DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers.

abstract：:MicroRNAs (miRNAs), as gene expression regulators, have been identified to be closely associated with tumorigenesis. Thus a loss-of-function study is more likely to reveal the biological roles of endogenous miRNAs. Genetic knockout, antisense oligonucleotide inhibitors, and miRNA sponge (miR‑SP) are usually performed ...

journal_title：Oncology reports

authors： Ma J,Wu Q,Zhang Y,Li J,Yu Y,Pan Q,Sun F

更新日期：2014-12-01 00:00:00

abstract：:Prostate specific antigen (PSA) is still the best available tumour marker in prostate cancer (PCa), but presents some limits. Therefore, there is a need for novel markers in the detection and management of PCa. The 80-kDa soluble form of E-cadherin (sE-cad) and the cytokine IL-6 are being discussed as supplemental ser...

journal_title：Oncology reports

authors： Iacopino F,Pinto F,Bertaccini A,Calarco A,Proietti G,Totaro A,Martorana G,Bassi P,Sica G

更新日期：2012-07-01 00:00:00

abstract：:Melanoma is the seventh most common malignancy in females and the fifth most common cancer in males worldwide. An increasing number of studies have reported that microRNA (miRNA) dysregulation is frequently observed in various types of human cancers, including melanoma. Abnormally expressed miRNAs play an important ro...

journal_title：Oncology reports

authors： Kang K,Zhang J,Zhang X,Chen Z

更新日期：2018-01-01 00:00:00

abstract：:In humans, four tropomyosin genes (TPM1, TPM2, TPM3, and TPM4) are known to produce a multitude of isoforms via alternate splicing and/or using alternate promoters. Expression of tropomyosin has been shown to be modulated at both the transcription and the translational levels. Tropomyosins are known to make up some of...

journal_title：Oncology reports

authors： Dube S,Thomas A,Abbott L,Benz P,Mitschow C,Dube DK,Poiesz BJ

更新日期：2016-06-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality worldwide. microRNAs (miRNAs) are small post-transcriptional regulatory non-coding RNAs that function as oncogenes or tumor suppressors in human cancers. Emerging evidence reveals that deregulation of miRNAs contributes to the progression of human lung cance...

journal_title：Oncology reports

authors： Jiang X,Chen X,Chen L,Ma Y,Zhou L,Qi Q,Liu Y,Zhang S,Luo J,Zhou X

更新日期：2015-02-01 00:00:00

abstract：:Apoptosis has to be drastically controlled in organs with important cell turnover such as the colon. Deregulation of this process is often present in tumor progression. Tissues of 82 patients treated for colorectal cancer (CRC) were analyzed using antibodies against AIF, p53, DR4, DR5, cleaved caspase-3 and the TUNEL ...

journal_title：Oncology reports

authors： Perraud A,Akil H,Nouaille M,Petit D,Labrousse F,Jauberteau MO,Mathonnet M

更新日期：2011-11-01 00:00:00

abstract：:No information is currently available regarding pancreatic cancer (PC) pattern of care in Italy. In the present study, a nationwide survey using a questionnaire was performed to enquire the local standards for PC diagnosis and radiotherapy treatment. Fifty-seven percent of 140 Italian centres completed questionnaire. ...

journal_title：Oncology reports

authors： Macchia G,Sainato A,Talamini R,Boz G,Bacigalupo A,Caravatta L,Fiore M,Friso ML,Fusco V,Lupattelli M,Mantello G,Mattiucci GC,Slim N,Sciacero P,Turri L,Valentini V,Morganti AG,Genovesi D

更新日期：2015-07-01 00:00:00

abstract：:The aim of the present study was to identify potential prognostic microRNA (miRNA) biomarkers for colon adenocarcinoma (COAD) prognostic prediction using the dataset of The Cancer Genome Atlas (TCGA). The genome‑wide miRNA sequencing dataset and corresponding COAD clinical information were downloaded from TCGA. Progno...

journal_title：Oncology reports

authors： Wei HT,Guo EN,Liao XW,Chen LS,Wang JL,Ni M,Liang C

更新日期：2018-10-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and has been described as one of the deadliest of cancers affecting the genitourinary tract. Tropomyosin is a two-stranded α-helical coiled coil protein found in cell cytoskeletons. One of its isoforms, tropomyosin-1 (TPM1) has been reported...

journal_title：Oncology reports

authors： Wang J,Guan J,Lu Z,Jin J,Cai Y,Wang C,Wang F

更新日期：2015-03-01 00:00:00

abstract：:Many prostate cancer (PCa) patients die of recurrent disease due to the emergence of hormone-independent cancer cells of which the mechanism is not fully understood. Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive ...

journal_title：Oncology reports

authors： Kim YR,Kang TW,To PK,Xuan Nguyen NT,Cho YS,Jung C,Kim MS

更新日期：2016-04-01 00:00:00

abstract：:The pathogenic mechanisms responsible for inflammatory bowel disease (IBD) are poorly understood. In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induced colitis, which exhibited several clinical and histological features similar to IBD. However, pathogenic facto...

journal_title：Oncology reports

authors： Araki Y,Mukaisyo K,Sugihara H,Hattori T

更新日期：2008-07-01 00:00:00

abstract：:The human homologue of Drosophila disc large tumor suppressor protein (hDlg) is one of the proteins known to act cooperatively in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. An abnormal expression of hDlg has been reported ...

journal_title：Oncology reports

authors： Niimi R,Matsumine A,Iino T,Murata T,Shintani K,Nakazora S,Nakamura T,Uehara Y,Kusuzaki K,Akiyama T,Uchida A

更新日期：2010-03-01 00:00:00

abstract：:Forkhead box F2 transcription factor (FoxF2) has been described to promote organ development, extracellular matrix (ECM) synthesis and epithelial-mesenchymal interaction. Although recent studies reported decreased FoxF2 expression in several types of cancers, indicating its potential role in carcinogenesis, the mechan...

journal_title：Oncology reports

authors： Zhang Y,Wang X,Wang Z,Tang H,Fan H,Guo Q

更新日期：2015-05-01 00:00:00

abstract：:Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however, once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. Matr...

journal_title：Oncology reports

authors： Roomi MW,Ivanov V,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2005-03-01 00:00:00

abstract：:The current study characterized peripheral blood mononuclear cells (PBMC) obtained from leukapheresis products of patients with non-small cell lung cancer (NSCLC) for cytokine release, the ability to incorporate tritiated thymidine following stimulation using PHA as well as the levels of both CD4 and CD8 regulatory T ...

journal_title：Oncology reports

authors： Yannelli JR,Tucker JA,Hidalgo G,Perkins S,Kryscio R,Hirschowitz EA

更新日期：2009-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) play crucial roles in the initiation and progression of various cancers, including melanoma. Recently, the genetic variants and deregulation of miR-605 have been reported to participate in carcinogenesis. However, the expression status of the miR-605 in melanoma tissues and its role in melanoma prog...

journal_title：Oncology reports

authors： Chen L,Cao Y,Rong D,Wang Y,Cao Y

更新日期：2017-08-01 00:00:00

abstract：:Homeobox containing 1 (HMBOX1) is a novel transcription repressor that is significantly downregulated in human liver cancer tissues and cell lines, but the exact biological function of HMBOX1 in liver cancer is still unknown. We observed a negative association between HMBOX1 expression level and the clinical stages of...

journal_title：Oncology reports

authors： Zhao H,Jia H,Han Q,Zhang J

更新日期：2018-09-01 00:00:00

abstract：:Pien Tze Huang (PZH) is a well-known traditional Chinese formula that was first prescribed by a royal physician in the Ming Dynasty. PZH has been used to treat various types of cancers including osteosarcoma. Previous studies have shown that PZH may effectively inhibit osteosarcoma cell growth in vivo and in vitro via...

journal_title：Oncology reports

authors： Zhang Y,Wang Q,Niu S,Liu J,Zhang L

更新日期：2014-02-01 00:00:00

abstract：:Malnutrition affects 40-50% of patients with ear, nose and throat (ENT) cancer. The aim of this study was to assess changes induced by a specific nutritional supplement enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes, as compared with a standard nutritional supplem...

journal_title：Oncology reports

authors： Roca-Rodríguez MM,García-Almeida JM,Lupiañez-Pérez Y,Rico JM,Toledo M,Alcaide-Torres J,Cardona F,Medina JA,Tinahones FJ

更新日期：2014-01-01 00:00:00

abstract：:The meningioma evolution remains problematic as 6 to 19% relapse after total resection. We have no criterion or marker to predict with certainty the tumour behaviour, and the WHO grading system is to a certain degree controversial. Telomerase expression seems to play an active role in conferring to the tumour cell ind...

journal_title：Oncology reports

authors： Kalala JP,Maes L,Vandenbroecke C,de Ridder L

更新日期：2005-02-01 00:00:00

abstract：:Despite significant homology between IRS-1 and IRS-2, recent studies have revealed distinct functions for these adaptor proteins in regulating breast cancer progression. Thus far, most of the studies on breast cancer have focused upon IRS-1, the biological pattern of IRS-2 is limited. We demonstrated that depletion of...

journal_title：Oncology reports

authors： Wu S,Zhou B,Xu L,Sun H

更新日期：2010-12-01 00:00:00

abstract：:p73 is a member of p53 tumor suppressor protein family. In spite of similarities of three meaningful domains between p53 and p73, the exact function of p73 protein is not established. To approach the relevance of p73 expression to a pathological parameter in human breast cancer, the apoptotic index (AI) and the mitoti...

journal_title：Oncology reports

authors： Yamamoto T,Oda K,Kubota T,Miyazaki K,Takenouti Y,Nimura Y,Hamaguchi M,Matsuda S

更新日期：2002-07-01 00:00:00

abstract：:The Houttuynia cordata Thunb (HCT) extract has been used as a traditional Chinese herb medicine and as well as an effective drug for treating allergic inflammation for thousands of years. In this study, we investigated the anti-cancer activity of HCT and its molecular mechanisms in the human colon adenocarcinoma cell ...

journal_title：Oncology reports

authors： Tang YJ,Yang JS,Lin CF,Shyu WC,Tsuzuki M,Lu CC,Chen YF,Lai KC

更新日期：2009-11-01 00:00:00

abstract：:Cancer research is currently focused on blocking the metastatic process at its early steps. Some particularly attractive targets are metastasis suppressor genes, which control cancer cell dissemination. The aim of this study was to clarify the relationship between the expression of KiSS1, a metastasis suppressor gene,...

journal_title：Oncology reports

authors： Okugawa Y,Inoue Y,Tanaka K,Toiyama Y,Shimura T,Okigami M,Kawamoto A,Hiro J,Saigusa S,Mohri Y,Uchida K,Kusunoki M

更新日期：2013-09-01 00:00:00

abstract：:Gentian violet (GV) is a cationic triphenylmethane dye, with potent antifungal and antibacterial activity. We recently reported that in vitro GV suppresses the differentiation of bone resorbing osteoclasts while stimulating the differentiation and activity of bone forming osteoblasts. Breast cancer is highly metastati...

journal_title：Oncology reports

authors： Yamaguchi M,Vikulina T,Weitzmann MN

更新日期：2015-10-01 00:00:00

abstract：:Trop2 is considered to have an important function in tumor metastasis and the promotion of epithelial‑mesenchymal transition (EMT). E‑cadherin is a crucial factor in intercellular adhesion and EMT transformation. In the present study, we detected the expression of Trop2 and E‑cadherin in breast cancer (BC) to better d...

journal_title：Oncology reports

authors： Zhao W,Kuai X,Zhou X,Jia L,Wang J,Yang X,Tian Z,Wang X,Lv Q,Wang B,Zhao Y,Huang W

更新日期：2018-08-01 00:00:00

abstract：:MicroRNAs are short RNAs that play a crucial role in all biological processes through post-transcriptional regulation for protein-coding genes and inducing mRNA degradation. Hepatitis B virus infection has been considered as a major risk factor in hepatocellular carcinoma, further research indicates that hepatitis B v...

journal_title：Oncology reports

authors： Wang Z,Wu Z,Huang P

更新日期：2017-08-01 00:00:00

abstract：:Intratumoral regions of low extracellular pH and low nutrition are common features of solid tumors. Although cancer cells normally die when they are removed from their environment, a small population of cells survive. In the present study, the subline LNCaP-F10, of the prostate canc...

journal_title：Oncology reports

authors： Iguchi K,Hayakawa Y,Ishii K,Matsumoto K,Usui S,Sugimura Y,Hirano K

更新日期：2012-12-01 00:00:00

abstract：:Casticin, one of the main components from Fructus Viticis, has been reported to inhibit the growth of various cancer cells, including the human cervical cancer cell line HeLa. The purpose of this study was to examine the apoptotic activity and molecular mechanism of casticin action on human cervical cancer cells. The ...

journal_title：Oncology reports

authors： Chen D,Cao J,Tian L,Liu F,Sheng X

更新日期：2011-11-01 00:00:00

abstract：:Tumour cell proliferation is an important biological prognostic parameter to be considered alongside clinical and histopathological parameters. It has been evaluated by immunohistochemistry using proliferative markers (PCNA, Ki67, etc.) and by flow cytometry considering DNA content, growth fraction (S + G2M) and S-pha...

journal_title：Oncology reports

authors： Tirelli G,Sidari L,Giacomarra V,Papanikolla L,Sasso F,Russolo M,Melato M

更新日期：2002-05-01 00:00:00