Abstract:
:The nitrostyrene scaffold was previously identified as a lead target structure for the development of effective compounds targeting Burkitt's lymphoma. The present study aimed to develop these compounds further in haematological malignancies, including chronic lymphocytic leukaemia (CLL). Cellular viability, flow cytometry and lactate dehydrogenase assays, amongst others, were used to examine the effects of nitrostyrene compounds on CLL cells, including a cell line representing disease with poor prognosis (HG‑3) and in ex vivo CLL patient samples (n=14). The results demonstrated that two representative nitrostyrene compounds potently induced apoptosis in CLL cells. The pro‑apoptotic effects of the compounds were found to be reactive oxygen species and caspase‑dependent, and had minimal effects on the viability of normal donor peripheral blood mononuclear cells. Nitrostyrene compounds exhibited synergistic augmentation of apoptosis when combined with the phosphatidylinositol 3‑kinase inhibitor idelalisib and demonstrated potent toxicity in ex vivo CLL cells, including those co‑cultured with bone marrow stromal cells, making them more resistant to apoptosis (n=8). These compounds also demonstrated activity in samples from patients with poor prognostic indicators; unmutated immunoglobulin heavy chain genes, expression of CD38 and deletions in chromosomes 17p and 11q. These results suggest that this class of pharmaceutically active compounds offer potential in the treatment of CLL.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Bright SA,Byrne AJ,Vandenberghe E,Browne PV,Mcelligott AM,Meegan MJ,Williams DCdoi
10.3892/or.2019.7068subject
Has Abstractpub_date
2019-05-01 00:00:00pages
3127-3136issue
5eissn
1021-335Xissn
1791-2431journal_volume
41pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Prostate cancer antigen 3 (PCA3) is a non-coding RNA fragment that is overexpressed in prostate cancer cells. However, the clinical applications of PCA3 are highly limited due to the instability of RNA and the lack of reliable and efficient RNA extraction and purification methods. Thus, in the present study, we compar...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4266
更新日期:2015-11-01 00:00:00
abstract::Phosphoinositide‑dependent kinase 1 (PDK1) is generally active in multiple myeloma (MM) and higher expression than other hematopoietic cells, which is associated with the drug resistance and the disease progression. Previous studies have demonstrated that PDK1 can be targeted therapeutically in MM. In the present stud...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6369
更新日期:2018-06-01 00:00:00
abstract::Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in several types of cancers. In non-small cell lung cancer (NSCLC), several genes are known to be frequently methylated and the correlation of their methylation with clinical features has been stud...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract::Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::Following the publication of this paper, it was drawn to the authors' attention by an interested reader that certain of the tumours featured in Fig. 6A of the above paper were strikingly similar to those featured in Fig. 8A of an article appearing in International Journal of Oncology (Fan F-Y, Deng R, Yi H, Sun H-P, Z...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7828
更新日期:2021-01-01 00:00:00
abstract::EVL belongs to the Ena/VASP (Enabled/vasodilator-stimulated phosphoprotein) family of proteins [Mena (mammalian Ena), VASP and EVL], which have a range of roles in regulating the actin cytoskeleton. Growing evidence suggests that Mena and VASP are involved in carcinogenesis, though little is known about the significan...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::Chronic myelogenous leukemia (CML) has a typical progressive course with transition from a chronic phase to a terminal blast crisis phase. However, the mechanisms that lead to disease progression remain unclear. Bone marrow mesenchymal stem cells (BMMSCs) play important roles in maintaining the bone marrow microenviro...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2518
更新日期:2013-08-01 00:00:00
abstract::It has been shown that overexpression of signal transducer and activator of transcription 3 (Stat3) contribute to the progression and metastasis of various solid tumors and that silencing Stat3 inhibits tumor growth in several types of cancer. Gene associated with retinoid-IFN-induced mortality 19 (GRIM-19), a Stat3-i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3233
更新日期:2014-08-01 00:00:00
abstract::We have investigated Lf immunoexpression as well as its biological meaning in 71 formalin-fixed, paraffin-embedded surgical samples of endometrial carcinomas (EC); 64 EC were endometrioid type, whereas 7 were non-endometrioid carcinomas. Immunohistochemistry was performed by primary antibodies against Lactoferrin (Lf)...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract::Gastric cancer (GC), a type of gastric mucosal epithelium disease caused by common malignant tumors, has become a major threat to human health and survival. Tumor necrosis factor‑α‑induced protein‑8 like‑2 (TIPE2) is a negative immune regulatory factor that is selectively expressed in immune organs, immune cells and v...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6576
更新日期:2018-09-01 00:00:00
abstract::A growing body of evidence suggests that microRNA-365 (miR-365) played crucial role in the initiation and development of many types of cancers. However, the biological role of miR-365 in human glioma remains unclear. Herein, the aims of this study were to investigate the role and underlying mechanisms of miR-365 in gl...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5458
更新日期:2017-04-01 00:00:00
abstract::Hepatocellular carcinoma is the most common type of liver cancer. The risk of hepatocellular carcinoma for type 2 diabetic patients is greater than that for non-diabetic individuals although the mechanism is unclear. The cancer suppressor resveratrol inhibits cancer cell proliferation partly through the STAT3 signalin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2748
更新日期:2013-12-01 00:00:00
abstract::Frequent frameshift mutations in the DNA mismatch repair genes hMSH3, and hMSH6, have been reported in colorectal and endometrial cancers with microsatellite instability, however, it is unclear whether they are similarly altered in ovarian endometrioid carcinoma. In this study, we examined frequency of frameshift muta...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::Dendritic cell-mediated cancer immunotherapy employs several ways to engage tumor antigens. We have demonstrated in both pre-clinical animal studies and early clinical trials that dendritomas, highly purified hybrids between dendritic cells (DC) and tumor cells, are superior activators of anti-tumor immunity. It has b...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2010-02-01 00:00:00
abstract::The present study investigated the expression and potential influence of SHC SH2 domain‑binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell proliferation and cell cycle progression, but its role in GC remains unclear. The TCGA database revealed that SHCBP1 is highly expressed in ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6952
更新日期:2019-03-01 00:00:00
abstract::High-density single nucleotide polymorphism (SNP) array is a recently introduced technology that genotypes more than 10,000 human SNPs on a single array. It has been shown that SNP arrays can be used to determine not only SNP genotype calls, but also DNA copy number (DCN) aberrations, which are common in solid tumors....
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.15.4.1057
更新日期:2006-01-01 00:00:00
abstract::Despite improvements in immunotherapy, little is known about dendritic cell (DC) subpopulations naturally occurring in the laryngeal cancer tissue (LCT) and peripheral blood (PB) of untreated laryngeal cancer (LC) patients. The purpose of the present study was to evaluate mature, im...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1754
更新日期:2012-07-01 00:00:00
abstract::Epidemiologic studies indicate the use of either statins or aspirin have beneficial effects in prostate cancer patients. The present study was undertaken to evaluate the effects and mechanisms of atorvastatin and aspirin alone or in combination in human prostate cancer cells cultured in vitro and grown as xenograft tu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5353
更新日期:2017-02-01 00:00:00
abstract::Soft tissue sarcomas are rare and aggressive tumors arising from connective tissues. Adjuvant radiotherapy is a commonly used treatment approach for the majority of sarcomas. We attempted to identify a gene signature that can predict radiosensitive patients who are most likely to have a better treatment response from ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5999
更新日期:2017-11-01 00:00:00
abstract::To elucidate the mechanism of resistance to 5-fluorouracil (5-FU) in human gastric cancer cells, we established a cell line MKN45/F2R, which acquired 5-FU resistance as a result of continuous exposure to increasing dosages of 5-FU over a year. The cell line showed 157-fold elevated 5-FU resistance compared to the MKN4...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-12-01 00:00:00
abstract::Prostate cancer (PCa) growth initially depends on circulating androgens. Gonadotropin-releasing hormone (GnRH) agonists are currently used for the treatment of PCa. However, after an initial responsiveness to hormonal deprivation, PCa progresses and metastasizes. Recently, also GnRH antagonists have been used for clin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.15.2.393
更新日期:2006-02-01 00:00:00
abstract::The clinicopathological significance of cell-cycle proteins has remained unclear in oral tongue squamous cell carcinomas (OTSCC). In the current study, we evaluated several cell-cycle proteins in relation to clinicopathological parameters and disease outcome for OTSCC. A total of 123 previously untreated patients with...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-10-01 00:00:00
abstract::To investigate the components of the prostaglandin biosynthetic pathway, the characteristics of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were examined for autopsied cases with small cell lung cancer (SCLC)...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract::The human homologue of Drosophila disc large tumor suppressor protein (hDlg) is one of the proteins known to act cooperatively in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. An abnormal expression of hDlg has been reported ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000678
更新日期:2010-03-01 00:00:00
abstract::MicroRNAs (miRNAs) have been shown to play an important role in diverse biological processes and cancer progression. The objective of the present study was to investigate the role of miR-497 in ovarian cancer angiogenesis. We found that miR-497 expression was downregulated in human ovarian cancer tissues, and the low ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3439
更新日期:2014-11-01 00:00:00
abstract::Different members of the Ets-family of transcription factors are involved in TMPRSS-2-Ets translocations frequently found in human prostate cancers. We previously reported that Ets-1, which is the prototype of Ets-family members, promotes both migration and invasion of melanoma, Hela and glioma cells. Here, we examine...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1156
更新日期:2011-04-01 00:00:00
abstract::Although the human telomerase reverse transcriptase (hTERT) promoter can regulate cancer-specific genes, it is generally too weak to be effective. We therefore attempted to improve the potency of synthetic hTERT promoters by fusing the core element (E) of the hTERT promoter (H) and the tripartite leader sequence (T) f...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract::Studies of tumor-infiltrating immune cells have revealed that immune escape plays an important role in tumor growth. The aim of the present study was to investigate the impact of metastasis affecting CD4+ T cell subsets in human clinical samples. Single-cell suspensions derived from tumor-draining lymph node (TDLN) an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4064
更新日期:2015-08-01 00:00:00
abstract::Normal breast development is controlled by a balance between cell proliferation and apoptosis. The balance between the two parameters is crucial for determining the growth or regression of breast tumours in response to therapies and treatments. Therefore, it is necessary to understand the role of apoptosis in tumour p...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::Genetically modified tumour cells producing cytokines such as interleukin 12 (IL-12) are potent activators of the antitumour immune responses and represent a promising therapeutic modality when combined with chemotherapy. The objective of this study was to examine whether IL-12-producing cellular vaccines can augment ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1221
更新日期:2011-06-01 00:00:00