Abstract:
:Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors of HBV, HBV X protein (HBx) is attracting increased attention. Although it is documented that HBx is a multifunctional regulator that modulates cell inflammation and apoptosis, the exact mechanism remains controversial. In the present study, we explored the effect of HBx on oxidative stress-induced apoptosis in normal liver cell line, HL-7702. Our results showed that the existence of HBx affected mitochon-drial biogenesis by modulating the opening of the mitochondrial permeability transition pore (MPTP). Notably, this phenomenon was associated with a pronounced translocation of Bax from the cytosol to the mitochon-dria during the period of exposure to oxidative stress with a release of cytochrome c and activation of cleaved caspase-3 and PARP. Moreover, MPTP blockage with cyclosporin A prevented the translocation of Bax, and inhibited oxidative stress-induced apoptotic killing in the HBx-expressing HL-7702 cells. Our findings suggest that HBx exhibits pro-apoptotic effects upon normal liver cells following exposure to oxidative stress by modulating the MPTP gateway.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Gao WY,Li D,Cai DE,Huang XY,Zheng BY,Huang YH,Chen ZX,Wang XZdoi
10.3892/or.2016.5225subject
Has Abstractpub_date
2017-01-01 00:00:00pages
48-56issue
1eissn
1021-335Xissn
1791-2431journal_volume
37pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::CYP1A1 expression in various tissues of 43 gastric cancer cases was analyzed with frozen tissue array-based immunohistochemical staining (IHC), RT-PCR, Western blot analysis and EROD (7-ethoxyresourfin-O-deethylase) assay. CYP1A1 was detected immunohistochemically in 86% (37/43) of gastric cancers, in both 57% (4/7) o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::CXC chemokine receptor 7 (CXCR7) has been implicated in tumor development and metastasis in multiple malignancies. Yet, the function and molecular mechanisms of CXCR7 in human osteosarcoma (OS) are still unclear. The aim of the present study was to investigate the role of CXCR7 in human OS. The expression of CXCR7 was...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3290
更新日期:2014-09-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC), the main subtype of esophageal cancer (EC), is a common lethal type of cancer with a high mortality rate. The aim of the present study was to select key relevant genes and identify potential mechanisms involved in the development of ESCC based on bioinformatics analysis. Mini...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7658
更新日期:2020-09-01 00:00:00
abstract::Prostate cancer is a leading cause of cancer-related death among men. Early diagnosis and treatment are successful against prostate cancer, yet the clinical treatment of advanced prostate cancer remains a challenge. Gemcitabine is used to treat a broad spectrum of solid tumors; however, the clinical response of prosta...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3696
更新日期:2015-03-01 00:00:00
abstract::Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation and histone modification markers. Changes in the epigenome significantly contribute to the initiation and progression of cancer. The goal of the present s...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7159
更新日期:2019-07-01 00:00:00
abstract::Hydrogen sulfide (H2S) participates in multifarious physiological and pathophysiologic progresses of cancer both in vitro and in vivo. We have previously demonstrated that exogenous H2S promoted liver cancer cells proliferation/anti‑apoptosis/angiogenesis/migration effects via amplifying the activation of NF-κB pathwa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4248
更新日期:2015-11-01 00:00:00
abstract::Combined chemotherapy with 5-fluorouracil and leucovorin (LV) has been widely used for the treatment of patients with colorectal cancer. Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), whic...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1206
更新日期:2011-05-01 00:00:00
abstract::Oxymatrine, the main alkaloid component in the traditional Chinese herbal medicine Sophora japonica (Sophora flavescens Ait), has been reported to have antitumor properties. However, the mechanisms of action in human pancreatic cancer are not well established to date. In the present study, we investigated the antiangi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2529
更新日期:2013-08-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, capable of degrading all the molecular components of extracellular matrix. MMPs have been shown to play critical roles in tumor cell invasion and metastasis. We verified the activity of MMPs in the sera ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1864
更新日期:2012-09-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are n...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7140
更新日期:2019-07-01 00:00:00
abstract::A patient who had undergone radical gastrectomy for synchronous gastric cancer (T(1)N(0)M(0), stage I) and duodenal cancer (Tis, stage 0) in November 1987 was found to have esophageal cancer in November 1994, and underwent radical thoracolaparotomy at our hospital (T(1)N(0)M(0), stage I). After follow-up for about 3.5...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract::The authors of the above article drew to our attention that they had identified three instances of data overlapping between data panels, suggesting that data purportedly showing results obtained under different experimental conditions had been derived from the same original source. Comparing between the two figures, t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7738
更新日期:2020-11-01 00:00:00
abstract::Isocitrate dehydrogenase 2 (IDH2) is a mitochondrial NADP-dependent isocitrate dehydrogenase. It is considered to be a novel tumor suppressor in several types of tumors. However, the role and related mechanism of IDH2 in osteosarcoma remain unknown. The expression and significance of IDH2 were investigated by immunohi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4553
更新日期:2016-04-01 00:00:00
abstract::Toll-like receptor (TLR)-mediated signaling induces cell migration or invasion in several tumors and various stages of cancer. Interactions of mesothelin, a 40-kDa cell surface glycoprotein, with cancer antigen 125 (CA125) is associated with drug resistance, metastasis, and poor clinical outcome of ovarian cancer pati...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5941
更新日期:2017-11-01 00:00:00
abstract::Ampelopsis sinica root (ASR) is a known hepatoprotective folk traditional Chinese medicine. The anti‑hepatoma activity of ethyl acetate extract from A. sinica root (ASRE) in vitro and in vivo and its possible mechanism were explored. This study was designed to investigate cytotoxicity by MTT assay, induction of apopto...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5504
更新日期:2017-04-01 00:00:00
abstract::The aim of the present study was to investigate the expression, function and underlying molecular mechanism of the long non‑coding (lnc) RNA RP1‑163G9.1 in patients with gastric adenocarcinoma (GA). The expression levels of lncRNA RP1‑163G9.1 were determined in 112 paired clinical GA tissues by reverse transcription‑q...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7127
更新日期:2019-06-01 00:00:00
abstract::Aberrant glycosylation, a common feature of malignant alteration, is partly due to changes in the expression of glycosyltransferases, including β1,3-N-acetyl-glucosaminyltrans-ferase 8 (β3Gn‑T8), which synthesizes poly-N-acetyllactosamine (poly-LacNAc) chains on β1,6 branched N‑glycans. Although the role of β3Gn‑T8 in...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4959
更新日期:2016-09-01 00:00:00
abstract::Expression of Src homology phosphotyrosine phosphatase 2 (SHP2) has been observed in human breast cancer. SHP2 is known to promote cell migration and invasiveness. However, the pathophysiologic role of SHP2 and its relevance to tumorigenesis are still largely unknown. In the present study, we aimed to evaluate the eff...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3201
更新日期:2014-07-01 00:00:00
abstract::The phosphatase and tensin homolog (PTEN) gene, an important tumor-suppressor gene, has been demonstrated to have the potential for inhibiting proliferation, migration and invasion in various types of cancer cells. The aim of the present study was to investigate the effect of PTEN expression on osteosarcoma (OS) cells...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3362
更新日期:2014-10-01 00:00:00
abstract::Human telomerase reverse transcriptase (hTERT) plays an important role in the development of tumors and has been investigated as a potent target for anticancer therapy. In the present study, we constructed a recombinant adenovirus, Ad-EGFP-C197 which was capable of expressing COOH‑terminal polypeptide of hTERT (amino ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4298
更新日期:2015-12-01 00:00:00
abstract::Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging as...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or_00000361
更新日期:2009-06-01 00:00:00
abstract::Diallyl disulfide (DADS) has shown potential as a therapeutic agent in various cancers. Previously, we found that myeloid cell leukemia sequence 1 (Mcl1) was downregulated in DADS-induced cell cycle arrest in HL-60 human leukemia cells. Here, we investigated the role of this protein...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1704
更新日期:2012-06-01 00:00:00
abstract::Although radiotherapy is routinely administered to high-risk endometrial carcinoma and offer a significant disease-free survival advantage, the therapeutic effect is sometimes limited by the occurrence of radioresistance. To determine the patterns of gene expression responsible for the radioresistance and to search fo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract::Cancer research is currently focused on blocking the metastatic process at its early steps. Some particularly attractive targets are metastasis suppressor genes, which control cancer cell dissemination. The aim of this study was to clarify the relationship between the expression of KiSS1, a metastasis suppressor gene,...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2558
更新日期:2013-09-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the most common form of adult liver cancer and accounts for approximately 90% of all cases of primary liver cancer annually. Rhotekin (RTKN), which functions as a cancer promoter, can be frequently detected in many human cancers, including gastric cancer, colorectal carcinoma and blad...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5290
更新日期:2017-02-01 00:00:00
abstract::Bisphosphonates (BPs) inhibit bone resorption by preventing osteoclast maturation and apoptosis induction. Recently, BPs have also been shown to have antitumor effects against various types of carcinomas in vitro and in vivo. In this study, we investigated the antitumor effect of zoledronic acid (ZOL), a third generat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1152
更新日期:2011-04-01 00:00:00
abstract::The activation of receptor tyrosine kinases (RTKs) results in cellular effects including cell proliferation, survival, migration and invasion; RTKs also play an important role in tumourigenesis. It has been reported that EGFR signalling controls the migration of oral squamous cell carcinoma (OSCC) SAS and HSC3 cells b...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5587
更新日期:2017-06-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. Tumor specific cellular and humoral immunotherapy may be a viable approach for the treatment of HCC. This study investigated specific inhibitory and cytotoxic effects on hepatocellular carcinoma (HCC) induced by the peptide, designated HBc Delt...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::Pancreatic cancer is the fourth most common cause of cancer-related mortality. In the present study, we employed 2 types of therapeutic stem cells expressing cytosine deaminase (CD) with or without human interferon-β (IFN‑β), HB1.F3.CD and HB1.F3.CD.IFN-β cells, respectively, to selectively treat pancreatic cancer. Th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2564
更新日期:2013-09-01 00:00:00
abstract::Tubulin is a major component of microtubules. Class III beta-tubulin (beta III) is a neuron-associated beta-tubulin isotype and expressed in the normal central and peripheral nervous systems. According to a previous study, beta III is not expressed in normal skin and squamous cell carcinoma. However, its expression ha...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000494
更新日期:2009-10-01 00:00:00