Involvement of CD147 isoform‑4 in the proliferation of SiHa cells: a possible molecular mechanism of cervical cancer.

abstract：:The roles and mechanisms of mini-chromosome maintenance complex component 7 (MCM7) amplification and overexpression in esophageal carcinogenesis were investigated. By analyzing the TCGA datasets, we found that MCM7 was amplified in approximately 12% of esophageal squamous cell carcinomas (ESCCs), and in more than 4% o...

journal_title：Oncology reports

authors： Qiu YT,Wang WJ,Zhang B,Mei LL,Shi ZZ

更新日期：2017-06-01 00:00:00

abstract：:Breast cancer is the most common cancer in women worldwide. Progression and aggressiveness of breast cancer is usually associated with its migration and invasion abilities. Recently, natural products with potential anticancer activity have become attractive candidates for alternative treatment of cancer. A fungal meta...

journal_title：Oncology reports

authors： Kasorn A,Loison F,Kangsamaksin T,Jongrungruangchok S,Ponglikitmongkol M

更新日期：2018-03-01 00:00:00

abstract：:The signal transducer and activator of transcription 3 (STAT3) are ideal targets for ovarian cancer. Previous studies showed that downregulation of STAT3 using specific short hairpin RNAs (shRNA) can significantly reduce ovarian tumor growth. However, RNA interference does not fully ablate target gene expression due t...

journal_title：Oncology reports

authors： Pan Y,Zhang L,Zhang X,Liu R

更新日期：2015-02-01 00:00:00

abstract：:In recent years an extensive series of synthetic combretastatin A-4 (CA-4)-azetidinone (β-lactam) hybrids were designed and synthesised with a view to improve the stability, therapeutic efficacy and aqueous solubility of CA-4. Lead compounds containing a 3,4,5-trimethoxy aromatic ring at position 1 and a variety of su...

journal_title：Oncology reports

authors： Greene LM,Wang S,O'Boyle NM,Bright SA,Reid JE,Kelly P,Meegan MJ,Zisterer DM

更新日期：2013-06-01 00:00:00

abstract：:The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

journal_title：Oncology reports

authors： Malas S,Harrasser M,Lacy KE,Karagiannis SN

更新日期：2014-09-01 00:00:00

abstract：:Activating mutations of Ras gene families have been found in a variety of human malignancies, including lung cancer, suggesting their dominant role in tumorigenesis. Many studies have showed that the Kras gene is activated by point mutations in approximately 15-20% of non-small cell lung cancers (NSCLCs), however, the...

journal_title：Oncology reports

authors： Sasaki H,Okuda K,Kawano O,Endo K,Yukiue H,Yokoyama T,Yano M,Fujii Y

更新日期：2007-09-01 00:00:00

abstract：:The impact of interferon-γ (IFN-γ) late preconditioning on myocardial ischemia-reperfusion injury during cardiopulmonary bypass (CPB) and the underlying mechanism were investigated. Using a porcine model of myocardial ischemia-reperfusion injury during CPB with a 60-min aorta cross-clamp, 20 pigs (15±0.5 kg) were trea...

journal_title：Oncology reports

authors： Yan X,Qiu W,Jia B,Zhong H,Li X,Chen Z

更新日期：2013-11-01 00:00:00

abstract：:Heparanase is endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane. Heparanase has been thought to have an important role in the process of cancer invasion and metastasis. Recent studies have revealed that heparanase has multifunctional mo...

journal_title：Oncology reports

authors： Naomoto Y,Takaoka M,Okawa T,Nobuhisa T,Gunduz M,Tanaka N

更新日期：2005-07-01 00:00:00

abstract：:The goal of this study was to evaluate the effect of the Na+/H+ exchanger-1 (NHE-1) antisense gene on drug-resistant human small cell lung cancer (SCLC) cell proliferation and apoptosis. A recombinant NHE-1 antisense gene was transfected into drug-resistant human SCLC H446/CDDP cells. Intracellular pH (pHi) was measur...

journal_title：Oncology reports

authors： Li S,Bao P,Li Z,Ouyang H,Wu C,Qian G

更新日期：2009-05-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promise for cancer therapy due to its unique capacity to selectively trigger apoptosis in cancer cells. However, TRAIL therapy is greatly hampered by its resistance. A preclinical successful strategy is to identify combination treatments that sensit...

journal_title：Oncology reports

authors： Li L,Wen XZ,Bu ZD,Cheng XJ,Xing XF,Wang XH,Zhang LH,Guo T,Du H,Hu Y,Fan B,Ji JF

更新日期：2016-05-01 00:00:00

abstract：:microRNAs (miRNAs), a class of small non-coding RNA molecules, can regulate gene expression by interacting with the 3'-untranslated regions (3'UTR) of target genes and influence various biological processes. We investigated the potential role of miR-24-3p in the development of bladder cancer by regulating DEDD, a memb...

journal_title：Oncology reports

authors： Yu G,Jia Z,Dou Z

更新日期：2017-02-01 00:00:00

abstract：:Primarily through in vitro studies, the Rho-family of small GTPases and their effector proteins have been implicated in mediating oncogenic properties of cancer cells. We sought to determine if pharmacological inhibition of the RhoA effector proteins known as Rho-kinases (ROCK) with the small molecule inhibitor Y-2763...

journal_title：Oncology reports

authors： Routhier A,Astuccio M,Lahey D,Monfredo N,Johnson A,Callahan W,Partington A,Fellows K,Ouellette L,Zhidro S,Goodrow C,Smith A,Sullivan K,Simone P,Le L,Vezuli B,Zohni M,West E,Gleason D,Bryan B

更新日期：2010-03-01 00:00:00

abstract：:Owing to aggressiveness and chemoresistance, pancreatic ductal adenocarcinoma (PDAC) is characterised by a poor prognosis. To address this disease-spe-cific dilemma we aimed to establish animal models, which can be used for identifying new specific tumor markers, as well as serving ...

journal_title：Oncology reports

authors： Eyol E,Murtaga A,Zhivkova-Galunska M,Georges R,Zepp M,Djandji D,Kleeff J,Berger MR,Adwan H

更新日期：2012-12-01 00:00:00

abstract：:Ovarian cancer (OC) is a common cancer of the human genital system. Circular RNAs (circRNAs) play an important role in carcinogenesis and progression of various cancers. The present study aimed to clarify the expression profile and functions of circ‑FAM53B in the progression of OC and reveal its underlying mechanisms....

journal_title：Oncology reports

authors： Sun D,Liu J,Zhou L

更新日期：2019-12-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations occur in a variety of human cancers, suggesting a possible role for mitochondrial respiratory functions in tumorigenesis. Recent studies have demonstrated that SDHD, a nuclear gene encoding one of the mitochondrial complex II subunits, acts as a tumor-suppressor for hereditary parag...

journal_title：Oncology reports

authors： Habano W,Sugai T,Nakamura S,Uesugi N,Higuchi T,Terashima M,Horiuchi S

更新日期：2003-09-01 00:00:00

abstract：:In this study the performance of various intelligent methodologies is compared in the task of pap-smear diagnosis. The selected intelligent methodologies are briefly described and explained, and then, the acquired results are presented and discussed for their comprehensibility and usefulness to medical staff, either f...

journal_title：Oncology reports

authors： Dounias G,Bjerregaard B,Jantzen J,Tsakonas A,Ampazis N,Panagi G,Panourgias E

更新日期：2006-01-01 00:00:00

abstract：:The BRAF T1799A mutation is a heterozygous point mutation and its reported prevalence in papillary thyroid carcinoma (PTC) has varied from 29 to 83%, with an overall mean of 44%. In Korea, the reported mutation rate reached 83% in PTC and 52% in micropapillary carcinoma. We hypothesized that the differences in prevale...

journal_title：Oncology reports

authors： Kim HS,Kim JO,Lee DH,Lee HC,Kim HJ,Kim JH,Jang YS,Lee JM,Kim SY,Kim YS

更新日期：2011-06-01 00:00:00

abstract：:Hyperplasia suppressor gene (HSG) is a novel gene that markedly suppresses the mitogenetic stimuli or injury mediated by vascular smooth muscle cell proliferation. Herein we provide experimental evidence to show that HSG can also play a key role in tumor proliferation. Down-regulation of HSG protein in hepatocellular ...

journal_title：Oncology reports

authors： Wang W,Zhu F,Wang S,Wei J,Jia C,Zhang Y,Zhou L,Xie H,Zheng S

更新日期：2010-07-01 00:00:00

abstract：:Dendritic cells (DCs) as 'professional' antigen-presenting cells (APCs) initiate and regulate immune responses to various antigens. DC-based vaccines have become a promising modality in cancer immunotherapy. Cytokeratin 19 (CK19) protein is expressed at high levels in lung cancer and many other tumor cells, suggesting...

journal_title：Oncology reports

authors： Sun QF,Zhao XN,Peng CL,Hao YT,Zhao YP,Jiang N,Xue H,Guo JZ,Yun CH,Cong B,Zhao XG

更新日期：2015-11-01 00:00:00

abstract：:Previously, we showed that the herbal extract EYK (Epimedium koreanum Nakai) can regulate the immune response. Other studies showed that EYK has beneficial effects in human lung cancer, angiogenesis and Alzheimer's disease (AD). However, it remains unknown whether EYK can affect cancer cell migration and invasion in h...

journal_title：Oncology reports

authors： Lee W,Nam JH,Cho HJ,Lee JY,Cho WK,Kim Υ,We YM,Ma JY,Hoe HS

更新日期：2017-12-01 00:00:00

abstract：:The mechanisms of drug resistance in cancer are not fully elucidated. To study the drug resistance of gastric cancer, we analyzed gene expression and DNA methylation profiles of 5-fluorouracil (5-FU)- and cisplatin (CDDP)-resistant gastric cancer cells and biopsy specimens. Drug-resistant gastric cancer cells were est...

journal_title：Oncology reports

authors： Maeda O,Ando T,Ohmiya N,Ishiguro K,Watanabe O,Miyahara R,Hibi Y,Nagai T,Yamada K,Goto H

更新日期：2014-04-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors of HBV, HBV X protein (HBx) is attracting increased attention. Although it is documented that HBx is a multifunctional regulator that modulates cell inflammation and apoptosis, the exact mechanism r...

journal_title：Oncology reports

authors： Gao WY,Li D,Cai DE,Huang XY,Zheng BY,Huang YH,Chen ZX,Wang XZ

更新日期：2017-01-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (SCC) is one of the most common fatal carcinomas worldwide and has some of the most malignant characteristics among gastrointestinal tumors. Although a high frequency of loss of heterozygosity (LOH) for various genes has been observed in esophageal SCCs, these findings do not provide...

journal_title：Oncology reports

authors： Shima H,Hiyama T,Tanaka S,Yoshihara M,Arihiro K,Chayama K

更新日期：2006-10-01 00:00:00

abstract：:The aim of the present study was to investigate the role of miR‑203a‑3p in colorectal cancer (CRC) and identify the target gene of microRNA (miR)‑203a‑3p. A total of 59 sets of cancer tissues and corresponding adjacent non‑tumor tissues were collected from CRC patients (aged 31‑78 years) between October 2016 and May 2...

journal_title：Oncology reports

authors： Qian Z,Gong L,Mou Y,Han Y,Zheng S

更新日期：2019-11-01 00:00:00

abstract：:In the present study, we identified a gene termed Nbla10993 whose expression levels are higher in favorable neuroblastomas versus unfavorable ones. Structural analysis showed that Nbla10993 is a novel splicing variant of the ER-associated protein of 140 kDa (ERAP140), which lacks the central acidic as well as the COOH...

journal_title：Oncology reports

authors： Arai H,Ozaki T,Niizuma H,Nakamura Y,Ohira M,Takano K,Matsumoto M,Nakagawara A

更新日期：2008-06-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is a malignant hematological disease. Tanshinone IIA (Tan IIA) has antitumor activity in vitro and in vivo. The aim of the present study was to investigate the effects of Tan IIA in combination with imatinib (IM) on the proliferation, apoptosis, migration and invasion of acute T lymp...

journal_title：Oncology reports

authors： Teng Z,Xu S,Lei Q

更新日期：2020-02-01 00:00:00

abstract：:Interleukin‑9 (IL‑9) can function as both a positive and negative regulator of immune response, however the role of IL‑9 in tumor immunity is poorly understood. Chronic lymphocytic leukemia (CLL) is the most common chronic lympho‑proliferative disorder. Twenty CLL patients from 2010 to 2011 were recruited in the study...

journal_title：Oncology reports

authors： Chen N,Feng L,Qu H,Lu K,Li P,Lv X,Wang X

更新日期：2018-06-01 00:00:00

abstract：:Ras-association domain family of proteins (RASSF) is characterized by the Ras-association (RA) domain at the C-terminal. Frequent inactivation of RASSF1A gene in human cancers suggests that other members of the family may also play an important role in tumorigenesis. By in silico gene searches, the number of RASSF fam...

journal_title：Oncology reports

authors： Chow LS,Lo KW,Kwong J,Wong AY,Huang DP

更新日期：2004-10-01 00:00:00

abstract：:Triple-negative breast cancer is a highly aggressive type of mammalian carcinoma. It is defined by a rather weak expression of estrogen-, progesterone- and Her2-receptor, and is thus difficult to treat, resulting in low disease-free and overall survival rates of the affected patients. Hence it is important to find new...

journal_title：Oncology reports

authors： Andergassen U,Kölbl AC,Mumm JN,Mahner S,Jeschke U

更新日期：2017-05-01 00:00:00

abstract：:Isocitrate dehydrogenase 2 (IDH2) is a mitochondrial NADP-dependent isocitrate dehydrogenase. It is considered to be a novel tumor suppressor in several types of tumors. However, the role and related mechanism of IDH2 in osteosarcoma remain unknown. The expression and significance of IDH2 were investigated by immunohi...

journal_title：Oncology reports

authors： Yi WR,Li ZH,Qi BW,Ernest ME,Hu X,Yu AX

更新日期：2016-04-01 00:00:00