Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.

abstract：:Esophageal squamous cell carcinoma (ESCC) is a common cancer with a very poor prognosis. New methods are needed to screen high-risk populations and identify curable tumors and precursor lesions early. Molecular markers may be useful in such screening efforts. This study was designed to determine the prevalence of p16,...

journal_title：Oncology reports

authors： Roth MJ,Abnet CC,Hu N,Wang QH,Wei WQ,Green L,D'Alelio M,Qiao YL,Dawsey SM,Taylor PR,Woodson K

更新日期：2006-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that contribute to modulating signaling pathways after radiation exposure and have emerged as a potential therapeutic target or biomarker in the radiation response of cancer. Exposing breast cancer cells to single-dose (SD) or multifractionated (MF) radiation may affect the...

journal_title：Oncology reports

authors： Leung CM,Chen TW,Li SC,Ho MR,Hu LY,Liu WS,Wu TT,Hsu PC,Chang HT,Tsai KW

更新日期：2014-05-01 00:00:00

abstract：:Gasdermin D (GSDMD) is a newly discovered pyroptosis executive protein, which can be cleaved by inflammatory caspases and is essential for secretion of IL‑1β, making it a critical mediator of inflammation. However, the precise role of GSDMD in carcinogenesis remains nearly unknown. Considering the vital role of inflam...

journal_title：Oncology reports

authors： Gao J,Qiu X,Xi G,Liu H,Zhang F,Lv T,Song Y

更新日期：2018-10-01 00:00:00

abstract：:Multigene-based combination therapy may be an effective practice in cancer gene therapy. Substantial studies have demonstrated that tumor suppressor p53 acetylation is indispensable for p53 activation. Inhibitor of growth 4 (ING4), as a novel tumor suppressor, is capable of remarkably enhancing p53 acetylation and its...

journal_title：Oncology reports

authors： Wu J,Zhu Y,Xu C,Xu H,Zhou X,Yang J,Xie Y,Tao M

更新日期：2016-01-01 00:00:00

abstract：:Mechanisms of synergistic effect of thermotherapy and chemotherapy on human lung adenocarcinoma cell growth are unclear. The purpose of this study was to investigate these effects and explore the function of ROS, Akt and caspase-3 in relation to these. A549 cells were subjected to different thermochemotherapy treatmen...

journal_title：Oncology reports

authors： Wang L,Liu X,Wu Y,Wu W,Wu Y

更新日期：2012-10-01 00:00:00

abstract：:A crucial step in the path to the malignant transformation of cells and tumor formation is immortalization, which essentially depends on telomere maintenance. The aim of this study was to investigate the role of telomerase in the progression of Barrett's esophagus. Telomerase activi...

journal_title：Oncology reports

authors： Qin X,Qi B,Zhao B

更新日期：2013-04-01 00:00:00

abstract：:To estimate the incidence of Epstein-Barr virus-associated gastric carcinoma (EBV-GC) in Colombia and to clarify its clinicopathological features, we examined 178 consecutive gastric carcinoma cases, diagnosed during the period from 1996 to 1998, at Hospital Universitario del Valle in Cali, Colombia. The mean age of t...

journal_title：Oncology reports

authors： Carrascal E,Koriyama C,Akiba S,Tamayo O,Itoh T,Eizuru Y,Garcia F,Sera M,Carrasquilla G,Piazuelo MB,Florez L,Bravo JC

更新日期：2003-07-01 00:00:00

abstract：:After having carefully checked the original data of Fig. 3, the authors noted that the student in their research group had inadvertently selected incorrect images for the 10 and 20 µM lycorine experiments to show the effect of lycorine on the migration of HepG2 cells during the figure compilation process. The correcte...

journal_title：Oncology reports

authors： Liu W,Zhang Q,Tang Q,Hu C,Huang J,Liu Y,Lu Y,Wang Q,Li G,Zhang R

更新日期：2019-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in the the gene regulation of carcinogenesis including breast cancer. miR‑519d has been studied in various types of cancer, but its role in breast cancer remains unclear. In the present study, we investigated the expression and biological function of miR-519d in breast cancer. U...

journal_title：Oncology reports

authors： Deng X,Zhao Y,Wang B

更新日期：2015-10-01 00:00:00

abstract：:Mitogene-inducible gene-6 (Mig-6) is involved in the intracellular signaling pathway as an adaptor molecule. Mig-6 expression is rapidly induced upon various kinds of mitogenic and stressful stimulations. We previously demonstrated that Mig-6 expression is induced by activated Ki-ras in human colon cancer cells and th...

journal_title：Oncology reports

authors： Mabuchi R,Sasazuki T,Shirasawa S

更新日期：2005-03-01 00:00:00

abstract：:Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Frequent metastasis and recurrence are the main reasons for the poor prognosis of PC patients. Thus, the discovery of new biomarkers and wider insights into the mechanisms involved in pancreatic tumorigenesis and metastasis is cruc...

journal_title：Oncology reports

authors： Ma D,Jing X,Shen B,Liu X,Cheng X,Wang B,Fu Z,Peng C,Qiu W

更新日期：2016-08-01 00:00:00

abstract：:The metabolism of arachidonic acid by either the cyclooxygenase or lipoxygenase (LOX) pathway is believed to play an important role in tumor promotion. We investigated the expression of 5- and 12-LOX in renal cell carcinoma (RCC), as well as the effects of their inhibitors on cell proliferation in 2 RCC cell lines (Ca...

journal_title：Oncology reports

authors： Matsuyama M,Yoshimura R,Mitsuhashi M,Tsuchida K,Takemoto Y,Kawahito Y,Sano H,Nakatani T

更新日期：2005-07-01 00:00:00

abstract：:Elucidating the effects of genes involved in tumors may improve therapeutic strategies for human cancer. Recently, several studies discovered that Akt1 plays a dual role in mediating cell proliferation, migration and invasion, depending on the cell type. However, the pathophysiological role of Akt1 in hepatocellular c...

journal_title：Oncology reports

authors： Chen L,Kang QH,Chen Y,Zhang YH,Li Q,Xie SQ,Wang CJ

更新日期：2014-02-01 00:00:00

abstract：:Gene expression patterns as well as gene interactions are under investigation for their involvement in tumour heterogeneity. The molecular classification of breast cancer based on hormone receptor expression, grade and HER2 receptor levels, is indicative but not adequate enough to c...

journal_title：Oncology reports

authors： Armakolas A,Stathopoulos GP,Nezos A,Theos A,Stathaki M,Koutsilieris M

更新日期：2012-12-01 00:00:00

abstract：:Chromosomal translocations are very common in human cancer. The molecular mechanisms of chromosomal translocations are complex and are not fully understood. Recent studies showed organization of genomes is higher-order in the nucleus and every chromosome or chromatin has its preferential position and territory. These ...

journal_title：Oncology reports

authors： Zheng J

更新日期：2013-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an aggressive disease with a poor outcome due to the high incidence of metastasis. Cancer stem cells (CSCs) have been identified to be responsible for tumor progression and may be generated by epithelial-mesenchymal transition (EMT) characteristics. CD133 is a specific surface marker ...

journal_title：Oncology reports

authors： Liu YM,Li XF,Liu H,Wu XL

更新日期：2015-12-01 00:00:00

abstract：:Circulating tumor cells (CTCs) or CTC clusters are considered as suitable and relevant targets for liquid biopsy as they more accurately indicate cancer progression, the therapeutic effects of treatment and allows for monitoring of cancer metastasis in real‑time. Among the various methods for isolating CTCs, size‑base...

journal_title：Oncology reports

authors： Xiang A,Xue M,Ren F,Wang L,Ye Z,Li D,Ji Q,Ji G,Lu Z

更新日期：2020-06-01 00:00:00

abstract：:Androgen receptor (AR) expression in prostate cancer (CaP) cells varies due to the multiple changes including epigenetic modifications such as DNA methylation and histone deacetylation. DNA methyltransferase and histone deacetylase inhibitors are promising for the treatment of CaP. The aim of our study was to analyze ...

journal_title：Oncology reports

authors： Fialova B,Smesny Trtkova K,Paskova L,Langova K,Kolar Z

更新日期：2013-05-01 00:00:00

abstract：:The deficiencies of nucleotide excision repair (NER) factors are involved in rare genetic diseases such as xeroderma pigmentosum (XP) with increased risk of developing cancer on sun-exposed areas of the skin. However, the abnormality of NER factors in human sporadic carcinoma remains unclear. Loss of heterozygosity (L...

journal_title：Oncology reports

authors： Miyashita H,Mori S,Tanda N,Nakayama K,Kanzaki A,Sato A,Morikawa H,Motegi K,Takebayashi Y,Fukumoto M

更新日期：2001-09-01 00:00:00

abstract：:Modulation of the activity of tumor suppressor p53 is a key event in the replication of many viruses. They could manipulate p53 function through modification of phosphorylation for their own purpose. However, there are scarce data on the relationship between high risk human papillomavirus (HPV) E6 protein and p53 phos...

journal_title：Oncology reports

authors： Zhang G,Sun L,Li Z,Si L,Song T,Huang C,Zhang W

更新日期：2009-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is a common gastrointestinal malignancy worldwide and is a lethal and aggressive malignancy with a dismal prognosis. EphrinB2 is a membrane-bound ligand and has an intracellular domain that also possesses an intrinsic signaling capacity called 'reverse signaling'. In the present study, CRC cell...

journal_title：Oncology reports

authors： Li P,Chen W,Wang Y,Fu X,Wen K,Qian J,Huang C,Fu Z

更新日期：2015-02-01 00:00:00

abstract：:CXCR4, a chemokine receptor, is considered to be involved in the metastastic formation of various types of cancer and could influence survival. More recently, CXCR4 was reported to be associated with peritoneal metastasis in gastric cancer, and CXCL12, its ligand, as a prognostic determinant among gastric cancer of va...

journal_title：Oncology reports

authors： Tsuboi K,Kodera Y,Nakanishi H,Ito S,Mochizuki Y,Nakayama G,Koike M,Fujiwara M,Yamamura Y,Nakao A

更新日期：2008-11-01 00:00:00

abstract：:A previous study by our group suggested that testis expressed 10 (Tex10) contributes to tumor progression by promoting stem cell‑like features in hepatocellular carcinoma. However, the relevance of pluripotency factor Tex10 in esophageal squamous cell carcinoma (ESCC) has remained elusive. The objective of the present...

journal_title：Oncology reports

authors： Xiang X,Xiong R,Yu C,Deng L,Bie J,Xiao D,Chen Z,Zhou Y,Li X,Liu K,Feng G

更新日期：2019-12-01 00:00:00

abstract：:Ginsenoside is known to have potential cancer-preventive activities. The major active components in red ginseng consist of a variety of ginsenosides including Rg3, Rg5 and Rk1, each of which has different pharmacological activities. Among these, Rg3 has been reported to exert anticancer activities through inhibition o...

journal_title：Oncology reports

authors： Choi YJ,Lee HJ,Kang DW,Han IH,Choi BK,Cho WH

更新日期：2013-09-01 00:00:00

abstract：:Hypoxia always exists in the processes involved in the development of lung cancer and contributes to an acidic microenvironment. Despite that hypoxia in the tumor microenvironment is associated with the formation of chemotherapeutic resistance, the exact role of an acidic microenvironment in the development of hypoxia...

journal_title：Oncology reports

authors： Hu CF,Huang YY,Wang YJ,Gao FG

更新日期：2016-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-related mortality worldwide. Aberrant expression of miRNAs play important roles in the development and progression of various types of cancers by modulating oncogenic and tumour-suppressor pathways. Therefore, exploring the ...

journal_title：Oncology reports

authors： Zhao J,Xu J,Zhang R

更新日期：2018-02-01 00:00:00

abstract：:Pien Tze Huang (PZH) is a well-known traditional Chinese formula that was first prescribed by a royal physician in the Ming Dynasty. PZH has been used to treat various types of cancers including osteosarcoma. Previous studies have shown that PZH may effectively inhibit osteosarcoma cell growth in vivo and in vitro via...

journal_title：Oncology reports

authors： Zhang Y,Wang Q,Niu S,Liu J,Zhang L

更新日期：2014-02-01 00:00:00

abstract：:No information is currently available regarding pancreatic cancer (PC) pattern of care in Italy. In the present study, a nationwide survey using a questionnaire was performed to enquire the local standards for PC diagnosis and radiotherapy treatment. Fifty-seven percent of 140 Italian centres completed questionnaire. ...

journal_title：Oncology reports

authors： Macchia G,Sainato A,Talamini R,Boz G,Bacigalupo A,Caravatta L,Fiore M,Friso ML,Fusco V,Lupattelli M,Mantello G,Mattiucci GC,Slim N,Sciacero P,Turri L,Valentini V,Morganti AG,Genovesi D

更新日期：2015-07-01 00:00:00

abstract：:The development and progression of epithelial cancers are the result of an imbalance in signals promoting and inhibiting cellular proliferation and apoptosis. The aim of this study is to evaluate the expression of cell-cycle and apoptosis regulators and correlate them with clinical outcome in the most frequent carcino...

journal_title：Oncology reports

authors： Abdulkader I,Sánchez L,Cameselle-Teijeiro J,Gude F,Chávez JE,López-López R,Forteza J,Fraga M

更新日期：2005-12-01 00:00:00

abstract：:Breast cancers especially in the late and metastatic stages remain refractory to treatment despite advances in surgical techniques and chemotherapy. Tumor-specific promoter-directed suicide gene therapy and adenoviral technology can be promising strategies for such advanced disease. Previous studies suggested that com...

journal_title：Oncology reports

authors： Yu B,Zhang Y,Zhan Y,Zha X,Wu Y,Zhang X,Dong Q,Kong W,Yu X

更新日期：2011-07-01 00:00:00