Tumor necrosis factor receptor associated factor-4: an adapter protein overexpressed in metastatic prostate cancer is regulated by microRNA-29a.

abstract：:Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in skeletal muscle during muscle atrophy. However, the role of muscle-specific E3 ubiquitin ligases during the process of muscle atrophy of cancer cachexia...

journal_title：Oncology reports

authors： Yuan L,Han J,Meng Q,Xi Q,Zhuang Q,Jiang Y,Han Y,Zhang B,Fang J,Wu G

更新日期：2015-05-01 00:00:00

abstract：:Gliomas are primary brain tumors associated with a poor prognosis partly due to resistance to conventional therapies. To overcome this problem, we investigated the combined effects of gamma knife radiosurgery (GKS) and an antiangiogenic agent, thalidomide (THD), or a chemotherapeutic agent, temozolomide (TMZ), on a ra...

journal_title：Oncology reports

authors： Lee JI,Itasaka S,Kim JT,Nam DH

更新日期：2006-05-01 00:00:00

abstract：:Apart from genetic mutations, epigenetic alteration is a common phenomenon that contributes to neoplastic transformation in colorectal cancer. Transcriptional silencing of tumor-suppressor genes without changes in the DNA sequence is explained by the existence of promoter hypermethylation. To test this hypothesis, we ...

journal_title：Oncology reports

authors： Kok-Sin T,Mokhtar NM,Ali Hassan NZ,Sagap I,Mohamed Rose I,Harun R,Jamal R

更新日期：2015-07-01 00:00:00

abstract：:The effects of a novel oral fluoropyrimidine derivative S-1 on peritoneal metastasis from gastric cancer were investigated. OCUM-2MD3 cells, a highly peritoneal-metastatic cell line, were injected intraperitoneally in nude mice. These mice were allocated to the following three groups (each group, n=10): the S-1 group,...

journal_title：Oncology reports

authors： Yamagata S,Nakata B,Hirakawa K

更新日期：2004-11-01 00:00:00

abstract：:Research has confirmed that abnormally expressed miRNAs are involved in the occurrence and development of hepatocellular carcinoma (HCC). In the present study, we confirmed that miR‑577 expression both in HCC tissues and cell lines was markedly downregulated. Clinically, downregulated expression of miR‑577 is notably ...

journal_title：Oncology reports

authors： Han S,Liu Z,Wang Y,Wang L,Yao B,Guo C,Song T,Tu K,Liu Q

更新日期：2018-06-01 00:00:00

abstract：:Despite the established importance of angiogenesis in the pathogenesis of solid tumours, there is still no consensus on how this is best measured or which method is the most appropriate in the determination of prognosis. Here we review the pros and cons of current methods of assessing angiogenesis, both clinical and i...

journal_title：Oncology reports

authors： Pollitt MJ,Hanby AM,Horgan K,Murphy CE,Jones PF,Speirs V

更新日期：2005-05-01 00:00:00

abstract：:Gastric cancer is a common malignancy worldwide. The prognosis of early stage gastric cancer patients has significantly improved in recent years. However, in progressive stage gastric cancer patients, the prognosis remains relatively poor due to tumor metastases. In our previous study, we showed that the expression of...

journal_title：Oncology reports

authors： Xiao WS,Li DF,Tang YP,Chen YZ,Deng WB,Chen J,Zhou WW,Liao AJ

更新日期：2018-11-01 00:00:00

abstract：:Bmi-1, a member of the polycomb family, it is involved in self renewal of stem cells and functions as an oncogene in many malignant human cancer types. Recent studies have demonstrated that Bmi-1 is a predictive factor for poor patient prognosis. However, the underlying mechanisms o...

journal_title：Oncology reports

authors： Liu ZG,Liu L,Xu LH,Yi W,Tao YL,Tu ZW,Li MZ,Zeng MS,Xia YF

更新日期：2012-04-01 00:00:00

abstract：:The actual predictive value of oestrogen receptor (ER) beta for treatment decisions in breast cancer is still unclear. Retrospective studies using preoperative systemic therapy (PST) revealed that chemotherapy but also endocrine therapy can lead to alterations in expression levels of ERalpha and progesterone receptor ...

journal_title：Oncology reports

authors： Wurster M,Ruoff A,Meisner C,Seeger H,Vogel U,Juhasz-Böss I,Solomayer E,Wallwiener D,Fehm T,Neubauer H

更新日期：2010-09-01 00:00:00

abstract：:Aquaporins (AQPs) are a family of small, integral membrane proteins that have been shown to play an important role in tumor development and metastasis. Several studies have demonstrated that expression of AQP3 contributes to the enhanced migration of epithelial cells and is related to differentiation, metastasis and v...

journal_title：Oncology reports

authors： Li A,Lu D,Zhang Y,Li J,Fang Y,Li F,Sun J

更新日期：2013-02-01 00:00:00

abstract：:ONECUT1 (HNF-6) is the prototype of a new class of homeodomain transcription factors, that controls the development of pancreatic ducts during mouse development. In the present study, the role of ONECUT1 and its targeted genes TCF2, PKHD1 and CYS1 was analyzed in human pancreatic ductal adenocarcinoma (PDAC). mRNA lev...

journal_title：Oncology reports

authors： Jiang X,Zhang W,Kayed H,Zheng P,Giese NA,Friess H,Kleeff J

更新日期：2008-01-01 00:00:00

abstract：:Rad52 encodes a protein which is required for recombinational repair of double-strand breaks. It is also associated with breast cancer predisposition genes BRCA1 and BRCA2. Mutations in the genes Rad51 or Rad52 result in severe defects in genetic recombination and the repair of double-strand DNA breaks. In order to ex...

journal_title：Oncology reports

authors： Tong D,Volm T,Eberhardt E,Krainer M,Leodolter S,Kreienberg R,Zeillinger R

更新日期：2003-09-01 00:00:00

abstract：:The meningioma evolution remains problematic as 6 to 19% relapse after total resection. We have no criterion or marker to predict with certainty the tumour behaviour, and the WHO grading system is to a certain degree controversial. Telomerase expression seems to play an active role in conferring to the tumour cell ind...

journal_title：Oncology reports

authors： Kalala JP,Maes L,Vandenbroecke C,de Ridder L

更新日期：2005-02-01 00:00:00

abstract：:Angiogenesis is a key factor in the growth and dissemination of malignant diseases, including breast cancer, with significant implications for its clinical management. It is known that microRNAs (miRNAs) play important roles in regulating tumor properties in cancers. However, whether miR-497 contributes to breast canc...

journal_title：Oncology reports

authors： Wu Z,Cai X,Huang C,Xu J,Liu A

更新日期：2016-03-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the function and mechanism of lncRNA NEAT1 in oral squamous cell carcinoma (OSCC) are unclear. In the present study, NEAT1 was significantly upregulated in OSCC cells and tissues. High expression of NEAT1 was correlated w...

journal_title：Oncology reports

authors： Huang G,He X,Wei XL

更新日期：2018-04-01 00:00:00

abstract：:Taxol (paclitaxel) and vinblastine (VBL) are both efficacious chemotherapeutic agents that target the microtubules of tumor cells, but each functions in a mutual antagonistic manner. Op18/stathmin is a small molecular phosphoprotein which promotes depolymerization of microtubules. Non-small cell lung cancer (NSCLC) NC...

journal_title：Oncology reports

authors： Shen F,Long D,Yu T,Chen X,Liao Y,Wu Y,Lin X

更新日期：2017-04-01 00:00:00

abstract：:Enhanced cell migration and invasion play key roles in cancer metastasis. However, the molecules involved in this process are not fully understood. In this study, a full-length human BNIPL-2 (Bcl-2/adenovirus E1B 19 kDa interacting protein 2 like-2) cDNA was transfected into human hepatocellular carcinoma cells with l...

journal_title：Oncology reports

authors： Xie L,Qin W,Li J,He X,Zhang H,Yao G,Shu H,Yao M,Wan D,Gu J

更新日期：2007-03-01 00:00:00

abstract：:It has been demonstrated that microRNA‑192 (miR‑192) serves important roles in different cancer types, including breast cancer, prostate cancer and colorectal cancer. However, its biological role and function in breast cancer remains largely unknown. The present study aimed to determine the role of miR‑192 in breast c...

journal_title：Oncology reports

authors： Chen P,Feng Y,Zhang H,Shi X,Li B,Ju W,Yu X,Zhang N,Luo X

更新日期：2019-11-01 00:00:00

abstract：:Early detection of transitional cell carcinoma (TCC) of the urinary bladder is essential for effective treatment. While several serum markers have been evaluated, none have been widely accepted for practical clinical use. Thus, urinary markers have been introduced and investigated to detect the evidence of bladder can...

journal_title：Oncology reports

authors： Wunderlich H,Reichelt O,Zermann DH,Schubert J,Berndt A,Kosmehl H

更新日期：2001-05-01 00:00:00

abstract：:Sentinel lymph node (SLN) biopsy is a useful way of assessing axillary nodal status and obviates unnecessary axillary lymph node dissection for patients with node-negative breast cancer. However, SLN can also be located in the internal mammary lymph node (IMN) chain or elsewhere. The practicability and relevance of in...

journal_title：Oncology reports

authors： Noguchi M

更新日期：2002-05-01 00:00:00

abstract：:The majority of patients with hormone receptor-positive metastatic breast cancer die from disease progression despite different types of anti-hormonal treatments. Preclinical studies have indicated that resistance to anti-hormonal therapies may be the result of an activated NF-κB si...

journal_title：Oncology reports

authors： Trinh XB,Sas L,Van Laere SJ,Prové A,Deleu I,Rasschaert M,Van de Velde H,Vinken P,Vermeulen PB,Van Dam PA,Wojtasik A,De Mesmaeker P,Tjalma WA,Dirix LY

更新日期：2012-03-01 00:00:00

abstract：:The expression of CDR1‑AS, a representative circular RNA, is closely linked with poor prognosis in gastrointestinal cancers, such as colon, liver, and pancreatic cancers. Although it is well known that CDR1‑AS antagonizes microRNA‑7 function through its sequence similarities in the brain, its biological function and l...

journal_title：Oncology reports

authors： Tanaka E,Miyakawa Y,Kishikawa T,Seimiya T,Iwata T,Funato K,Odawara N,Sekiba K,Yamagami M,Suzuki T,Ishibashi R,Otsuka M,Koike K

更新日期：2019-10-01 00:00:00

abstract：:Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addi...

journal_title：Oncology reports

authors： Gu Y,Wang J,Peng L

更新日期：2017-01-01 00:00:00

abstract：:Formation of cancer stem cells (CSCs) and increased cells proliferation are involved in tumorigenesis, tumour recurrence and therapy resistance and microRNA is essential for the development of the biological traits of CSCs and the increased cells proliferation. Studying molecular mechanism of tumorigenesis, tumour rec...

journal_title：Oncology reports

authors： Liu Y,Miao L,Ni R,Zhang H,Li L,Wang X,Li X,Wang J

更新日期：2016-12-01 00:00:00

abstract：:The aim of this study was to investigate the status of the c‑Myc‑related molecule Mina53 and the clinical impact of Mina53 nuclear localization in patients with stage II and III colorectal cancer (CRC). Patients (n=250) who underwent complete resection of CRC at our department were enrolled in this study, and tissue m...

journal_title：Oncology reports

authors： Fujino S,Kinugasa T,Sudo T,Mizobe T,Yoshida T,Yoshida N,Ohchi T,Tajiri K,Yuge K,Nagasu S,Katagiri M,Akagi Y

更新日期：2018-07-01 00:00:00

abstract：:Gastric cancer is the second most common fatal malignancy in the world. Proteomics studies of clinical tumor samples have led to the identification of specific protein markers of gastric cancer detection and better understanding the carcinogenesis of gastric cancer. Gastric cancer tissue of epithelial origin and adjac...

journal_title：Oncology reports

authors： Wu C,Luo Z,Chen X,Wu C,Yao D,Zhao P,Liu L,Shi B,Zhu L

更新日期：2009-06-01 00:00:00

abstract：:The objective of the present study was to explore the in vitro and in vivo anticancer effects of Platycodin D (PD), derived from Platycodin grandiflorum, on highly metastatic MDA-MB-231 breast cancer cells. Using the MTT assay, we found that PD inhibited MDA-MB-231 cell growth in a concentration-dependent manner, with...

journal_title：Oncology reports

authors： Kong Y,Lu ZL,Wang JJ,Zhou R,Guo J,Liu J,Sun HL,Wang H,Song W,Yang J,Xu HX

更新日期：2016-09-01 00:00:00

abstract：:Extracellular matrix remodeling crucial to tumorigenesis involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs). MMP production is stimulated by multiple factors, including the extracellular matrix metallo-proteinase inducer EMMPRIN/CD147. Overexpression of EMMPRIN...

journal_title：Oncology reports

authors： Takahashi M,Suzuki S,Ishikawa K

更新日期：2012-01-01 00:00:00

abstract：:MAP kinase signaling proteins have major implications in the molecular oncogenesis of breast cancers and have been extensively investigated as putative targets for therapy. This study reports the investigation of the expression of P38 MAPK and its phosphorylated form (p-P38 MAPK) in clinical specimens of invasive brea...

journal_title：Oncology reports

authors： Merlin JL,Harlé A,Lion M,Ramacci C,Leroux A

更新日期：2013-10-01 00:00:00

abstract：:Breast cancers especially in the late and metastatic stages remain refractory to treatment despite advances in surgical techniques and chemotherapy. Tumor-specific promoter-directed suicide gene therapy and adenoviral technology can be promising strategies for such advanced disease. Previous studies suggested that com...

journal_title：Oncology reports

authors： Yu B,Zhang Y,Zhan Y,Zha X,Wu Y,Zhang X,Dong Q,Kong W,Yu X

更新日期：2011-07-01 00:00:00