Abstract:
:Forkhead box F2 transcription factor (FoxF2) has been described to promote organ development, extracellular matrix (ECM) synthesis and epithelial-mesenchymal interaction. Although recent studies reported decreased FoxF2 expression in several types of cancers, indicating its potential role in carcinogenesis, the mechanistic role of FoxF2 is yet to be explored. MicroRNAs (miRNAs) are strongly implicated in carcinogenesis. The oncogenetic properties of miR-182 have been described in multiple cancers. In the present study, we aimed to investigate the role of miR-182 in colorectal cancer (CRC) and identify the regulation of FoxF2 by miR-182. Bioinformatic analyses on gene expression profiling datasets showed decreased FoxF2 expression in colorectal adenomas, primary tumors compared to normal colon epithelial and a negative association between FoxF2 and β-catenin expression. Restoration of FoxF2 in CRC cells suppressed β-catenin expression and simultaneously inhibited cell growth and invasion. Furthermore, we observed that miR-182 was aberrantly upregulated in CRC. Knockdown of miR-182 in CRC cells impeded cell growth and invasion. The direct binding of miR-182 to the 3' untranslated region (3'UTR) of FoxF2 mRNA was confirmed using a luciferase reporter gene assay. Importantly, elevated FoxF2 expression was observed in miR-182-knockdown cells with a simultaneous reduction in β-catenin. In conclusion, the present study describes a potential mechanism underlying an miR-182/FoxF2 link contributing to CRC development. miR-182-induced downregulation of FoxF2 partly accounts for increased activity of β-catenin signaling. Inhibition of miR-182 represents a potential strategy against CRC.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Zhang Y,Wang X,Wang Z,Tang H,Fan H,Guo Qdoi
10.3892/or.2015.3833subject
Has Abstractpub_date
2015-05-01 00:00:00pages
2592-8issue
5eissn
1021-335Xissn
1791-2431journal_volume
33pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::After having carefully checked the original data of Fig. 3, the authors noted that the student in their research group had inadvertently selected incorrect images for the 10 and 20 µM lycorine experiments to show the effect of lycorine on the migration of HepG2 cells during the figure compilation process. The correcte...
journal_title:Oncology reports
pub_type: 杂志文章,已发布勘误
doi:10.3892/or.2019.7362
更新日期:2019-12-01 00:00:00
abstract::External abdomino-pelvic irradiation after primary surgery in early stages of epithelial ovarian carcinoma has been used as adjuvant therapy. The aims of this study were to evaluate efficacy and tolerability of abdomino-pelvic radiotherapy in ovarian carcinomas and to find predictive factors for recurrent disease. Fro...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-08-01 00:00:00
abstract::Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein which plays multiple roles in different types of cancer. Our previous study showed that SPARC overexpression inhibited the growth and angiogenesis of tumors, and reduced expression of vascular endothelial growth factor (VEGF). However, the relation...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3118
更新日期:2014-05-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) and pancreatic cancer are at the forefront of chemotherapy-resistant tumors with poor prognosis. Even with innovative treatment regimens, response rates remain low and the duration of response is short. We examined whether the suppression of DNA methylation was capable of enhancing the s...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-10-01 00:00:00
abstract::S-1 is an oral antitumor agent that contains tegafur, which is converted to fluorouracil (5-FU) in the human body. Cytochrome P450 2A6 (CYP2A6) is the principal enzyme responsible for bioconversion of tegafur to 5-FU. A number of CYP2A6 polymorphisms have been associated with variat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1678
更新日期:2012-05-01 00:00:00
abstract::The human Igf-1 gene not only produces insulin‑like growth factor-I (IGF-I), but also different carboxy‑terminal extensions, known as E peptides, through alternative splicing. We and others have shown that human Eb peptide (hEb) derived from Igf-1 has intrinsic biological activity and is localized to nuclei of transfe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3329
更新日期:2014-09-01 00:00:00
abstract::Cyclin D1 expression is closely related with ER status in breast cancer. We executed this study to evaluate whether therapeutic response to tamoxifen varies with levels of cyclin D1 expression in 66 ER positive breast cancer patients having solitary bone metastasis. Treatment response to tamoxifen and correlation betw...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract::Activation of p53-independent pathways plays an important role in phytochemical-induced apoptosis and is considered to be a crucial factor in the invasion and metastasis of cancer. Previous studies have shown that combined effects of Stephania tetrandra with medicinal herbs exhibit beneficial effects in cancer patient...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2352
更新日期:2013-06-01 00:00:00
abstract::The advent of pathotropic (disease-seeking) targeting has transported genetic medicine across the threshold of history with the progressive clinical validation of Rexin-G, a tumor-targeted nanosized anti-cancer agent. Achieving noteworthy single-agent efficacy and survival benefits in otherwise intractable cancers, th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2010.829
更新日期:2010-10-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is highly resistant to chemotherapy, leading to a poor prognosis of advanced disease. Inhibitors of histone deacetylase (HDACi) induce re-differentiation in tumor cells and thereby re-establish sensitivity towards apoptotic stimuli. HDACi are entering the clinical stage of tumor treatmen...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.15.1.227
更新日期:2006-01-01 00:00:00
abstract::Rad52 encodes a protein which is required for recombinational repair of double-strand breaks. It is also associated with breast cancer predisposition genes BRCA1 and BRCA2. Mutations in the genes Rad51 or Rad52 result in severe defects in genetic recombination and the repair of double-strand DNA breaks. In order to ex...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in tumor invasion, but their prognostic significance is still under discussion. We set out to analyze the epithelial and stromal expression of MMP-2, MMP-7, MMP-9, MT1-MMP, TIMP-1 and TIMP-2 in advanced epithelial ovarian cancers and to ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1608
更新日期:2012-04-01 00:00:00
abstract::The present study aimed to explore the relationship between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKIs) and the expression of the cancer stem cell (CSC)‑related markers. Specimens of 72 cases of lung adenocarcinoma with significantly different therapeutic effects of the firs...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7454
更新日期:2020-02-01 00:00:00
abstract::Mammary small cell carcinoma (SmCC) is a very rare neoplasm with a poor prognosis compared with other invasive carcinomas. We studied the histological and immunohistochemical profiles of two cases of mammary SmCC, and compared them with those of five cases of carcinoma with endocrine features (CEF) and five cases of i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-04-01 00:00:00
abstract::Casein kinase 2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is involved in regulating many processes such as cell proliferation, differentiation and apoptosis. CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma. In the present study, we found that...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5233
更新日期:2017-01-01 00:00:00
abstract::Subsequently to the publication of this paper, the authors have realized that the affilitation address omitted the name of the university at which this research was conducted (Capital Medical University). Therefore, the author affiliations for this paper should have appeared as follows (changes are highlighted in bold...
journal_title:Oncology reports
pub_type: 杂志文章,已发布勘误
doi:10.3892/or.2019.7385
更新日期:2019-12-01 00:00:00
abstract::Splenic metastasis from a lung cancer is infrequently noted, however, the pattern of the metastasis has not been studied, thus we conducted a retrospective study. Twelve of the consecutive 997 patients with lung cancer, who were admitted to our division, developed splenic metastasis. The pattern of splenic metastasis ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1239
更新日期:2001-11-01 00:00:00
abstract::Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5250
更新日期:2017-01-01 00:00:00
abstract::Fecal microRNAs (miRNAs) are increasingly explored as non-invasive markers of colorectal cancer (CRC). However, its holistic profile in Asian CRC patients remains elusive. In the present study, the global human fecal miRNAs in Asian Chinese CRC patients was assayed to elucidate novel diagnostic fecal markers. Addition...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3193
更新日期:2014-07-01 00:00:00
abstract::A phase II trial was conducted to evaluate the tolerability and efficacy of incorporating cetuximab and simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) into a well-described 5-fluorouracil (5-FU) and hydroxyurea (HU)-based chemoradiation regimen. Patients with stage IVa-IVb or high-risk ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1679
更新日期:2012-05-01 00:00:00
abstract::Four tumour suppressor genes (Chk1, Chk2, Apaf1 and Rb1) in nine human malignant melanoma cell lines were screened for a loss of gene expression, point mutations and small deletions/insertions by cDNA-based DGGE/SCCP analysis. In two cell lines alterations of the investigated genes could be demonstrated. This result c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin lymphoma. A20 and mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) are known to be related to DLBCL pathogenesis and progression. This study aimed to assess the effects of phorbol myristate acetate/ionomycin (PMA/IONO) on the growth a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4899
更新日期:2016-08-01 00:00:00
abstract::The present study investigated the effect of macrophage colony-stimulating factor (M-CSF) on the immune functions and blood cell counts of patients with ovarian carcinoma receiving cytotoxic chemotherapy (CTX). Seventy-five consecutive patients with white blood cell counts less than 3,000/microl after CTX were randoml...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.4.767
更新日期:2001-07-01 00:00:00
abstract::The incidence of malignant melanoma is increasing. The discovery of agents specifically targeting the mutated cascades has provided a good response for patients with oncogenic B-Raf proto-оncogene, serine/threonine kinase (BRAF). However, numerous studies continue to focus on novel methods of treatment to overcome acq...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6430
更新日期:2018-07-01 00:00:00
abstract::Patients with hepatocellular carcinoma (HCC) have a poor prognosis, and novel molecular targets for treating recurrence and progression of the disease along with associated biomarkers are urgently required. In the present study, expression and the regulatory mechanism of TUSC1 (tumor suppressor candidate 1) were inves...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2939
更新日期:2014-03-01 00:00:00
abstract::Circulating tumor cells (CTCs) or CTC clusters are considered as suitable and relevant targets for liquid biopsy as they more accurately indicate cancer progression, the therapeutic effects of treatment and allows for monitoring of cancer metastasis in real‑time. Among the various methods for isolating CTCs, size‑base...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7567
更新日期:2020-06-01 00:00:00
abstract::Human Pinx1 protein, associated with shelterin proteins, is widely revealed as a haploinsufficient tumor suppressor. Growing evidence has manifested the deregulation of PinX1 in distinct cancers. Nonetheless, the loss status of PinX1 and its diagnostic, prognostic and clinicopathological significance in Basal-like bre...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5696
更新日期:2017-07-01 00:00:00
abstract::One of the possible ways to augment dendritic cell (DC) efficacy in presentation of tumor antigens to effector T cells is pulsing them with tumor-cell lysates and incubation with certain immunostimulators. We present the results of an immunotherapeutic approach in a murine B78-H1 mo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2193
更新日期:2013-03-01 00:00:00
abstract::To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the co...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1282
更新日期:2011-08-01 00:00:00