Advanced non-seminomatous germ cell cancer of the testis with brain metastases: feasibility of additional brain irradiation and whole body hyperthermia plus chemotherapy.

abstract：:Pancreatic cancer is one of the most deadly carcinomas worldwide. Although gemcitabine as the standard chemotherapy agent has been proven to be effective, the response rate remains at 5.4% and the 5-year survival rate is extremely poor. Ursolic acid (UA) is a small molecule compound...

journal_title：Oncology reports

authors： Li J,Liang X,Yang X

更新日期：2012-08-01 00:00:00

abstract：:Despite tremendous effort and progress in the diagnostics of pancreatic cancer with respect to imaging techniques and molecular genetics, only very few patients can be cured by surgery leading to a 5-year survival rate of only 3%. Especially the lack of chemotherapeutical options in this entity requires a better under...

journal_title：Oncology reports

authors： Domagk D,Schaefer KL,Eisenacher M,Braun Y,Wai DH,Schleicher C,Diallo-Danebrock R,Bojar H,Roeder G,Gabbert HE,Domschke W,Poremba C

更新日期：2007-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is known to play a central role in tumour angiogenesis. Up to now inconclusive data have been published on the clinical-biological significance of circulating VEGF and on the most suitable blood fraction for measuring it. The aims of this pilot study were to assess VEGF in blo...

journal_title：Oncology reports

authors： Ranieri G,Coviello M,Chiriatti A,Stea B,Montemurro S,Quaranta M,Dittadi R,Paradiso A

更新日期：2004-02-01 00:00:00

abstract：:Tanshinone IIA (Tan‑IIA; C19H18O3) is derived from Danshen (the roots of Salvia miltiorrhiza), and has been reported to possess anti‑inflammatory and antioxidant activities. Tan‑IIA can inhibit BxPC‑3 human pancreatic cancer cells in vitro through inducing endoplasmic reticulum stress and apoptosis via mitochondrial p...

journal_title：Oncology reports

authors： Su CC

更新日期：2018-11-01 00:00:00

abstract：:Aquaporins (AQPs) are a family of small, integral membrane proteins that have been shown to play an important role in tumor development and metastasis. Several studies have demonstrated that expression of AQP3 contributes to the enhanced migration of epithelial cells and is related to differentiation, metastasis and v...

journal_title：Oncology reports

authors： Li A,Lu D,Zhang Y,Li J,Fang Y,Li F,Sun J

更新日期：2013-02-01 00:00:00

abstract：:Ginsenoside is known to have potential cancer-preventive activities. The major active components in red ginseng consist of a variety of ginsenosides including Rg3, Rg5 and Rk1, each of which has different pharmacological activities. Among these, Rg3 has been reported to exert anticancer activities through inhibition o...

journal_title：Oncology reports

authors： Choi YJ,Lee HJ,Kang DW,Han IH,Choi BK,Cho WH

更新日期：2013-09-01 00:00:00

abstract：:Metastasis-associated protein 1 (MTA1) is highly upregulated in cancer cells with metastatic potential; however, the molecular mechanism by which MTA1 increases the metastatic potential of cancer cells is far from clear. We characterized the functional consequences of MTA1 overexpression on p53-induced apoptosis of ca...

journal_title：Oncology reports

authors： Moon HE,Cheon H,Lee MS

更新日期：2007-11-01 00:00:00

abstract：:The actual predictive value of oestrogen receptor (ER) beta for treatment decisions in breast cancer is still unclear. Retrospective studies using preoperative systemic therapy (PST) revealed that chemotherapy but also endocrine therapy can lead to alterations in expression levels of ERalpha and progesterone receptor ...

journal_title：Oncology reports

authors： Wurster M,Ruoff A,Meisner C,Seeger H,Vogel U,Juhasz-Böss I,Solomayer E,Wallwiener D,Fehm T,Neubauer H

更新日期：2010-09-01 00:00:00

abstract：:To clarify hepatocarcinogenesis by the heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), we investigated the global expression of genes in rat liver. Rats were continuously fed MeIQx 100 ppm in their diet, and were sacrificed at weeks 4 and 16 for early time points, and week 104 for tumor samp...

journal_title：Oncology reports

authors： Kang JS,Wanibuchi H,Murai T,Morimura K,Kinoshita A,Fukushima S

更新日期：2007-04-01 00:00:00

abstract：:Immune responses are frequently depressed in patients with cancer. One of the reasons for a poor immune response is the presence of increased levels of immunosuppressive substances associated with tumor growth. Transforming growth factor-beta (TGF-beta), a representative immunosuppressive cytokine, plays various roles...

journal_title：Oncology reports

authors： Yamamoto Y,Ueda Y,Itoh T,Iwamoto A,Yamagishi H,Shimagaki M,Teramoto K

更新日期：2006-12-01 00:00:00

abstract：:Epigenetic alterations have been reported in colorectal neoplasia which can either complement or in some cases be predisposed to genetic alterations such as K-ras mutations. We examined the promoter methylation status of the CDKN2A and O6-methylguanine-DNA methyltransferase (MGMT) genes, after sodium bisulfite convers...

journal_title：Oncology reports

authors： Menigatti M,Pedroni M,Verrone AM,Borghi F,Scarselli A,Benatti P,Losi L,Di Gregorio C,Schär P,Marra G,Ponz de Leon M,Roncucci L

更新日期：2007-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) play crucial roles in the initiation and progression of various cancers, including melanoma. Recently, the genetic variants and deregulation of miR-605 have been reported to participate in carcinogenesis. However, the expression status of the miR-605 in melanoma tissues and its role in melanoma prog...

journal_title：Oncology reports

authors： Chen L,Cao Y,Rong D,Wang Y,Cao Y

更新日期：2017-08-01 00:00:00

abstract：:The human Igf-1 gene not only produces insulin‑like growth factor-I (IGF-I), but also different carboxy‑terminal extensions, known as E peptides, through alternative splicing. We and others have shown that human Eb peptide (hEb) derived from Igf-1 has intrinsic biological activity and is localized to nuclei of transfe...

journal_title：Oncology reports

authors： Durzyńska J,Barton E

更新日期：2014-09-01 00:00:00

abstract：:Recent research indicates that the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway may play an important role in chronic inflammation which promotes cancer progression, yet the mechanism is not clear. The present study aimed to investigate the role of the JAK/STAT3 pathway in the gr...

journal_title：Oncology reports

authors： Fang J,Chu L,Li C,Chen Y,Hu F,Zhang X,Zhao H,Liu Z,Xu Q

更新日期：2015-01-01 00:00:00

abstract：:CD147, a multifunction glycoprotein of the immuno-globulin family, is associated with many types of tumors, and the overexpression of CD147 can enhance malignancy. However, the role of CD147 in cervical cancer remains unclear. In the present study, cervical cancer cells were found to express much more CD147 protein an...

journal_title：Oncology reports

authors： Wu Y,Zhou X,Zheng PS

更新日期：2011-09-01 00:00:00

abstract：:The aim of this study was to investigate the function of the ING1 gene in lung carcinoma. To detect the inhibitory effect of ING1 in human lung cancer, recombinant ING1b plasmids were transfected into two lung cancer cell lines with different p53 status, A549 with wild-type p53 (wtp53) and SK-MES-1 with mutant p53. Ap...

journal_title：Oncology reports

authors： Luo ZG,Tang H,Li B,Zhu Z,Ni CR,Zhu MH

更新日期：2011-04-01 00:00:00

abstract：:Apoptosis is a process associated with development and progression of breast cancer. The association between connexins and programmed cell death has only been demonstrated in a few studies. The aim of the present study was the evaluation of Cx26 and Cx43 expression in breast cancer in correlation with Bcl-2 and Bak pr...

journal_title：Oncology reports

authors： Kanczuga-Koda L,Sulkowski S,Tomaszewski J,Koda M,Sulkowska M,Przystupa W,Golaszewska J,Baltaziak M

更新日期：2005-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is a major cause of cancer-related mortality in the world. Recently, a number of studies have demonstrated that cancer stem cells (CSCs) present in colorectal cancer tissues, are responsible for resistance to conventional therapies. Therefore, effective recog...

journal_title：Oncology reports

authors： Wang C,Xie J,Guo J,Manning HC,Gore JC,Guo N

更新日期：2012-10-01 00:00:00

abstract：:Aberrant nuclear factor-erythroid 2 (NRF2) expression correlates with tumor development. We investigated NRF2 expression in ovarian epithelial carcinoma (OEC), aiming to identify associations with clinicopathological factors, hormones and induced reactive oxygen species (ROS). Immun...

journal_title：Oncology reports

authors： Liao H,Zhou Q,Zhang Z,Wang Q,Sun Y,Yi X,Feng Y

更新日期：2012-06-01 00:00:00

abstract：:B-cell‑specific Moloney murine leukaemia virus integration site-1 (BMI-1) contributes to the growth of tumour cells post-irradiation (IR). The aim of the present study was to characterize the effects of BMI-1 on cell viability, radiosensitivity and its mechanisms of action in oesophageal squamous cell cancer (ESCC). W...

journal_title：Oncology reports

authors： Yang XX,Ma M,Sang MX,Zhang XY,Liu ZK,Song H,Zhu SC

更新日期：2018-02-01 00:00:00

abstract：:Cyclin Y (CCNY) is a newly identified PFTK1 interacting protein and has been found to be associated with the proliferation and tumorigenesis of human non-small cell lung cancer. In the present study, we analyzed the expression levels of CCNY in 65 cases of breast cancer (BC) tissues and in four BC cell lines, BT-474, ...

journal_title：Oncology reports

authors： Yan F,Wang X,Zhu M,Hu X

更新日期：2016-11-01 00:00:00

abstract：:Chemotherapy plays a major role in cancer management; however, acquired drug resistance remains a significant problem for ovarian cancer treatment. Chemoresistance is regulated by the coordinated expression of a set of genes. Thus, the identification of genes specifically modulated in the process provides an important...

journal_title：Oncology reports

authors： Li L,Luan Y,Li X,Tang B,Zhang W,Li D,Zhao J,Wang G,Ding H,Reed E,Li QQ

更新日期：2005-05-01 00:00:00

abstract：:A number of possible preventive agents for cancers in different organs have been reported, however, little information is available regarding the effective agents for the development of gastric cancers. The rice components are known to be effective for the prevention of the development of cancers. Our group has demons...

journal_title：Oncology reports

authors： Tomita H,Kuno T,Yamada Y,Oyama T,Asano N,Miyazaki Y,Baba S,Taguchi A,Hara A,Iwasaki T,Kobayashi H,Mori H

更新日期：2008-01-01 00:00:00

abstract：:Prostate and breast cancer overexpressed 1 (PBOV1) is significantly upregulated in prostate, breast and bladder cancer, while its expression status in ovarian cancer and its clinical significance are unclear. We examined the expression levels of PBOV1 mRNA and protein in ovarian cancer cell lines and primary tissues u...

journal_title：Oncology reports

authors： Wang L,Niu CH,Wu S,Wu HM,Ouyang F,He M,He SY

更新日期：2016-01-01 00:00:00

abstract：:Programmed cell death 2 (PDCD2) is a highly conserved nuclear protein, and aberrant PDCD2 expression alters cell apoptosis. The present study aimed to investigate PDCD2 expression in gastric cancer. Tissue specimens from 34 gastric cancer patients were collected for analysis of PDCD2 expression using immunohistochemis...

journal_title：Oncology reports

authors： Zhang J,Wei W,Jin HC,Ying RC,Zhu AK,Zhang FJ

更新日期：2015-01-01 00:00:00

abstract：:EVL belongs to the Ena/VASP (Enabled/vasodilator-stimulated phosphoprotein) family of proteins [Mena (mammalian Ena), VASP and EVL], which have a range of roles in regulating the actin cytoskeleton. Growing evidence suggests that Mena and VASP are involved in carcinogenesis, though little is known about the significan...

journal_title：Oncology reports

authors： Hu LD,Zou HF,Zhan SX,Cao KM

更新日期：2008-04-01 00:00:00

abstract：:Four tumour suppressor genes (Chk1, Chk2, Apaf1 and Rb1) in nine human malignant melanoma cell lines were screened for a loss of gene expression, point mutations and small deletions/insertions by cDNA-based DGGE/SCCP analysis. In two cell lines alterations of the investigated genes could be demonstrated. This result c...

journal_title：Oncology reports

authors： Papp T,Niemetz A,Dosdahl N,Kumar K,Schiffmann D

更新日期：2007-01-01 00:00:00

abstract：:Pin-1 has been shown to regulate several phases of the cell cycle and is strikingly overexpressed in many human cancers. Vascular endothelial growth factor (VEGF)-C is a potent lymphangiogenic factor produced by tumor and stromal cells. However, little is known about the roles of Pin-1 and VEGF-C in breast carcinoma. ...

journal_title：Oncology reports

authors： Kim BC,Han SI,Lim SC

更新日期：2009-12-01 00:00:00

abstract：:Post-transcriptional modification of p53 by phosphorylation has been proposed as an important mechanism of p53 stabilization and functional regulation. However, little is known about the phosphorylation state of mutant p53 protein overexpressed in human tumors. We evaluated immunohistochemically the p53 phosphorylatio...

journal_title：Oncology reports

authors： Matsumoto M,Furihata M,Kurabayashi A,Ohtsuki Y

更新日期：2004-11-01 00:00:00

abstract：:The pre-S mutant LHBs, especially the pre-S2 type, is believed to be crucial in HBV-associated hepatocellular carcinogenesis. However, the mechanism of HBV-induced hepatocellular carcinoma is not fully understood. To identify the mechanism, pre-S2 LHBs-interacting proteins were stud...

journal_title：Oncology reports

authors： Lei Y,Liu H,Yang Y,Wang X,Ren N,Li B,Liu S,Cheng J,Fu X,Zhang J

更新日期：2012-01-01 00:00:00