(-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway.

Abstract:

:Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addition, OC inhibited proliferation, migration, invasion and tube formation in human umbilical vascular endothelial cells. In vivo, it exhibited potent activity in suppressing tumor growth in a subcutaneous xenograft model. Furthermore, OC suppressed proliferation and angiogenesis as measured by immunohistochemical staining of Ki-67 and CD31. In addition, OC was found to inhibit metastasis of melanoma in a lung metastasis model. Mechanistically, OC significantly suppressed signal transducer and activator of transcription 3 (STAT3) phosphorylation, decreased STAT3 nuclear localization and inhibited STAT3 transcriptional activity. OC also downregulated STAT3 target genes, including Mcl-1, Bcl-xL, MMP-2, MMP-9, VEGF, which are involved in apoptosis, invasion and angiogenesis of melanoma. These results support further investigation of OC as a potential anti-melanoma drug.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Gu Y,Wang J,Peng L

doi

10.3892/or.2016.5270

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

483-491

issue

1

eissn

1021-335X

issn

1791-2431

journal_volume

37

pub_type

杂志文章
  • In vivo and in situ imaging of head and neck squamous cell carcinoma using near-infrared fluorescent quantum dot probes conjugated with epidermal growth factor receptor monoclonal antibodies in mice.

    abstract::In this study, we applied near-infrared fluorescent quantum dots (NIRF-QDs) for non-invasive in vivo and in situ imaging of head and neck squamous cell carcinoma (HNSCC). The U14 squamous cancer cell line with high expression of epidermal growth factor receptor (EGFR) was implanted subcutaneously into the head and nec...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1705

    authors: Yang K,Zhao C,Cao YA,Tang H,Bai YL,Huang H,Zhao CR,Chen R,Zhao D

    更新日期:2012-06-01 00:00:00

  • EVI5 is a novel independent prognostic predictor in hepatocellular carcinoma after radical hepatectomy.

    abstract::The present study explored the correlation of ecotropic viral integration site 5 (EVI5) expression with clinicopathological features and prognosis in hepatocellular carcinoma (HCC). A total of 205 HCC patients were included retrospectively. Quantitative real-time polymerase chain reaction (RT-qPCR) and western blottin...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5862

    authors: Tang J,Ou J,Xu C,Yi C,Xue F,Xu L,Lai F,Tang J,Li S,Kang T,Ding W,Wang B

    更新日期:2017-10-01 00:00:00

  • CRISPR/Cas9-mediated genome engineering of CXCR4 decreases the malignancy of hepatocellular carcinoma cells in vitro and in vivo.

    abstract::CXC chemokine receptor 4 (CXCR4) is associated with poor clinical outcomes and decreased survival in hepatocellular carcinoma (HCC). In the present study, we targeted CXCR4 by CRISPR/Cas9 in HepG2 cells and observed the effects both in vitro and in vivo. The results indicated that after targeting CXCR4 the expression ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5601

    authors: Wang X,Zhang W,Ding Y,Guo X,Yuan Y,Li D

    更新日期:2017-06-01 00:00:00

  • Huntingtin-associated protein 1: a potential biomarker of breast cancer.

    abstract::It is reported that patients with Huntington's disease (HD) have a low incidence of cancer. In this study, we investigated the expression of huntingtin-associated protein 1 (HAP1), the ligand of HD's production, in breast tumor and normal tissues. We found that HAP1 expression was significantly lower in tumor compared...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2303

    authors: Zhu L,Song X,Tang J,Wu J,Ma R,Cao H,Ji M,Jing C,Wang Z

    更新日期:2013-05-01 00:00:00

  • Combined use of PI3K and MEK inhibitors synergistically inhibits lung cancer with EGFR and KRAS mutations.

    abstract::EGFR and KRAS mutations are the two most common driver mutations in non-small cell lung cancer (NSCLC). Molecular target-based therapy using small molecules such as gefitinib has been used for inhibiting EGFR with good initial responses; however, drug resistance is common when using a mono-targeting strategy. At prese...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.4770

    authors: Jiang ZB,Huang J,Xie C,Li X,Liu L,He J,Pan H,Huang L,Fan XX,Yao XJ,Xie Y,Li N,Liu L,He JX,Leung EL

    更新日期:2016-07-01 00:00:00

  • Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway.

    abstract::Osteosarcoma (OS) is the most common type of bone cancer. Even with early diagnosis and aggressive treatment, the prognosis for OS is poor. In the present study, we investigated the proliferation and invasion inhibitory effect of apigenin on human OS cells and the possible molecular mechanisms involved. The cell viabi...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4022

    authors: Liu X,Li L,Lv L,Chen D,Shen L,Xie Z

    更新日期:2015-08-01 00:00:00

  • N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma.

    abstract::N-myc downstream regulated gene 1 (NDRG1)/Cap43 is a 43 kDa protein that is widely distributed in the body. Its expression is regulated by nickel, cobalt, hypoxic condition and others; it is reported to be weaker in tumors than normal tissues; and NDRG1/Cap43 is considered to act suppressively to tumor metastasis. Thi...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Akiba J,Ogasawara S,Kawahara A,Nishida N,Sanada S,Moriya F,Kuwano M,Nakashima O,Yano H

    更新日期:2008-12-01 00:00:00

  • CLDN5 affects lncRNAs acting as ceRNA dynamics contributing to regulating blood‑brain barrier permeability in tumor brain metastasis.

    abstract::The blood‑brain barrier (BBB) constitutes an efficient organization of tight junctions that limits the delivery of tumor to the brain. The principal tight junction protein in BBB is claudin‑5 (CLDN5), but its mechanism of action remains largely unknown. Long non‑coding RNAs (lncRNAs) are aberrantly expressed in many c...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6208

    authors: Ma SC,Li Q,Peng JY,Zhouwen JL,Zhang DN,Zhang CB,Jiang WG,Jia W

    更新日期:2018-03-01 00:00:00

  • Treatment with HER-2 phosphorylation agonists enhance tumor ability to stimulate epitope specific CTL in vitro.

    abstract::The transmembrane (TM) receptor encoded by the HER-2 proto-oncogene (HER-2) is amplified in several types of human carcinomas and premalignant states and provides an important target for cancer therapy. While overexpression of HER-2 should lead to increased CTL epitope formation due to the attendant increase in higher...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Castilleja A,Ward NE,Epstein RB,Kudelka AP,Gershenson DM,Efferson CL,O'Brian CA,Ioannides CG

    更新日期:2002-09-01 00:00:00

  • The inhibitory effects of deep-sea water on doxorubicin‑induced epithelial-mesenchymal transition.

    abstract::It has been revealed that the induction of epithelial‑mesenchymal transition (EMT) is associated with drug resistance, leading to tumor recurrence and metastasis. Recent studies have shown that chemotherapeutic agents, besides their therapeutic effects, can induce EMT and enhance invasive and metastatic properties of ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5726

    authors: Chun SY,Kim S,Nam KS

    更新日期:2017-08-01 00:00:00

  • Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats.

    abstract::One of the dose-limiting toxicities of irinotecan (CPT-11) is delayed-onset diarrhea, which is the greatest barrier to treatment with CPT-11-containing regimens. CPT-11 is converted to its active metabolite, SN-38, which is conjugated by hepatic uridine diphosphate glucuronosyl transferase to SN-38 glucuronide (SN-38G...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Yamamoto M,Kurita A,Asahara T,Takakura A,Katono K,Iwasaki M,Ryuge S,Wada M,Onoda S,Yanaihara T,Yokoba M,Mitsufuji H,Nishii Y,Fukui T,Masuda N

    更新日期:2008-10-01 00:00:00

  • Comparative effects of histone deacetylase inhibitors on p53 target gene expression, cell cycle and apoptosis in MCF-7 breast cancer cells.

    abstract::Histone deacetylase inhibitors are currently being evaluated for their therapeutic potential and have shown considerable promise as adjuvant therapies for a number of cancers. This study compared the effects of 2 hydroxamic acid based inhibitors, CG-1521 and SAHA, on gene expression...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1590

    authors: Knutson AK,Welsh J,Taylor T,Roy S,Wang WL,Tenniswood M

    更新日期:2012-03-01 00:00:00

  • Optimal subset of signature miRNAs consisting of 7 miRNAs that can serve as a novel diagnostic and prognostic predictor for the progression of cervical cancer.

    abstract::Cervical cancer is the second most commonly diagnosed cancer in women. Novel prognostic biomarkers are required to predict the progression of cervical cancer. Cervical cancer expression data were obtained from The Cancer Genome Atlas (TCGA) database. MicroRNAs (miRNAs) significantly differentially expressed between ea...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2019.7097

    authors: Shi C,Yang Y,Zhang L,Zhang T,Yu J,Qin S,Gao Y

    更新日期:2019-06-01 00:00:00

  • Vascular endothelial growth factor activating matrix metalloproteinase in ascitic fluid during peritoneal dissemination of ovarian cancer.

    abstract::The role of vascular endothelial growth factor (VEGF) during peritoneal dissemination of ovarian carcinoma and the association with tumor microvessel density (MVD) and matrix metalloproteinase (MMP) activity was investigated. To this end, MVD, tumor tissue and ascitic fluid levels of VEGF, and MMP activity of ascitic ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Yabushita H,Shimazu M,Noguchi M,Kishida T,Narumiya H,Sawaguchi K,Noguchi M

    更新日期:2003-01-01 00:00:00

  • miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC.

    abstract::miR-367 is one of the most abundant miRNAs in human embryonic stem cells (hESCs) and is mainly involved in maintaining the pluripotency of stem cells. However, its role in cancer development remains poorly understood. In the present study, we explored the function and mechanism of the endogenous miR-367 in non-small c...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5755

    authors: Xiao G,Gao X,Sun X,Yang C,Zhang B,Sun R,Huang G,Li X,Liu J,Du N,Liu D,Liang R,Ren H,Qin S

    更新日期:2017-08-01 00:00:00

  • Interpretation of Pin-1 and VEGF-C expression in breast infiltrating duct carcinoma.

    abstract::Pin-1 has been shown to regulate several phases of the cell cycle and is strikingly overexpressed in many human cancers. Vascular endothelial growth factor (VEGF)-C is a potent lymphangiogenic factor produced by tumor and stromal cells. However, little is known about the roles of Pin-1 and VEGF-C in breast carcinoma. ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000578

    authors: Kim BC,Han SI,Lim SC

    更新日期:2009-12-01 00:00:00

  • Inhibitor of DNA-binding protein 1 knockdown arrests the growth of colorectal cancer cells and suppresses hepatic metastasis in vivo.

    abstract::Inhibitor of DNA-binding protein 1 (ID1) is commonly abnormally overexpressed in colorectal cancer (CRC); yet, the functional significance of ID1 in the growth and invasive properties of CRC cells remains largely unclear. The present study investigated the effects of ID1 downregulation on the cell growth and metastati...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3172

    authors: Lai X,Liao J,Lin W,Huang C,Li J,Lin J,Chen Q,Ye Y

    更新日期:2014-07-01 00:00:00

  • Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.

    abstract::The present study was performed to investigate the protective effects of tannic acid (TA) on liver injury induced by arsenic trioxide (ATO) and to elucidate the mechanism involved as related to the Kelch‑like ECH‑associated protein 1 (Keap1)‑nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response eleme...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2020.7764

    authors: Li M,Liu P,Xue Y,Liang Y,Shi J,Han X,Zhang J,Chu X,Chu L

    更新日期:2020-11-01 00:00:00

  • miR-182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer.

    abstract::Forkhead box F2 transcription factor (FoxF2) has been described to promote organ development, extracellular matrix (ECM) synthesis and epithelial-mesenchymal interaction. Although recent studies reported decreased FoxF2 expression in several types of cancers, indicating its potential role in carcinogenesis, the mechan...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.3833

    authors: Zhang Y,Wang X,Wang Z,Tang H,Fan H,Guo Q

    更新日期:2015-05-01 00:00:00

  • PBOV1 correlates with progression of ovarian cancer and inhibits proliferation of ovarian cancer cells.

    abstract::Prostate and breast cancer overexpressed 1 (PBOV1) is significantly upregulated in prostate, breast and bladder cancer, while its expression status in ovarian cancer and its clinical significance are unclear. We examined the expression levels of PBOV1 mRNA and protein in ovarian cancer cell lines and primary tissues u...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4396

    authors: Wang L,Niu CH,Wu S,Wu HM,Ouyang F,He M,He SY

    更新日期:2016-01-01 00:00:00

  • Expression of retinoid X receptor alpha is decreased in 3'-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in rats.

    abstract::The identification of the specific molecular targets, which underlie liver carcinogenesis is essential for the establishment of an effective strategy for the prevention and/or treatment of hepatocellular carcinomas (HCCs). We previously found that a malfunction of RXRalpha due to its aberrant phosphorylation was assoc...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Ando N,Shimizu M,Okuno M,Matsushima-Nishiwaki R,Tsurumi H,Tanaka T,Moriwaki H

    更新日期:2007-10-01 00:00:00

  • Antibody therapies for melanoma: new and emerging opportunities to activate immunity (Review).

    abstract::The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

    journal_title:Oncology reports

    pub_type: 杂志文章,评审

    doi:10.3892/or.2014.3275

    authors: Malas S,Harrasser M,Lacy KE,Karagiannis SN

    更新日期:2014-09-01 00:00:00

  • Persistent anti-tumor effects via recombinant adeno-associated virus encoding herpes thymidine kinase gene monitored by PET-imaging.

    abstract::Despite the well-documented advantages of the recombinant adeno-associated virus (rAAV) as a gene delivery vehicle, including its non-pathogenic and long-term therapeutic gene expression, there have been very limited studies on its potential for producing persistent anti-tumor effects, particularly in vivo. To address...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1190

    authors: Kim JY,Kim JH,Khim M,Lee HS,Jung JH,Moon DH,Jeong S,Lee H

    更新日期:2011-05-01 00:00:00

  • Evaluation of 5-fluorouracil applicability by multi-point collagen gel droplet embedded drug sensitivity test.

    abstract::The drug sensitivity of tumor cells is one of key issues to explore individualized therapy for cancer patients. One of such methods is in vitro anticancer drug sensitivity test which is generally based on one drug concentration and contact time. In this study, 5-fluorouracil (5-FU) sensitivity of cancer cells from col...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Ochiai T,Nishimura K,Noguchi H,Kitajima M,Tsuruoka Y,Takahashi Y

    更新日期:2005-07-01 00:00:00

  • The effect of NET-1 on the proliferation, migration and endocytosis of the SMMC-7721 HCC cell line.

    abstract::To explore the effect of NET-1 on the proliferation, migration and endocytosis in the hepatocellular carcinoma (HCC) cell line SMMC-7721, we constructed the pU6H1-NET-1-siRNA (NET-1siRNA) and pcDNA3.1/myc-NET-1 (myc-NET-1) vectors and transfected them into SMMC-7721 cells. The expression levels of NET-1 mRNA and prote...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1698

    authors: Wang GL,Chen L,Wei YZ,Zhou JM,Wu YY,Zhang YX,Qin J,Zhu YY

    更新日期:2012-06-01 00:00:00

  • Detection of an elevated HER2 expression in MCF-7 breast cancer cells overexpressing estrogen receptor beta1.

    abstract::The estrogen receptor (ER) expression and HER2 amplification are important factors in determining the prognosis and therapy of breast cancer. Interactions between the two signaling pathways for example resulted in ERalpha-dependent regulation of HER2 expression in breast cancer cells. In this study, we investigated to...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Lattrich C,Juhasz-Boess I,Ortmann O,Treeck O

    更新日期:2008-03-01 00:00:00

  • Association of annexin A2 with cancer development (Review).

    abstract::Annexin A2 (ANXA2) is a well-known calcium-dependent phospholipid binding protein widely distributed in the nucleus, cytoplasm and extracellular surface of various eukaryotic cells. It has been recognized as a pleiotropic protein affecting a wide range of molecular and cellular processes. Dysregulation and abnormal ex...

    journal_title:Oncology reports

    pub_type: 杂志文章,评审

    doi:10.3892/or.2015.3837

    authors: Xu XH,Pan W,Kang LH,Feng H,Song YQ

    更新日期:2015-05-01 00:00:00

  • KLF4 inhibits colorectal cancer cell proliferation dependent on NDRG2 signaling.

    abstract::Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor, which was confirmed as a tumor suppressor gene in colorectal cancers. KLF4 inhibits colorectal cancer cells proliferation through upregulating p21WAF1/Cip1 and downregulating cyclin D1. We firstly reported that N-Myc downstream regulated gene 2 (NDRG2...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5736

    authors: Ma Y,Wu L,Liu X,Xu Y,Shi W,Liang Y,Yao L,Zheng J,Zhang J

    更新日期:2017-08-01 00:00:00

  • Effects of MDR1/P-glycoprotein expression on prognosis in advanced colorectal cancer after surgery.

    abstract::Resistance to chemotherapeutic agents is a major problem for successful cancer treatment. P-glycoprotein (Pgp), a product of the multidrug resistance (MDR)1 gene expressed in cancer cells, is one of the mechanism of MDR. However, there are few reports regarding the effects of Pgp on prognosis of colorectal cancer (CRC...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.8.4.815

    authors: Tokunaga Y,Hosogi H,Hoppou T,Nakagami M,Tokuka A,Ohsumi K

    更新日期:2001-07-01 00:00:00

  • Growth inhibition and apoptosis of human B-cell lymphoma in vitro and in vivo by Bcl-2 short hairpin RNA.

    abstract::Bcl-2 is overexpressed in various types of human tumors, including Burkitt's lymphoma, and it is involved in tumorigenesis and chemoresistance, therefore, it is regarded as a potential target of gene therapy. In this study, RNA interference using short hairpin RNA (shRNA)-mediated R...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.2081

    authors: Liu Y,Shen Y,Qin C,Shi Y,Rong G,Yu X

    更新日期:2013-01-01 00:00:00