Upregulation of BTG1 enhances the radiation sensitivity of human breast cancer in vitro and in vivo.


:X-ray-based radiotherapy is one of the most effective therapeutic strategies for breast cancer patients. However, radioresistance and side-effects continue to be the most challenging issues. B-cell translocation gene 1 (BTG1) is a member of the BTG/Tob family, which inhibits cancer growth and promotes apoptosis. We, therefore, hypothesized that BTG1 plays an important role in the radiosensitivity of breast cancer cells. In the present study, breast cancer cell lines that stably overexpressed BTG1 were used to investigate the effects of BTG1 on cell radiosensitivity in vitro. We found that overexpression of BTG1 enhanced the radiosensitivity both of p53-mutant breast cancer MDA-MB-231 cells and p53 wild-type breast cancer MCF-7 cells. We also found that overexpression of BTG1 along with irradiation induced cell cycle G2/M phase arrest, promoted the formation of reactive oxygen species (ROS), increased the rate of chromosomal aberrations and increased cell apoptosis. Further investigation indicated that BTG1 overexpression along with irradiation was involved in inhibition of the PI3K/Akt signaling pathway. Importantly, the finding that BTG1 promoted ionizing radiosensitivity of breast cancer cells in vitro was confirmed in an animal model. Taken together, our data suggest that BTG1 overexpression combined with radiation therapy increases the therapeutic efficacy of breast cancer treatment via regulation of the cell cycle and apoptosis-related signaling pathways.


Oncol Rep


Oncology reports


Zhu R,Li W,Xu Y,Wan J,Zhang Z




Has Abstract


2015-12-01 00:00:00












  • Dysregulation of TMPRSS3 and TNFRSF11B correlates with tumorigenesis and poor prognosis in patients with breast cancer.

    abstract::The present study was carried out to investigate the clinical significance of TMPRSS3 and TNFRSF11B in breast cancer. Thus, the expression levels of TMPRSS3 and TNFRSF11B and the correlation with prognosis in patients with breast cancer were analyzed in silico using gene microarray and hierarchical clustering analysis...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Luo P,Lu G,Fan LL,Zhong X,Yang H,Xie R,Lv Z,Lv QZ,Fu D,Yang LX,Ma Y

    更新日期:2017-04-01 00:00:00

  • Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways.

    abstract::Ovarian cancer (OC) is a common cancer of the human genital system. Circular RNAs (circRNAs) play an important role in carcinogenesis and progression of various cancers. The present study aimed to clarify the expression profile and functions of circ‑FAM53B in the progression of OC and reveal its underlying mechanisms....

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Sun D,Liu J,Zhou L

    更新日期:2019-12-01 00:00:00

  • Esculetin inhibits cell proliferation through the Ras/ERK1/2 pathway in human colon cancer cells.

    abstract::Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Park SS,Park SK,Lim JH,Choi YH,Kim WJ,Moon SK

    更新日期:2011-01-01 00:00:00

  • AKAPs competing peptide HT31 disrupts the inhibitory effect of PKA on RhoA activity.

    abstract::A-kinase can inhibit RhoA activation through phosphorylating ser188 of RhoA. AKAP is a novel protein that can target PKA to different subcellular compartment. Evidence has been presented that PKA anchorage by AKAP is important for the kinase to exert its function. This study analyzed the role of PKA anchorage in PKA-i...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Wang Y,Chen Y,Chen M,Xu W

    更新日期:2006-10-01 00:00:00

  • TTF1-induced apoptosis of HepG-2 cells through a mitochondrial pathway.

    abstract::The Chinese medicinal herb Sorbaria sorbifolia, native to Changbai Mountain, can induce apoptosis in HepG-2 cells. We studied the mechanism by which 5, 2', 4'-trihydroxy-6,7, 5'-trimethoxyflavone (TTF1) isolated from acetic ether extracts of Sorbaria sorbifolia induces apoptosis in HepG-2 cells. The results showed tha...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Li Y,Bian L,Cui F,Li L,Zhang X

    更新日期:2011-09-01 00:00:00

  • REV3L modulates cisplatin sensitivity of non-small cell lung cancer H1299 cells.

    abstract::Lung cancer remains the leading cause of cancer-related mortality worldwide and non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cases of lung cancer. Cisplatin plays a significant role in the management of human lung cancer. Translesion DNA synthesis (TLS) is involved in DNA damage repair. ...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Wang W,Sheng W,Yu C,Cao J,Zhou J,Wu J,Zhang H,Zhang S

    更新日期:2015-09-01 00:00:00

  • The antitumor effect of human cord blood-derived dendritic cells modified by the livin α gene in lung cancer cell lines.

    abstract::The growth of malignant tumors is associated with mechanisms of immune escape and inhibition of apoptosis. Livin is a novel member of the inhibitors of apoptosis (IAP) protein family that inhibits cell apoptosis. Livin is specifically expressed by the majority of tumor cells, but it is not expressed in normal adult ti...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Chen H,Jin Y,Chen T,Zhang M,Ma W,Xiong X,Tao X

    更新日期:2013-02-01 00:00:00

  • Suppression of VEGF expression through interruption of the HIF‑1α and Akt signaling cascade modulates the anti‑angiogenic activity of DAPK in ovarian carcinoma cells.

    abstract::Death-associated protein kinase (DAPK) plays an important role in apoptosis regulation and has been shown to maintain antitumor and metastasis suppressor properties. In the present study, we investigated whether DAPK overexpression may mediate vascular endothelial growth factor (VEGF)/hypoxia-inducible factor-1α (HIF-...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Park ST,Kim BR,Park SH,Lee JH,Lee EJ,Lee SH,Rho SB

    更新日期:2014-02-01 00:00:00

  • Overexpression of the hBiot2 gene is associated with development of human cervical cancer.

    abstract::The novel gene human Biot2 (hBiot2) was first reported by our laboratory. Previously, we indicated its function of proliferation and carcinogenesis in human endometrial cancer. In the present study, we aimed to investigate whether hBiot2 played a similar role in human cervical cancer. We tested hBiot2 expression profi...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Shen YM,He X,Deng HX,Xie YP,Wang CT,Wei YQ,Zhao X

    更新日期:2011-01-01 00:00:00

  • Acylated and unacylated ghrelin inhibit apoptosis in myoblasts cocultured with colon carcinoma cells.

    abstract::Cancer cachexia is a life‑threatening syndrome associated with myofiber damage. Tumor factors impair muscle regeneration by promoting myoblast apoptosis. Ghrelin is a multifunctional hormone with an anti‑apoptotic effect, but its mechanism of action is not fully understood. In the present study, we investigated whethe...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Zeng X,Chen S,Lin Y,Ke Z

    更新日期:2018-03-01 00:00:00

  • Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells.

    abstract::Nuclear factor (NF)-κB is the key transcription factor involved in the inflammatory responses, and its activation aggravates tumors. Peptidoglycan (PGN), a main cell wall component of Gram-positive bacteria, stimulates Toll-like receptor 2 (TLR-2) and activates a number of inflammat...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Echigo R,Sugimoto N,Yachie A,Ohno-Shosaku T

    更新日期:2012-10-01 00:00:00

  • A new curcumin analogue exhibits enhanced antitumor activity in nasopharyngeal carcinoma.

    abstract::The aim of the present study was to evaluate the antitumor effects of the curcumin analogue GL63 on radioresistant nasopharyngeal carcinoma (NPC) CNE2R cells and parental CNE2 cells. The cell viability and proliferation of NPC cells were detected by MTT assay and colony formation assay. The suppressive effect on tumor...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Pan Y,Xiao J,Liang G,Wang M,Wang D,Wang S,Yang H

    更新日期:2013-07-01 00:00:00

  • Efficacy of hybrid 2-port hand-assisted laparoscopic surgery (Mukai's operation) for patients with primary colorectal cancer.

    abstract::In this study, a total of 108 patients with primary colorectal cancer who underwent hybrid 2-port hand-assisted laparoscopic surgery (HALS) were classified as 58 patients with colon cancer and 50 patients with rectal cancer. The mean operating time, mean blood loss, postoperative complications, and mean postoperative ...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Mukai M,Kishima K,Tajima T,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Ogoshi K,Makuuchi H

    更新日期:2009-10-01 00:00:00

  • Upregulation of long non-coding RNA PRNCR1 in colorectal cancer promotes cell proliferation and cell cycle progression.

    abstract::Colorectal cancer (CRC) is one of the most common cancers worldwide. Long non-coding RNAs (lncRNAs) have been confirmed to play a critical regulatory role in various biological processes including carcinogenesis, which indicates that lncRNAs are valuable biomarkers and therapeutic targets. The novel lncRNA prostate ca...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Yang L,Qiu M,Xu Y,Wang J,Zheng Y,Li M,Xu L,Yin R

    更新日期:2016-01-01 00:00:00

  • Role of 4‑aminobutyrate aminotransferase (ABAT) and the lncRNA co‑expression network in the development of myelodysplastic syndrome.

    abstract::IncRNAs play an important role in the regulation of gene expression. The present study profiled differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in myelodysplastic syndrome (MDS) to construct a 4‑aminobutyrate aminotransferase (ABAT)‑DEL‑DEM co‑expression network in MDS development using the Agilent human Bead...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Chen Y,Zhao G,Li N,Luo Z,Wang X,Gu J

    更新日期:2019-08-01 00:00:00

  • Effects of the histone deacetylase inhibitor valproic acid on the sensitivity of anaplastic thyroid cancer cell lines to imatinib.

    abstract::New therapeutic approaches are mandatory for anaplastic thyroid cancer. We investigated the ability of a new combined treatment using valproic acid (VPA), the only clinically available histone deacetylase inhibitor, and the tyrosine-kinase inhibitor imatinib mesylate to control the cell growth of anaplastic thyroid ca...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Catalano MG,Pugliese M,Poli R,Bosco O,Bertieri R,Fortunati N,Boccuzzi G

    更新日期:2009-02-01 00:00:00

  • Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, migration effects and accelerates cell cycle progression in multiple myeloma cells via activating the Akt pathway.

    abstract::Hydrogen sulfide (H2S), regarded as the third gaseous transmitter, mediates and induces various biological effects. The present study investigated the effects of H2S on multiple myeloma cell progression via amplifying the activation of Akt pathway in multiple myeloma cells. The level of H2S produced in multiple myelom...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Zheng D,Chen Z,Chen J,Zhuang X,Feng J,Li J

    更新日期:2016-10-01 00:00:00

  • The inhibition of proliferation and migration of glioma spheroids exposed to temozolomide is less than additive if combined with irradiation.

    abstract::The aim of this study was to investigate the effect of temozolomide (TZM) in combination with X-rays on proliferation and migration in human glioma spheroids. Multicellular spheroids were derived from GaMg and U87 cell lines. Spheroids were treated with various concentrations of TZM (5 micromol, 0.025 mmol, 0.05 mmol)...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Fehlauer F,Muench M,Richter E,Rades D

    更新日期:2007-04-01 00:00:00

  • ZNF703 acts as an oncogene that promotes progression in gastric cancer.

    abstract::ZNF703, a member of the NET/Nlz family of zinc finger transcription factors, contributes to aspects of developmental growth and patterning across evolutionarily diverse species. ZNF703 has been identified as a novel oncogene in human breast cancer. In the present study, we investigated the expression of ZNF703 in gast...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Yang G,Ma F,Zhong M,Fang L,Peng Y,Xin X,Zhong J,Yuan F,Gu H,Zhu W,Zhang Y

    更新日期:2014-04-01 00:00:00

  • Expression of p73 gene, cell proliferation and apoptosis in breast cancer: Immunohistochemical and clinicopathological study.

    abstract::p73 is a member of p53 tumor suppressor protein family. In spite of similarities of three meaningful domains between p53 and p73, the exact function of p73 protein is not established. To approach the relevance of p73 expression to a pathological parameter in human breast cancer, the apoptotic index (AI) and the mitoti...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Yamamoto T,Oda K,Kubota T,Miyazaki K,Takenouti Y,Nimura Y,Hamaguchi M,Matsuda S

    更新日期:2002-07-01 00:00:00

  • Antitumor effect of gefitinib on head and neck squamous cell carcinoma enhanced by trastuzumab.

    abstract::The overexpression of EGFR and/or HER-2 is associated with tumor cell resistance to chemotherapy, radiotherapy, disease progression and poor prognosis in patients with a variety of malignant tumors. Treatment combining the EGFR-targeting drug, gefitinib (ZD1839, Iressa) with the HER-2-targeting drug, trastuzumab (Herc...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Kondo N,Ishiguro Y,Kimura M,Sano D,Fujita K,Sakakibara A,Taguchi T,Toth G,Matsuda H,Tsukuda M

    更新日期:2008-08-01 00:00:00

  • Compound K-induced apoptosis of human hepatocellular carcinoma MHCC97-H cells in vitro.

    abstract::An intestinal bacterial metabolite of ginseng protopanaxadiol saponin, 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol (compound K), has been reported to induce apoptosis in a variety of cancer cells. However, the precise mechanisms induced by compound K in human hepatocellular carcinoma (HCC) cells remain unclear. In...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Zheng ZZ,Ming YL,Chen LH,Zheng GH,Liu SS,Chen QX

    更新日期:2014-07-01 00:00:00

  • Radioprotective effects of various cytokines in peripheral blood mononuclear cells and C3H mice.

    abstract::The purpose of this study was to investigate the radioprotective effect of HGFs (GM-CSF, IL-3 and SCF) in irradiated human peripheral blood mononuclear cells (PBMCs) in vitro, and the survival effect of lethally irradiated C3H mice in vivo. The irradiation of human PBMCs using a (137)Cs irradiator showed a dose-depend...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Kim JY,Oh SJ,Park HK,Yoon JS,Kim ES,Kim ES,Kim CS,Lee YY,Kim BK

    更新日期:2005-06-01 00:00:00

  • Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer.

    abstract::Thioridazine, an antipsychotic drug, has been reported to induce apoptosis in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs). However, whether it elicits anticancer effects in gastric cancer has never been reported. In the present study, we examined the ability of thioridazine to...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Mu J,Xu H,Yang Y,Huang W,Xiao J,Li M,Tan Z,Ding Q,Zhang L,Lu J,Wu X,Liu Y

    更新日期:2014-05-01 00:00:00

  • miR‑30a‑5p inhibits hypoxia/reoxygenation‑induced oxidative stress and apoptosis in HK‑2 renal tubular epithelial cells by targeting glutamate dehydrogenase 1 (GLUD1).

    abstract::MicroRNAs (miRNAs) are reported to be involved in renal hypoxia/reoxygenation (H/R) damage. To investigate this further, human kidney (HK‑2) cells were cultured, subjected to H/R and the function of miR‑30a‑5p and glutamate dehydrogenase 1 (GLUD1) was evaluated. The results showed that, miR‑30‑5p was downregulated and...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: He Y,Lang X,Cheng D,Zhang T,Yang Z,Xiong R

    更新日期:2020-10-01 00:00:00

  • The establishment of supramolecular immunobead real-time PCR and the identification of Cox-2 as a metastasis-related marker in colorectal carcinoma.

    abstract::Cyclooxygenase-2 (Cox-2) is an inducible enzyme that converts arachidonic acid to prostaglandins, and it is hypothesized to induce carcinogenesis and metastasis in colorectal cancer. Our previous data also indicated that a higher expression level of Cox-2 was correlated with colorec...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Li ZG,Wang XY,Chang JL,Xie WB,Liu TF,Zhang QL,Deng YJ,Ding YQ

    更新日期:2012-09-01 00:00:00

  • TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells.

    abstract::Esophageal cancer is one of the most aggressive cancers in the world. Novel preventive and therapeutic strategies tend to target the key molecules involved in the signaling transduction pathways for cell growth. It is known that FAK and mTOR are important controllers of cell growth. TAE226, a novel small molecule comp...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Wang ZG,Fukazawa T,Nishikawa T,Watanabe N,Sakurama K,Motoki T,Takaoka M,Hatakeyama S,Omori O,Ohara T,Tanabe S,Fujiwara Y,Shirakawa Y,Yamatsuji T,Tanaka N,Naomoto Y

    更新日期:2008-12-01 00:00:00

  • Analysis of the gene expression profile in response to human epididymis protein 4 in epithelial ovarian cancer cells.

    abstract::Currently, there are emerging multiple studies on human epididymis protein 4 (HE4) in ovarian cancer. HE4 possesses higher sensitivity and specificity than CA125 in the confirmative early diagnosis for ovarian cancer. Although much attention has been given to explore its clinical application, research of the basic mec...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Zhu L,Guo Q,Jin S,Feng H,Zhuang H,Liu C,Tan M,Liu J,Li X,Lin B

    更新日期:2016-09-01 00:00:00

  • Atorvastatin partially inhibits the epithelial-mesenchymal transition in A549 cells induced by TGF-β1 by attenuating the upregulation of SphK1.

    abstract::Statins are the most effective drugs used in the reduction of intracellular synthesis of cholesterol. Numerous studies have confirmed that statins reduce the risk of multiple types of cancers. Statin use in cancer patients is associated with reduced cancer-related mortality. Epithelial-to-mesenchymal transition (EMT),...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Fan Z,Jiang H,Wang Z,Qu J

    更新日期:2016-08-01 00:00:00

  • Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review).

    abstract::Epstein-Barr virus (EBV) is a ubiquitous pathogen that was first identified as a human cancer virus. Many human cancers are associated with EBV, and we demonstrated that EBV infects macrophages. Macrophages infected with EBV show a close correlation with many human cancers, and thus more attention must be given to the...

    journal_title:Oncology reports

    pub_type: 杂志文章,评审


    authors: Shimakage M

    更新日期:2014-11-01 00:00:00