Stimulation of peroxisome proliferator-activated receptor γ inhibits estrogen receptor α transcriptional activity in endometrial carcinoma cells.

abstract：:The restricted expression of Wilms tumor 1 (WT1) and cyclin A1 (CCNA1) in normal tissues, as opposed to their abnormal expression in leukemia demonstrates the applicability of WT1 and CCNA1 as cancer antigens for immunotherapy, and as markers for prognosis and relapse. In this study, the WT1 and CCNA1 mRNA levels were...

journal_title：Oncology reports

authors： Pandey S,Moazam M,Ghimirey N,Kuerbitz SJ,Fraizer GC

更新日期：2019-11-01 00:00:00

abstract：:EGFR, p27kip1 and Skp2, have been implicated in human cancer development. We have studied these molecules in a search for molecular markers that may have prognostic value in head and neck squamous cell carcinomas (HNSCC). Tissue samples of 62 patients were collected and immunohistochemical analysis was carried out for...

journal_title：Oncology reports

authors： Carracedo DG,Astudillo A,Rodrigo JP,Suarez C,Gonzalez MV

更新日期：2008-09-01 00:00:00

abstract：:Acquisition of resistance to paclitaxel is a major obstacle to successful treatment of breast cancer patients, but the molecular mechanisms underlying the development of drug resistance remain largely unclear. The aim of the present study was to investigate the role and mechanism of action of miR‑200c‑3p in the resist...

journal_title：Oncology reports

authors： Chen J,Tian W,He H,Chen F,Huang J,Wang X,Chen Z

更新日期：2018-12-01 00:00:00

abstract：:Exogenous overexpression of hRFI, originally isolated in our laboratory, inhibits not only death receptor-mediated apoptosis but also the mitochondrial apoptosis induced by several chemotherapeutic agents including 5-fluorouracil (5-FU). Recently, it has become clear that hRFI targets and degradates caspase-8 and -10 ...

journal_title：Oncology reports

authors： Sasaki S,Watanabe T,Kobunai T,Konishi T,Nagase H,Sugimoto Y,Oka T,Nagawa H

更新日期：2006-05-01 00:00:00

abstract：:ZNF703, a member of the NET/Nlz family of zinc finger transcription factors, contributes to aspects of developmental growth and patterning across evolutionarily diverse species. ZNF703 has been identified as a novel oncogene in human breast cancer. In the present study, we investigated the expression of ZNF703 in gast...

journal_title：Oncology reports

authors： Yang G,Ma F,Zhong M,Fang L,Peng Y,Xin X,Zhong J,Yuan F,Gu H,Zhu W,Zhang Y

更新日期：2014-04-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) signaling has been shown to play a critical role in the development of epithelial-mesenchymal transition (EMT). PAI-1 is one of the most important target genes in the TGF-β/Smad signaling pathway, which can hinder the degradation of ECM composition and may promote cell invasion a...

journal_title：Oncology reports

authors： Wang X,Liu C,Wang J,Fan Y,Wang Z,Wang Y

更新日期：2017-02-01 00:00:00

abstract：:B-cell‑specific Moloney murine leukaemia virus integration site-1 (BMI-1) contributes to the growth of tumour cells post-irradiation (IR). The aim of the present study was to characterize the effects of BMI-1 on cell viability, radiosensitivity and its mechanisms of action in oesophageal squamous cell cancer (ESCC). W...

journal_title：Oncology reports

authors： Yang XX,Ma M,Sang MX,Zhang XY,Liu ZK,Song H,Zhu SC

更新日期：2018-02-01 00:00:00

abstract：:Chromatin assembly factor 1 subunit B (CHAF1B) participates in DNA synthesis and repair. High CHAF1B expression has been associated with a poor prognosis in several types of cancers. However, no study has evaluated the clinical significance and biological function of CHAF1B in non‑small cell lung cancer (NSCLC). In th...

journal_title：Oncology reports

authors： Duan Y,Liu T,Li S,Huang M,Li X,Zhao H,Li J

更新日期：2019-04-01 00:00:00

abstract：:MicroRNA-17-5p has been proven upregulated in many human malignancies and correlated with tumor progression. However, its expression and clinical significance in osteosarcoma is still unclear. Thus, the aim of the present study was to explore the effects of miR-17-5p in osteosarcoma tumorigenesis and development. The ...

journal_title：Oncology reports

authors： Wang W,Zhang L,Zheng K,Zhang X

更新日期：2016-03-01 00:00:00

abstract：:The androgen receptor (AR) plays an essential role in the development and progression of prostate cancer. Castration-resistant prostate cancer (CRPC) is a consequence of androgen deprivation therapy. Unchecked CRPC followed by metastasis is lethal. Some CRPCs show decreased AR gene expression due to epigenetic mechani...

journal_title：Oncology reports

authors： Fialova B,Luzna P,Gursky J,Langova K,Kolar Z,Trtkova KS

更新日期：2016-10-01 00:00:00

abstract：:The nitrostyrene scaffold was previously identified as a lead target structure for the development of effective compounds targeting Burkitt's lymphoma. The present study aimed to develop these compounds further in haematological malignancies, including chronic lymphocytic leukaemia (CLL). Cellular viability, flow cyto...

journal_title：Oncology reports

authors： Bright SA,Byrne AJ,Vandenberghe E,Browne PV,Mcelligott AM,Meegan MJ,Williams DC

更新日期：2019-05-01 00:00:00

abstract：:Histone acetylation is one of the key chromatin modifications that control gene transcription during development and tumorigenesis. Recently, it was reported that the histone deacetylase inhibitor, Trichostatin A (TSA), induces growth arrest and apoptosis in tumors. However, the mol...

journal_title：Oncology reports

authors： Anh TD,Ahn MY,Kim SA,Yoon JH,Ahn SG

更新日期：2012-02-01 00:00:00

abstract：:Immature colon carcinoma transcript-1 (ICT1) is a newly identified oncogene, which regulates proliferation, cell cycle progression and apoptosis of cancer cells. However, the clinical significance, biological function and underlying mechanisms of ICT1 in hepatocellular carcinoma (HCC) remain poorly known. In the prese...

journal_title：Oncology reports

authors： Chang W,Yu Z,Tian M,Lin X

更新日期：2017-12-01 00:00:00

abstract：:Synthetic oligodeoxynucleotides (ODNs) with the CpG-motifs are recognized by toll-like receptor 9 (TLR9), which elicits an immune response. Serum starvation of Raw264.7 cells increased tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression. However, treatment wit...

journal_title：Oncology reports

authors： Lim EJ,Park DW,Jeong TW,Chin BR,Bae YS,Baek SH

更新日期：2012-04-01 00:00:00

abstract：:Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited...

journal_title：Oncology reports

authors： Saiko P,Ozsvar-Kozma M,Graser G,Lackner A,Grusch M,Madlener S,Krupitza G,Jaeger W,Hidvegi M,Agarwal RP,Fritzer-Szekeres M,Szekeres T

更新日期：2009-03-01 00:00:00

abstract：:Osteosarcoma harbors highly metastatic properties, accounting for postoperative recurrence and metastasis. Actin-like protein 6A (ACTL6A) regulates cell proliferation, migration and differentiation. However, the biologic role of ACTL6A in osteosarcoma remains unknown. In this study, the results showed that, by analysi...

journal_title：Oncology reports

authors： Sun W,Wang W,Lei J,Li H,Wu Y

更新日期：2017-04-01 00:00:00

abstract：:In recent years, several antioxidant substances have been found to have an antiproliferative effect on various types of carcinomas. α-lipoic acid (ALA) induces apoptosis in several types of cancer cell lines, but it is difficult to apply α-lipoic acid in clinical use as it is easily oxidized and unstable. Recently, we...

journal_title：Oncology reports

authors： Hiratsuka T,Inomata M,Kono Y,Yokoyama S,Shiraishi N,Kitano S

更新日期：2013-06-01 00:00:00

abstract：:Forkhead box F2 transcription factor (FoxF2) has been described to promote organ development, extracellular matrix (ECM) synthesis and epithelial-mesenchymal interaction. Although recent studies reported decreased FoxF2 expression in several types of cancers, indicating its potential role in carcinogenesis, the mechan...

journal_title：Oncology reports

authors： Zhang Y,Wang X,Wang Z,Tang H,Fan H,Guo Q

更新日期：2015-05-01 00:00:00

abstract：:Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. However, few studies have defined functional roles and mechanis...

journal_title：Oncology reports

authors： Yan L,Wang Y,Wang ZZ,Rong YT,Chen LL,Li Q,Liu T,Chen YH,Li YD,Huang ZH,Peng J

更新日期：2016-01-01 00:00:00

abstract：:Evidence has shown that microRNAs play important roles in tumor development, progression, and metastasis. miR-128 has been reported to be deregulated in different tumor types, whereas the function of miR-128 in colorectal carcinoma (CRC) largely remains to be elucidated. The aim of the present study was to investigate...

journal_title：Oncology reports

authors： Wu L,Shi B,Huang K,Fan G

更新日期：2015-11-01 00:00:00

abstract：:Nucleostemin (NS) plays an important role in tumorigenesis and progression. Most studies consider that NS plays its role through combining with p53 and inhibiting it, however our previous studies revealed that NS could also function without the existence of p53. To date, few studies have focused on the p53-independent...

journal_title：Oncology reports

authors： Sun X,Jia Y,Wei Y,Liu S,Yue B

更新日期：2014-08-01 00:00:00

abstract：:One of the dose-limiting toxicities of irinotecan (CPT-11) is delayed-onset diarrhea, which is the greatest barrier to treatment with CPT-11-containing regimens. CPT-11 is converted to its active metabolite, SN-38, which is conjugated by hepatic uridine diphosphate glucuronosyl transferase to SN-38 glucuronide (SN-38G...

journal_title：Oncology reports

authors： Yamamoto M,Kurita A,Asahara T,Takakura A,Katono K,Iwasaki M,Ryuge S,Wada M,Onoda S,Yanaihara T,Yokoba M,Mitsufuji H,Nishii Y,Fukui T,Masuda N

更新日期：2008-10-01 00:00:00

abstract：:The present study aimed to assess the in vitro and in vivo magnetic resonance imaging (MRI) features of chlorotoxin (CTX)-conjugated superparamagnetic iron oxide (SPIO) nanoprobes. CTX-conjugated nanoprobes were composed of SPIO coated with polyethylene glycol (PEG) and conjugated with CTX. The nanoprobes were termed ...

journal_title：Oncology reports

authors： Chen Z,Xiao EH,Kang Z,Zeng WB,Tan HL,Li HB,Bian DJ,Shang QL

更新日期：2016-05-01 00:00:00

abstract：:Emerging evidence suggests that cancer cells present profound epigenetic alterations in addition to featuring classic genetic mutations. Valproic acid (VPA), a histone deacetylase inhibitor, can potently inhibit tumor growth and induce differentiation. However, the effect and underlying mechanism of VPA on head and ne...

journal_title：Oncology reports

authors： Lee SH,Nam HJ,Kang HJ,Samuels TL,Johnston N,Lim YC

更新日期：2015-10-01 00:00:00

abstract：:We investigated cell susceptibility to hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines (RYSTs) and attempted to correlate this with the known potentially relevant molecular determinants of apoptosis, p53 protein status, Bcl-2 family of proteins and heat shock proteins (Hsp). Parent cell line, NMT-1...

journal_title：Oncology reports

authors： Islam MS,Mitsuhashi N,Akimoto T,Sakurai H,Hasegawa M,Ishikawa H,Niibe H

更新日期：2001-05-01 00:00:00

abstract：:After having carefully checked the original data of Fig. 3, the authors noted that the student in their research group had inadvertently selected incorrect images for the 10 and 20 µM lycorine experiments to show the effect of lycorine on the migration of HepG2 cells during the figure compilation process. The correcte...

journal_title：Oncology reports

authors： Liu W,Zhang Q,Tang Q,Hu C,Huang J,Liu Y,Lu Y,Wang Q,Li G,Zhang R

更新日期：2019-12-01 00:00:00

abstract：:To evaluate the prognostic values of different protein expression in the progression of squamous cell carcinoma of the head and neck (SCCHN) patients, we conducted immunohistochemical (IHC) analysis in tissue samples of different patients enrolled on SWOG protocol S0420. S0420 was a phase II trial to evaluate the effi...

journal_title：Oncology reports

authors： Mehta S,Moon J,Hashmi M,Leblanc M,Huang CH,Rinehart E,Wolf GT,Urba SG,Banerjee SK,Williamson S

更新日期：2013-06-01 00:00:00

abstract：:We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...

journal_title：Oncology reports

authors： Takeuchi S,Zhao S,Kuge Y,Zhao Y,Nishijima K,Hatano T,Shimizu Y,Kinoshita I,Tamaki N,Dosaka-Akita H

更新日期：2011-09-01 00:00:00

abstract：:Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the di...

journal_title：Oncology reports

authors： Yang Q,Guo B,Sun H,Zhang J,Liu S,Hexige S,Yu X,Wang X

更新日期：2017-04-01 00:00:00

abstract：:Using a series of potential biomarkers relevant to mechanisms of protein synthesis, we observed that estrogen receptor (ER)-positive breast tumor cells exist in two distinct yet interconvertible phenotypic states (of roughly equal proportion) which differ in the degree of differentiation and use of IRES-mediated trans...

journal_title：Oncology reports

authors： Vaklavas C,Zinn KR,Samuel SL,Meng Z,Grizzle WE,Choi H,Blume SW

更新日期：2018-06-01 00:00:00