Upregulation of ABCG2 via the PI3K-Akt pathway contributes to acidic microenvironment-induced cisplatin resistance in A549 and LTEP-a-2 lung cancer cells.

abstract：:Glutamine RF‑amide peptide (QRFP) belongs to the RFamide neuropeptide family, which is involved in a wide spectrum of biological activities, ranging from food intake and cardiovascular functioning to analgesia, aldosterone secretion, locomotor activity and reproduction. Recently, QRFP has been demonstrated to exert it...

journal_title：Oncology reports

authors： Kawan MA,Kyrou I,Ramanjaneya M,Williams K,Jeyaneethi J,Randeva HS,Karteris E

更新日期：2019-02-01 00:00:00

abstract：:A phase I study of S-1 and biweekly docetaxel (DOC) combination therapy was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic parameters. Fourteen patients with advanced or recurrent gastric cancer were analyzed. The treatment consisted of S-1 [body surface area (BSA) <1.25 m2:80 mg/day, 1.25...

journal_title：Oncology reports

authors： Takahashi I,Emi Y,Kakeji Y,Tokunaga E,Ushiro S,Oki E,Watanabe M,Baba H,Maehara Y

更新日期：2006-04-01 00:00:00

abstract：:The molecular mechanisms underlying the biological effects of carbon ions are unclear. The aim of this study was to explore the Wnt/β‑catenin pathway in regulating carbon ion (12C6+) radiation‑induced cellular toxicity. HLY78 is a Wnt‑specific small molecular modulator, whose effects on 12C6+ radiation‑induced damage ...

journal_title：Oncology reports

authors： Si J,Zhang J,Gan L,Guo M,Xie Y,Di C,Sun C,Wang F,Yan J,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:BTG1, which belongs to the BTG/Tob family, regulates cell cycle progression in a variety of cell types and appears to play roles in inhibiting proliferation, promoting apoptosis and stimulating cellular differentiation in multiple cell types. However, it remains unclear whether BTG1 is a breast cancer suppressor gene,...

journal_title：Oncology reports

authors： Zhu R,Zou ST,Wan JM,Li W,Li XL,Zhu W

更新日期：2013-11-01 00:00:00

abstract：:Breast cancer is one of the most common malignancies diagnosed in women and it is increasing in incidence. Siegesbeckia glabrescens (SG) has been used in traditional oriental medicine to treat cardiovascular diseases such as hypertension and angina pectoris. This study examined whether or not SG could induce apoptosis...

journal_title：Oncology reports

authors： Jun SY,Choi YH,Shin HM

更新日期：2006-06-01 00:00:00

abstract：:In humans, four tropomyosin genes (TPM1, TPM2, TPM3, and TPM4) are known to produce a multitude of isoforms via alternate splicing and/or using alternate promoters. Expression of tropomyosin has been shown to be modulated at both the transcription and the translational levels. Tropomyosins are known to make up some of...

journal_title：Oncology reports

authors： Dube S,Thomas A,Abbott L,Benz P,Mitschow C,Dube DK,Poiesz BJ

更新日期：2016-06-01 00:00:00

abstract：:Epigenetic mechanisms of histone acetylation/deacetylation play an important role in the regulation of gene expression associated with the cell cycle and apoptosis. Recently, sodium butyrate, a histone deacetylase (HDAC) inhibitor, has been shown to exhibit anticancer effects via di...

journal_title：Oncology reports

authors： Shin H,Lee YS,Lee YC

更新日期：2012-04-01 00:00:00

abstract：:Ampelopsis sinica root (ASR) is a known hepatoprotective folk traditional Chinese medicine. The anti‑hepatoma activity of ethyl acetate extract from A. sinica root (ASRE) in vitro and in vivo and its possible mechanism were explored. This study was designed to investigate cytotoxicity by MTT assay, induction of apopto...

journal_title：Oncology reports

authors： Wang JZ,Huang BS,Cao Y,Chen KL,Li J

更新日期：2017-04-01 00:00:00

abstract：:Although the human telomerase reverse transcriptase (hTERT) promoter can regulate cancer-specific genes, it is generally too weak to be effective. We therefore attempted to improve the potency of synthetic hTERT promoters by fusing the core element (E) of the hTERT promoter (H) and the tripartite leader sequence (T) f...

journal_title：Oncology reports

authors： Kim SJ,Lee HS,Shin JH,Kim CG,Jeong S,Park K,Choe H,Lee H

更新日期：2006-11-01 00:00:00

abstract：:ONECUT1 (HNF-6) is the prototype of a new class of homeodomain transcription factors, that controls the development of pancreatic ducts during mouse development. In the present study, the role of ONECUT1 and its targeted genes TCF2, PKHD1 and CYS1 was analyzed in human pancreatic ductal adenocarcinoma (PDAC). mRNA lev...

journal_title：Oncology reports

authors： Jiang X,Zhang W,Kayed H,Zheng P,Giese NA,Friess H,Kleeff J

更新日期：2008-01-01 00:00:00

abstract：:Gene expression patterns as well as gene interactions are under investigation for their involvement in tumour heterogeneity. The molecular classification of breast cancer based on hormone receptor expression, grade and HER2 receptor levels, is indicative but not adequate enough to c...

journal_title：Oncology reports

authors： Armakolas A,Stathopoulos GP,Nezos A,Theos A,Stathaki M,Koutsilieris M

更新日期：2012-12-01 00:00:00

abstract：:Histone deacetylases (HDACs) have been shown to play important roles in the regulation of chromatin remodeling by histone deacetylation, and their expression is induced in several types of cancer. In addition, they are known to be associated with resistance to anticancer drugs. However, the relevance of HDAC4 in chemo...

journal_title：Oncology reports

authors： Yu SL,Lee DC,Son JW,Park CG,Lee HY,Kang J

更新日期：2013-09-01 00:00:00

abstract：:To better understand the molecular mechanisms of carcinogenesis induced in uterine endometrium by therapeutic anti-estrogenic Tamoxifen (TAM) exposure, 27 uterine tumors (4 benign endometrial polyps and 23 carcinomas) associated with TAM exposure were analyzed for the presence and spectrum of p53 and K-ras mutations. ...

journal_title：Oncology reports

authors： Fujiwara K,Enomoto T,Fujita M,Kanda T,Fujii S,Ito K,Wakasa K,Ishiko O,Ueda M,Yamaguchi S,Kimura T,Umesaki N

更新日期：2008-05-01 00:00:00

abstract：:Hypoxia was shown to increase tumor cell invasion into the extracellular matrix in vitro. This result suggests that heparanase (Hpa), one of the key enzymes involved in tumor invasion and metastasis, may be regulated by hypoxia. RT-PCR, Western blot and Matrigel invasive assays were used to study the regulation of Hpa...

journal_title：Oncology reports

authors： Wu W,Pan C,Meng K,Zhao L,Du L,Liu Q,Lin R

更新日期：2010-01-01 00:00:00

abstract：:The androgen receptor (AR) plays an essential role in the development and progression of prostate cancer. Castration-resistant prostate cancer (CRPC) is a consequence of androgen deprivation therapy. Unchecked CRPC followed by metastasis is lethal. Some CRPCs show decreased AR gene expression due to epigenetic mechani...

journal_title：Oncology reports

authors： Fialova B,Luzna P,Gursky J,Langova K,Kolar Z,Trtkova KS

更新日期：2016-10-01 00:00:00

abstract：:Gastric cancer (GC) is a severe public health problem worldwide, particularly in China. Radiotherapy is the main locoregional treatment for various types of unresectable tumor, including GC. However, many patients fail to respond to radiotherapy due to the intrinsic radioresistance of cancer cells. This study was desi...

journal_title：Oncology reports

authors： Geng W,Tian D,Wang Q,Shan S,Zhou J,Xu W,Shan H

更新日期：2019-08-01 00:00:00

abstract：:Melanoma is the seventh most common malignancy in females and the fifth most common cancer in males worldwide. An increasing number of studies have reported that microRNA (miRNA) dysregulation is frequently observed in various types of human cancers, including melanoma. Abnormally expressed miRNAs play an important ro...

journal_title：Oncology reports

authors： Kang K,Zhang J,Zhang X,Chen Z

更新日期：2018-01-01 00:00:00

abstract：:Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal...

journal_title：Oncology reports

authors： Li S,Wang C,Yu X,Wu H,Hu J,Wang S,Ye Z

更新日期：2017-01-01 00:00:00

abstract：:Although improvements in the chemotherapy modalities for pancreatic cancer have been realized, pancreatic cancer remains one of the most lethal malignancies. New-generation cancer immunotherapy methods, such as blocking of the PD-1/PD-L1 pathway, are consistently being investigated to improve the survival of pancreati...

journal_title：Oncology reports

authors： Doi T,Ishikawa T,Okayama T,Oka K,Mizushima K,Yasuda T,Sakamoto N,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Naito Y,Itoh Y

更新日期：2017-03-01 00:00:00

abstract：:miR-95 has been revealed to be aberrantly expressed in multiple types of cancer and to regulate tumor development. Moreover, miR-95 has been revealed to be downregulated in gastric cancer. However, the detailed function of miR-95 in gastric cancer has remained largely unknown. In the present study, we found that miR-9...

journal_title：Oncology reports

authors： Zhang W,Sun J,Chen J,Xu C,Zhang L

更新日期：2019-02-01 00:00:00

abstract：:Primary and metastatic cancers that affect bones are frequently associated with severe and intractable pain. The mechanisms underlying the development of bone cancer pain are largely unknown. In the present study, we investigated whether inhibition of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to t...

journal_title：Oncology reports

authors： Cai J,Fang D,Liu XD,Li S,Ren J,Xing GG

更新日期：2015-03-01 00:00:00

abstract：:Improvements in detection, treatment and prognosis for patients with non-small cell lung cancer (NSCLC) depend on the molecular understanding of tumor development and progression. Using Affymetrix GeneChips comprising 59,620 elements, we determined the gene expression profiles of 89 NSCLC and 15 normal lung samples. W...

journal_title：Oncology reports

authors： Hofmann HS,Bartling B,Simm A,Murray R,Aziz N,Hansen G,Silber RE,Burdach S

更新日期：2006-09-01 00:00:00

abstract：:Digital subtraction imaging was compared to helical CT, DSA, and US angiography to assess its usefulness in the evaluation of vascularity in hepatocellular carcinoma (HCC). Digital subtraction imaging using Levovist as the contrast agent was performed in 41 patients with 43 nodules (22 men and 19 women, aged 50 to 83 ...

journal_title：Oncology reports

authors： Yamamoto K,Shiraki K,Deguchi M,Sugimoto K,Sakai T,Ohmori S,Murata K,Hashimoto A,Shimizu A,Okuda Y,Nakano T

更新日期：2002-07-01 00:00:00

abstract：:Expression of miR-365 has been reported to be downregulated in hepatocellular carcinoma (HCC). However, the biological function and underlying mechanism of miR-365 in HCC growth and metastasis remain unclear. The aim of the present study was to explore the role of miR-365 in HCC progression. We found that miR-365 expr...

journal_title：Oncology reports

authors： Liu Y,Zhang W,Liu S,Liu K,Ji B,Wang Y

更新日期：2017-03-01 00:00:00

abstract：:Metastasis-associated protein 1 (MTA1) is highly upregulated in cancer cells with metastatic potential; however, the molecular mechanism by which MTA1 increases the metastatic potential of cancer cells is far from clear. We characterized the functional consequences of MTA1 overexpression on p53-induced apoptosis of ca...

journal_title：Oncology reports

authors： Moon HE,Cheon H,Lee MS

更新日期：2007-11-01 00:00:00

abstract：:The aim of the present study was to identify potential prognostic microRNA (miRNA) biomarkers for colon adenocarcinoma (COAD) prognostic prediction using the dataset of The Cancer Genome Atlas (TCGA). The genome‑wide miRNA sequencing dataset and corresponding COAD clinical information were downloaded from TCGA. Progno...

journal_title：Oncology reports

authors： Wei HT,Guo EN,Liao XW,Chen LS,Wang JL,Ni M,Liang C

更新日期：2018-10-01 00:00:00

abstract：:Lymph node metastases are responsible for shorter survival in oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the node metastasis frequency and survival according to the node metastasis features in 121 neck dissections (NDs) performed for OSCC, identifying evidence-based correlations an...

journal_title：Oncology reports

authors： Contaldo M,Di Napoli A,Pannone G,Franco R,Ionna F,Feola A,De Rosa A,Santoro A,Sbordone C,Longo F,Pasquali D,Loreto C,Ricciardiello F,Esposito G,D'Angelo L,Itro A,Bufo P,Tombolini V,Serpico R,Di Domenico M

更新日期：2013-12-01 00:00:00

abstract：:The occurrence of primary extraskeletal Ewing's sarcoma (EES) of the spinal epidural space has been rarely reported in the literature. The clinical, radiologic and pathologic features of a case of EES occurring in the thoracic epidural space are presented. A 37-year-old woman presented with a one-year history of back ...

journal_title：Oncology reports

authors： Yasuda T,Suzuki K,Kanamori M,Hori T,Huang D,Bridge JA,Kimura T

更新日期：2011-09-01 00:00:00

abstract：:The BRAF T1799A mutation is a heterozygous point mutation and its reported prevalence in papillary thyroid carcinoma (PTC) has varied from 29 to 83%, with an overall mean of 44%. In Korea, the reported mutation rate reached 83% in PTC and 52% in micropapillary carcinoma. We hypothesized that the differences in prevale...

journal_title：Oncology reports

authors： Kim HS,Kim JO,Lee DH,Lee HC,Kim HJ,Kim JH,Jang YS,Lee JM,Kim SY,Kim YS

更新日期：2011-06-01 00:00:00

abstract：:We investigated the role of mitochondrial function in the invasiveness of human colorectal cancer (CRC) cell lines, using paired primary SW480 and metastatic SW620 cells, and appraised the clinical relevance of the alteration of mtDNA copy number in 33 pairs of CRC specimens after surgical resection. Suppression of mi...

journal_title：Oncology reports

authors： Lin CS,Liu LT,Ou LH,Pan SC,Lin CI,Wei YH

更新日期：2018-01-01 00:00:00