays a critical role in muscular atrophy associated with cancer cachexia, we aimed to investigate the potential of luteolin to alleviate cancer‑associated cachexia in a Lewis lung ca...

journal_title：Oncology reports

authors： Chen T,Li B,Xu Y,Meng S,Wang Y,Jiang Y

更新日期：2018-08-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries, and mainly originates from an accumulation of abnormal B cells caused by the dysregulation of cell proliferation and apoptosis rates. The aberration of apoptosis-related genes in CLL cells results in defective apoptosis of CLL cells i...

journal_title：Oncology reports

authors： Fu C,Gong Y,Shi X,Sun Z,Niu M,Sang W,Xu L,Zhu F,Wang Y,Xu K

更新日期：2016-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) play a vital role in tumour biological and pathologic processes. In the present study, we aimed to detect the expression and biological role of miR-216b in glioma. Our data showed that miR-216b was significantly downregulated in human glioma tissues and cells. Ectopic expression of miR-216b inhibite...

journal_title：Oncology reports

authors： Zhang T,Ma G,Zhang Y,Huo H,Zhao Y

更新日期：2017-09-01 00:00:00

abstract：:Mangosteen (Garcinia mangostana) is a tree found in South-East Asia and the pericarp of its fruit has been used in folk medicine for the treatment of many human illnesses. Mangosteen fruit rinds contain a high concentration of xanthone, which is a type of polyphenol. One type of xanthone, α-mangostin, has been reporte...

journal_title：Oncology reports

authors： Fukuda M,Sakashita H,Hayashi H,Shiono J,Miyake G,Komine Y,Taira F,Sakashita H

更新日期：2017-12-01 00:00:00

abstract：:MA128, a novel herbal medicine, was previously identified and its effectiveness in the treatment of asthma and atopic dermatitis (AD) was demonstrated. In particular, post-inflammatory hyperpigmentation (PIH) in AD mice was improved by treatment with MA128. In addition, MA128 exhibited anti-melanogenic activity by inh...

journal_title：Oncology reports

authors： Kim A,Im M,Yim NH,Hwang YH,Yang HJ,Ma JY

更新日期：2015-08-01 00:00:00

abstract：:Despite improvements in immunotherapy, little is known about dendritic cell (DC) subpopulations naturally occurring in the laryngeal cancer tissue (LCT) and peripheral blood (PB) of untreated laryngeal cancer (LC) patients. The purpose of the present study was to evaluate mature, im...

journal_title：Oncology reports

authors： Klatka J,Grywalska E,Tabarkiewicz J,Polak A,Rolinski J

更新日期：2012-07-01 00:00:00

abstract：:Astilbin exhibits several pharmacological activities, including hypoglycemic, anti-oxidant and anti-inflammatory properties. The aim of the present study was to investigate the pro-apoptotic activities of astilbin on breast cancer in cells and mice. It was demonstrated that astilbin significantly reduced the cell viab...

journal_title：Oncology reports

authors： Sun X,Zhang H,Zhang Y,Yang Q,Zhao S

更新日期：2018-10-01 00:00:00

abstract：:In the development and progression of cancer, tumor suppressor genes may be silenced by mechanisms such as methylation. Thus the discovery of new genes silenced by methylation may uncover new tumor suppressor genes, and improve our understanding of cancer biology. In this study we investigated the methylation of 19 ge...

journal_title：Oncology reports

authors： Tsunoda S,Smith E,De Young NJ,Wang X,Tian ZQ,Liu JF,Jamieson GG,Drew PA

更新日期：2009-04-01 00:00:00

abstract：:To evaluate the efficacy of long-term postoperative adjuvant chemotherapy with low-dose cisplatin (CDDP) plus 5-fluorouracil (5-FU) (CDDP/5-FU), we retrospectively examined 167 patients with squamous cell carcinoma of the esophagus who received the treatment after curative surgery (R0 resection). We classified the pat...

journal_title：Oncology reports

authors： Shiozaki A,Yamagishi H,Itoi H,Fujiwara H,Kikuchi S,Okamoto K,Ichikawa D,Fuji N,Ochiai T,Sonoyama T,Ueda Y

更新日期：2005-04-01 00:00:00

abstract：:The Houttuynia cordata Thunb (HCT) extract has been used as a traditional Chinese herb medicine and as well as an effective drug for treating allergic inflammation for thousands of years. In this study, we investigated the anti-cancer activity of HCT and its molecular mechanisms in the human colon adenocarcinoma cell ...

journal_title：Oncology reports

authors： Tang YJ,Yang JS,Lin CF,Shyu WC,Tsuzuki M,Lu CC,Chen YF,Lai KC

更新日期：2009-11-01 00:00:00

abstract：:Previous studies have shown that S100P contributes to the development of a number of tumors. However, its prognostic significance in colorectal cancer (CRC) has not been demonstrated. This study aimed to confirm the expression of S100P in colorectal cancer as well as the epigenetic mechanism underlying its gene expres...

journal_title：Oncology reports

authors： Wang Q,Zhang YN,Lin GL,Qiu HZ,Wu B,Wu HY,Zhao Y,Chen YJ,Lu CM

更新日期：2012-07-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), and microvessel density (MVD) have been reported to be significantly related to carcinogenesis and to tumoral progression. The aim of the study was to analyse immunohistochemically the overexpression of COX-2 and VEGF, and the MVD between one another...

journal_title：Oncology reports

authors： Raspollini MR,Amunni G,Villanucci A,Boddi V,Baroni G,Taddei A,Taddei GL

更新日期：2004-02-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are associated with invasion and metastasis of several human malignant tumors. Especially so MMP-7, as it is mainly produced by the actual cancer cells. However, the expression of MMP-7 in transitional cell carcinoma (TCC) of the urinary bladder has not been previously investigated. We...

journal_title：Oncology reports

authors： Sumi T,Yoshida H,Hyun Y,Yasui T,Matsumoto Y,Hattori K,Sugimura K,Kawashima H,Nakatani T,Ishiko O

更新日期：2003-03-01 00:00:00

abstract：:Combined chemotherapy with 5-fluorouracil and leucovorin (LV) has been widely used for the treatment of patients with colorectal cancer. Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), whic...

journal_title：Oncology reports

authors： Tsukioka S,Sakamoto E,Tsujimoto H,Nakagawa F,Saito H,Uchida J,Kiniwa M,Fukushima M

更新日期：2011-05-01 00:00:00

abstract：:RNA‑binding motif 3 (RBM3) is a cold‑shock protein that has been previously shown to attenuate cancer stem cell‑like features in prostate cancer (PCa) cells. However, the mechanism underlying RBM3 regulation in PCa cells is largely unknown. The present study investigated the impact of RBM3 expression on the whole tran...

journal_title：Oncology reports

authors： Dong Q,Lv C,Zhang G,Yu Z,Kong C,Fu C,Zeng Y

更新日期：2018-10-01 00:00:00

abstract：:The ING1 gene is involved in the regulation of the cell cycle, senescence, and apoptosis and is a novel candidate tumor suppressor gene. ING2, another gene in the ING family, was identified and cloned. The functions of ING1 and ING2 largely depend on the activity of p53. To determine whether an alteration in these gen...

journal_title：Oncology reports

authors： Okano T,Gemma A,Hosoya Y,Hosomi Y,Nara M,Kokubo Y,Yoshimura A,Shibuya M,Nagashima M,Harris CC,Kudoh S

更新日期：2006-03-01 00:00:00

abstract：:Monoclonal antibody therapy for immune checkpoint blockade has achieved promising results for several types of malignant tumors. For the future treatment of gastrointestinal stromal tumors (GISTs) by immune checkpoint blockade, expression of immune checkpoint-related molecules that suppress antitumor immunity in GISTs...

journal_title：Oncology reports

authors： Komita H,Koido S,Hayashi K,Kan S,Ito M,Kamata Y,Suzuki M,Homma S

更新日期：2015-10-01 00:00:00

abstract：:The aim of this study is to evaluate characteristics in lung cancer patients with chronic obstructive pulmonary disease (COPD). Among 966 lung cancer patients admitted to our division over a period of 24 years, 73 patients were diagnosed as having COPD. There were 68 (93.2%) men and 5 women; of the tumors 43 (58.9%) w...

journal_title：Oncology reports

authors： Kurishima K,Satoh H,Ishikawa H,Yamashita YT,Homma T,Ohtsuka M,Sekizawa K

更新日期：2001-01-01 00:00:00

abstract：:Doxorubicin (Dox) is one of the most commonly used and highly effective antineoplastic agents, but the clinical application of this broad spectrum drug is largely hampered by its poor stability and serious toxicity to normal tissues. Hence, it is essential to improve the therapeutic effect and decrease the systematic ...

journal_title：Oncology reports

authors： Zheng L,Gou M,Zhou S,Yi T,Zhong Q,Li Z,He X,Chen X,Zhou L,Wei Y,Qian Z,Zhao X

更新日期：2011-06-01 00:00:00

abstract：:After having carefully checked the original data of Fig. 3, the authors noted that the student in their research group had inadvertently selected incorrect images for the 10 and 20 µM lycorine experiments to show the effect of lycorine on the migration of HepG2 cells during the figure compilation process. The correcte...

journal_title：Oncology reports

authors： Liu W,Zhang Q,Tang Q,Hu C,Huang J,Liu Y,Lu Y,Wang Q,Li G,Zhang R

更新日期：2019-12-01 00:00:00

abstract：:The pathogenic mechanisms responsible for inflammatory bowel disease (IBD) are poorly understood. In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induced colitis, which exhibited several clinical and histological features similar to IBD. However, pathogenic facto...

journal_title：Oncology reports

authors： Araki Y,Mukaisyo K,Sugihara H,Hattori T

更新日期：2008-07-01 00:00:00

abstract：:The objective of this study was to investigate the effect of silencing gene protein phosphatase 1H (PPM1H) on malignant phenotype of human pancreatic cancer cell line BxPC-3. In order to explore the function of PPM1H in pancreatic cancer cells, real-time PCR and western blotting were used to detect the expression of P...

journal_title：Oncology reports

authors： Zhu H,Qin H,Li DM,Liu J,Zhao Q

更新日期：2016-11-01 00:00:00

abstract：:Podoplanin is a 38 kDa mucin-type transmembrane glycoprotein that was first identified in rat glomerular epithelial cells (podocytes). It is expressed in normal lymphatic endothelium, but is absent from vascular endothelial cells. D2-40 is a commercially available mouse monoclonal antibody which binds to an epitope on...

journal_title：Oncology reports

authors： Xu Y,Ogose A,Kawashima H,Hotta T,Ariizumi T,Li G,Umezu H,Endo N

更新日期：2011-03-01 00:00:00

abstract：:Vaccine strategies for the treatment of human papillomavirus-induced cervical cancer are based mainly on the human papillomavirus 16 E7 (HPV16 E7) oncoprotein. The immunogenicity of the E7 gene has been enhanced by its fusion to many different genes. Here, we linked a short sequence coding for the E7 peptide (aa 44-60...

journal_title：Oncology reports

authors： Pokorna D,Cerovska N,Smahel M,Moravec T,Ludvikova V,Mackova J,Synkova H,Duskova M,Hozak P,Veleminsky J

更新日期：2005-10-01 00:00:00

abstract：:It is well known that low-dose metronomic chemotherapy has antiangiogenic activity. The aim of the present trial was to investigate the antiangiogenic properties of weekly docetaxel in patients with metastatic breast cancer. In total, 157 metastatic breast cancer patients received 3...

journal_title：Oncology reports

authors： Pectasides D,Papaxoinis G,Kotoula V,Fountzilas H,Korantzis I,Koutras A,Dimopoulos AM,Papakostas P,Aravantinos G,Varthalitis I,Kosmidis P,Skarlos D,Bournakis E,Bafaloukos D,Kalofonos HP,Kalogeras KT,Fountzilas G

更新日期：2012-01-01 00:00:00

abstract：:DLC-1 (deleted in liver cancer-1) is a potential tumor suppressor gene, which is inactive in liver carcinogenesis. To observe the effects of DLC-1 gene expression on cell proliferation and migration in the human colon cancer cell line, RNAi Lipo-recombinant of the DLC-1 gene (pGCsil-DLC-1) was constructed and transduc...

journal_title：Oncology reports

authors： Jin Y,Tian X,Shang Y,Huang P

更新日期：2008-03-01 00:00:00

abstract：:Gastric cancer (GC) is a severe public health problem worldwide, particularly in China. Radiotherapy is the main locoregional treatment for various types of unresectable tumor, including GC. However, many patients fail to respond to radiotherapy due to the intrinsic radioresistance of cancer cells. This study was desi...

journal_title：Oncology reports

authors： Geng W,Tian D,Wang Q,Shan S,Zhou J,Xu W,Shan H

更新日期：2019-08-01 00:00:00

abstract：:Telomerase activation is prevalent in most epithelial tumors, and may be a critical step in cellular immortalization and carcinogenesis. However, telomerase activity in tumors of mesenchymal origin is not well understood. In the present study, we examined telomerase activity in clinical samples from osteosarcoma and s...

journal_title：Oncology reports

authors： Terasaki T,Kyo S,Takakura M,Maida Y,Tsuchiya H,Tomita K,Inoue M

更新日期：2004-06-01 00:00:00

abstract：:Esophageal carcinosarcoma (ECS) is a rare malignant neoplasm associated with a poor patient prognosis. It is characterized by the presence of both malignant epithelial and mesenchymal components. Molecular-targeted therapy of several receptor tyrosine kinases (RTKs) has been reported to be effective in the treatment o...

journal_title：Oncology reports

authors： Sano A,Sakurai S,Kato H,Suzuki S,Yokobori T,Sakai M,Tanaka N,Inose T,Sohda M,Nakajima M,Fukai Y,Miyazaki T,Ojima H,Hosoya Y,Enomoto T,Kanda T,Ajioka Y,Kuwano H

更新日期：2013-06-01 00:00:00

abstract：:Oral mucositis is a severe complication of radiotherapy. Hence, it may constitute a serious medical safety risk for astronauts during extended space flights, such as missions to Mars, during which they are exposed to heavy-ion irradiation. For risk assessment of developing radiation-induced mucositis, a three-dimensio...

journal_title：Oncology reports

authors： Tschachojan V,Schroer H,Averbeck N,Mueller-Klieser W

更新日期：2014-11-01 00:00:00