Upregulation of BTG1 enhances the radiation sensitivity of human breast cancer in vitro and in vivo.

abstract：:Hypoxic tumor cells are known to be more resistant to conventional chemotherapy and radiation than normoxic cells. However, the effects of 2-methoxyestradiol (2-ME), an anti-angiogenic, antiproliferative and pro-apoptotic drug, on hypoxic lung cancer cells are unknown. The aim of the present study was to compare the e...

journal_title：Oncology reports

authors： Aquino-Gálvez A,González-Ávila G,Delgado-Tello J,Castillejos-López M,Mendoza-Milla C,Zúñiga J,Checa M,Maldonado-Martínez HA,Trinidad-López A,Cisneros J,Torres-Espíndola LM,Hernández-Jiménez C,Sommer B,Cabello-Gutiérrez C,Guti

更新日期：2016-01-01 00:00:00

abstract：:Cancer immunotherapy is a promising new approach to cancer treatment. It has been demonstrated that a high number of tumor-specific cytotoxic T cells (CTLs) is associated with increased disease-specific survival in lung cancer patients. Identification of superior CTL epitopes from tumor antigens is essential for the d...

journal_title：Oncology reports

authors： Yoshimura M,Tada Y,Ofuzi K,Yamamoto M,Nakatsura T

更新日期：2014-07-01 00:00:00

abstract：:The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a predictor of prognosis and response to cytotoxic treatments. Its immunoexpression was assessed in 63 ...

journal_title：Oncology reports

authors： Jardim BV,Moschetta MG,Leonel C,Gelaleti GB,Regiani VR,Ferreira LC,Lopes JR,Zuccari DA

更新日期：2013-09-01 00:00:00

abstract：:Luteolin was recently demonstrated to suppress tumor growth by interfering with nuclear factor (NF)‑κB activation. As the NF‑κB pathway plays a critical role in muscular atrophy associated with cancer cachexia, we aimed to investigate the potential of luteolin to alleviate cancer‑associated cachexia in a Lewis lung ca...

journal_title：Oncology reports

authors： Chen T,Li B,Xu Y,Meng S,Wang Y,Jiang Y

更新日期：2018-08-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) signaling has been shown to play a critical role in the development of epithelial-mesenchymal transition (EMT). PAI-1 is one of the most important target genes in the TGF-β/Smad signaling pathway, which can hinder the degradation of ECM composition and may promote cell invasion a...

journal_title：Oncology reports

authors： Wang X,Liu C,Wang J,Fan Y,Wang Z,Wang Y

更新日期：2017-02-01 00:00:00

abstract：:The lipogenic enzyme fatty acid synthase (FAS) is differentially overexpressed and hyperactivated in a biologically aggressive subset of breast carcinomas and minimally in most normal adult tissues, rendering it an interesting target for anti-neoplastic therapy development. Current trends in the treatment of human bre...

journal_title：Oncology reports

authors： Menendez JA,Colomer R,Lupu R

更新日期：2004-08-01 00:00:00

abstract：:Loss of E-cadherin expression and gain of N-cadherin expression ('cadherin switch') is shown to be characteristic in epithelial to mesenchymal transition (EMT), a mechanism associated with cancer progression. Furthermore, the prognostic role of P-cadherin in different cancers is controversial. The aim of this study wa...

journal_title：Oncology reports

authors： Jäger T,Becker M,Eisenhardt A,Tilki D,Tötsch M,Schmid KW,Romics I,Rübben H,Ergün S,Szarvas T

更新日期：2010-04-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most commonly diagnosed malignancies, and 90% of advanced prostate cancer patients relapse after therapy. Trophinin associated protein (TROAP) is essential for centrosome integrity and proper bipolar organisation of spindle assembly during mitosis and plays an essential role in prol...

journal_title：Oncology reports

authors： Ye J,Chu C,Chen M,Shi Z,Gan S,Qu F,Pan X,Yang Q,Tian Y,Wang L,Yang W,Cui X

更新日期：2019-02-01 00:00:00

abstract：:Tetraarsenic oxide (As4O6, TAO) is a new arsenic compound that inhibits cell growth and induces apoptosis in human cervical cancer cell lines. In the present study, we report that the growth of tumor cells (CaSki) was inhibited by treatment with TAO alone or in combination with cisp...

journal_title：Oncology reports

authors： Byun JM,Jeong DH,Lee DS,Kim JR,Park SG,Kang MS,Kim YN,Lee KB,Sung MS,Kim KT

更新日期：2013-04-01 00:00:00

abstract：:Cancer represents a significant challenge for humankind, as early diagnosis and treatment are difficult to achieve. To systemically investigate the effect of sex, body mass index (BMI) and age on cancer incidence and prognosis, the data from 14,504 cases of cancer were downloaded from The Cancer Genome Atlas (TCGA). B...

journal_title：Oncology reports

authors： Huang X,Shu C,Chen L,Yao B

更新日期：2018-09-01 00:00:00

abstract：:Ovarian cancer is the leading cause of death among malignancies of the female reproductive system. The 5-year survival rates of ovarian cancer (OC) patients are very poor as a result of recurrent disease and emergence of drug resistance; thus, studies to find predictive markers and factors for drug resistance are ongo...

journal_title：Oncology reports

authors： Gao Y,Liu X,Li T,Wei L,Yang A,Lu Y,Zhang J,Li L,Wang S,Yin F

更新日期：2017-05-01 00:00:00

abstract：:Orotate phosphoribosyl transferase (OPRT) is an enzyme playing an important role in exertion of the effect of 5-fluorouracil (5-FU). A type of gene polymorphism, single nucleotide polymorphism (SNP), is considered to be a factor affecting individual differences in exertion of drug effects, and its analysis has recentl...

journal_title：Oncology reports

authors： Kitajima M,Takita N,Hata M,Maeda T,Sakamoto K,Kamano T,Ochiai T

更新日期：2006-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are associated with invasion and metastasis of several human malignant tumors. Especially so MMP-7, as it is mainly produced by the actual cancer cells. However, the expression of MMP-7 in transitional cell carcinoma (TCC) of the urinary bladder has not been previously investigated. We...

journal_title：Oncology reports

authors： Sumi T,Yoshida H,Hyun Y,Yasui T,Matsumoto Y,Hattori K,Sugimura K,Kawashima H,Nakatani T,Ishiko O

更新日期：2003-03-01 00:00:00

abstract：:Loss of proliferative control and failure to undergo cellular differentiation are key events during carcinogenesis. We recently identified a new potential tumor suppressor gene named MTUS1 (mitochondrial tumor suppressor 1), down-regulated in undifferentiated tumor cell lines, inhibiting tumor cell proliferation after...

journal_title：Oncology reports

authors： Zuern C,Heimrich J,Kaufmann R,Richter KK,Settmacher U,Wanner C,Galle J,Seibold S

更新日期：2010-01-01 00:00:00

abstract：:The carcinogenic process in previously normal human colonic mucosa involves hyperproliferation and adenoma formation, but it is not known why only a tiny proportion of adenomas undergo malignant transformation. There is accumulating evidence in favour of the hypothesis that inflammatory processes are a prerequisite fo...

journal_title：Oncology reports

authors： Sharma RA,Dalgleish AG,Steward WP,O'Byrne KJ

更新日期：2003-09-01 00:00:00

abstract：:Elimination of leukoplakia is one of the strategies for prevention of oral cancer. However, the efficacy of reducing malignant transformation for the treated leukoplakia has rarely been reported despite a number of studies addressing its malignant transformation to oral cancer after intervention. The obstacle to do so...

journal_title：Oncology reports

authors： Shiu MN,Chen TH

更新日期：2003-11-01 00:00:00

abstract：:The advent of pathotropic (disease-seeking) targeting has transported genetic medicine across the threshold of history with the progressive clinical validation of Rexin-G, a tumor-targeted nanosized anti-cancer agent. Achieving noteworthy single-agent efficacy and survival benefits in otherwise intractable cancers, th...

journal_title：Oncology reports

authors： Hall FL,Levy JP,Reed RA,Petchpud WN,Chua VS,Chawla SP,Gordon EM

更新日期：2010-10-01 00:00:00

abstract：:Despite intense research in the field of breast cancer it still remains the most common cancer in women in the Western world. A decreasing trend in mortality was mainly achieved by improved early detection which led to an increased incidence of ductal carcinoma in situ (DCIS) of the breast. For the patient's prognosis...

journal_title：Oncology reports

authors： Schmid BC,Rudas M,Fabjani G,Speiser P,Kaserer K,Leodolter S,Zeillinger R

更新日期：2003-11-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer, and numerous oncogenes are associated with this disease. Oxysterol‑binding protein‑related protein 8 (ORP8) is essential for cell growth, migration and the modulation of mitochondrial respiration and morphology. However, the underlying role of ...

journal_title：Oncology reports

authors： Li J,Cui J,Li Z,Fu X,Li J,Li H,Wang S,Zhang M

更新日期：2020-05-01 00:00:00

abstract：:To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the co...

journal_title：Oncology reports

authors： Ge MH,Chen C,Xu JJ,Ling ZQ

更新日期：2011-08-01 00:00:00

abstract：:The aim of this study was to define the clinical implications of semi-quantitative telomerase activity in gynecological tumors by comparing the telomerase activity of cancerous lesion and the adjacent non-cancerous lesion. In 118 cases of gynecologic tumors, including 41 uterine cervical tumors, 43 uterine body tumors...

journal_title：Oncology reports

authors： Sakamoto M,Toyoizumi T,Kikuchi Y,Okamoto A,Nakayama H,Aoki D,Yamamoto K,Hata H,Sugishita T,Tenjin Y

更新日期：2000-09-01 00:00:00

abstract：:Investigations into extracellular vesicles (EVs) have significantly increased since their role in physiological and pathological processes has become more clearly understood. Furthermore, it has become increasingly clear that several subpopulations of EVs exist, such as exosomes (EXOs) and microvesicles (MVs). Various...

journal_title：Oncology reports

authors： Giusti I,Di Francesco M,Cantone L,D'Ascenzo S,Bollati V,Carta G,Dolo V

更新日期：2015-11-01 00:00:00

abstract：:Rad52 encodes a protein which is required for recombinational repair of double-strand breaks. It is also associated with breast cancer predisposition genes BRCA1 and BRCA2. Mutations in the genes Rad51 or Rad52 result in severe defects in genetic recombination and the repair of double-strand DNA breaks. In order to ex...

journal_title：Oncology reports

authors： Tong D,Volm T,Eberhardt E,Krainer M,Leodolter S,Kreienberg R,Zeillinger R

更新日期：2003-09-01 00:00:00

abstract：:Prostate cancer is a leading cause of cancer-related death among men. Early diagnosis and treatment are successful against prostate cancer, yet the clinical treatment of advanced prostate cancer remains a challenge. Gemcitabine is used to treat a broad spectrum of solid tumors; however, the clinical response of prosta...

journal_title：Oncology reports

authors： Guo Z,Zhang X,Li X,Xie F,Su B,Zhang M,Zhou L

更新日期：2015-03-01 00:00:00

abstract：:Polysaccharides derived from Inonotus obliquus (PIO) are known to possess multiple pharmacological activities including antitumor activity. However, the possible molecular mechanisms of these activities are unknown. In the present study, we determined the anti-metastatic potential and signaling pathways of PIO in the ...

journal_title：Oncology reports

authors： Lee KR,Lee JS,Kim YR,Song IG,Hong EK

更新日期：2014-05-01 00:00:00

abstract：:High-density single nucleotide polymorphism (SNP) array is a recently introduced technology that genotypes more than 10,000 human SNPs on a single array. It has been shown that SNP arrays can be used to determine not only SNP genotype calls, but also DNA copy number (DCN) aberrations, which are common in solid tumors....

journal_title：Oncology reports

authors： Wang Y,Makedon F,Pearlman J

更新日期：2006-01-01 00:00:00

abstract：:Inhibition of epidermal growth factor receptor (EGFR) signalling has emerged as a new treatment strategy for oral squamous cell carcinoma (OSCC). Previously, we found that loss of EGFR expression in OSCC was associated with epithelial-mesenchymal transition (EMT), and may have functional implications with regard to re...

journal_title：Oncology reports

authors： Kitahara H,Hirai M,Kato K,Bou-Gharios G,Nakamura H,Kawashiri S

更新日期：2016-12-01 00:00:00

abstract：:The present study aimed to investigate the effects of cold atmospheric plasma (CAP)‑activated Ringer's solution on osteosarcoma cell lines MG63 and U2OS, and to identify the molecular mechanism underlying these effects. CAP‑activated Ringer's solution was used to treat osteosarcoma cell lines MG63 and U2OS for 30 min....

journal_title：Oncology reports

authors： Xu S,Wang Y,Que Y,Ma C,Cai S,Wang H,Yang X,Yang C,Cheng C,Zhao G,Hu Y

更新日期：2020-05-01 00:00:00

abstract：:Iodine-125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. However, the radiobiological mechanism underlying brachytherapy remains unclear. Therefore, we investigated the influence of continuous and low-energy 125I irradiation on the cell cycle dist...

journal_title：Oncology reports

authors： Zhang WF,Jin WD,Li B,Wang MC,Li XG,Mao WY,Luo KY

更新日期：2014-08-01 00:00:00

abstract：:The ING1 gene is involved in the regulation of the cell cycle, senescence, and apoptosis and is a novel candidate tumor suppressor gene. ING2, another gene in the ING family, was identified and cloned. The functions of ING1 and ING2 largely depend on the activity of p53. To determine whether an alteration in these gen...

journal_title：Oncology reports

authors： Okano T,Gemma A,Hosoya Y,Hosomi Y,Nara M,Kokubo Y,Yoshimura A,Shibuya M,Nagashima M,Harris CC,Kudoh S

更新日期：2006-03-01 00:00:00