MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the PI3K/AKT and MAPK/ERK pathways in ovarian cancer.

abstract：:The human Igf-1 gene not only produces insulin‑like growth factor-I (IGF-I), but also different carboxy‑terminal extensions, known as E peptides, through alternative splicing. We and others have shown that human Eb peptide (hEb) derived from Igf-1 has intrinsic biological activity and is localized to nuclei of transfe...

journal_title：Oncology reports

authors： Durzyńska J,Barton E

更新日期：2014-09-01 00:00:00

abstract：:Cucurbitacin D (CuD), isolated from plants from the Cucurbitaceae family, is a potential antitumour agent since it inhibits proliferation, migration and metastasis of cancer cells. Despite CuD antitumour activity in cancer cells, the effects of CuD on gastric cancer cell lines remain unclear. The present study aimed t...

journal_title：Oncology reports

authors： Zhang YZ,Wang CF,Zhang LF

更新日期：2018-06-01 00:00:00

abstract：:Melanoma is the most aggressive cutaneous cancer due to its propensity to metastasise and proliferate. Melanoma accounts for 80‑90% of skin‑cancer related deaths worldwide. Alhough numerous published studies have attempted to define the markers of diagnosis and prognosis of melanoma, a sensitive and specific biomarker...

journal_title：Oncology reports

authors： Wei C,Lu N,Wang L,Zhang Y,Feng Z,Yang Y,Qi F,Gu J

更新日期：2018-06-01 00:00:00

abstract：:Gentian violet (GV) is a cationic triphenylmethane dye, with potent antifungal and antibacterial activity. We recently reported that in vitro GV suppresses the differentiation of bone resorbing osteoclasts while stimulating the differentiation and activity of bone forming osteoblasts. Breast cancer is highly metastati...

journal_title：Oncology reports

authors： Yamaguchi M,Vikulina T,Weitzmann MN

更新日期：2015-10-01 00:00:00

abstract：:Pancreatic cancer is one of the most deadly carcinomas worldwide. Although gemcitabine as the standard chemotherapy agent has been proven to be effective, the response rate remains at 5.4% and the 5-year survival rate is extremely poor. Ursolic acid (UA) is a small molecule compound...

journal_title：Oncology reports

authors： Li J,Liang X,Yang X

更新日期：2012-08-01 00:00:00

abstract：:Interleukin‑9 (IL‑9) can function as both a positive and negative regulator of immune response, however the role of IL‑9 in tumor immunity is poorly understood. Chronic lymphocytic leukemia (CLL) is the most common chronic lympho‑proliferative disorder. Twenty CLL patients from 2010 to 2011 were recruited in the study...

journal_title：Oncology reports

authors： Chen N,Feng L,Qu H,Lu K,Li P,Lv X,Wang X

更新日期：2018-06-01 00:00:00

abstract：:Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid pre...

journal_title：Oncology reports

authors： Lu L,Chen J,Li M,Tang L,Wu R,Jin L,Liang Z

更新日期：2018-04-01 00:00:00

abstract：:Bone marrow-derived endothelial progenitor cells (EPC) play an important role in neovascularisation and tumor growth. However, the clinical relevance of EPCs on blood vessel formation in non-small cell lung cancer (NSCLC) is unclear. EPC numbers in circulation are very low and therefore their detection is technically ...

journal_title：Oncology reports

authors： Pircher A,Kähler CM,Skvortsov S,Dlaska M,Kawaguchi G,Schmid T,Gunsilius E,Hilbe W

更新日期：2008-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is known to play a central role in tumour angiogenesis. Up to now inconclusive data have been published on the clinical-biological significance of circulating VEGF and on the most suitable blood fraction for measuring it. The aims of this pilot study were to assess VEGF in blo...

journal_title：Oncology reports

authors： Ranieri G,Coviello M,Chiriatti A,Stea B,Montemurro S,Quaranta M,Dittadi R,Paradiso A

更新日期：2004-02-01 00:00:00

abstract：:Gallbladder cancer (GBC) is a lethal aggressive malignant neoplasm of the biliary tract. Potential prognostic markers and therapeutic targets for this disease are urgently required. Cancer‑associated fibroblasts (CAFs) play a key role in tumorigenesis and the development of cancer. Nicotinamide adenine dinucleotide ph...

journal_title：Oncology reports

authors： Wang FT,Hassan M,Ansari KH,Xu GL,Li XP,Fan YZ

更新日期：2019-10-01 00:00:00

abstract：:Membrane-associated RING-CH (MARCH) belongs to the family of RING-CH type E3 ubiquitin ligases. MARCH1 ubiquitinates and downregulates MHC class II expression in APCs and targets major players of the immune system. However, the role of MARCH1 in ovarian cancer has not been elucidated. The present study investigated th...

journal_title：Oncology reports

authors： Meng Y,Hu J,Chen Y,Yu T,Hu L

更新日期：2016-11-01 00:00:00

abstract：:Colorectal cancer (CRC) is a common gastrointestinal malignancy worldwide and is a lethal and aggressive malignancy with a dismal prognosis. EphrinB2 is a membrane-bound ligand and has an intracellular domain that also possesses an intrinsic signaling capacity called 'reverse signaling'. In the present study, CRC cell...

journal_title：Oncology reports

authors： Li P,Chen W,Wang Y,Fu X,Wen K,Qian J,Huang C,Fu Z

更新日期：2015-02-01 00:00:00

abstract：:We conducted a clinical pharmacological evaluation of paclitaxel/carboplatin combination in Japanese patients with non-small cell lung cancer. The purpose of this study was to identify the optimal dose of this combination and to investigate the relationships between the pharmacokinetic profiles of these 2 drugs, serum...

journal_title：Oncology reports

authors： Daga H,Isobe T,Miyazaki M,Fujitaka K,Kondo K,Kohno N

更新日期：2004-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) and estrogen receptor (ER) belong to a family of nuclear hormone receptors that have been demonstrated to affect each other's transcriptional activity. At present, little is known regarding the effect of PPARγ on ER-mediated transcriptional activity in endometrial c...

journal_title：Oncology reports

authors： Zhang G,Hou X,Gao S

更新日期：2015-03-01 00:00:00

abstract：:It is well known that crucifers have antitumor effects and 3,3'-diindolylmethane (DIM) is one of the major bioactive components, and the associated molecular mechanisms in a short-term high-dose manner are widely discussed. However, the antitumor effects of DIM in a long-term low-dose manner in nasopharyngeal carcinom...

journal_title：Oncology reports

authors： Li F,Chen C,Chen SM,Xiao BK,Tao ZZ

更新日期：2016-02-01 00:00:00

abstract：:Mathematical modeling and serial magnetic resonance imaging (MRI) used to calculate patient-specific rates of tumor diffusion, D, and proliferation, ρ, can be combined to simulate glioblastoma multiforme (GBM) growth. We showed that the proportion and distribution of tumor cells below the MRI threshold are determined ...

journal_title：Oncology reports

authors： Hathout L,Patel V

更新日期：2016-08-01 00:00:00

abstract：:Eukaryotic elongation factor 2 (eEF2) is an essential factor for protein synthesis. Previous studies have shown that the eEF2 gene was overexpressed and plays an oncogenic role in various types of cancers and that eEF2 gene product elicited both humoral immune responses to produce eEF2-specific IgG autoantibody in can...

journal_title：Oncology reports

authors： Nakajima H,Murakami Y,Morii E,Akao T,Tatsumi N,Odajima S,Fukuda M,Machitani T,Iwai M,Kawata S,Hojo N,Oka Y,Sugiyama H,Oji Y

更新日期：2016-04-01 00:00:00

abstract：:Aberrant nuclear factor-erythroid 2 (NRF2) expression correlates with tumor development. We investigated NRF2 expression in ovarian epithelial carcinoma (OEC), aiming to identify associations with clinicopathological factors, hormones and induced reactive oxygen species (ROS). Immun...

journal_title：Oncology reports

authors： Liao H,Zhou Q,Zhang Z,Wang Q,Sun Y,Yi X,Feng Y

更新日期：2012-06-01 00:00:00

abstract：:Spindle-cell ameloblastic carcinoma is a classification proposed for a group of rare odontogenic carcinomas with sarcomatoid components and is distinguished from odontogenic carcinosarcoma. We report a case of spindle-cell ameloblastic carcinoma of the right mandible that occurred in a 67-year-old Japanese man. Growth...

journal_title：Oncology reports

authors： Kawauchi S,Hayatsu Y,Takahashi M,Furuya T,Oga A,Niwa S,Sasaki K

更新日期：2003-01-01 00:00:00

abstract：:The monoterpene perillyl alcohol (POH) is a naturally occurring compound derived from citrus fruits, mint and herbs. It exhibited chemotherapeutic potential against various malignant tumors in preclinical models and is currently being tested in clinical trials in patients with refractory advanced cancers. POH inhibits...

journal_title：Oncology reports

authors： Koyama M,Sowa Y,Hitomi T,Iizumi Y,Watanabe M,Taniguchi T,Ichikawa M,Sakai T

更新日期：2013-02-01 00:00:00

abstract：:Enhanced cell migration and invasion play key roles in cancer metastasis. However, the molecules involved in this process are not fully understood. In this study, a full-length human BNIPL-2 (Bcl-2/adenovirus E1B 19 kDa interacting protein 2 like-2) cDNA was transfected into human hepatocellular carcinoma cells with l...

journal_title：Oncology reports

authors： Xie L,Qin W,Li J,He X,Zhang H,Yao G,Shu H,Yao M,Wan D,Gu J

更新日期：2007-03-01 00:00:00

abstract：:MA128, a novel herbal medicine, was previously identified and its effectiveness in the treatment of asthma and atopic dermatitis (AD) was demonstrated. In particular, post-inflammatory hyperpigmentation (PIH) in AD mice was improved by treatment with MA128. In addition, MA128 exhibited anti-melanogenic activity by inh...

journal_title：Oncology reports

authors： Kim A,Im M,Yim NH,Hwang YH,Yang HJ,Ma JY

更新日期：2015-08-01 00:00:00

abstract：:The presence of hypoxic regions within solid tumors is caused by an imbalance between cell proliferation and angiogenesis. Such regions may facilitate the onset of recurrence after radiation therapy and chemotherapy, as hypoxic cells show resistance to these treatments. We found that tempol, a nitroxide, strongly indu...

journal_title：Oncology reports

authors： Kagiya G,Ogawa R,Choudhuri R,Cook JA,Hatashita M,Tanaka Y,Koda K,Yamashita K,Kubo M,Kawakami F,Mitchell JB

更新日期：2015-08-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors of HBV, HBV X protein (HBx) is attracting increased attention. Although it is documented that HBx is a multifunctional regulator that modulates cell inflammation and apoptosis, the exact mechanism r...

journal_title：Oncology reports

authors： Gao WY,Li D,Cai DE,Huang XY,Zheng BY,Huang YH,Chen ZX,Wang XZ

更新日期：2017-01-01 00:00:00

abstract：:The antitumor effect of photodynamic therapy (PDT) mediated by a novel photosensitizer I (Ps I; {γ-[N-poly(ethyleneglycol)]folic acid}-5,10,15-tris(3-hydroxyphenyl)-20-(4-carboxyphenyl)chlorin), in which chlorin was used as a photoactive unit, folic acid as a tumor‑targeting warhead, and polyethylene glycol as a linke...

journal_title：Oncology reports

authors： Li PX,Mu JH,Xiao HL,Li DH

更新日期：2015-01-01 00:00:00

abstract：:Mutations of the von Hippel-Lindau (VHL) tumor suppressor gene cause hereditary and sporadic renal cell carcinomas (RCCs). The best characterized function of VHL protein is suppression of the α subunit of hypoxia inducible factor (HIF). Additional VHL functions have been reported, including induction of senescence upo...

journal_title：Oncology reports

authors： Macher-Goeppinger S,Bermejo JL,Schirmacher P,Pahernik S,Hohenfellner M,Roth W

更新日期：2013-11-01 00:00:00

abstract：:The NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme is implicated in protection against oxidative stress and carcinogenesis. NQO1 C609T genetic polymorphism was reported to be associated with an increased risk for cancers, including breast cancer. However, there is still lack of evidence whether higher oxidative stress...

journal_title：Oncology reports

authors： Tseng LM,Yin PH,Tsai YF,Chi CW,Wu CW,Lee LM,Lee HC

更新日期：2009-05-01 00:00:00

abstract：:Urokinase plasminogen activator (uPA) and metalloproteinases (MMP) play key roles in invasion and metastasis, degrading extracellular matrix compounds and modulating tumor cell motility. Their regulation is an attractive therapeutic target for controlling tumor metastasis. Previously we have demonstrated that urokinas...

journal_title：Oncology reports

authors： Todaro LB,Ladeda V,Bal de Kier Joffé E,Farías EF

更新日期：2003-05-01 00:00:00

abstract：:Previous reports showed that breast and gastric cancers overexpressing c-erbB-2 protein have a greater metastatic potential and worse prognosis than tumors in which this protein is not overexpressed. The present study was undertaken to examine the significance of c-erbB-2 protein expression as a prognostic factor in c...

journal_title：Oncology reports

authors： Ishida H,Sadahiro S,Suzuki T,Ishikawa K,Tajima T,Makuuchi H

更新日期：2000-11-01 00:00:00

abstract：:Homeobox containing 1 (HMBOX1) is a novel transcription repressor that is significantly downregulated in human liver cancer tissues and cell lines, but the exact biological function of HMBOX1 in liver cancer is still unknown. We observed a negative association between HMBOX1 expression level and the clinical stages of...

journal_title：Oncology reports

authors： Zhao H,Jia H,Han Q,Zhang J

更新日期：2018-09-01 00:00:00