Abstract:
:Cyclin D1 expression is closely related with ER status in breast cancer. We executed this study to evaluate whether therapeutic response to tamoxifen varies with levels of cyclin D1 expression in 66 ER positive breast cancer patients having solitary bone metastasis. Treatment response to tamoxifen and correlation between cyclin D1 expression and biologic data of the patients were analyzed. Cyclin D1 expression was detected in 46 patients (69.7%) and significantly reduced in poorly differentiated cancer (p=0.023). Patients with cyclin D1-expressing tumors showed better response to tamoxifen but the difference was not statistically significant. Cyclin D1 expression was associated with differentiation of the breast cancer but not useful in discriminating a good responder to tamoxifen treatment.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Han S,Park K,Bae BN,Kim KH,Kim HJ,Kim YD,Kim HYkeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
141-4issue
1eissn
1021-335Xissn
1791-2431journal_volume
10pub_type
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