Overall survival with and without laryngeal function preservation in 580 patients with hypopharyngeal squamous cell carcinoma.

abstract：:The clinical applications of Rhizoma paridis in traditional Chinese medicine are well known. However, the therapeutic potential of Rhizoma paridis and its active component such as Paris saponin I (polyphyllin D) and Paris saponin II (PSII) (formosanin C) in cancer treatments have not yet been fully explored. Recent st...

journal_title：Oncology reports

authors： Yang M,Zou J,Zhu H,Liu S,Wang H,Bai P,Xiao X

更新日期：2015-05-01 00:00:00

abstract：:Spindle-cell ameloblastic carcinoma is a classification proposed for a group of rare odontogenic carcinomas with sarcomatoid components and is distinguished from odontogenic carcinosarcoma. We report a case of spindle-cell ameloblastic carcinoma of the right mandible that occurred in a 67-year-old Japanese man. Growth...

journal_title：Oncology reports

authors： Kawauchi S,Hayatsu Y,Takahashi M,Furuya T,Oga A,Niwa S,Sasaki K

更新日期：2003-01-01 00:00:00

abstract：:The effectiveness of granulocyte colony-stimulating factor (G-CSF) for granulocytopenia has been widely recognized. However, although granulocyte counts rapidly increase after a few injection of G-CSF, a large proportion of the increased granulocytes disappear from peripheral blood within a few days following G-CSF wi...

journal_title：Oncology reports

authors： Ogawa Y,Kobayashi T,Nishioka A,Kariya S,Garcia Del Saz E,Seguchi H,Yoshida S

更新日期：2001-09-01 00:00:00

abstract：:Several investigators have demonstrated that TGF-beta stimulated clone-22 (TSC-22) regulates cell growth and differentiation, and cell death. TSC-22 is a putative transcriptional regulator containing a leucine zipper-like structure and a nuclear export signal. We previously showed the cytoplasmic localization of TSC-2...

journal_title：Oncology reports

authors： Hino S,Kawamata H,Omotehara F,Uchida D,Begum NM,Yoshida H,Sato M,Fujimori T

更新日期：2002-03-01 00:00:00

abstract：:Previously, we showed that the herbal extract EYK (Epimedium koreanum Nakai) can regulate the immune response. Other studies showed that EYK has beneficial effects in human lung cancer, angiogenesis and Alzheimer's disease (AD). However, it remains unknown whether EYK can affect cancer cell migration and invasion in h...

journal_title：Oncology reports

authors： Lee W,Nam JH,Cho HJ,Lee JY,Cho WK,Kim Υ,We YM,Ma JY,Hoe HS

更新日期：2017-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) that negatively regulate gene expression play a key role in the development and progression of cancer. Aberrant expression of hsa-miR-187 (miR-187) has been reported in various malignancies. However, the function of miR-187 in tumor progression remains controversial and its role in non-small cell lu...

journal_title：Oncology reports

authors： Cai Y,Ruan J,Yao X,Zhao L,Wang B

更新日期：2017-05-01 00:00:00

abstract：:We studied the role of chemotherapy in cancer cachexia, which is well known to lower QOL and responsiveness to chemotherapy. In BALB/c mice we used two clones derived from the murine colon 26 adenocarcinoma cell line; clone 5, a non-cachexigenic tumor and clone 20, a cachexigenic tumor, in which IL-6 mRNA was selectiv...

journal_title：Oncology reports

authors： Takahashi Y,Yasumoto K,Mai M

更新日期：2005-07-01 00:00:00

abstract：:To study the role of the chemokine receptor CCR7 in the metastatic process, a murine CCR7 gene was transduced in two mammary cancer cell lines with different origins and molecular features; TS/A, derived from a spontaneous mammary cancer of BALB/c strain, and N202.1A, derived from a HER-2/neu transgenic mammary cancer...

journal_title：Oncology reports

authors： Croci S,Nicoletti G,Landuzzi L,Palladini A,Chiarini F,Nanni P,Lollini PL,De Giovanni C

更新日期：2007-08-01 00:00:00

abstract：:High activity 125I brachytherapy has efficacy in selected recurrent malignant brain tumors, but limited efficacy and risk of radiation necrosis have prompted investigation of additional adjunctive therapies. This study aims to assess the toxicity of interstitial conductive hyperthermia used concurrently with 125I brac...

journal_title：Oncology reports

authors： Narayan P,Crocker I,Elder E,Olson JJ

更新日期：2004-01-01 00:00:00

abstract：:We investigated the role of mitochondrial function in the invasiveness of human colorectal cancer (CRC) cell lines, using paired primary SW480 and metastatic SW620 cells, and appraised the clinical relevance of the alteration of mtDNA copy number in 33 pairs of CRC specimens after surgical resection. Suppression of mi...

journal_title：Oncology reports

authors： Lin CS,Liu LT,Ou LH,Pan SC,Lin CI,Wei YH

更新日期：2018-01-01 00:00:00

abstract：:Cisplatin, an important chemotherapeutic agent against testicular germ cell cancer, induces testicular toxicity on Leydig and Sertoli cells, leading to serious side-effects such as azoospermia and infertility. In a previous study, it was found that simvastatin enhanced the sensitivity of Leydig tumor cells to chemothe...

journal_title：Oncology reports

authors： Wang L,Peng J,Huang H,Wang Q,Yu M,Tao L

更新日期：2015-10-01 00:00:00

abstract：:Aberrantly expressed miRNAs play a crucial role in the progression of lung adenocarcinoma. However, to date, the role of miR‑888 in lung adenocarcinoma progression is unclear. In the present study, the biological function of miR‑888 and its underlying mechanism in lung adenocarcinoma progression were explored. RT‑qPCR...

journal_title：Oncology reports

authors： Cao JX

更新日期：2019-06-01 00:00:00

abstract：:The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of r...

journal_title：Oncology reports

authors： Shoji H,Motegi M,Takakusagi Y,Asao T,Kuwano H,Takahashi T,Ogoshi K

更新日期：2017-02-01 00:00:00

abstract：:Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid pre...

journal_title：Oncology reports

authors： Lu L,Chen J,Li M,Tang L,Wu R,Jin L,Liang Z

更新日期：2018-04-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-related mortality worldwide. Aberrant expression of miRNAs play important roles in the development and progression of various types of cancers by modulating oncogenic and tumour-suppressor pathways. Therefore, exploring the ...

journal_title：Oncology reports

authors： Zhao J,Xu J,Zhang R

更新日期：2018-02-01 00:00:00

abstract：:Triosephosphate isomerase (TPI) is highly expressed in many types of human tumors and is involved in migration and invasion of cancer cells. However, TPI clinicopathological significance and malignant function in gastric cancer (GC) have not been well defined. The present study aimed to examine TPI expression in GC ti...

journal_title：Oncology reports

authors： Chen T,Huang Z,Tian Y,Wang H,Ouyang P,Chen H,Wu L,Lin B,He R

更新日期：2017-09-01 00:00:00

abstract：:Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in several types of cancers. In non-small cell lung cancer (NSCLC), several genes are known to be frequently methylated and the correlation of their methylation with clinical features has been stud...

journal_title：Oncology reports

authors： Hanabata T,Tsukuda K,Toyooka S,Yano M,Aoe M,Nagahiro I,Sano Y,Date H,Shimizu N

更新日期：2004-07-01 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine tumors (GEP‑NETs) are relatively uncommon. Unfortunately, epidemiological studies on the incidence of GEP‑NETs worldwide have reported a marked increase in the detection of these tumors. Although they often exhibit relatively indolent clinical courses, GEP‑NETs have the potential ...

journal_title：Oncology reports

authors： Tang C,Gong L,Zou W,Zhang J,Zhou Y,Wu X,Lu F,Ouyang C,Liu X

更新日期：2016-12-01 00:00:00

abstract：:Breast cancer is the most common malignancy in women, and metastasis is the leading cause of death in breast cancer patients. Previous studies have shown that epithelial‑mesenchymal transition (EMT) is involved in the metastasis of breast cancer, but the metabolic reprogramming and regulation mechanisms involved in th...

journal_title：Oncology reports

authors： Liu QQ,Huo HY,Ao S,Liu T,Yang L,Fei ZY,Zhang ZQ,Ding L,Cui QH,Lin J,Yu M,Xiong W

更新日期：2020-09-01 00:00:00

abstract：:Inhibins are dimeric glycoproteins, composed of an α-subunit and one of two possible β-subunits (βA or βB), with substantial roles in human reproduction and in endocrine-responsive tumours. Recently a novel β subunit named βC was described, although it is still unclear if normal or cancerous cervical epithelial cells ...

journal_title：Oncology reports

authors： Blankenstein T,Jückstock J,Shabani N,Kunze S,Brüning A,Bergauer F,Mylonas I

更新日期：2011-01-01 00:00:00

abstract：:Human papillomavirus (HPV) L1 capsid protein is only produced during a productive HPV infection at the end of the natural viral life cycle and is a major target of the immune response in women with HPV-related squamous intraepithelial lesions. We evaluated the usefulness of L1 detection by immunocytochemistry in high-...

journal_title：Oncology reports

authors： Norman I,Hjerpe A,Andersson S

更新日期：2013-08-01 00:00:00

abstract：:Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found th...

journal_title：Oncology reports

authors： Wu X,Zhou J,Cai D,Li M

更新日期：2017-08-01 00:00:00

abstract：:The aim of the present study was to search for an effective regimen among existing chemotherapies for head and neck squamous cell carcinoma (HNSCC). Among the tested drugs, we focused on combined SN-38, which is the active metabolite produced from irinotecan hydrochloride - a type I DNA topoisomerase inhibitor - after...

journal_title：Oncology reports

authors： Nanbu T,Umemura N,Ohkoshi E,Nanbu K,Sakagami H,Shimada J

更新日期：2018-01-01 00:00:00

abstract：:Cell cycle-related molecules play crucial roles in maintaining genomic stability, and can also serve as biomarkers of cell cycle phase distribution at the same time. In this study, we used multiparameter analysis of various biomarkers to investigate their utility for the evaluation ...

journal_title：Oncology reports

authors： Haruki T,Shomori K,Shiomi T,Taniguchi Y,Nakamura H,Ito H

更新日期：2012-09-01 00:00:00

abstract：:The human multidrug resistance gene 1 (MDR-1) encodes a plasma membrane P-glycoprotein (P-gp) that functions as the transmembrane efflux pump for various structurally unrelated anticancer agents and toxins. Polymorphisms in the MDR-1 gene may have an impact on the expression and function of P-gp, thereby influencing t...

journal_title：Oncology reports

authors： Zubor P,Lasabova Z,Hatok J,Stanclova A,Danko J

更新日期：2007-07-01 00:00:00

abstract：:Vimentin is a member of the intermediate filament family, and the NF-kappaB binding site is located in the human vimentin promoter. To gain insight into the role of NF-kappaB in the regulation of the vimentin gene during 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent differentiation of HL-60 cells, the effect of...

journal_title：Oncology reports

authors： Zheng M,Son MY,Park C,Park JI,Jo EK,Yoon WH,Park SK,Hwang BD,Lim K

更新日期：2005-09-01 00:00:00

abstract：:Despite significant advances in micro-metastasis detection methods, little is known about the relationship between micro-metastasis and primary tumors. The purpose of this study was to assess the ability of expression of the breast cancer-related markers, HER-2/neu, COX-2, VEGF and PDGF-B, as a predictor for micro-met...

journal_title：Oncology reports

authors： Zhu L,Loo WT,Cheng CW,Chow LW

更新日期：2006-05-01 00:00:00

abstract：:Resistance to chemotherapeutic agents is a major problem for successful cancer treatment. P-glycoprotein (Pgp), a product of the multidrug resistance (MDR)1 gene expressed in cancer cells, is one of the mechanism of MDR. However, there are few reports regarding the effects of Pgp on prognosis of colorectal cancer (CRC...

journal_title：Oncology reports

authors： Tokunaga Y,Hosogi H,Hoppou T,Nakagami M,Tokuka A,Ohsumi K

更新日期：2001-07-01 00:00:00

abstract：:The immune suppression of sentinel lymph node (SN) is directly influenced by primary tumors. It has been reported that the T-helper type 1 (Th1) to T-helper type 2 (Th2) ratio or T-cytotoxic type 1 (Tc1) to T-cytotoxic type 2 (Tc2) ratio of lymph node lymphocytes could be used to evaluate direct immunological circumst...

journal_title：Oncology reports

authors： Ehi K,Ishigami S,Masamoto I,Uenosono Y,Natsugoe S,Arigami T,Arima H,Kijima Y,Yoshinaka H,Yanagita S,Kozono T,Funasako Y,Maruyama I,Aikou T

更新日期：2008-03-01 00:00:00

abstract：:Aberrant glycosylation, a common feature of malignant alteration, is partly due to changes in the expression of glycosyltransferases, including β1,3-N-acetyl-glucosaminyltrans-ferase 8 (β3Gn‑T8), which synthesizes poly-N-acetyllactosamine (poly-LacNAc) chains on β1,6 branched N‑glycans. Although the role of β3Gn‑T8 in...

journal_title：Oncology reports

authors： Jiang Z,Liu Z,Zou S,Ni J,Shen L,Zhou Y,Hua D,Wu S

更新日期：2016-09-01 00:00:00