Antitumor activity of monomethoxy poly(ethylene glycol)-poly (ε-caprolactone) micelle-encapsulated doxorubicin against mouse melanoma.

abstract：:Gliomas are primary brain tumors associated with a poor prognosis partly due to resistance to conventional therapies. To overcome this problem, we investigated the combined effects of gamma knife radiosurgery (GKS) and an antiangiogenic agent, thalidomide (THD), or a chemotherapeutic agent, temozolomide (TMZ), on a ra...

journal_title：Oncology reports

authors： Lee JI,Itasaka S,Kim JT,Nam DH

更新日期：2006-05-01 00:00:00

abstract：:Erythropoietin (Epo) is a key regulator of erythroid cell proliferation, differentiation and apoptosis. In the form of the recombinant protein, it is widely used to treat various types of anemias, including that associated with cancer and with the myelosuppressive effects of chemotherapy, particularly platinum-based r...

journal_title：Oncology reports

authors： Kriška J,Solár P,Varinská L,Solárová Z,Kimáková P,Mojžiš J,Fedoročko P,Sytkowski AJ

更新日期：2013-09-01 00:00:00

abstract：:Numerous human chemoprevention studies have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) possess chemopreventive effects against a variety of malignant tumors. However, there have been many clinical studies on aspirin, but not ibuprofen, even though ibuprofen is one of the most clinically and safel...

journal_title：Oncology reports

authors： Todo M,Horinaka M,Tomosugi M,Tanaka R,Ikawa H,Sowa Y,Ishikawa H,Fujiwara H,Otsuji E,Sakai T

更新日期：2013-11-01 00:00:00

abstract：:The aim of the present study was to investigate the role of miR‑203a‑3p in colorectal cancer (CRC) and identify the target gene of microRNA (miR)‑203a‑3p. A total of 59 sets of cancer tissues and corresponding adjacent non‑tumor tissues were collected from CRC patients (aged 31‑78 years) between October 2016 and May 2...

journal_title：Oncology reports

authors： Qian Z,Gong L,Mou Y,Han Y,Zheng S

更新日期：2019-11-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) is a potent chemopreventive and therapeutic agent and exerts its effects by inducing growth arrest. In the present study, we demonstrated that ATRA activated the expression of p53 via Axin and induced cell cycle arrest at the G1/S phase and apoptosis of glioma cells. Briefly, C6 cells we...

journal_title：Oncology reports

authors： Lu J,Zhang F,Yuan Y,Ding C,Zhang L,Li Q

更新日期：2013-06-01 00:00:00

abstract：:Evidence has shown that microRNAs play important roles in tumor development, progression, and metastasis. miR-128 has been reported to be deregulated in different tumor types, whereas the function of miR-128 in colorectal carcinoma (CRC) largely remains to be elucidated. The aim of the present study was to investigate...

journal_title：Oncology reports

authors： Wu L,Shi B,Huang K,Fan G

更新日期：2015-11-01 00:00:00

abstract：:Patients with brain metastases in disseminated non-seminomatous germ cell cancer of the testis are treated by combined modality, e.g., cisplatin-containing chemotherapy, whole brain irradiation and/or surgical excision. However, cure rates of patients refractory to that standard treatment are low (5-year survival rate...

journal_title：Oncology reports

authors： Feyerabend T,Wiedemann GJ,Steeves R

更新日期：2001-03-01 00:00:00

abstract：:The activity of NADPH oxidase is increased in malignant skin keratinocytes. We demonstrated that inhibition of NADPH oxidase activity by diphenyleneiodonium (DPI) suppressed free radical production, inhibited cell growth and promoted cell differentiation of B16 melanoma cells, as indicated by cell morphology, increase...

journal_title：Oncology reports

authors： Zhao Y,Liu J,McMartin KE

更新日期：2008-05-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a rare but severe primary hemopoietic system tumor of childhood, most frequent in children 4 years and younger. There are currently no specific anticancer therapies targeting JMML, and the underlying gene expression changes have not been revealed. To define molecular targets ...

journal_title：Oncology reports

authors： Zhao W,Wang L,Yu Y

更新日期：2018-12-01 00:00:00

abstract：:Sesquiterpene lactones have been confirmed to have potential antitumor activity. Here, we demonstrated that Eupalinolide O (EO), a novel sesquiterpene lactone isolated from Eupatorium lindleyanum DC., showed significant anticancer activity against human MDA-MB-468 breast cancer cells. The cytotoxicity induced by EO wa...

journal_title：Oncology reports

authors： Yang B,Zhao Y,Lou C,Zhao H

更新日期：2016-11-01 00:00:00

abstract：:The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

journal_title：Oncology reports

authors： Malas S,Harrasser M,Lacy KE,Karagiannis SN

更新日期：2014-09-01 00:00:00

abstract：:Fat accumulation in adipose tissues is a risk factor for the development of human cancers. However, there are no studies describing the fat accumulation in adipose tissue or its distribution in human endometrial cancer. We first examined fat accumulation in adipose tissues separately on CT images of 122 patients with ...

journal_title：Oncology reports

authors： Nakamura K,Hongo A,Kodama J,Hiramatsu Y

更新日期：2011-07-01 00:00:00

abstract：:Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein which plays multiple roles in different types of cancer. Our previous study showed that SPARC overexpression inhibited the growth and angiogenesis of tumors, and reduced expression of vascular endothelial growth factor (VEGF). However, the relation...

journal_title：Oncology reports

authors： Zhang J,Wang P,Zhu J,Wang W,Yin J,Zhang C,Chen Z,Sun L,Wan Y,Wang X,Chen G,Liu Y

更新日期：2014-05-01 00:00:00

abstract：:Previous reports showed that breast and gastric cancers overexpressing c-erbB-2 protein have a greater metastatic potential and worse prognosis than tumors in which this protein is not overexpressed. The present study was undertaken to examine the significance of c-erbB-2 protein expression as a prognostic factor in c...

journal_title：Oncology reports

authors： Ishida H,Sadahiro S,Suzuki T,Ishikawa K,Tajima T,Makuuchi H

更新日期：2000-11-01 00:00:00

abstract：:The altered expression of certain genes is frequently detected as a hallmark of malignant tumors. These differentially expressed genes have the potential to become molecular markers. We purified the fecal mRNA from patients with colorectal cancer to identify novel candidates by using oligo-nucleotide microarray hybrid...

journal_title：Oncology reports

authors： Chien CC,Chang CC,Yang SH,Chen SH,Huang CJ

更新日期：2006-04-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) contribute to the development of various malignant neoplasms, including glioblastoma multiforme (GBM). The present study aimed to explore the pathogenesis of GBM and to identify latent therapeutic agents for patients with GBM, based on an in silico analysis. Gene chips that provide miRNA exp...

journal_title：Oncology reports

authors： Xiong DD,Xu WQ,He RQ,Dang YW,Chen G,Luo DZ

更新日期：2019-04-01 00:00:00

abstract：:We report immunohistochemical (IHC) and molecular findings in a rare case of a carcinoid tumor of the extrahepatic bile ducts in a 33-year-old woman, who presented with a 3.9x2.8x2.6 cm mass within the right and common hepatic ducts. She underwent surgery and a carcinoid tumor was identified. This lesion is of interes...

journal_title：Oncology reports

authors： Ligato S,Furmaga W,Cartun RW,Hull D,Tsongalis GJ

更新日期：2005-03-01 00:00:00

abstract：:Although improvements in the chemotherapy modalities for pancreatic cancer have been realized, pancreatic cancer remains one of the most lethal malignancies. New-generation cancer immunotherapy methods, such as blocking of the PD-1/PD-L1 pathway, are consistently being investigated to improve the survival of pancreati...

journal_title：Oncology reports

authors： Doi T,Ishikawa T,Okayama T,Oka K,Mizushima K,Yasuda T,Sakamoto N,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Naito Y,Itoh Y

更新日期：2017-03-01 00:00:00

abstract：:There has been increasing evidence that numerous bioactive dietary agents can hamper the process of carcinogenesis by targeting epigenetic alterations including DNA methylation. This therapeutic approach is considered as a significant goal for cancer therapy due to the reversible nature of epigenetic-mediated gene sil...

journal_title：Oncology reports

authors： Khan MA,Hussain A,Sundaram MK,Alalami U,Gunasekera D,Ramesh L,Hamza A,Quraishi U

更新日期：2015-04-01 00:00:00

abstract：:Curcumin, a phenolic compound extracted from Zingiberaceae turmeric, has strong anti-inflammatory, antioxidant and antitumor properties. However, the anticarcinogenic mechanism of curcumin has yet to be fully elucidated. Epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1) is invol...

journal_title：Oncology reports

authors： Sun XD,Liu XE,Huang DS

更新日期：2013-06-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a key kinase acting downstream of growth factor receptor PI3K and AKT signaling, leading to processes resulting in increased cell size and proliferation through translation control. Rapamycin, a specific inhibitor of mTOR, results predomin...

journal_title：Oncology reports

authors： Miyake N,Chikumi H,Takata M,Nakamoto M,Igishi T,Shimizu E

更新日期：2012-09-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant intracranial tumor. Although the affected patients are usually treated with surgery combined with radiotherapy and chemotherapy, the median survival time for GBM patients is still approximately 12‑14 months. Identifying the key molecular mechanisms and targets of GBM...

journal_title：Oncology reports

authors： Miao L,Jiang Z,Wang J,Yang N,Qi Q,Zhou W,Feng Z,Li W,Zhang Q,Huang B,Chen A,Zhang D,Zhao P,Li X

更新日期：2019-08-01 00:00:00

abstract：:Aberrant expression of microRNAs has been identified as regulators of biological processes of hepatocellular carcinoma (HCC) by negatively regulating protein-coding mRNAs. Several studies have demonstrated that miR-638 expression was dysregulated in various human cancers. However, the clinical significance and underly...

journal_title：Oncology reports

authors： Zhang Y,Zhang D,Jiang J,Dong L

更新日期：2017-01-01 00:00:00

abstract：:Gastric cancer rich in stromal tissue, such as diffuse-type disease, carries a poor prognosis. In some cancers, expression of vimentin, a mesenchymal maker, is associated with poor survival. The expression of mesenchymal markers such as vimentin is observed after epithelial-mesenchymal transition (EMT), an important i...

journal_title：Oncology reports

authors： Otsuki S,Inokuchi M,Enjoji M,Ishikawa T,Takagi Y,Kato K,Yamada H,Kojima K,Sugihara K

更新日期：2011-05-01 00:00:00

abstract：:The progress of the application of adenovirus in cancer gene therapy is hindered by the lack of expression of native adenovirus receptor on a variety of cancer types. Hence, strategies are needed to retarget the adenoviral vector to non-native cellular surface receptors. In the present study, a new peptide SWDIAWPPLKV...

journal_title：Oncology reports

authors： Wang D,Li W,Zhang H,Mao Q,Xia H

更新日期：2014-05-01 00:00:00

abstract：:We aimed to examine the relationship between the preoperative GSA index [uptake ratio of the liver to the liver plus heart at 15 min (LHL15) to uptake ratio of the heart at 15 min to that at 3 min (HH15) ratio] calculated from 99mTc‑labeled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) sc...

journal_title：Oncology reports

authors： Nishikawa H,Osaki Y,Komekado H,Sakamoto A,Saito S,Nishijima N,Nasu A,Arimoto A,Kita R,Kimura T

更新日期：2015-03-01 00:00:00

abstract：:The efficacy of chemotherapy for hepatocellular carcinoma (HCC) remains unsatisfactory, primarily due to inherent self‑defense mechanisms (e.g., mitophagy and autophagy). In the present study, we aimed to explore the pro‑apoptotic effects of targeting mitophagy to potentiate the efficacy of chemotherapy for HCC. HCC c...

journal_title：Oncology reports

authors： Ma M,Lin XH,Liu HH,Zhang R,Chen RX

更新日期：2020-03-01 00:00:00

abstract：:In breast cancer, neuregulin-1 (NRG1) is known as a ligand for the HER3 receptor, which has no intrinsic tyrosine kinase activity. When activated by NRG1 binding, the HER3 receptor forms a heterodimer with other HER family receptors and mediates downstream signaling pathways, leading to multiple effects including grow...

journal_title：Oncology reports

authors： Jeong H,Kim J,Lee Y,Seo JH,Hong SR,Kim A

更新日期：2014-09-01 00:00:00

abstract：:Bmal1 is a core factor in the regulation of circadian rhythms. Previous studies have shown that Bmal1 suppresses tumor growth in cell culture and animal models and is downregulated in certain types of cancer. The aim of the present study was to investigated whether Bmal1 influences the invasiveness of cancer cells. We...

journal_title：Oncology reports

authors： Jung CH,Kim EM,Park JK,Hwang SG,Moon SK,Kim WJ,Um HD

更新日期：2013-06-01 00:00:00

abstract：:Four tumour suppressor genes (Chk1, Chk2, Apaf1 and Rb1) in nine human malignant melanoma cell lines were screened for a loss of gene expression, point mutations and small deletions/insertions by cDNA-based DGGE/SCCP analysis. In two cell lines alterations of the investigated genes could be demonstrated. This result c...

journal_title：Oncology reports

authors： Papp T,Niemetz A,Dosdahl N,Kumar K,Schiffmann D

更新日期：2007-01-01 00:00:00