The natural compound codonolactone attenuates TGF-β1-mediated epithelial-to-mesenchymal transition and motility of breast cancer cells.

abstract：:We compared effects of a high fat diet and a carcinogen on cellular elements of the spleen and mammary gland tumors in rats. Animals were fed a 15% olive-oil diet and a group of them were exposed to a carcinogen, dimethylbenz(a)anthacene (DMBA), in two doses of 10 mg/rat. Results of the experiments were evaluated afte...

journal_title：Oncology reports

authors： Kossoy G,Yarden G,Ben-Hur H,Kossoy N,Stark A,Madar Z,Zusman I

更新日期：2001-03-01 00:00:00

abstract：:Prostate cancer (PCa) remains a leading cause of mortality among men in the United States and Western Europe. The molecular mechanism of PCa pathogenesis has not been fully elucidated. In the present study, the expression profile of E2F transcription factor 7 (E2F7) in PCa was examined using immunohistochemistry and r...

journal_title：Oncology reports

authors： Wang Y,Pei X,Xu P,Tan Z,Zhu Z,Zhang G,Jiang Z,Deng Z

更新日期：2020-09-01 00:00:00

abstract：:Glucose‑6‑phosphate dehydrogenase (G6PD) is a cytoplasmic enzyme found in human erythrocytes that provides reduced NADPH for cell metabolism. Glutathione produced by the G6PD pathway can reduce the degree of harm caused by reactive oxygen species such as oxygen‑containing free radicals, peroxides and lipid peroxides. ...

journal_title：Oncology reports

authors： Li R,Wang W,Yang Y,Gu C

更新日期：2020-12-01 00:00:00

abstract：:Agaricus blazei is well known as a traditional medicinal mushroom and it has been shown to exhibit immunostimulatory and anti-cancer activity. However, the cellular and molecular mechanism of cell cycle arrest and apoptosis of cancer cells is poorly understood. In this study, we have investigated whether A. blazei ext...

journal_title：Oncology reports

authors： Jin CY,Choi YH,Moon DO,Park C,Park YM,Jeong SC,Heo MS,Lee TH,Lee JD,Kim GY

更新日期：2006-12-01 00:00:00

abstract：:The promigratory molecule L1CAM is overexpressed in various tumors, often representing an unfavorable prognostic marker. Recently, we identified L1CAM expression in pancreatic ductal adenocarcinoma (PDAC) cells accounting for chemoresistance and increased cell migration. Thus, the present study aims at further elucida...

journal_title：Oncology reports

authors： Bergmann F,Wandschneider F,Sipos B,Moldenhauer G,Schniewind B,Welsch T,Schirrmacher P,Klöppel G,Altevogt P,Schäfer H,Sebens Müerköster S

更新日期：2010-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present stud...

journal_title：Oncology reports

authors： Wu Y,Yao N,Feng Y,Tian Z,Yang Y,Zhao Y

更新日期：2019-09-01 00:00:00

abstract：:The present study aimed to identify novel histone modification markers in gastric cancer (GC) by chromatin immunoprecipitation microarray (ChIP-chip) analysis and to determine whether these markers were able to discriminate between normal and GC cells. We also tested for correlations with DNA methylation. We probed a ...

journal_title：Oncology reports

authors： Zhu X,Liu J,Xu X,Zhang C,Dai D

更新日期：2015-05-01 00:00:00

abstract：:We examined pathomorphologically small nodular lesions in hepatitis C virus-related cirrhosis (type C cirrhosis). Small nodular lesions seen in the non-cancerous areas of 128 consecutively resected hepatocellular carcinomas (HCCs) associated with type C cirrhosis were selected for the study. From these, 18 large regen...

journal_title：Oncology reports

authors： Miyaaki H,Fujimoto M,Kurogi M,Nakashima O,Eguchi K,Kojiro M

更新日期：2005-12-01 00:00:00

abstract：:Currently, various types of keratins have been reported to be highly expressed in cancer cells and to be associated with a malignant phenotype. In the present study, it was found that expression levels of keratin 6 (K6), keratin 16 (K16), and keratin 17 (K17) were highly elevated in SNU601 cells resistant to cisplatin...

journal_title：Oncology reports

authors： Lim SC,Parajuli KR,Han SI

更新日期：2019-08-01 00:00:00

abstract：:High mobility group N (HMGNs) are members of the high mobility group protein family, and are involved in the development and progression of several tumors. HMGN1 and HMGN5 were previously shown to be associated with the bioactivities of osteosarcoma. However, the effects and molecular mechanisms of HMGN2 on osteosarco...

journal_title：Oncology reports

authors： Liang G,Xu E,Yang C,Zhang C,Sheng X,Zhou X

更新日期：2015-03-01 00:00:00

abstract：:Prostate cancer (PCa) is the second most common type of male malignancy worldwide. The transcription factor zinc finger E‑box binding homeobox 1 (ZEB1) is associated with epithelial‑mesenchymal transition and is also involved in regulation of androgen receptor (AR) expression, the main ligands of which are testosteron...

journal_title：Oncology reports

authors： Herrera D,Orellana-Serradell O,Villar P,Torres MJ,Paciucci R,Castellón EA,Contreras HR

更新日期：2019-02-01 00:00:00

abstract：:Mitochondrial transcription factor A (TFAM), a high-mobility group (HMG) protein, plays a central role in mitochondrial DNA (mtDNA) replication, transcription and inheritance. It has been shown that TFAM is associated with tumorigenesis. However, little is known regarding the posttranscriptional regulation of TFAM in ...

journal_title：Oncology reports

authors： Jiang J,Yang J,Wang Z,Wu G,Liu F

更新日期：2013-11-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promise for cancer therapy due to its unique capacity to selectively trigger apoptosis in cancer cells. However, TRAIL therapy is greatly hampered by its resistance. A preclinical successful strategy is to identify combination treatments that sensit...

journal_title：Oncology reports

authors： Li L,Wen XZ,Bu ZD,Cheng XJ,Xing XF,Wang XH,Zhang LH,Guo T,Du H,Hu Y,Fan B,Ji JF

更新日期：2016-05-01 00:00:00

abstract：:HIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1alpha upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody spec...

journal_title：Oncology reports

authors： Palit V,Phillips RM,Puri R,Shah T,Bibby MC

更新日期：2005-10-01 00:00:00

abstract：:Recently, overexpression of EphA2, a member of the Eph family of receptor tyrosine kinases, has been reported in several cancers. Reduced expression of E-cadherin, an intercellular adhesion molecule of epithelial cells, has been reported to be associated with aggressive clinicopathological phenotypes in various cancer...

journal_title：Oncology reports

authors： Saito T,Masuda N,Miyazaki T,Kanoh K,Suzuki H,Shimura T,Asao T,Kuwano H

更新日期：2004-03-01 00:00:00

abstract：:It has been shown that overexpression of signal transducer and activator of transcription 3 (Stat3) contribute to the progression and metastasis of various solid tumors and that silencing Stat3 inhibits tumor growth in several types of cancer. Gene associated with retinoid-IFN-induced mortality 19 (GRIM-19), a Stat3-i...

journal_title：Oncology reports

authors： Wang GM,Ren ZX,Wang PS,Su C,Zhang WX,Liu ZG,Zhang L,Zhao XJ,Chen G

更新日期：2014-08-01 00:00:00

abstract：:The mechanisms leading to squamous cell carcinoma of head and neck (SCCHN) metastasis are not fully understood. Although evidence shows that the chemokine receptor 7 (CCR7) and its ligand CCL19 may regulate tumor dissemination, their role is not clearly defined in SCCHN. Matrix metalloproteinases break consisting of t...

journal_title：Oncology reports

authors： Guo N,Liu F,Yang L,Huang J,Ding X,Sun C

更新日期：2014-08-01 00:00:00

abstract：:Despite significant homology between IRS-1 and IRS-2, recent studies have revealed distinct functions for these adaptor proteins in regulating breast cancer progression. Thus far, most of the studies on breast cancer have focused upon IRS-1, the biological pattern of IRS-2 is limited. We demonstrated that depletion of...

journal_title：Oncology reports

authors： Wu S,Zhou B,Xu L,Sun H

更新日期：2010-12-01 00:00:00

abstract：:Inhibins are dimeric glycoproteins, composed of an α-subunit and one of two possible β-subunits (βA or βB), with substantial roles in human reproduction and in endocrine-responsive tumours. Recently a novel β subunit named βC was described, although it is still unclear if normal or cancerous cervical epithelial cells ...

journal_title：Oncology reports

authors： Blankenstein T,Jückstock J,Shabani N,Kunze S,Brüning A,Bergauer F,Mylonas I

更新日期：2011-01-01 00:00:00

abstract：:The present study evaluated activity and toxicity of modulated doses of gemcitabine associated to oxaliplatin in patients with secondary CIRS and with locally advanced pancreatic adenocarcinoma (LAPC) and metastatic pancreatic adenocarcinoma (MPC). Since January 2006, untreated LAPC and MPC patients have been assessed...

journal_title：Oncology reports

authors： Tudini M,Palluzzi E,Cannita K,Mancini M,Santomaggio A,Bruera G,Baldi PL,Pelliccione M,Ricevuto E,Ficorella C

更新日期：2012-02-01 00:00:00

abstract：:Triple-negative breast cancer is a highly aggressive type of mammalian carcinoma. It is defined by a rather weak expression of estrogen-, progesterone- and Her2-receptor, and is thus difficult to treat, resulting in low disease-free and overall survival rates of the affected patients. Hence it is important to find new...

journal_title：Oncology reports

authors： Andergassen U,Kölbl AC,Mumm JN,Mahner S,Jeschke U

更新日期：2017-05-01 00:00:00

abstract：:The aim of this study was to assess the anti-tumor effect and mechanisms of cimetidine in N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced bladder carcinogenesis model. Sixty-three male BALB/c mice and 67 male Wister rats were treated with BBN and cimetidine to examine the anti-tumor effect of cimetidine. Immunohi...

journal_title：Oncology reports

authors： Chihara Y,Fujimoto K,Miyake M,Hiasa Y,Hirao Y

更新日期：2009-07-01 00:00:00

abstract：:B7-H1 is a co-inhibitory molecule belonging to the B7 family. The B7-H1 protein is only expressed on macrophage lineage of cells in normal tissues, but is overexpressed in most types of tumor. The aberrant expression of cell surface B7-H1 on cancer cells is generally associated with high-risk prognostic factors. The t...

journal_title：Oncology reports

authors： Zhang C,Wang W,Qin X,Xu Y,Huang T,Hao Q,Li W,Wu S,Zhang Y

更新日期：2013-11-01 00:00:00

abstract：:Death-associated protein kinase (DAPK) plays an important role in apoptosis regulation and has been shown to maintain antitumor and metastasis suppressor properties. In the present study, we investigated whether DAPK overexpression may mediate vascular endothelial growth factor (VEGF)/hypoxia-inducible factor-1α (HIF-...

journal_title：Oncology reports

authors： Park ST,Kim BR,Park SH,Lee JH,Lee EJ,Lee SH,Rho SB

更新日期：2014-02-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) accounts for over 80% of all diagnosed lung cancer cases. Lung cancer is the leading cause of cancer‑related deaths worldwide. Most NSCLC cells overexpress vascular endothelial growth factor‑A (VEGF‑A) which plays a pivotal role in tumour angiogenesis. Anti‑angiogenic therapies inclu...

journal_title：Oncology reports

authors： Eguchi R,Wakabayashi I

更新日期：2020-07-01 00:00:00

abstract：:Angiogenesis is a key factor in the growth and dissemination of malignant diseases, including breast cancer, with significant implications for its clinical management. It is known that microRNAs (miRNAs) play important roles in regulating tumor properties in cancers. However, whether miR-497 contributes to breast canc...

journal_title：Oncology reports

authors： Wu Z,Cai X,Huang C,Xu J,Liu A

更新日期：2016-03-01 00:00:00

abstract：:The metastasis-associated (MTA) gene family is a critical component of the nucleosome remodeling and histone deacetylase complex, and plays an important role in metastatic processes. We systematically evaluated dysregulation of the MTA family to clarify their clinical significance in gastric cancer (GC). One hundred a...

journal_title：Oncology reports

authors： Okugawa Y,Mohri Y,Tanaka K,Kawamura M,Saigusa S,Toiyama Y,Ohi M,Inoue Y,Miki C,Kusunoki M

更新日期：2016-10-01 00:00:00

abstract：:Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addi...

journal_title：Oncology reports

authors： Gu Y,Wang J,Peng L

更新日期：2017-01-01 00:00:00

abstract：:Human chorionic gonadotropin β (β-hCG) is a well-known and accurate marker for the diagnosis and monitoring of pregnancy, trophoblastic tumors and ovarian germ cell tumors. Recently, β-hCG has been found to be closely related to poor prognosis and metastasis in various other malignant tumors, while its role and mechan...

journal_title：Oncology reports

authors： Liu N,Peng SM,Zhan GX,Yu J,Wu WM,Gao H,Li XF,Guo XQ

更新日期：2017-09-01 00:00:00

abstract：:Circulating tumor cells (CTCs) or CTC clusters are considered as suitable and relevant targets for liquid biopsy as they more accurately indicate cancer progression, the therapeutic effects of treatment and allows for monitoring of cancer metastasis in real‑time. Among the various methods for isolating CTCs, size‑base...

journal_title：Oncology reports

authors： Xiang A,Xue M,Ren F,Wang L,Ye Z,Li D,Ji Q,Ji G,Lu Z

更新日期：2020-06-01 00:00:00