Abstract:
:WNT signaling pathway networks with Hedgehog, Notch and FGF signaling pathways during carcinogenesis and embryogenesis. FZD8 is up-regulated in HeLa S3 and A549 cells. Here we identified and characterized rat Fzd8 gene by using bioinformatics. Rat Fzd8 gene was identified within AC131883.2 genome sequence. Rat Fzd8 (684 aa) showed 99.1, 96.8, 71.8 and 71.6% total amino-acid identity with mouse Fzd8, human FZD8, zebrafish fzd8 and Xenopus fzd8, respectively. Vertebrate Fzd8 orthologs were seven-transmembrane receptors with Frizzled (Fz) domain within the N-terminal extracellular region, leucine zipper motif around the fifth transmembrane domain, and Dishevelled (Dvl)-binding motif within the C-terminal cytoplasmic region. Two Asn-linked glycosylation sites within the N-terminal extracellular region were conserved among vertebrate Fzd8 orhologs. One Asn-linked glycosylation site within the second extracellular loop was conserved among mammalian Fzd8 orthologs, but not in Xenopus and zebrafish fzd8 orthologs. These facts indicate the molecular evolution of Fzd8 orthologs. The 5'-flanking region and exonic region were well conserved among mammalian Fzd8 orthologs. Nucleotide position 92950-94221 of AC131883.2 genome sequence was identified as the evolutionarily conserved promoter region of rat Fzd8 gene, and nucleotide position 133421-132134 of AL121749.14 genome sequence as the evolutionarily conserved promoter region of human FZD8 gene. Match program revealed that ELK1- and PAX4-binding sites were conserved between rat Fzd8 and human FZD8 promoters. This is the first report on the rat Fzd8 gene as well as on comparative genomics for Fzd8 orthologs.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Katoh Y,Katoh Mkeywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
993-7issue
5eissn
1021-335Xissn
1791-2431journal_volume
13pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Many prostate cancer (PCa) patients die of recurrent disease due to the emergence of hormone-independent cancer cells of which the mechanism is not fully understood. Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4563
更新日期:2016-04-01 00:00:00
abstract::Extranodal natural killer (NK)/T cell lymphoma, nasal type (ENKL) is a rare type of non‑Hodgkin's lymphoma that is associated with limited effective treatment options and unfavorable survival rate, which is partly the result of multidrug resistance (MDR). The presence of side population (SP) cells‑SNK‑6/ADM‑SP (SSP) c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7722
更新日期:2020-10-01 00:00:00
abstract::Tumor invasion and migration are major causes of mortality in patients with cervical carcinoma. Tumors under hypoxic conditions are more invasive and have a higher metastasic activity. Lysyl oxidase (LOX) is a hypoxia-responsive gene. LOX has been shown to be essential for hypoxia-induced metastasis in breast cancer. ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2146
更新日期:2013-02-01 00:00:00
abstract::Lung cancer remains the leading cause of cancer-related mortality worldwide and non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cases of lung cancer. Cisplatin plays a significant role in the management of human lung cancer. Translesion DNA synthesis (TLS) is involved in DNA damage repair. ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4121
更新日期:2015-09-01 00:00:00
abstract::Glioblastoma (GBM) is the most common type of primary central nervous system tumor in adults, which has high mortality and morbidity rates, and short survival time, namely <15 months after the diagnosis and application of standard therapy, which includes surgery, radiation therapy and chemotherapy; thus, novel therape...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7472
更新日期:2020-03-01 00:00:00
abstract::Mother-to-infant transmission of hepatitis B virus (HBV) can occur as an intrauterine, intrapartum or postpartum infection. In the present study, we induced a multifunctional viral regulator of HBV gene products, HBx, and its different fragments to overexpress in a tropho-blast cell line, HTR-8/SVneo. We then identifi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4172
更新日期:2015-10-01 00:00:00
abstract::All-trans retinoic acid (ATRA) is a potent chemopreventive and therapeutic agent and exerts its effects by inducing growth arrest. In the present study, we demonstrated that ATRA activated the expression of p53 via Axin and induced cell cycle arrest at the G1/S phase and apoptosis of glioma cells. Briefly, C6 cells we...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2391
更新日期:2013-06-01 00:00:00
abstract::Glucocorticoids such as dexamethasone are widely used as comedication in the treatment of head and neck cancer, e.g., to improve appetite and decrease weight loss and fatigue in patients with advanced disease or as antiallergic and antiemetic prophylaxis during anti-EGFR therapy. However, the literature suggests that ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000421
更新日期:2009-07-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of human esophageal cancer in East Asia. In the present study, we explored the tumor suppressive function of microRNA-181d (miR-181d) in ESCC. Quantitative RT-PCR was used to assess gene levels of miR‑181d in both ESCC cell lines and clinical samples...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5028
更新日期:2016-10-01 00:00:00
abstract::In a human cancer cell line, we previously found a mutation in codon 322 of the extracellular signal-regulated kinase (ERK2E322K), the protein showed a faster migration when compared to wild-type in SDS-PAGE and constitutive phosphorylation. However, the reason for the faster migration, and the biochemical and biologi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract::Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, ...
journal_title:Oncology reports
pub_type: 杂志文章,随机对照试验
doi:10.3892/or.2018.6841
更新日期:2019-01-01 00:00:00
abstract::Implicated in several physiologic processes, including tumour-host, some transglutaminases (TGase) have been noted to play a regulatory role in the extracellular matrix in cell adhesion and migration of cancer cells. This study sought to determine the level of expression of TGases and their possible clinical significa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract::The gene Nm23, which encodes for a nucleoside diphosphate kinase, has been defined as a metastasis-suppressor gene because of the inverse correlation between its expression and the metastatic capacity of the tumor cells. For colorectal cancer, however, the findings are equivocal. The aim of our study was to assess, in...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtai...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4313
更新日期:2015-12-01 00:00:00
abstract::MicroRNA (miRNA) is a type of endogenous non‑coding RNA implicated in various cellular processes. Studies have shown that miR-124 is involved in the malignant progression of cancer, but little is known concerning its potential role in breast cancer. Therefore, the purpose of this study was to conduct a functional anal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5163
更新日期:2016-12-01 00:00:00
abstract::Metastasis is the main cause of death in osteosarcoma. Targeting the process of metastasis is a main strategy for osteosarcoma therapy. As a traditional Chinese medicine, Zanthoxylum nitidum (Roxb) has been applied to treat various diseases, including cancer. However, no evidence has been shown on the anti-metastasis ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4846
更新日期:2016-08-01 00:00:00
abstract::The novel gene human Biot2 (hBiot2) was first reported by our laboratory. Previously, we indicated its function of proliferation and carcinogenesis in human endometrial cancer. In the present study, we aimed to investigate whether hBiot2 played a similar role in human cervical cancer. We tested hBiot2 expression profi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Gastric cancer is currently the fourth most common cancer and the third leading cause of cancer‑associated mortality worldwide. Studies have identified that certain biomarkers contribute to the prognosis, diagnosis and treatment of gastric cancer. However, the biomarkers of gastric cancer are rarely used clinically. T...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6794
更新日期:2019-01-01 00:00:00
abstract::Solid tumors are abnormal tissues containing tumor and non-tumor cells, also known as tumor stromal cells. However, the malignant potential of tumor stromal cells remains largely unknown. The aim of the present study was to investigate the malignant potential of host bone marrow‑derived stroma cells in transplanted su...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4281
更新日期:2015-12-01 00:00:00
abstract::We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1338
更新日期:2011-09-01 00:00:00
abstract::Phosphoinositide‑dependent kinase 1 (PDK1) is generally active in multiple myeloma (MM) and higher expression than other hematopoietic cells, which is associated with the drug resistance and the disease progression. Previous studies have demonstrated that PDK1 can be targeted therapeutically in MM. In the present stud...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6369
更新日期:2018-06-01 00:00:00
abstract::The isothiocyanates (ITCs) have long been known to possess chemopreventive activities for a variety of neoplasms including breast cancer, but the molecular mechanism by which ITCs prevent breast cancer development has not been established. In this study, we investigated the effects of benzyl and phenethyl isothiocyana...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) is directly involved in cell growth, proliferation and self-renewal of cancer stem cells (CSCs). The aim of the present study was to assess the role of Bmi1 in the maintenance of stemness properties and tumorigenicity of human bladder CSC-like side ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2919
更新日期:2014-02-01 00:00:00
abstract::Breast cancer is the worldwide leading cause of cancer incidence among women. Night shift work exposure has been recently considered one of the significant breast cancer risk factors in industrialized countries. The mechanisms by which this work exposure may be responsible for cance...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2012.1839
更新日期:2012-08-01 00:00:00
abstract::Overexpression or amplification of G1 cyclins has been demonstrated in various types of human cancers. Overexpression of cyclin D1, an accelerator of cell cycle, is thought to be an early event in colonic multistage carcinogenesis, but its expression at transformation from benign to neoplastic foci is not clear. We an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::The phosphatase and tensin homolog (PTEN) gene, an important tumor-suppressor gene, has been demonstrated to have the potential for inhibiting proliferation, migration and invasion in various types of cancer cells. The aim of the present study was to investigate the effect of PTEN expression on osteosarcoma (OS) cells...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3362
更新日期:2014-10-01 00:00:00
abstract::Secalonic acid F (SAF) has been previously identified, however, little is known about its cytotoxic activity and related cytotoxic mechanism. The aim of this study was to evaluate the cytotoxic activity of SAF isolated from a deep sea originated fungus Penicillium sp. F11 in HL60 ce...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2062
更新日期:2012-12-01 00:00:00
abstract::Phosphatidylinositol 3 kinases (PI-3 kinases) play a crucial role in the inositol phospholipid signaling pathway. The effect of wortmannin, an inhibitor of PI-3 kinases, on the suppression of thermotolerance development was investigated in the temperature-sensitive cell line tsAF8. When wortmannin was added immediatel...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Oxymatrine, the main alkaloid component in the traditional Chinese herbal medicine Sophora japonica (Sophora flavescens Ait), has been reported to have antitumor properties. However, the mechanisms of action in human pancreatic cancer are not well established to date. In the present study, we investigated the antiangi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2529
更新日期:2013-08-01 00:00:00
abstract::It has been shown that overexpression of signal transducer and activator of transcription 3 (Stat3) contribute to the progression and metastasis of various solid tumors and that silencing Stat3 inhibits tumor growth in several types of cancer. Gene associated with retinoid-IFN-induced mortality 19 (GRIM-19), a Stat3-i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3233
更新日期:2014-08-01 00:00:00