Transcribed ultraconserved region Uc.63+ promotes resistance to cisplatin through regulation of androgen receptor signaling in bladder cancer.

abstract：:Esophageal squamous cell carcinoma (ESCC) is a common cancer with a very poor prognosis. New methods are needed to screen high-risk populations and identify curable tumors and precursor lesions early. Molecular markers may be useful in such screening efforts. This study was designed to determine the prevalence of p16,...

journal_title：Oncology reports

authors： Roth MJ,Abnet CC,Hu N,Wang QH,Wei WQ,Green L,D'Alelio M,Qiao YL,Dawsey SM,Taylor PR,Woodson K

更新日期：2006-06-01 00:00:00

abstract：:Chemokines are small chemotactic cytokines that can induce the migration of leukocytes, activate inflammatory/immune responses and have recently been implicated in the regulation of tumor growth and organ-specific spread. In this setting, the macrophage inflammatory protein-1alpha (CCL3) chemokine displays a diversity...

journal_title：Oncology reports

authors： Silva TA,Ribeiro FL,Oliveira-Neto HH,Watanabe S,Alencar Rde C,Fukada SY,Cunha FQ,Leles CR,Mendonça EF,Batista AC

更新日期：2007-11-01 00:00:00

abstract：:Gastric cancer is a common malignancy worldwide. The prognosis of early stage gastric cancer patients has significantly improved in recent years. However, in progressive stage gastric cancer patients, the prognosis remains relatively poor due to tumor metastases. In our previous study, we showed that the expression of...

journal_title：Oncology reports

authors： Xiao WS,Li DF,Tang YP,Chen YZ,Deng WB,Chen J,Zhou WW,Liao AJ

更新日期：2018-11-01 00:00:00

abstract：:Cucurbitacin D (CuD), isolated from plants from the Cucurbitaceae family, is a potential antitumour agent since it inhibits proliferation, migration and metastasis of cancer cells. Despite CuD antitumour activity in cancer cells, the effects of CuD on gastric cancer cell lines remain unclear. The present study aimed t...

journal_title：Oncology reports

authors： Zhang YZ,Wang CF,Zhang LF

更新日期：2018-06-01 00:00:00

abstract：:Boron affects human steroid hormone levels. Circulating testosterone and estradiol levels have been proposed to modify prostate cancer risk. However, the association between dietary boron intake and the risk of prostate cancer has not been evaluated by any epidemiological study. We explored the association between die...

journal_title：Oncology reports

authors： Cui Y,Winton MI,Zhang ZF,Rainey C,Marshall J,De Kernion JB,Eckhert CD

更新日期：2004-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to play an important role in diverse biological processes and cancer progression. The objective of the present study was to investigate the role of miR-497 in ovarian cancer angiogenesis. We found that miR-497 expression was downregulated in human ovarian cancer tissues, and the low ...

journal_title：Oncology reports

authors： Wang W,Ren F,Wu Q,Jiang D,Li H,Shi H

更新日期：2014-11-01 00:00:00

abstract：:Lung cancer is the most frequent and deadliest cancer in the world, especially in China. However, the molecular mechanisms involved in lung cancer remain unclear. Occludin (OCLN), one of the first identified tight junction proteins, has been revealed to be a necessary integral protein for tight junction structure and ...

journal_title：Oncology reports

authors： Wang M,Liu Y,Qian X,Wei N,Tang Y,Yang J

更新日期：2018-07-01 00:00:00

abstract：:Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addi...

journal_title：Oncology reports

authors： Gu Y,Wang J,Peng L

更新日期：2017-01-01 00:00:00

abstract：:Ras-association domain family of proteins (RASSF) is characterized by the Ras-association (RA) domain at the C-terminal. Frequent inactivation of RASSF1A gene in human cancers suggests that other members of the family may also play an important role in tumorigenesis. By in silico gene searches, the number of RASSF fam...

journal_title：Oncology reports

authors： Chow LS,Lo KW,Kwong J,Wong AY,Huang DP

更新日期：2004-10-01 00:00:00

abstract：:The aims of this study were to investigate the expression levels of beta-catenin, Pin1 and cyclin D1 in salivary adenoid cystic carcinomas (SACC ) and to evaluate its clinical importance, furthermore, to elucidate whether beta-catenin expression was aberrant in SACC and whether Pin1 was involved in aberrant beta-caten...

journal_title：Oncology reports

authors： Zhou CX,Gao Y

更新日期：2006-09-01 00:00:00

abstract：:In a screen for thoracic malignancy-associated markers, thyroid stimulating hormone receptor (TSHR) was identified as a candidate as it binds to the previously-characterized lung cancer marker NKX2-1. We screened for mutations in all coding regions of the TSHR gene in 96 lung adenoc...

journal_title：Oncology reports

authors： Kim JW,Lee S,Lui N,Choi H,Mulvihill M,Fang LT,Kang HC,Kwon YW,Jablons D,Kim IJ

更新日期：2012-10-01 00:00:00

abstract：:Gastric cancer is the second most common fatal malignancy in the world. Proteomics studies of clinical tumor samples have led to the identification of specific protein markers of gastric cancer detection and better understanding the carcinogenesis of gastric cancer. Gastric cancer tissue of epithelial origin and adjac...

journal_title：Oncology reports

authors： Wu C,Luo Z,Chen X,Wu C,Yao D,Zhao P,Liu L,Shi B,Zhu L

更新日期：2009-06-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is a malignant hematological disease. Tanshinone IIA (Tan IIA) has antitumor activity in vitro and in vivo. The aim of the present study was to investigate the effects of Tan IIA in combination with imatinib (IM) on the proliferation, apoptosis, migration and invasion of acute T lymp...

journal_title：Oncology reports

authors： Teng Z,Xu S,Lei Q

更新日期：2020-02-01 00:00:00

abstract：:At present, acute promyelocytic leukemia (APL) is the most curable form of acute myeloid leukemia and can be treated using all-trans retinoic acid and arsenic trioxide. However, the current treatment of APL is associated with some issues such as drug toxicity, resistance and relapse. Therefore, other strategies are ne...

journal_title：Oncology reports

authors： Zhao Y,Zhong L,Liu L,Yao SF,Chen M,Li LW,Shan ZL,Xiao CL,Gan LG,Xu T,Liu BZ

更新日期：2018-08-01 00:00:00

abstract：:Apart from genetic mutations, epigenetic alteration is a common phenomenon that contributes to neoplastic transformation in colorectal cancer. Transcriptional silencing of tumor-suppressor genes without changes in the DNA sequence is explained by the existence of promoter hypermethylation. To test this hypothesis, we ...

journal_title：Oncology reports

authors： Kok-Sin T,Mokhtar NM,Ali Hassan NZ,Sagap I,Mohamed Rose I,Harun R,Jamal R

更新日期：2015-07-01 00:00:00

abstract：:Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend on different cellular mechanisms ...

journal_title：Oncology reports

authors： Zhou J,Hu Q,Zhang X,Zheng J,Xie B,Xu Z,Zhang W

更新日期：2018-04-01 00:00:00

abstract：:Esophageal cancer is one of the most aggressive cancers in the world. Novel preventive and therapeutic strategies tend to target the key molecules involved in the signaling transduction pathways for cell growth. It is known that FAK and mTOR are important controllers of cell growth. TAE226, a novel small molecule comp...

journal_title：Oncology reports

authors： Wang ZG,Fukazawa T,Nishikawa T,Watanabe N,Sakurama K,Motoki T,Takaoka M,Hatakeyama S,Omori O,Ohara T,Tanabe S,Fujiwara Y,Shirakawa Y,Yamatsuji T,Tanaka N,Naomoto Y

更新日期：2008-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common form of adult liver cancer and accounts for approximately 90% of all cases of primary liver cancer annually. Rhotekin (RTKN), which functions as a cancer promoter, can be frequently detected in many human cancers, including gastric cancer, colorectal carcinoma and blad...

journal_title：Oncology reports

authors： Zhou J,Zhang Y,Qi Y,Yu D,Shao Q,Liang J

更新日期：2017-02-01 00:00:00

abstract：:New therapeutic approaches are mandatory for anaplastic thyroid cancer. We investigated the ability of a new combined treatment using valproic acid (VPA), the only clinically available histone deacetylase inhibitor, and the tyrosine-kinase inhibitor imatinib mesylate to control the cell growth of anaplastic thyroid ca...

journal_title：Oncology reports

authors： Catalano MG,Pugliese M,Poli R,Bosco O,Bertieri R,Fortunati N,Boccuzzi G

更新日期：2009-02-01 00:00:00

abstract：:Accumulation of an excess amount of reactive oxygen species (ROS) can cause hepatotoxicity that may result in liver damage. Therefore, development of anti-oxidative agents is needed for reducing liver toxicity. This study investigated the anti-oxidative and hepatoprotective activity of lithospermic acid, a plant-deriv...

journal_title：Oncology reports

authors： Chan KW,Ho WS

更新日期：2015-08-01 00:00:00

abstract：:Gliomas are primary brain tumors associated with a poor prognosis partly due to resistance to conventional therapies. To overcome this problem, we investigated the combined effects of gamma knife radiosurgery (GKS) and an antiangiogenic agent, thalidomide (THD), or a chemotherapeutic agent, temozolomide (TMZ), on a ra...

journal_title：Oncology reports

authors： Lee JI,Itasaka S,Kim JT,Nam DH

更新日期：2006-05-01 00:00:00

abstract：:The drug sensitivity of tumor cells is one of key issues to explore individualized therapy for cancer patients. One of such methods is in vitro anticancer drug sensitivity test which is generally based on one drug concentration and contact time. In this study, 5-fluorouracil (5-FU) sensitivity of cancer cells from col...

journal_title：Oncology reports

authors： Ochiai T,Nishimura K,Noguchi H,Kitajima M,Tsuruoka Y,Takahashi Y

更新日期：2005-07-01 00:00:00

abstract：:Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited...

journal_title：Oncology reports

authors： Saiko P,Ozsvar-Kozma M,Graser G,Lackner A,Grusch M,Madlener S,Krupitza G,Jaeger W,Hidvegi M,Agarwal RP,Fritzer-Szekeres M,Szekeres T

更新日期：2009-03-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common malignancies, and is the second leading cause of cancer-related deaths worldwide. Macrophages infiltrated in the tumor microenvironment (TME) called tumor-associated macrophages (TAMs) are key orchestrators in TME. In GC, it has been reported that infiltration of TAMs is a...

journal_title：Oncology reports

authors： Guo J,Yan Y,Yan Y,Guo Q,Zhang M,Zhang J,Goltzman D

更新日期：2017-10-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, is involved in suppressing the growth of several tumors. We showed that PPAR-gamma is expressed in Barrett's adenocarcinoma cell lines and inhibited the growth of these lines through the induction of G1...

journal_title：Oncology reports

authors： Takashima T,Fujiwara Y,Hamaguchi M,Sasaki E,Tominaga K,Watanabe T,Oshitani N,Higuchi K,Arakawa T

更新日期：2005-04-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) in exosomes play crucial roles in the onset, progression and metastasis of cancer by regulating the stability of target mRNAs or by inhibiting translation. In the present study, differentially expressed miRNAs were identified in exosomes of 27 breast cancer patients and 3 healthy controls using...

journal_title：Oncology reports

authors： Wu H,Wang Q,Zhong H,Li L,Zhang Q,Huang Q,Yu Z

更新日期：2020-01-01 00:00:00

abstract：:It has been revealed that the induction of epithelial‑mesenchymal transition (EMT) is associated with drug resistance, leading to tumor recurrence and metastasis. Recent studies have shown that chemotherapeutic agents, besides their therapeutic effects, can induce EMT and enhance invasive and metastatic properties of ...

journal_title：Oncology reports

authors： Chun SY,Kim S,Nam KS

更新日期：2017-08-01 00:00:00

abstract：:Primary and metastatic cancers that affect bones are frequently associated with severe and intractable pain. The mechanisms underlying the development of bone cancer pain are largely unknown. In the present study, we investigated whether inhibition of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to t...

journal_title：Oncology reports

authors： Cai J,Fang D,Liu XD,Li S,Ren J,Xing GG

更新日期：2015-03-01 00:00:00

abstract：:Zinc finger protein 307 (ZNF307) is a new Krüppel-associated box zinc-finger protein gene and a member of the zinc-finger family of transcriptional factors. Notably, the role of ZNF307 and its underlying mechanisms involved in hepatocarcinogenesis are poorly investigated. In the present study, we found that the expres...

journal_title：Oncology reports

authors： Liang Y,Li Q,Chen K,Ni W,Zhan Z,Ye F,Li Y,Fang Y,Zhang F,Chen L,Ding Y

更新日期：2017-10-01 00:00:00

abstract：:Pancreatic cancer is the fourth most common cause of cancer-related mortality. In the present study, we employed 2 types of therapeutic stem cells expressing cytosine deaminase (CD) with or without human interferon-β (IFN‑β), HB1.F3.CD and HB1.F3.CD.IFN-β cells, respectively, to selectively treat pancreatic cancer. Th...

journal_title：Oncology reports

authors： Kim DJ,Yi BR,Lee HR,Kim SU,Choi KC

更新日期：2013-09-01 00:00:00