EVL (Ena/VASP-like) expression is up-regulated in human breast cancer and its relative expression level is correlated with clinical stages.

abstract：:The ability to detect K-ras oncogene may provide additional information for the management of patients with non-small cell lung cancer (NSCLC). In the present study, we detected the K-ras oncogene in 76 patients with NSCLC by two methods: direct sequencing of K-ras in tumor tissues and membrane array detection of the ...

journal_title：Oncology reports

authors： Chong IW,Chang MY,Sheu CC,Wang CY,Hwang JJ,Huang MS,Lin SR

更新日期：2007-07-01 00:00:00

abstract：:Genetically modified tumour cells producing cytokines such as interleukin 12 (IL-12) are potent activators of the antitumour immune responses and represent a promising therapeutic modality when combined with chemotherapy. The objective of this study was to examine whether IL-12-producing cellular vaccines can augment ...

journal_title：Oncology reports

authors： Mikyšková R,Indrová M,Símová J,Bieblová J,Bubeník J,Reiniš M

更新日期：2011-06-01 00:00:00

abstract：:Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. The present study was performed to characterize the role of Fzd2 in the migration and invasion of oral squamous cell carcinomas (OSCC) in...

journal_title：Oncology reports

authors： Zhang E,Li Z,Xu Z,Duan W,Sun C,Lu L

更新日期：2015-12-01 00:00:00

abstract：:P5, which is a member of the protein disulfide isomerase family, possesses isomerase and chaperone activity in vitro; however, the physiological functions of this enzyme in cells remain unclear. To understand the important roles of P5 in cancer cells, the present study examined its expression on the surface of normal ...

journal_title：Oncology reports

authors： Horibe T,Torisawa A,Masuda Y,Kawakami K

更新日期：2019-02-01 00:00:00

abstract：:BTG1, which belongs to the BTG/Tob family, regulates cell cycle progression in a variety of cell types and appears to play roles in inhibiting proliferation, promoting apoptosis and stimulating cellular differentiation in multiple cell types. However, it remains unclear whether BTG1 is a breast cancer suppressor gene,...

journal_title：Oncology reports

authors： Zhu R,Zou ST,Wan JM,Li W,Li XL,Zhu W

更新日期：2013-11-01 00:00:00

abstract：:Gastric cancer is a common malignancy worldwide. The prognosis of early stage gastric cancer patients has significantly improved in recent years. However, in progressive stage gastric cancer patients, the prognosis remains relatively poor due to tumor metastases. In our previous study, we showed that the expression of...

journal_title：Oncology reports

authors： Xiao WS,Li DF,Tang YP,Chen YZ,Deng WB,Chen J,Zhou WW,Liao AJ

更新日期：2018-11-01 00:00:00

abstract：:Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging as...

journal_title：Oncology reports

authors： Maleddu A,Pantaleo MA,Nannini M,Di Battista M,Saponara M,Lolli C,Biasco G

更新日期：2009-06-01 00:00:00

abstract：:MicroRNA‑21 (miR‑21) is a potential therapeutic target for melanoma. Whether miR‑21 inhibitor affects the anti‑cancer activity of doxorubicin assisted by c(RGDyK)‑modified liposome (DLN) in melanoma and the underlying mechanisms are largely unknown. In this study, in vitro and animal models were used to explore the ef...

journal_title：Oncology reports

authors： Wei X,You X,Zhang J,Zhou C

更新日期：2019-07-01 00:00:00

abstract：:The decision to repeat transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is based on correct evaluation of response to therapy. The purpose of this study was to investigate whether apparent diffusion coefficient (ADC), a quantitative parameter of diffusion-weighted imaging (DWI), can p...

journal_title：Oncology reports

authors： Kubota K,Yamanishi T,Itoh S,Murata Y,Miyatake K,Yasunami H,Morio K,Hamada N,Nishioka A,Ogawa Y

更新日期：2010-09-01 00:00:00

abstract：:Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the di...

journal_title：Oncology reports

authors： Yang Q,Guo B,Sun H,Zhang J,Liu S,Hexige S,Yu X,Wang X

更新日期：2017-04-01 00:00:00

abstract：:Trop2 is considered to have an important function in tumor metastasis and the promotion of epithelial‑mesenchymal transition (EMT). E‑cadherin is a crucial factor in intercellular adhesion and EMT transformation. In the present study, we detected the expression of Trop2 and E‑cadherin in breast cancer (BC) to better d...

journal_title：Oncology reports

authors： Zhao W,Kuai X,Zhou X,Jia L,Wang J,Yang X,Tian Z,Wang X,Lv Q,Wang B,Zhao Y,Huang W

更新日期：2018-08-01 00:00:00

abstract：:Ovarian cancer (OC) is a common cancer of the human genital system. Circular RNAs (circRNAs) play an important role in carcinogenesis and progression of various cancers. The present study aimed to clarify the expression profile and functions of circ‑FAM53B in the progression of OC and reveal its underlying mechanisms....

journal_title：Oncology reports

authors： Sun D,Liu J,Zhou L

更新日期：2019-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous pathogen that was first identified as a human cancer virus. Many human cancers are associated with EBV, and we demonstrated that EBV infects macrophages. Macrophages infected with EBV show a close correlation with many human cancers, and thus more attention must be given to the...

journal_title：Oncology reports

authors： Shimakage M

更新日期：2014-11-01 00:00:00

abstract：:Paired box 6 (PAX6) is a transcription factor that has oncogenic features. In breast cancer, PAX6 facilitates tumor progression; however, the underlying mechanism is largely unknown. The majority of breast cancer‑related mortalities are associated with metastasis of cancer cells. Therefore, the present study aimed to ...

journal_title：Oncology reports

authors： Jin M,Gao D,Wang R,Sik A,Liu K

更新日期：2020-08-01 00:00:00

abstract：:Alterations in DNA methylation have a central role in the development and outcome of most human malignancies. Non‑small cell lung cancer (NSCLC), the most common lung cancer, leads to the largest number of cancer‑related deaths worldwide. FBJ murine osteosarcoma viral oncogene homolog B (FOSB) is a key component of th...

journal_title：Oncology reports

authors： Kim DS,Lee WK,Park JY

更新日期：2020-02-01 00:00:00

abstract：:In this study, we investigated the sequence variation and different transcriptional activities of the upstream regulatory region (URR) in HPV 16 E7 variants in cervical cancer tissue from Korean women. Using PCR-directed sequencing, the presence of sequence variations in URRs were analyzed and the sites of sequence va...

journal_title：Oncology reports

authors： Kim YB,Song YS,Jeon YT,Park JS,Um SJ,Kim JW,Park NH,Kang SB,Lee HP

更新日期：2005-08-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) can act as carcinogenic or cancer suppressive factors during the pathogenesis, invasion and metastasis of non‑small cell lung cancer (NSCLC). The current study explored the role of long intergenic non‑protein coding RNA 00887 (LINC00887) and competing endogenous RNAs (ceRNAs). It was rev...

journal_title：Oncology reports

authors： Tian Y,Yu M,Sun L,Liu L,Huo S,Shang W,Sheng S,Wang J,Sun J,Hu Q,Dou Y,Zhu J,Ren X,Yang S

更新日期：2019-09-01 00:00:00

abstract：:We investigated a phase III randomized trial to compare efficacy and tolerance of CDDP + 5-FU to CDDP + VP16, both given intravenously in patients with unresectable advanced head and neck cancer. The 197 eligible patients were paired off successively on the basis of tumor sites and UICC stage. Comparisons were made th...

journal_title：Oncology reports

authors： Prévost A,Mérol JC,Aimé P,Moutel K,Roger-Liautaud F,Nasca S,Legros M,Coninx P

更新日期：2005-09-01 00:00:00

abstract：:Hypoxia promotes the invasive and metastatic potential of tumour cells. A recent study has shown that the activation of the chemokine receptor CXCR4 by lack of oxygen in breast cancer is HIF-1-dependent. We have previously demonstrated that CXCR4 signalling is involved in the establishment of lymph node metastasis in ...

journal_title：Oncology reports

authors： Ishikawa T,Nakashiro K,Klosek SK,Goda H,Hara S,Uchida D,Hamakawa H

更新日期：2009-03-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) occurs frequently in cervical carcinogenesis. miRNAs function as tumor-suppressors or oncogenes and are involved in tumor behavior. However, the expression and function of miR-27b in cervical carcinogenesis remain unknown. In the present study, we observed that miR-27b was significa...

journal_title：Oncology reports

authors： Yao J,Deng B,Zheng L,Dou L,Guo Y,Guo K

更新日期：2016-03-01 00:00:00

abstract：:The tumor necrosis factor receptor (TNFR)-associated factor 4 (TRAF4) is a member of TRAF family proteins that act as major signal transducers of the TNF receptor and the interleukin-1 receptor/Toll-like receptor (IL-1R/TLR) superfamily. TRAF4 has been reported to be overexpressed in various human cancers. However, th...

journal_title：Oncology reports

authors： Ahmed F,Shiraishi T,Vessella RL,Kulkarni P

更新日期：2013-12-01 00:00:00

abstract：:Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are considered to be key enzymes affecting the prognosis for patients with various cancers. We tried to prove the correlation of TP and DPD expression in hepatocellular carcinoma (HCC) and liver metastasis. We quantified TP and DPD levels by an enz...

journal_title：Oncology reports

authors： Hotta T,Kobayashi Y,Taniguchi K,Johata K,Sahara M,Watanabe T,Ochiai M,Tanimura H,Tsubota YT

更新日期：2004-08-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibitors have been proven to represent superior clinical agents targeting DNA repair mechanisms in cancer therapy. We investigated PARP inhibitory effects of the natural and synthetic flavonoids (quercetin, rutin, monoglucosyl rutin and maltooligosyl rutin) and tested the synthetic...

journal_title：Oncology reports

authors： Maeda J,Roybal EJ,Brents CA,Uesaka M,Aizawa Y,Kato TA

更新日期：2014-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an important mediator of tumor angiogenesis. A high serum VEGF level has been shown to predict poor response to chemotherapy and poor survival in several cancers, but its prognostic value in hepatocellular carcinoma (HCC) remains unknown. We conducted a prospective study to...

journal_title：Oncology reports

authors： Poon RT,Lau C,Yu WC,Fan ST,Wong J

更新日期：2004-05-01 00:00:00

abstract：:Kruppel-like factor 9 (KLF9), a transcription factor, is critical for the inhibition of growth and development of tumors, whereas its effects in pancreatic cancer remains unclear. The purpose of the present study was to investigate the expression and functional significance of KLF9 in vitro, by assessing the expressio...

journal_title：Oncology reports

authors： Zhong Z,Zhou F,Wang D,Wu M,Zhou W,Zou Y,Li J,Wu L,Yin X

更新日期：2018-12-01 00:00:00

abstract：:Cell cycle-related molecules play crucial roles in maintaining genomic stability, and can also serve as biomarkers of cell cycle phase distribution at the same time. In this study, we used multiparameter analysis of various biomarkers to investigate their utility for the evaluation ...

journal_title：Oncology reports

authors： Haruki T,Shomori K,Shiomi T,Taniguchi Y,Nakamura H,Ito H

更新日期：2012-09-01 00:00:00

abstract：:The promigratory molecule L1CAM is overexpressed in various tumors, often representing an unfavorable prognostic marker. Recently, we identified L1CAM expression in pancreatic ductal adenocarcinoma (PDAC) cells accounting for chemoresistance and increased cell migration. Thus, the present study aims at further elucida...

journal_title：Oncology reports

authors： Bergmann F,Wandschneider F,Sipos B,Moldenhauer G,Schniewind B,Welsch T,Schirrmacher P,Klöppel G,Altevogt P,Schäfer H,Sebens Müerköster S

更新日期：2010-10-01 00:00:00

abstract：:Primarily through in vitro studies, the Rho-family of small GTPases and their effector proteins have been implicated in mediating oncogenic properties of cancer cells. We sought to determine if pharmacological inhibition of the RhoA effector proteins known as Rho-kinases (ROCK) with the small molecule inhibitor Y-2763...

journal_title：Oncology reports

authors： Routhier A,Astuccio M,Lahey D,Monfredo N,Johnson A,Callahan W,Partington A,Fellows K,Ouellette L,Zhidro S,Goodrow C,Smith A,Sullivan K,Simone P,Le L,Vezuli B,Zohni M,West E,Gleason D,Bryan B

更新日期：2010-03-01 00:00:00

abstract：:Notch signaling plays a critical role in embryonic vascular development and tumor angiogenesis. The present study was conducted to investigate the prognostic role of the angiogenesis-related Notch ligand and the receptor in acute myeloid leukemia (AML) and assess whether their expre...

journal_title：Oncology reports

authors： Zhang J,Ma D,Ye J,Zang S,Lu F,Yang M,Qu X,Sun X,Ji C

更新日期：2012-10-01 00:00:00

abstract：:Immunotherapy of cancer offers great promise, however translation into human studies has yielded relatively poor results to date. The concept of combining cancer vaccination with angiogenesis inhibition is appealing, due to favorable safety profile of both approaches, as well as possible biological synergies. Here we ...

journal_title：Oncology reports

authors： Chan RC,Gutierrez B,Ichim TE,Lin F

更新日期：2009-11-01 00:00:00