Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells.

abstract：:Human chorionic gonadotropin β (β-hCG) is a well-known and accurate marker for the diagnosis and monitoring of pregnancy, trophoblastic tumors and ovarian germ cell tumors. Recently, β-hCG has been found to be closely related to poor prognosis and metastasis in various other malignant tumors, while its role and mechan...

journal_title：Oncology reports

authors： Liu N,Peng SM,Zhan GX,Yu J,Wu WM,Gao H,Li XF,Guo XQ

更新日期：2017-09-01 00:00:00

abstract：:MA128, a novel herbal medicine, was previously identified and its effectiveness in the treatment of asthma and atopic dermatitis (AD) was demonstrated. In particular, post-inflammatory hyperpigmentation (PIH) in AD mice was improved by treatment with MA128. In addition, MA128 exhibited anti-melanogenic activity by inh...

journal_title：Oncology reports

authors： Kim A,Im M,Yim NH,Hwang YH,Yang HJ,Ma JY

更新日期：2015-08-01 00:00:00

abstract：:Notch signaling plays a critical role in embryonic vascular development and tumor angiogenesis. The present study was conducted to investigate the prognostic role of the angiogenesis-related Notch ligand and the receptor in acute myeloid leukemia (AML) and assess whether their expre...

journal_title：Oncology reports

authors： Zhang J,Ma D,Ye J,Zang S,Lu F,Yang M,Qu X,Sun X,Ji C

更新日期：2012-10-01 00:00:00

abstract：:Mutations in the epidermal growth factor receptor (EGFR) make lung adenocarcinoma cells sensitive to EGFR tyrosine kinase inhibitors (TKIs). Long-term cancer therapy may cause the occurrence of acquired resistance to EGFR TKIs. Long non-coding RNAs (lncRNAs) play important roles in tumor formation, tumor metastasis an...

journal_title：Oncology reports

authors： Wu Y,Yu DD,Hu Y,Yan D,Chen X,Cao HX,Yu SR,Wang Z,Feng JF

更新日期：2016-06-01 00:00:00

abstract：:The development and progression of epithelial cancers are the result of an imbalance in signals promoting and inhibiting cellular proliferation and apoptosis. The aim of this study is to evaluate the expression of cell-cycle and apoptosis regulators and correlate them with clinical outcome in the most frequent carcino...

journal_title：Oncology reports

authors： Abdulkader I,Sánchez L,Cameselle-Teijeiro J,Gude F,Chávez JE,López-López R,Forteza J,Fraga M

更新日期：2005-12-01 00:00:00

abstract：:Hyperplasia suppressor gene (HSG) is a novel gene that markedly suppresses the mitogenetic stimuli or injury mediated by vascular smooth muscle cell proliferation. Herein we provide experimental evidence to show that HSG can also play a key role in tumor proliferation. Down-regulation of HSG protein in hepatocellular ...

journal_title：Oncology reports

authors： Wang W,Zhu F,Wang S,Wei J,Jia C,Zhang Y,Zhou L,Xie H,Zheng S

更新日期：2010-07-01 00:00:00

abstract：:Soft tissue sarcomas comprise a heterogeneous group of mesenchymal tumors with varying biological behavior ranging from indolent tumors with no or minimal metastatic risk to aggressive and frequently metastasizing tumors. Among the more common aggressive adult soft tissue sarcomas are malignant fibrous histiocytoma, s...

journal_title：Oncology reports

authors： Alford SH,Vrana MS,Waite L,Heim-Hall J,Sylvia VL,Williams RP

更新日期：2007-12-01 00:00:00

abstract：:Male breast cancer (MBC) is extremely rare, with an incidence in the general US population of <1%. It tends to be diagnosed at later stages than breast cancer in females, likely because of low awareness on the part of the patient and low suspicion by the physician. Risk factors include genetic predisposition, alterati...

journal_title：Oncology reports

authors： Johansen Taber KA,Morisy LR,Osbahr AJ 3rd,Dickinson BD

更新日期：2010-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an aggressive disease with a poor outcome due to the high incidence of metastasis. Cancer stem cells (CSCs) have been identified to be responsible for tumor progression and may be generated by epithelial-mesenchymal transition (EMT) characteristics. CD133 is a specific surface marker ...

journal_title：Oncology reports

authors： Liu YM,Li XF,Liu H,Wu XL

更新日期：2015-12-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most commonly diagnosed malignancies, and 90% of advanced prostate cancer patients relapse after therapy. Trophinin associated protein (TROAP) is essential for centrosome integrity and proper bipolar organisation of spindle assembly during mitosis and plays an essential role in prol...

journal_title：Oncology reports

authors： Ye J,Chu C,Chen M,Shi Z,Gan S,Qu F,Pan X,Yang Q,Tian Y,Wang L,Yang W,Cui X

更新日期：2019-02-01 00:00:00

abstract：:Mice are particularly susceptible to carcinogens when exposure starts early in life. We evaluated the expression of stem cell antigen-1 (Sca-1) gene in the lung of variously aged CD-1 mice, either untreated or exposed to environmental cigarette smoke (ECS) and/or to a light source. Sca-1 expression progressively decre...

journal_title：Oncology reports

authors： Izzotti A,D'Agostini F,Larghero P,Cartiglia C,Travaini G,Balansky R,Steele VE,De Flora S

更新日期：2009-09-01 00:00:00

abstract：:It has been revealed by our previous proteomic study that the expression profile is different between well‑differentiated and poorly differentiated hepatocellular carcinoma (HCC). Among those differently expressed proteins, peroxiredoxin2 (PRDX2) was our protein of interest. The present study aimed to further investig...

journal_title：Oncology reports

authors： Bai B,Lin Y,Hu J,Wang H,Li L,Zhao S,Zhang J,Meng W,Yue P,Bai Z,Li X

更新日期：2019-03-01 00:00:00

abstract：:DLC-1 (deleted in liver cancer-1) is a potential tumor suppressor gene, which is inactive in liver carcinogenesis. To observe the effects of DLC-1 gene expression on cell proliferation and migration in the human colon cancer cell line, RNAi Lipo-recombinant of the DLC-1 gene (pGCsil-DLC-1) was constructed and transduc...

journal_title：Oncology reports

authors： Jin Y,Tian X,Shang Y,Huang P

更新日期：2008-03-01 00:00:00

abstract：:Breast cancer is one of the most common malignancies diagnosed in women and it is increasing in incidence. Siegesbeckia glabrescens (SG) has been used in traditional oriental medicine to treat cardiovascular diseases such as hypertension and angina pectoris. This study examined whether or not SG could induce apoptosis...

journal_title：Oncology reports

authors： Jun SY,Choi YH,Shin HM

更新日期：2006-06-01 00:00:00

abstract：:Emerging evidence suggests that cancer cells present profound epigenetic alterations in addition to featuring classic genetic mutations. Valproic acid (VPA), a histone deacetylase inhibitor, can potently inhibit tumor growth and induce differentiation. However, the effect and underlying mechanism of VPA on head and ne...

journal_title：Oncology reports

authors： Lee SH,Nam HJ,Kang HJ,Samuels TL,Johnston N,Lim YC

更新日期：2015-10-01 00:00:00

abstract：:Tetraspanins are transmembrane adaptor proteins involved in the regulation of various fundamental cellular processes. For a number of malignant diseases, the level of expression of members of the tetraspanin family was found to correlate with tumor cell invasiveness, ability to form metastases, and poor clinical outco...

journal_title：Oncology reports

authors： Sauer G,Kurzeder C,Grundmann R,Kreienberg R,Zeillinger R,Deissler H

更新日期：2003-03-01 00:00:00

abstract：:Cisplatin (CDDP)‑based combination chemotherapy is the standard for muscle‑invasive bladder cancer (MIBC). However, nearly all patients undergoing CDDP chemotherapy become refractory due to the development of CDDP resistance. Therefore, clarification of the mechanisms of CDDP resistance is urgently needed. The transcr...

journal_title：Oncology reports

authors： Sekino Y,Sakamoto N,Ishikawa A,Honma R,Shigematsu Y,Hayashi T,Sentani K,Oue N,Teishima J,Matsubara A,Yasui W

更新日期：2019-05-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a highly lethal malignant tumor arising from the biliary tract epithelium. Chronic inflammatory conditions, including primary sclerosing cholangitis, liver fluke infestation, and hepatolithiasis, are considered risk factors, but the cause is still unknown in most cases. Recent advances in m...

journal_title：Oncology reports

authors： Isomoto H

更新日期：2009-08-01 00:00:00

abstract：:New therapeutic strategies are needed for colorectal cancer (CRC) treatment. MicroRNAs are involved in cancer‑pertinent cellular processes, including chemoresistance. As miR‑302a is an embryonic stem cell‑specific microRNA, studies on miR‑302a have focused on its role in human stem cells. Studies analyzing miR‑302 fun...

journal_title：Oncology reports

authors： Liu N,Li J,Zhao Z,Han J,Jiang T,Chen Y,Hou N,Huang C

更新日期：2017-01-01 00:00:00

abstract：:Abnormal lymphangiogenesis is associated with several diseases such as tumor metastasis and lymphangioma. Human lymphangioma originated from the transformation of lymphatic endothelium is a benign malformation of lymphatic vessels and its pathogenesis has up to date not been illuminated and its cell model has also not...

journal_title：Oncology reports

authors： You L,Wu M,Chen Y,Xu G,Wei J,Li Q,Song A,Zhao L,Li S,Han Z,Zhou J,Lu Y,Wang S,Ma D,Meng L

更新日期：2010-01-01 00:00:00

abstract：:Squamous cell carcinoma (SCC) is histologically the most prominent type of cervical cancer. There is accumulating evidence suggesting that microRNAs (miRNAs) play important regulatory roles in the biological processes of cervical squamous cell carcinoma (CSCC). Deciphering the miRNA regulatory network in CSCC could de...

journal_title：Oncology reports

authors： Lin W,Feng M,Chen G,Zhou Z,Li J,Ye Y

更新日期：2017-03-01 00:00:00

abstract：:Gastric cancer is the second most common fatal malignancy in the world. Proteomics studies of clinical tumor samples have led to the identification of specific protein markers of gastric cancer detection and better understanding the carcinogenesis of gastric cancer. Gastric cancer tissue of epithelial origin and adjac...

journal_title：Oncology reports

authors： Wu C,Luo Z,Chen X,Wu C,Yao D,Zhao P,Liu L,Shi B,Zhu L

更新日期：2009-06-01 00:00:00

abstract：:The growth of malignant tumors is associated with mechanisms of immune escape and inhibition of apoptosis. Livin is a novel member of the inhibitors of apoptosis (IAP) protein family that inhibits cell apoptosis. Livin is specifically expressed by the majority of tumor cells, but it is not expressed in normal adult ti...

journal_title：Oncology reports

authors： Chen H,Jin Y,Chen T,Zhang M,Ma W,Xiong X,Tao X

更新日期：2013-02-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common type of primary central nervous system tumor in adults, which has high mortality and morbidity rates, and short survival time, namely <15 months after the diagnosis and application of standard therapy, which includes surgery, radiation therapy and chemotherapy; thus, novel therape...

journal_title：Oncology reports

authors： Yang K,Tang XJ,Xu FF,Liu JH,Tan YQ,Gao L,Sun Q,Ding X,Liu BH,Chen QX

更新日期：2020-03-01 00:00:00

abstract：:Androgen receptor (AR) expression in prostate cancer (CaP) cells varies due to the multiple changes including epigenetic modifications such as DNA methylation and histone deacetylation. DNA methyltransferase and histone deacetylase inhibitors are promising for the treatment of CaP. The aim of our study was to analyze ...

journal_title：Oncology reports

authors： Fialova B,Smesny Trtkova K,Paskova L,Langova K,Kolar Z

更新日期：2013-05-01 00:00:00

abstract：:The clinical significance of NK-like T CD3+/CD16+CD56+ cells in chronic lymphocytic leukemia (CLL) is still a subject of controversy. There are few previous descriptions that this cell population can be qualitatively or quantitatively deficient in CLL patients. In the present study we investigated the clinical value o...

journal_title：Oncology reports

authors： Bojarska-Junak A,Hus I,Sieklucka M,Wasik-Szczepanek E,Mazurkiewicz T,Polak P,Dmoszynska A,Rolinski J

更新日期：2010-09-01 00:00:00

abstract：:Human colon cancer cells were implanted s.c. in nude mice. After 6 days, the mice were divided into four groups, 10 in each. During the first 5 days, the first and second groups were injected i.p. with leucovorin (LV)/5-fluorouracil (FU), and the third and fourth groups with sterile saline solution. During the subsequ...

journal_title：Oncology reports

authors： El-Salhy M

更新日期：2004-06-01 00:00:00

abstract：:Adoptive immunotherapy requires the isolation of CD8+ T cells specific for tumor-associated antigens, their expansion in vitro and their transfusion to the patient to mediate a therapeutic effect. MUC1 is an important adenocarcinoma antigen immunogenic for T cells. The MUC1-derived SAPDTRPA (MUC1-8-mer) peptide is a p...

journal_title：Oncology reports

authors： Atzin-Méndez JA,López-González JS,Báez R,Arenas-Del Angel MC,Montaño LF,Silva-Adaya D,Lascurain R,Gorocica P

更新日期：2016-01-01 00:00:00

abstract：:Patients with brain metastases in disseminated non-seminomatous germ cell cancer of the testis are treated by combined modality, e.g., cisplatin-containing chemotherapy, whole brain irradiation and/or surgical excision. However, cure rates of patients refractory to that standard treatment are low (5-year survival rate...

journal_title：Oncology reports

authors： Feyerabend T,Wiedemann GJ,Steeves R

更新日期：2001-03-01 00:00:00

abstract：:Hydrogen sulfide (H2S) participates in multifarious physiological and pathophysiologic progresses of cancer both in vitro and in vivo. We have previously demonstrated that exogenous H2S promoted liver cancer cells proliferation/anti‑apoptosis/angiogenesis/migration effects via amplifying the activation of NF-κB pathwa...

journal_title：Oncology reports

authors： Zhen Y,Zhang W,Liu C,He J,Lu Y,Guo R,Feng J,Zhang Y,Chen J

更新日期：2015-11-01 00:00:00