Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma.


:The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtained and analyzed. Survival curves were analyzed using the Kaplan‑Meier method for survival and Cox models for hazard ratios (HRs) with 95% confidence intervals (CIs). LF was preserved in 403 cases and not preserved in 177 cases. The 3‑ and 5‑year survival rates were 70.9 and 52.7%, respectively, in the LF preservation group and 48.4 and 30.5%, respectively, in the no LF preservation group. Compared with the patients without LF preservation, patients with LF preservation had a significantly reduced risk of overall death (HR=0.63, 95% CI: 0.50-0.80). LF preservation positively affects the prognosis of patients with HSCC.


Oncol Rep


Oncology reports


Zhou J,Li Y,Wei D,Qian Y,Li W,Liu D,Li G,Pan X,Lei D




Has Abstract


2015-12-01 00:00:00












  • RNAi-mediated knockdown of the c-jun gene sensitizes radioresistant human nasopharyngeal carcinoma cell line CNE-2R to radiation.

    abstract::This study aimed to investigate the effect of RNA interference (RNAi)-mediated downregulation of the expression of the c-jun gene (a proto-oncogene) on the radiosensitivity of a radioresistant human nasopharyngeal carcinoma cell line (CNE-2R) and to validate its potential as an anticancer target. A lentiviral vector w...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Guo SY,Zhu XD,Ge LY,Qu S,Li L,Su F,Guo Y

    更新日期:2015-03-01 00:00:00

  • p16, MGMT, RARbeta2, CLDN3, CRBP and MT1G gene methylation in esophageal squamous cell carcinoma and its precursor lesions.

    abstract::Esophageal squamous cell carcinoma (ESCC) is a common cancer with a very poor prognosis. New methods are needed to screen high-risk populations and identify curable tumors and precursor lesions early. Molecular markers may be useful in such screening efforts. This study was designed to determine the prevalence of p16,...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Roth MJ,Abnet CC,Hu N,Wang QH,Wei WQ,Green L,D'Alelio M,Qiao YL,Dawsey SM,Taylor PR,Woodson K

    更新日期:2006-06-01 00:00:00

  • pseudo-G-Rh2 induces mitochondrial-mediated apoptosis in SGC-7901 human gastric cancer cells.

    abstract::This study was designed to investigate the effect of pseudo-G-Rh2, a novel metabolite of ginsenoside Rh2, on the apoptosis of SGC-7901 human gastric cancer cells. Pseudo-G-Rh2 demonstrated antitumor activity and significantly inhibited the proliferation of SGC-7901 cells in a concen...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Qu X,Qu S,Yu X,Xu H,Chen Y,Ma X,Sui D

    更新日期:2011-12-01 00:00:00

  • Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy.

    abstract::Hepatocellular carcinoma (HCC) is highly resistant to chemotherapy, leading to a poor prognosis of advanced disease. Inhibitors of histone deacetylase (HDACi) induce re-differentiation in tumor cells and thereby re-establish sensitivity towards apoptotic stimuli. HDACi are entering the clinical stage of tumor treatmen...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Schuchmann M,Schulze-Bergkamen H,Fleischer B,Schattenberg JM,Siebler J,Weinmann A,Teufel A,Wörns M,Fischer T,Strand S,Lohse AW,Galle PR

    更新日期:2006-01-01 00:00:00

  • Molecular and immunological aspects of p53 and p53-autoantibodies in head and neck squamous cell carcinoma.

    abstract::The tumour suppressor protein p53 (wild-type = wt-p53) is of major importance in the genetic integrity of the cell. Mutations of the p53-gene (mt-p53) are the most frequent genetic aberrations identified in different tumour entities. As analyzed in a wide variety of human malignomas, mt-p53 evokes a specific immune re...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Cordes C,Von Lingen J,Görögh T,Ambrosch P,Gottschlich S,Hoffmann M

    更新日期:2009-12-01 00:00:00

  • Long-term effects of short hairpin RNA-targeted human telomerase reverse transcriptase on suppression of SGC-7901 cell proliferation by inhibition of telomerase activity.

    abstract::Human telomerase reverse transcriptase (hTERT) is an attractive target for cancer gene therapy. However, the poor inhibition of telomerase and a time lag between the inhibition and arrest of cell proliferation limits its use in cancer gene therapy. RNA interference (RNAi) has been proposed as a potential technique for...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Qian X,Cheng J,Chen A,Wang Y,Tao Y,Cao J,Feng Z

    更新日期:2008-02-01 00:00:00

  • Dysregulation of apoptosis is a major mechanism in the lymph node involvement in colorectal carcinoma.

    abstract::The purpose of this study was to define gene expression profile changes in colorectal tumors in order to identify target genes involved in neoplastic progression. cDNA microarray analysis was used to detect differences in gene expression profiles between colon tumor samples obtained from 20 patients in different tumor...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Bandres E,Catalan V,Sola I,Honorato B,Cubedo E,Cordeu L,Andion E,Escalada A,Zarate R,Salgado E,Zabalegui N,García F,Garcia-Foncillas J

    更新日期:2004-08-01 00:00:00

  • MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2.

    abstract::MicroRNA-455 (miR-455) has been considered as a novel cancer-related miRNA and dysregulated expression frequently occurs in various human types of cancer. However, its clinical significance, its biological function and the underlying molecular signaling involved in hepatocellular carcinoma (HCC) remain to be elucidate...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Qin L,Zhang Y,Lin J,Shentu Y,Xie X

    更新日期:2016-12-01 00:00:00

  • Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer.

    abstract::Ulcerative colitis (UC) is an important risk factor for colorectal cancer (CRC). Histone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC. At present, there are no studies comparing histone modification patterns of UC and CRC in the literature. Therefore the aim o...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Gerçeker E,Boyacıoglu SO,Kasap E,Baykan A,Yuceyar H,Yıldırım H,Ayhan S,Ellidokuz E,Korkmaz M

    更新日期:2015-10-01 00:00:00

  • CHST15 promotes the proliferation of TE‑1 cells via multiple pathways in esophageal cancer.

    abstract::Esophageal squamous cell carcinoma (ESCC) is a common type of esophageal cancer and is prevalent worldwide. Understanding the mechanisms underlying its formation and the search for more effective therapeutic strategies are critical due to the occurrence of chemotherapeutic drug resistance. The aim of the present study...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Wang X,Cheng G,Zhang T,Deng L,Xu K,Xu X,Wang W,Zhou Z,Feng Q,Chen D,Bi N,Wang L

    更新日期:2020-01-01 00:00:00

  • Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: prognostic implications.

    abstract::EGFR, p27kip1 and Skp2, have been implicated in human cancer development. We have studied these molecules in a search for molecular markers that may have prognostic value in head and neck squamous cell carcinomas (HNSCC). Tissue samples of 62 patients were collected and immunohistochemical analysis was carried out for...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Carracedo DG,Astudillo A,Rodrigo JP,Suarez C,Gonzalez MV

    更新日期:2008-09-01 00:00:00

  • Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma.

    abstract::The therapeutic potential of membrane complement regulatory protein (mCRP)-neutralizing antibodies is unsatisfactory, which perhaps lies in the complex role of mCRPs in tumor occurrence and development. As a member of the mCRPs, CD46 is a transmembrane protein with a cytoplasmic domain and is implicated more in the co...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Lu Z,Zhang C,Cui J,Song Q,Wang L,Kang J,Li P,Hu X,Song H,Yang J,Sun Y

    更新日期:2014-02-01 00:00:00

  • DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma.

    abstract::DEK, a transcription factor, is involved in mRNA splicing, transcriptional control, cell division and differentiation. Recent studies suggest that DEK overexpression can promote tumorigenesis in a wide range of cancer cell types. However, little is known concerning the status of DEK in pancreatic ductal adenocarcinoma...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Sun J,Bi F,Yang Y,Zhang Y,Jin A,Li J,Lin Z

    更新日期:2017-02-01 00:00:00

  • Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor β1.

    abstract::Ubiquitin specific protease 22 (USP22) is an oncogene that is upregulated in many cancer types, and aberrant expression of USP22 correlates with clinical outcome. However, its potential functional impact in epithelial ovarian cancer (EOC) has not been determined. Here, we report that USP22 was upregulated in EOC speci...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Ji M,Shi H,Xie Y,Zhao Z,Li S,Chang C,Cheng X,Li Y

    更新日期:2015-01-01 00:00:00

  • The novel bis-benzylisoquinoline PY35 reverses P-glycoprotein-mediated multidrug resistance.

    abstract::Multidrug resistance (MDR) to chemotherapeutic drugs is the main cause of chemotherapy failure in cancer treatment, and it generally results from expression of ATP-dependent efflux pump P-glycoprotein (P-gp). MDR reversal agents typically act by inhibiting the drug efflux activity of P-gp, thereby increasing intracell...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Cao Z,Wright M,Cheng J,Huang X,Liu L,Wu L,Yang P

    更新日期:2014-09-01 00:00:00

  • Tumor-associated macrophages induce the expression of FOXQ1 to promote epithelial-mesenchymal transition and metastasis in gastric cancer cells.

    abstract::Gastric cancer (GC) is one of the most common malignancies, and is the second leading cause of cancer-related deaths worldwide. Macrophages infiltrated in the tumor microenvironment (TME) called tumor-associated macrophages (TAMs) are key orchestrators in TME. In GC, it has been reported that infiltration of TAMs is a...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Guo J,Yan Y,Yan Y,Guo Q,Zhang M,Zhang J,Goltzman D

    更新日期:2017-10-01 00:00:00

  • Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells.

    abstract::Epigenetic anticancer drugs such as histone deacetylase (HDAC) inhibitors have been combined with existing anticancer drugs for synergistic or additive effects. In the present study, we found that a very low concentration of depsipeptide, an HDAC inhibitor, potentiated the antitumor activity of 5-fluorouracil (5-FU) i...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Okada K,Hakata S,Terashima J,Gamou T,Habano W,Ozawa S

    更新日期:2016-10-01 00:00:00

  • L‑Deprenyl exerts cytotoxicity towards acute myeloid leukemia through inhibition of mitochondrial respiration.

    abstract::The identification of large numbers of genetic mutations in immature myeloid cells has made it difficult to identify specific targets for acute myeloid leukemia (AML) therapy. Although current pharmacological targets for controlling cancer are focused on identifying genetic mutations, it is hard to develop the specifi...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Ryu I,Ryu MJ,Han J,Kim SJ,Lee MJ,Ju X,Yoo BH,Lee YL,Jang Y,Song IC,Chung W,Oh E,Heo JY,Kweon GR

    更新日期:2018-12-01 00:00:00

  • EVI5 is a novel independent prognostic predictor in hepatocellular carcinoma after radical hepatectomy.

    abstract::The present study explored the correlation of ecotropic viral integration site 5 (EVI5) expression with clinicopathological features and prognosis in hepatocellular carcinoma (HCC). A total of 205 HCC patients were included retrospectively. Quantitative real-time polymerase chain reaction (RT-qPCR) and western blottin...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Tang J,Ou J,Xu C,Yi C,Xue F,Xu L,Lai F,Tang J,Li S,Kang T,Ding W,Wang B

    更新日期:2017-10-01 00:00:00

  • Clinical significance of altered S100A2 expression in gastric cancer.

    abstract::The S100A2 gene has been reported to be a putative tumor‑suppressor gene. Nevertheless, overexpression of S100A2 has been found in certain types of cancer. This study investigated S100A2 expression in tissue specimens of gastritis, intestinal metaplasia, adenomatous dysplasia and ga...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Zhao Y,Zhang TB,Wang Q

    更新日期:2013-04-01 00:00:00

  • Persistent anti-tumor effects via recombinant adeno-associated virus encoding herpes thymidine kinase gene monitored by PET-imaging.

    abstract::Despite the well-documented advantages of the recombinant adeno-associated virus (rAAV) as a gene delivery vehicle, including its non-pathogenic and long-term therapeutic gene expression, there have been very limited studies on its potential for producing persistent anti-tumor effects, particularly in vivo. To address...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Kim JY,Kim JH,Khim M,Lee HS,Jung JH,Moon DH,Jeong S,Lee H

    更新日期:2011-05-01 00:00:00

  • Downregulation of survivin expression and elevation of caspase-3 activity involved in pitavastatin-induced HepG 2 cell apoptosis.

    abstract::The aim of the present study was to research the apoptosis of human hepatocellular carcinoma cell line HepG 2 induced by pitavastatin. HepG 2 cells were treated with increasing doses of pitavastatin or with mevalonic acid for 48 h. The proliferation of cells was detected with WST-8. The morphology of the nucleus was o...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Wang J,Xu Z,Zhang M

    更新日期:2007-08-01 00:00:00

  • Retinoic acid induces differentiation in neuroblastoma via ROR1 by modulating retinoic acid response elements.

    abstract::Neuroblastoma is the most common inheritable, solid neoplasm in children found under the age of 7 and accounts for approximately 7% of childhood cancers. A common treatment that has been prescribed for over a decade is retinoid therapy [using all‑trans retinoic acid (RA)]. Treatment with this differentiating agent has...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Illendula A,Fultang N,Peethambaran B

    更新日期:2020-09-01 00:00:00

  • Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models.

    abstract::Daily vs. weekly dosing with EGFR inhibitors (gefitinib and lapatinib) and an AKT inhibitor (MK2206) were compared in two rodent breast cancer models. Female Sprague-Dawley rats were administered methylnitrosourea (MNU) at 50 days of age, and gefitinib (daily/weekly dosing at 10/70 mg/kg BW) or lapatinib (daily/weekly...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Lubet RA,Steele VE,Juliana MM,Bode A,Moeinpour F,Grubbs CJ

    更新日期:2018-09-01 00:00:00

  • CX3CL1 increases invasiveness and metastasis by promoting epithelial-to-mesenchymal transition through the TACE/TGF-α/EGFR pathway in hypoxic androgen-independent prostate cancer cells.

    abstract::Epithelial-to-mesenchymal transition (EMT) endows cancer cells with enhanced invasive and metastatic potential during cancer progression. Fractalkine, also known as chemokine (C-X3-C motif) ligand 1 (CX3CL1), the only member recognized so far that belongs to the CX3C chemokine subfamily, was reported to participate in...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Tang J,Xiao L,Cui R,Li D,Zheng X,Zhu L,Sun H,Pan Y,Du Y,Yu X

    更新日期:2016-02-01 00:00:00

  • Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer.

    abstract::Thymidylate synthase (TS) is the rate-limiting enzyme in the synthesis of pyrimidine nucleotides, required for DNA synthesis, and is also a critical target for fluoropyrimidines, which are widely used in the treatment of gastrointestinal tumours. We examined TS expression in tumours from 86 patients with advanced colo...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Bendardaf R,Lamlum H,Elzagheid A,Ristamäki R,Pyrhönen S

    更新日期:2005-09-01 00:00:00

  • Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death.

    abstract::Antimycin A (AMA) inhibits the mitochondrial electron transport between cytochromes b and c. However, the relationship between AMA and lung cancer cells is poorly understood. In this study, we investigated the involvement of reactive oxygen species (ROS) and glutathione (GSH) in AMA-treated lung cancer Calu-6 cell dea...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Han YH,Park WH

    更新日期:2009-01-01 00:00:00

  • Reduced expression of SRY-box containing gene 17 correlates with an unfavorable melanoma patient survival.

    abstract::SRY-box containing gene 17 (Sox17), a transcription factor, is considered as an antagonist to canonical Wnt/β‑catenin signaling in several types of malignant tumors. As the influence of Sox17 in the pathogenesis of human melanoma is still unknown, the investigation of Sox17 expression in melanoma is warranted and its ...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Lu J,Zhang G,Cheng Y,Tang Y,Dong Z,McElwee KJ,Li G

    更新日期:2014-12-01 00:00:00

  • Everolimus exhibits efficacy as a radiosensitizer in a model of non-small cell lung cancer.

    abstract::Signaling pathways that activate mTOR (mammalian target of rapamycin) are altered in many human cancers and these alterations are associated with prognosis and treatment response. mTOR inhibition can restore sensitivity to DNA damaging agents such as cisplatin. The rapamycin derivat...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Mauceri HJ,Sutton HG,Darga TE,Kocherginsky M,Kochanski J,Weichselbaum RR,Vokes EE

    更新日期:2012-05-01 00:00:00

  • BMI-1 suppression increases the radiosensitivity of oesophageal carcinoma via the PI3K/Akt signaling pathway.

    abstract::B-cell‑specific Moloney murine leukaemia virus integration site-1 (BMI-1) contributes to the growth of tumour cells post-irradiation (IR). The aim of the present study was to characterize the effects of BMI-1 on cell viability, radiosensitivity and its mechanisms of action in oesophageal squamous cell cancer (ESCC). W...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Yang XX,Ma M,Sang MX,Zhang XY,Liu ZK,Song H,Zhu SC

    更新日期:2018-02-01 00:00:00