BTG1 inhibits breast cancer cell growth through induction of cell cycle arrest and apoptosis.

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, and only 15% of lung cancer patients live more than 5 years. microRNAs (miRNAs) are endogenously expressed non-coding RNAs, and dysregulation of miRNAs is a common feature in human cancers including lung cancer. In this study, w...

journal_title：Oncology reports

authors： Chen Y,Min L,Zhang X,Hu S,Wang B,Liu W,Wang R,Gu X,Shen W,Lv H,Zou J,Chen Y,Xu X,Chen L

更新日期：2013-10-01 00:00:00

abstract：:We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...

journal_title：Oncology reports

authors： Takeuchi S,Zhao S,Kuge Y,Zhao Y,Nishijima K,Hatano T,Shimizu Y,Kinoshita I,Tamaki N,Dosaka-Akita H

更新日期：2011-09-01 00:00:00

abstract：:Hereditary multiple exostoses (HME) is an autosomal dominant bone disorder characterized by the presence of multiple benign cartilage-capped tumors. EXT1 located on chromosome 8q23-q24 and EXT2 located on 11p11-p12 are the main disease-causing genes which are responsible for ~90% of HME cases. Mutations of EXT1 or EXT...

journal_title：Oncology reports

authors： Cao L,Liu F,Kong M,Fang Y,Gu H,Chen Y,Zhao C,Zhang S,Bi Q

更新日期：2014-02-01 00:00:00

abstract：:S-1 is an oral antitumor agent that contains tegafur, which is converted to fluorouracil (5-FU) in the human body. Cytochrome P450 2A6 (CYP2A6) is the principal enzyme responsible for bioconversion of tegafur to 5-FU. A number of CYP2A6 polymorphisms have been associated with variat...

journal_title：Oncology reports

authors： Fang WJ,Mou HB,Jin DZ,Zheng YL,Zhao P,Mao CY,Peng L,Huang MZ,Xu N

更新日期：2012-05-01 00:00:00

abstract：:The impact of interferon-γ (IFN-γ) late preconditioning on myocardial ischemia-reperfusion injury during cardiopulmonary bypass (CPB) and the underlying mechanism were investigated. Using a porcine model of myocardial ischemia-reperfusion injury during CPB with a 60-min aorta cross-clamp, 20 pigs (15±0.5 kg) were trea...

journal_title：Oncology reports

authors： Yan X,Qiu W,Jia B,Zhong H,Li X,Chen Z

更新日期：2013-11-01 00:00:00

abstract：:As tumor-associated antigens are not well characterized for the majority of human tumors, polyvalent vaccines prepared with whole-tumor antigens are an attractive approach for tumor vaccination. Vascular endothelial growth factor receptor-2 (VEGFR2), as a model antigen with which to...

journal_title：Oncology reports

authors： Yan HX,Cheng P,Wei HY,Shen GB,Fu LX,Ni J,Wu Y,Wei YQ

更新日期：2013-04-01 00:00:00

abstract：:The restricted expression of Wilms tumor 1 (WT1) and cyclin A1 (CCNA1) in normal tissues, as opposed to their abnormal expression in leukemia demonstrates the applicability of WT1 and CCNA1 as cancer antigens for immunotherapy, and as markers for prognosis and relapse. In this study, the WT1 and CCNA1 mRNA levels were...

journal_title：Oncology reports

authors： Pandey S,Moazam M,Ghimirey N,Kuerbitz SJ,Fraizer GC

更新日期：2019-11-01 00:00:00

abstract：:High mobility group N (HMGNs) are members of the high mobility group protein family, and are involved in the development and progression of several tumors. HMGN1 and HMGN5 were previously shown to be associated with the bioactivities of osteosarcoma. However, the effects and molecular mechanisms of HMGN2 on osteosarco...

journal_title：Oncology reports

authors： Liang G,Xu E,Yang C,Zhang C,Sheng X,Zhou X

更新日期：2015-03-01 00:00:00

abstract：:X-ray-based radiotherapy is one of the most effective therapeutic strategies for breast cancer patients. However, radioresistance and side-effects continue to be the most challenging issues. B-cell translocation gene 1 (BTG1) is a member of the BTG/Tob family, which inhibits cancer growth and promotes apoptosis. We, t...

journal_title：Oncology reports

authors： Zhu R,Li W,Xu Y,Wan J,Zhang Z

更新日期：2015-12-01 00:00:00

abstract：:Lung cancer is one of the most common cancers worldwide and accounts for 28% of all cancer-related deaths. The expression of the β2‑adrenergic receptor (β2‑AR), one of the stress‑inducible receptors, has been reported to be closely correlated with malignant tumors. However, the role of β2‑AR activation in human lung e...

journal_title：Oncology reports

authors： Hu P,He J,Liu S,Wang M,Pan B,Zhang W

更新日期：2016-09-01 00:00:00

abstract：:Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in several types of cancers. In non-small cell lung cancer (NSCLC), several genes are known to be frequently methylated and the correlation of their methylation with clinical features has been stud...

journal_title：Oncology reports

authors： Hanabata T,Tsukuda K,Toyooka S,Yano M,Aoe M,Nagahiro I,Sano Y,Date H,Shimizu N

更新日期：2004-07-01 00:00:00

abstract：:Despite significant advances in micro-metastasis detection methods, little is known about the relationship between micro-metastasis and primary tumors. The purpose of this study was to assess the ability of expression of the breast cancer-related markers, HER-2/neu, COX-2, VEGF and PDGF-B, as a predictor for micro-met...

journal_title：Oncology reports

authors： Zhu L,Loo WT,Cheng CW,Chow LW

更新日期：2006-05-01 00:00:00

abstract：:Loss of proliferative control and failure to undergo cellular differentiation are key events during carcinogenesis. We recently identified a new potential tumor suppressor gene named MTUS1 (mitochondrial tumor suppressor 1), down-regulated in undifferentiated tumor cell lines, inhibiting tumor cell proliferation after...

journal_title：Oncology reports

authors： Zuern C,Heimrich J,Kaufmann R,Richter KK,Settmacher U,Wanner C,Galle J,Seibold S

更新日期：2010-01-01 00:00:00

abstract：:Poly (aspartic acid-co-lactic acid) (PAL) has been investigated as a new biodegradable material for Drug Delivery Systems (DDS). Similar to the poly (lactic acid-co-glycolic acid) (PLGA) nanospheres, the PAL nanospheres can control-release encapsulated drugs by hydrolysis and adhere to the mucous membranes to improve ...

journal_title：Oncology reports

authors： Hara K,Tsujimoto H,Huang CC,Kawashima Y,Mimura H,Miwa N

更新日期：2006-12-01 00:00:00

abstract：:The isothiocyanates (ITCs) have long been known to possess chemopreventive activities for a variety of neoplasms including breast cancer, but the molecular mechanism by which ITCs prevent breast cancer development has not been established. In this study, we investigated the effects of benzyl and phenethyl isothiocyana...

journal_title：Oncology reports

authors： Kang L,Ding L,Wang ZY

更新日期：2009-01-01 00:00:00

abstract：:In the present study, we analyzed the influence of brefeldin A (BFA) and castanospermine (CAS) on the activity, stability and localization of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in various resistant cell lines. The impact of BFA and CAS on cell viability was assessed using the MTT test. We...

journal_title：Oncology reports

authors： Wojtowicz K,Januchowski R,Sosińska P,Nowicki M,Zabel M

更新日期：2016-05-01 00:00:00

abstract：:Adenoid cystic carcinoma (ACC) is a generally slow-growing but highly malignant salivary gland neoplasm with remarkable capacities for local invasion and lung metastasis. The precise characteristics of ACC are not fully understood because there was no suitable animal model. We have successfully established a new human...

journal_title：Oncology reports

authors： Hashitani S,Urade M,Zushi Y,Segawa E,Okui S,Sakurai K

更新日期：2007-01-01 00:00:00

abstract：:WNT signaling pathway networks with Hedgehog, Notch and FGF signaling pathways during carcinogenesis and embryogenesis. FZD8 is up-regulated in HeLa S3 and A549 cells. Here we identified and characterized rat Fzd8 gene by using bioinformatics. Rat Fzd8 gene was identified within AC131883.2 genome sequence. Rat Fzd8 (6...

journal_title：Oncology reports

authors： Katoh Y,Katoh M

更新日期：2005-05-01 00:00:00

abstract：:We investigated the prevalence of human papillomavirus (HPV) in a clinical series of 72 patients with head and neck squamous cell carcinoma (HNSCC) using a retrospective and prospective study design. The majority of patients were smokers and/or drinkers and were treated with concomitant chemoradiotherapy (CCR). Furthe...

journal_title：Oncology reports

authors： Duray A,Descamps G,Decaestecker C,Sirtaine N,Gilles A,Khalifé M,Chantrain G,Depuydt CE,Delvenne P,Saussez S

更新日期：2013-07-01 00:00:00

abstract：:The aim of this study was to investigate the effect of temozolomide (TZM) in combination with X-rays on proliferation and migration in human glioma spheroids. Multicellular spheroids were derived from GaMg and U87 cell lines. Spheroids were treated with various concentrations of TZM (5 micromol, 0.025 mmol, 0.05 mmol)...

journal_title：Oncology reports

authors： Fehlauer F,Muench M,Richter E,Rades D

更新日期：2007-04-01 00:00:00

abstract：:OCT4B1, a splice variant of OCT4, is a key regulator in maintaining the properties of pluripotency and self-renewal in embryonic stem (ES) cells. Recent results have shown that OCT4B1 is involved in tumorigenesis. However, the contribution of OCT4B1 in the tumorigenesis and drug resistance of colon cancer remains to b...

journal_title：Oncology reports

authors： Wen KM,Zhang GH,Li J,Chen ZQ,Cheng YL,Su X,Zeng QL

更新日期：2015-12-01 00:00:00

abstract：:The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtai...

journal_title：Oncology reports

authors： Zhou J,Li Y,Wei D,Qian Y,Li W,Liu D,Li G,Pan X,Lei D

更新日期：2015-12-01 00:00:00

abstract：:Vitamin K2 (VK2) has been shown to have a potent anti-tumor effect against several cancer types including hepatocellular carcinoma (HCC), but the mechanisms remain to be elucidated. Matrix metalloproteinase (MMP) plays an important role in the invasion and metastasis of cancer cells, but it is not known whether VK2 re...

journal_title：Oncology reports

authors： Ide Y,Zhang H,Hamajima H,Kawaguchi Y,Eguchi Y,Mizuta T,Yamamoto K,Fujimoto K,Ozaki I

更新日期：2009-09-01 00:00:00

abstract：:The aim of this study is to evaluate characteristics in lung cancer patients with chronic obstructive pulmonary disease (COPD). Among 966 lung cancer patients admitted to our division over a period of 24 years, 73 patients were diagnosed as having COPD. There were 68 (93.2%) men and 5 women; of the tumors 43 (58.9%) w...

journal_title：Oncology reports

authors： Kurishima K,Satoh H,Ishikawa H,Yamashita YT,Homma T,Ohtsuka M,Sekizawa K

更新日期：2001-01-01 00:00:00

abstract：:Few studies on sarcomas have examined the relationships between microsatellite alterations in particular loci, tumor prognosis and tumorigenesis, because sarcomas are uncommon and those prognoses can be confounded by coexisting factors, such as tumor site. We studied the relationship between microsatellite alterations...

journal_title：Oncology reports

authors： Iyoda A,Hiroshima K,Toyozaki T,Baba M,Fujisawa T,Yusa T,Ohwada H

更新日期：2001-07-01 00:00:00

abstract：:Angiogenesis is crucial for the development and metastasis of human brain glioma. Based on our previous successful construction of a lentivirus-mediated alphastatin (an endogenous angiogenesis inhibitor) gene transfer system and our findings that alphastatin exhibited potent inhibit...

journal_title：Oncology reports

authors： Che H,Song J,Guo S,Wang W,Gao G

更新日期：2013-03-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer, and numerous oncogenes are associated with this disease. Oxysterol‑binding protein‑related protein 8 (ORP8) is essential for cell growth, migration and the modulation of mitochondrial respiration and morphology. However, the underlying role of ...

journal_title：Oncology reports

authors： Li J,Cui J,Li Z,Fu X,Li J,Li H,Wang S,Zhang M

更新日期：2020-05-01 00:00:00

abstract：:The effectiveness of granulocyte colony-stimulating factor (G-CSF) for granulocytopenia has been widely recognized. However, although granulocyte counts rapidly increase after a few injection of G-CSF, a large proportion of the increased granulocytes disappear from peripheral blood within a few days following G-CSF wi...

journal_title：Oncology reports

authors： Ogawa Y,Kobayashi T,Nishioka A,Kariya S,Garcia Del Saz E,Seguchi H,Yoshida S

更新日期：2001-09-01 00:00:00

abstract：:Although radiotherapy is routinely administered to high-risk endometrial carcinoma and offer a significant disease-free survival advantage, the therapeutic effect is sometimes limited by the occurrence of radioresistance. To determine the patterns of gene expression responsible for the radioresistance and to search fo...

journal_title：Oncology reports

authors： Du XL,Jiang T,Wen ZQ,Li QS,Gao R,Wang F

更新日期：2009-03-01 00:00:00

abstract：:Casticin, one of the main components from Fructus Viticis, has been reported to inhibit the growth of various cancer cells, including the human cervical cancer cell line HeLa. The purpose of this study was to examine the apoptotic activity and molecular mechanism of casticin action on human cervical cancer cells. The ...

journal_title：Oncology reports

authors： Chen D,Cao J,Tian L,Liu F,Sheng X

更新日期：2011-11-01 00:00:00