Abstract:
:The occurrence of primary extraskeletal Ewing's sarcoma (EES) of the spinal epidural space has been rarely reported in the literature. The clinical, radiologic and pathologic features of a case of EES occurring in the thoracic epidural space are presented. A 37-year-old woman presented with a one-year history of back pain. Magnetic resonance imaging demonstrated an epidural mass at the T8-9 level. Laminectomy and partial resection of the tumor were performed. The differential diagnosis of a spinal epidural mass is broad. Histopathological and molecular cytogenetic examinations confirmed an EES arising from the thoracic epidural space. Despite receiving both chemotherapy and radiotherapy, the patient died of respiratory insufficiency due to medulla oblongata metastasis 22 months after the initial consultation. Awareness of this entity will allow this rare diagnosis to be considered and facilitate appropriate management. A review of the literature on spinal epidural EES is also presented.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Yasuda T,Suzuki K,Kanamori M,Hori T,Huang D,Bridge JA,Kimura Tdoi
10.3892/or.2011.1326subject
Has Abstractpub_date
2011-09-01 00:00:00pages
711-5issue
3eissn
1021-335Xissn
1791-2431journal_volume
26pub_type
杂志文章,评审相关文献
ONCOLOGY REPORTS文献大全abstract::Accumulating evidence has shown that aberrantly expressed microRNAs (miRNAs) are associated with tumor development and progression. Our previous study found that microRNA-375 (miR-375) was downregulated in colorectal cancer (CRC), but little is known concerning the role of miR-375 and the related mechanism in CRC deve...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4834
更新日期:2016-07-01 00:00:00
abstract::MicroRNAs (miRNAs) play an important role in the genesis and development of gastric cancer. In the present study, we determined whether miRNA-135a-5p expression was increased in gastric cancer compared with adjacent non-tumor tissues using 20 pairs of gastric cancer and para-carcinoma tissue samples which were assesse...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3546
更新日期:2014-12-01 00:00:00
abstract::Human glioblastoma is a malignant and aggressive primary human brain solid tumor characterized by severe hypoxia. Hypoxia can induce autophagy, which may result in chemoresistance and malignant progression of cancer cells. MicroRNAs (miRNAs) have been reported to modulate hypoxia‑induced autophagy in various types of ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6929
更新日期:2019-03-01 00:00:00
abstract::The modifying effect of dietary tuna (Thunnus thynnus orientalis) orbital oil rich in docosahexaenoic acid (DHA) and vitamin D3 (VD3) on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) was investigated in male F344 rats. Animals were given three weekly subcutaneous injections of AOM (15...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.7.5.1069
更新日期:2000-09-01 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) is an oncogene that promotes cell survival, proliferation, and motility. In the present study, we explored the mechanism involved in the inhibition by epigallocatechin-3-gallate (EGCG) of STAT3 signaling as detected by surface plasmon resonance (SPR)-binding a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2743
更新日期:2013-12-01 00:00:00
abstract::It has been recently reported that side population (SP) cells in nasopharyngeal carcinoma (NPC) cell lines display characteristics of cancer stem-like cells. However, the biological behavior and the significance of these cells for NPC progression remain unclear. In this study, we is...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1781
更新日期:2012-07-01 00:00:00
abstract::We studied the role of chemotherapy in cancer cachexia, which is well known to lower QOL and responsiveness to chemotherapy. In BALB/c mice we used two clones derived from the murine colon 26 adenocarcinoma cell line; clone 5, a non-cachexigenic tumor and clone 20, a cachexigenic tumor, in which IL-6 mRNA was selectiv...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-07-01 00:00:00
abstract::Arginine is a critical amino acid in specific cancer types including hepatocellular carcinoma (HCC) and melanoma. Novel molecular mechanisms and therapeutic targets in arginine metabolism-mediated cancer formation await further identification. Our laboratory has previously demonstrated that arginine metabolic enzyme a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5334
更新日期:2017-02-01 00:00:00
abstract::The aim of this study was to assess the ability of a new magnetic resonance (MR) angiography technique that does not use contrast enhancement medium to depict the vascularity of musculoskeletal neoplasms, and evaluate its clinical utility. We performed 3D fresh blood imaging (FBI) MR angiography in 57 patients with bo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::Ligularia fischeri (LF) has been used as an edible herb and traditional medicine for the treatment of inflammatory and infectious diseases. In the present study, we report the effects and molecular mechanism of the ethanolic extract of LF on cell proliferation, invasion and tube formation in human umbilical vein endot...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4000
更新日期:2015-07-01 00:00:00
abstract::KIAA1199 is a gene included in the Human Unidentified Gene-Encoded (HUGE) large protein database which contains more than 2,400 members identified in the Kazusa cDNA sequencing project. Early studies described KIAA1199 as an inner ear-specific protein in which 3 point mutations were found to be associated with non‑syn...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2014.3038
更新日期:2014-04-01 00:00:00
abstract::Prostate cancer (PCa) is the second most common type of male malignancy worldwide. The transcription factor zinc finger E‑box binding homeobox 1 (ZEB1) is associated with epithelial‑mesenchymal transition and is also involved in regulation of androgen receptor (AR) expression, the main ligands of which are testosteron...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6885
更新日期:2019-02-01 00:00:00
abstract::Targeted gene therapy needs to be implemented for future therapies to ensure efficient activity at the site of patient primary tumors or metastases without causing intolerable side-effects. One of the elements of gene therapy is vector, which includes viral and non-viral vector. In the present study, we constructed a ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3486
更新日期:2014-12-01 00:00:00
abstract::Burkitt's lymphoma (BL) is a fast growing cancer of the human lymphatic system, and an extremely invasive B-cell non-Hodgkin's lymphoma. We explored the mechanism of apoptosis in Raji cells associated with the post-transcriptional regulation factors. To confirm that the predicted microRNA-520a (miR-520a) is matched wi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4975
更新日期:2016-09-01 00:00:00
abstract::The Houttuynia cordata Thunb (HCT) extract has been used as a traditional Chinese herb medicine and as well as an effective drug for treating allergic inflammation for thousands of years. In this study, we investigated the anti-cancer activity of HCT and its molecular mechanisms in the human colon adenocarcinoma cell ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000535
更新日期:2009-11-01 00:00:00
abstract::Ubiquitin specific protease 22 (USP22) is an oncogene that is upregulated in many cancer types, and aberrant expression of USP22 correlates with clinical outcome. However, its potential functional impact in epithelial ovarian cancer (EOC) has not been determined. Here, we report that USP22 was upregulated in EOC speci...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3580
更新日期:2015-01-01 00:00:00
abstract::Sedum sarmentosum Bunge, a traditional Chinese herbal medicine, has a wide range of clinical applications including antibiosis, anti-inflammation and anti-oxidation. In the present study, we identified that its extract (SSBE) exerts pancreatic anticancer activity in vitro and in vivo. In the cultured pancreatic cancer...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4679
更新日期:2016-05-01 00:00:00
abstract::The aim of the present study was to uncover potential prognostic microRNA (miRNA) markers in head and neck squamous cell carcinoma (HNSCC). miRNA expression profile and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. Survival analysis was conducted by Kaplan-Meier method. Then, candidate prog...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4698
更新日期:2016-06-01 00:00:00
abstract::The S100A2 gene has been reported to be a putative tumor‑suppressor gene. Nevertheless, overexpression of S100A2 has been found in certain types of cancer. This study investigated S100A2 expression in tissue specimens of gastritis, intestinal metaplasia, adenomatous dysplasia and ga...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2236
更新日期:2013-04-01 00:00:00
abstract::Gastric cancer (GC) is one of the most lethal malignancies worldwide. To reduce its high mortality, sensitive and specific biomarkers for early detection are urgently needed. Recent studies have reported that tumor-specific long non-coding RNAs (lncRNAs) seem to be potential biomarkers for the early diagnosis and trea...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4531
更新日期:2016-03-01 00:00:00
abstract::Recently, emerging evidence shows that a number of long non‑coding RNAs (lncRNAs) recruit polycomb group (PcG) proteins to specific chromatin loci to silence relevant gene expression. In the present study, we provided evidence that lncRNA candidates, selected by bioinformatic analysis and nervous system polycomb 1 (NS...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7000
更新日期:2019-04-01 00:00:00
abstract::Colon cancer is the main cause of cancer mortality worldwide. Its poor prognosis is mainly ascribed to high recurrence rates. Identifying novel prognostic biomarkers and therapeutic key points for management is crucial and important. Long non-coding RNAs (lncRNAs) are a class of RNAs, which have various roles in carci...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6412
更新日期:2018-07-01 00:00:00
abstract::The challenging possibility of selectively inducing mitotic death in tumor cells by combining genotoxic agents with the inhibition of G2 checkpoints of the cell cycle is the subject of intensive investigation. We show that very low concentrations (3.5 and 5 nM) of okadaic acid induce mitotic death in two glioblastoma ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-02-01 00:00:00
abstract::We investigated the effects of quercetin on 7,12-dimethylbenz(a)anthracene (DMBA)-induced oxidative stress and the expression of CYP1A1 and CYP1B1 in mice. Quercetin was administered orally to mice at 100 or 250 mg/kg BW for 18 days, after which DMBA (34 mg/kg BW) was administered intragastrically twice. Quercetin sho...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1753
更新日期:2012-07-01 00:00:00
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promise for cancer therapy due to its unique capacity to selectively trigger apoptosis in cancer cells. However, TRAIL therapy is greatly hampered by its resistance. A preclinical successful strategy is to identify combination treatments that sensit...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4666
更新日期:2016-05-01 00:00:00
abstract::Cellular senescence is a state of irreversible growth arrest that can be triggered by multiple mechanisms, including telomere shortening, the epigenetic derepression of the INK4α/ARF locus and DNA damage. Senescence has been considered a tumor‑suppressing mechanism that permanently arrests cells at risk for malignant ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4473
更新日期:2016-02-01 00:00:00
abstract::At present, acute promyelocytic leukemia (APL) is the most curable form of acute myeloid leukemia and can be treated using all-trans retinoic acid and arsenic trioxide. However, the current treatment of APL is associated with some issues such as drug toxicity, resistance and relapse. Therefore, other strategies are ne...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6513
更新日期:2018-08-01 00:00:00
abstract::We have previously demonstrated that gastric and intestinal endocrine cell (End-cell) marker expression is important for assessment of the histogenesis of endocrine cell tumors. However, the End-cell phenotypes of carcinoid tumors in the rectum remain largely unclear. We therefore examined marker expression of rectal ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Correlation between inhibition of cell motility and anti-invasive activity by the water extract of HangAmDan-B (HAD-B), a crude extract of eight Korean medicinal animals and plants, in NCI-H460 human non-small cell lung cancer (NSCLC) cells was investigated. Within the concentration...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1440
更新日期:2011-12-01 00:00:00
abstract::Flavonoids exhibit chemopreventive and chemotherapeutic effects. Butein, a bioactive flavonoid isolated from numerous native plants, has been shown to induce apoptosis in human cancer cells. In the current study, the molecular mechanisms of butein action on cell proliferation and apoptosis of neuroblastoma cells were ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1632
更新日期:2012-04-01 00:00:00