Anti-hepatoma activities of ethyl acetate extract from Ampelopsis sinica root.

abstract：:Single nucleotide polymorphisms (SNPs) in the p53, MDM2 and p21 genes of the p53 pathway have been extensively studied. The main aim of the current retrospective study was to evaluate the possible predictive value of SNPs in the p53 pathway in locoregionally advanced nasopharyngeal carcinoma (NPC) in response to radio...

journal_title：Oncology reports

authors： Xie X,Jin H,Hu J,Zeng Y,Zhou J,Ouyang S,Yang W,Hu B,Wang H

更新日期：2014-01-01 00:00:00

abstract：:There has been increasing evidence that numerous bioactive dietary agents can hamper the process of carcinogenesis by targeting epigenetic alterations including DNA methylation. This therapeutic approach is considered as a significant goal for cancer therapy due to the reversible nature of epigenetic-mediated gene sil...

journal_title：Oncology reports

authors： Khan MA,Hussain A,Sundaram MK,Alalami U,Gunasekera D,Ramesh L,Hamza A,Quraishi U

更新日期：2015-04-01 00:00:00

abstract：:The nitrostyrene scaffold was previously identified as a lead target structure for the development of effective compounds targeting Burkitt's lymphoma. The present study aimed to develop these compounds further in haematological malignancies, including chronic lymphocytic leukaemia (CLL). Cellular viability, flow cyto...

journal_title：Oncology reports

authors： Bright SA,Byrne AJ,Vandenberghe E,Browne PV,Mcelligott AM,Meegan MJ,Williams DC

更新日期：2019-05-01 00:00:00

abstract：:Epigenetic anticancer drugs such as histone deacetylase (HDAC) inhibitors have been combined with existing anticancer drugs for synergistic or additive effects. In the present study, we found that a very low concentration of depsipeptide, an HDAC inhibitor, potentiated the antitumor activity of 5-fluorouracil (5-FU) i...

journal_title：Oncology reports

authors： Okada K,Hakata S,Terashima J,Gamou T,Habano W,Ozawa S

更新日期：2016-10-01 00:00:00

abstract：:Antineoplastons are naturally occurring peptides and amino acid derivatives found in human blood and urine. antineoplastons have been shown to control neoplastic growth. In the present study, we investigated demethylation effect of the antineoplaston AS2-1 (a mixture of phenylacetylglutamine and phenylacetate in the r...

journal_title：Oncology reports

authors： Ushijima M,Ogata Y,Tsuda H,Akagi Y,Matono K,Shirouzu K

更新日期：2014-01-01 00:00:00

abstract：:Primarily through in vitro studies, the Rho-family of small GTPases and their effector proteins have been implicated in mediating oncogenic properties of cancer cells. We sought to determine if pharmacological inhibition of the RhoA effector proteins known as Rho-kinases (ROCK) with the small molecule inhibitor Y-2763...

journal_title：Oncology reports

authors： Routhier A,Astuccio M,Lahey D,Monfredo N,Johnson A,Callahan W,Partington A,Fellows K,Ouellette L,Zhidro S,Goodrow C,Smith A,Sullivan K,Simone P,Le L,Vezuli B,Zohni M,West E,Gleason D,Bryan B

更新日期：2010-03-01 00:00:00

abstract：:Phosphoinositide‑dependent kinase 1 (PDK1) is generally active in multiple myeloma (MM) and higher expression than other hematopoietic cells, which is associated with the drug resistance and the disease progression. Previous studies have demonstrated that PDK1 can be targeted therapeutically in MM. In the present stud...

journal_title：Oncology reports

authors： Zhang J,Yang C,Zhou F,Chen X

更新日期：2018-06-01 00:00:00

abstract：:Primary and metastatic cancers that affect bones are frequently associated with severe and intractable pain. The mechanisms underlying the development of bone cancer pain are largely unknown. In the present study, we investigated whether inhibition of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to t...

journal_title：Oncology reports

authors： Cai J,Fang D,Liu XD,Li S,Ren J,Xing GG

更新日期：2015-03-01 00:00:00

abstract：:Codonolactone (CLT), a natural product, is the major bioactive component of Atractylodes lancea, and also found in a range of other medical herbs, such as Codonopsis pilosula, Chloranthus henryi Hemsl and Atractylodes macrocephala Koidz. This sesquiterpene lactone has been demonstrated to exhibit a range of activities...

journal_title：Oncology reports

authors： Fu J,Ke X,Tan S,Liu T,Wang S,Ma J,Lu H

更新日期：2016-01-01 00:00:00

abstract：:In this study, we demonstrate an important role of activation of the hypoxia-inducible factor-1 (HIF-1) pathway in endometrial carcinogenesis and tumor phenotype development of endometrial carcinoma, and suggest a unique role of the HIF-1-target gene, differentiated embryo chondrocyte 2 (DEC2), in carcinogenesis. Hypo...

journal_title：Oncology reports

authors： Yunokawa M,Tanimoto K,Nakamura H,Nagai N,Kudo Y,Kawamoto T,Kato Y,Hiyama E,Hiyama K,Nishiyama M

更新日期：2007-04-01 00:00:00

abstract：:Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation and histone modification markers. Changes in the epigenome significantly contribute to the initiation and progression of cancer. The goal of the present s...

journal_title：Oncology reports

authors： Kamińska K,Białkowska A,Kowalewski J,Huang S,Lewandowska MA

更新日期：2019-07-01 00:00:00

abstract：:Casein kinase 2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is involved in regulating many processes such as cell proliferation, differentiation and apoptosis. CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma. In the present study, we found that...

journal_title：Oncology reports

authors： Zhu X,Ouyang Y,Zhong F,Wang Q,Ding L,Zhang P,Chen L,Liu H,He S

更新日期：2017-01-01 00:00:00

abstract：:Store‑operated calcium entry (SOCE) is critical for regulating the proliferation and metastasis of various cancer types. The present study aimed to investigate the role of SOCE on nicotine‑promoted proliferation of non‑small cell lung cancer (NSCLC) A549 cells. Cell proliferation was evaluated by BrdU incorporation as...

journal_title：Oncology reports

authors： Wang Y,He J,Jiang H,Zhang Q,Yang H,Xu X,Zhang C,Xu C,Wang J,Lu W

更新日期：2018-10-01 00:00:00

abstract：:The clinicopathological significance of cell-cycle proteins has remained unclear in oral tongue squamous cell carcinomas (OTSCC). In the current study, we evaluated several cell-cycle proteins in relation to clinicopathological parameters and disease outcome for OTSCC. A total of 123 previously untreated patients with...

journal_title：Oncology reports

authors： Goto M,Tsukamoto T,Inada K,Mizoshita T,Ogawa T,Terada A,Hyodo I,Shimozato K,Hasegawa Y,Tatematsu M

更新日期：2005-10-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) and estrogen receptor (ER) belong to a family of nuclear hormone receptors that have been demonstrated to affect each other's transcriptional activity. At present, little is known regarding the effect of PPARγ on ER-mediated transcriptional activity in endometrial c...

journal_title：Oncology reports

authors： Zhang G,Hou X,Gao S

更新日期：2015-03-01 00:00:00

abstract：:Numerous human chemoprevention studies have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) possess chemopreventive effects against a variety of malignant tumors. However, there have been many clinical studies on aspirin, but not ibuprofen, even though ibuprofen is one of the most clinically and safel...

journal_title：Oncology reports

authors： Todo M,Horinaka M,Tomosugi M,Tanaka R,Ikawa H,Sowa Y,Ishikawa H,Fujiwara H,Otsuji E,Sakai T

更新日期：2013-11-01 00:00:00

abstract：:Lymph node metastases are responsible for shorter survival in oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the node metastasis frequency and survival according to the node metastasis features in 121 neck dissections (NDs) performed for OSCC, identifying evidence-based correlations an...

journal_title：Oncology reports

authors： Contaldo M,Di Napoli A,Pannone G,Franco R,Ionna F,Feola A,De Rosa A,Santoro A,Sbordone C,Longo F,Pasquali D,Loreto C,Ricciardiello F,Esposito G,D'Angelo L,Itro A,Bufo P,Tombolini V,Serpico R,Di Domenico M

更新日期：2013-12-01 00:00:00

abstract：:OCT4B1, a splice variant of OCT4, is a key regulator in maintaining the properties of pluripotency and self-renewal in embryonic stem (ES) cells. Recent results have shown that OCT4B1 is involved in tumorigenesis. However, the contribution of OCT4B1 in the tumorigenesis and drug resistance of colon cancer remains to b...

journal_title：Oncology reports

authors： Wen KM,Zhang GH,Li J,Chen ZQ,Cheng YL,Su X,Zeng QL

更新日期：2015-12-01 00:00:00

abstract：:Astilbin exhibits several pharmacological activities, including hypoglycemic, anti-oxidant and anti-inflammatory properties. The aim of the present study was to investigate the pro-apoptotic activities of astilbin on breast cancer in cells and mice. It was demonstrated that astilbin significantly reduced the cell viab...

journal_title：Oncology reports

authors： Sun X,Zhang H,Zhang Y,Yang Q,Zhao S

更新日期：2018-10-01 00:00:00

abstract：:Berbamine is an herbal compound derived from Berberis amurensis, which is used in Chinese traditional medicine. However, few studies have investigated this anti-tumor effect or the underlying mechanisms of berbamine on lymphoma cells. We investigate the effect, as well as the mechanism of action, of 4-chlorobenzoyl be...

journal_title：Oncology reports

authors： Du HP,Shen JK,Yang M,Wang YQ,Yuan XQ,Ma QL,Jin J

更新日期：2010-03-01 00:00:00

abstract：:Cetuximab, an IgG1 monoclonal antibody against the epidermal growth factor receptor (EGFR), is widely used for the treatment of metastatic colorectal cancer (mCRC). One of the mechanisms of action is considered to be antibody-dependent cell-mediated cytotoxicity (ADCC) triggered by Fcγ-R on natural killer cells. Howev...

journal_title：Oncology reports

authors： Seo Y,Ishii Y,Ochiai H,Fukuda K,Akimoto S,Hayashida T,Okabayashi K,Tsuruta M,Hasegawa H,Kitagawa Y

更新日期：2014-05-01 00:00:00

abstract：:Protocadherin-10 (PCDH10), a member of non-clustered protocadherin family which plays important roles in calcium-dependent cell-cell signal transduction and adhesion. PCDH10 functions as a tumor suppressor gene and its expression is downregulated by promoter methylation in many malignances. In the present study, we ex...

journal_title：Oncology reports

authors： Qiu C,Bu X,Jiang Z

更新日期：2016-07-01 00:00:00

abstract：:We conducted a clinical pharmacological evaluation of paclitaxel/carboplatin combination in Japanese patients with non-small cell lung cancer. The purpose of this study was to identify the optimal dose of this combination and to investigate the relationships between the pharmacokinetic profiles of these 2 drugs, serum...

journal_title：Oncology reports

authors： Daga H,Isobe T,Miyazaki M,Fujitaka K,Kondo K,Kohno N

更新日期：2004-06-01 00:00:00

abstract：:Hypoxic tumor cells are known to be more resistant to conventional chemotherapy and radiation than normoxic cells. However, the effects of 2-methoxyestradiol (2-ME), an anti-angiogenic, antiproliferative and pro-apoptotic drug, on hypoxic lung cancer cells are unknown. The aim of the present study was to compare the e...

journal_title：Oncology reports

authors： Aquino-Gálvez A,González-Ávila G,Delgado-Tello J,Castillejos-López M,Mendoza-Milla C,Zúñiga J,Checa M,Maldonado-Martínez HA,Trinidad-López A,Cisneros J,Torres-Espíndola LM,Hernández-Jiménez C,Sommer B,Cabello-Gutiérrez C,Guti

更新日期：2016-01-01 00:00:00

abstract：:Orofacial viral infections are common in immunocompromised patients. Herpes simplex virus (HSV) infections are the most common. Varicella-Zoster virus (VZV) infections are less common, but usually more severe. Epstein-Barr virus (EBV) may produce ulcers, lymphoproliferative syndromes or oral hairy leukoplakia (HL). Hu...

journal_title：Oncology reports

authors： Samonis G,Mantadakis E,Maraki S

更新日期：2000-11-01 00:00:00

abstract：:The aim of this study was to define the clinical implications of semi-quantitative telomerase activity in gynecological tumors by comparing the telomerase activity of cancerous lesion and the adjacent non-cancerous lesion. In 118 cases of gynecologic tumors, including 41 uterine cervical tumors, 43 uterine body tumors...

journal_title：Oncology reports

authors： Sakamoto M,Toyoizumi T,Kikuchi Y,Okamoto A,Nakayama H,Aoki D,Yamamoto K,Hata H,Sugishita T,Tenjin Y

更新日期：2000-09-01 00:00:00

abstract：:Mutations in the epidermal growth factor receptor (EGFR) make lung adenocarcinoma cells sensitive to EGFR tyrosine kinase inhibitors (TKIs). Long-term cancer therapy may cause the occurrence of acquired resistance to EGFR TKIs. Long non-coding RNAs (lncRNAs) play important roles in tumor formation, tumor metastasis an...

journal_title：Oncology reports

authors： Wu Y,Yu DD,Hu Y,Yan D,Chen X,Cao HX,Yu SR,Wang Z,Feng JF

更新日期：2016-06-01 00:00:00

abstract：:Medulloblastoma is the most common malignant tumor of the central nervous system in children. The insulin-like growth factor-I receptor (IGF-IR) is an important growth factor for medulloblastoma. The novel IGF-I receptor (IGF-IR) kinase inhibitor NVP-ADW742 has in vitro activity against tumors. Daoy cells were treated...

journal_title：Oncology reports

authors： Zhou H,Rao J,Lin J,Yin B,Sheng H,Lin F,Zhang N,Yang L

更新日期：2011-06-01 00:00:00

abstract：:Mechanisms of synergistic effect of thermotherapy and chemotherapy on human lung adenocarcinoma cell growth are unclear. The purpose of this study was to investigate these effects and explore the function of ROS, Akt and caspase-3 in relation to these. A549 cells were subjected to different thermochemotherapy treatmen...

journal_title：Oncology reports

authors： Wang L,Liu X,Wu Y,Wu W,Wu Y

更新日期：2012-10-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor, which was confirmed as a tumor suppressor gene in colorectal cancers. KLF4 inhibits colorectal cancer cells proliferation through upregulating p21WAF1/Cip1 and downregulating cyclin D1. We firstly reported that N-Myc downstream regulated gene 2 (NDRG2...

journal_title：Oncology reports

authors： Ma Y,Wu L,Liu X,Xu Y,Shi W,Liang Y,Yao L,Zheng J,Zhang J

更新日期：2017-08-01 00:00:00