Nras and Kras mutation in Japanese lung cancer patients: Genotyping analysis using LightCycler.

abstract：:High mobility group box-B1 (HMGB1), an autophagy activator, is crucial in tumorigenesis. However, its extracellular role and signaling in gastric cancer remain unclear. Samples were collected from gastric cancer patients and healthy controls. Immunohistochemistry and immunocytochemistry were used to determine the loca...

journal_title：Oncology reports

authors： Zhang QY,Wu LQ,Zhang T,Han YF,Lin X

更新日期：2015-04-01 00:00:00

abstract：:Frequent invasion of oral cancers into the neighboring jaw bones is a major cause of increased mortality. Moreover, majority of patients with these oral cancers suffer from functional inconveniences and esthetic disadvantages during clinical course and after surgical treatments. Understanding of the mechanisms underly...

journal_title：Oncology reports

authors： Kitagawa Y,Hiraga T,Yura Y,Yoneda T

更新日期：2005-02-01 00:00:00

abstract：:Telomerase activation is prevalent in most epithelial tumors, and may be a critical step in cellular immortalization and carcinogenesis. However, telomerase activity in tumors of mesenchymal origin is not well understood. In the present study, we examined telomerase activity in clinical samples from osteosarcoma and s...

journal_title：Oncology reports

authors： Terasaki T,Kyo S,Takakura M,Maida Y,Tsuchiya H,Tomita K,Inoue M

更新日期：2004-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in the genesis and development of gastric cancer. In the present study, we determined whether miRNA-135a-5p expression was increased in gastric cancer compared with adjacent non-tumor tissues using 20 pairs of gastric cancer and para-carcinoma tissue samples which were assesse...

journal_title：Oncology reports

authors： Pan Y,Ren F,Zhang W,Liu G,Yang D,Hu J,Feng K,Feng Y

更新日期：2014-12-01 00:00:00

abstract：:One of the most important clinical problems in the treatment of human solid carcinoma is the intrinsic/acquired resistance. Cisplatin is a platinum compound that is one of the most effective agents in clinic. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin re...

journal_title：Oncology reports

authors： Nakayama K,Miyazaki K,Kanzaki A,Fukumoto M,Takebayashi Y

更新日期：2001-11-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the main subtype of malignant kidney cancer. Long non‑coding RNA (lncRNA) serves a key role in predicting survival in patients with cancer. The present study aimed to develop an lncRNA‑related signature of prognostic values for patients with ccRCC. RNA sequencing data of 454 ...

journal_title：Oncology reports

authors： Liu T,Sui J,Zhang Y,Zhang XM,Wu WJ,Yang S,Xu SY,Hong WW,Peng H,Yin LH,Pu YP,Liang GY

更新日期：2018-09-01 00:00:00

abstract：:The medicinal properties of extracts from the hemp plant Cannabis sativa have been known for centuries but only in the 90s membrane receptors for the Cannabis major principle were discovered in mammalian cells. Later on the endogenous ligands for the cannabinoid receptors were identified and the term 'endocannabinoid ...

journal_title：Oncology reports

authors： Bifulco M,Laezza C,Gazzerro P,Pentimalli F

更新日期：2007-04-01 00:00:00

abstract：:Dendritic cell-mediated cancer immunotherapy employs several ways to engage tumor antigens. We have demonstrated in both pre-clinical animal studies and early clinical trials that dendritomas, highly purified hybrids between dendritic cells (DC) and tumor cells, are superior activators of anti-tumor immunity. It has b...

journal_title：Oncology reports

authors： Branham-O'Connor M,Li J,Kotturi HS,Yu X,Wagner TE,Wei Y

更新日期：2010-02-01 00:00:00

abstract：:microRNAs (miRNAs), a class of small non-coding RNA molecules, can regulate gene expression by interacting with the 3'-untranslated regions (3'UTR) of target genes and influence various biological processes. We investigated the potential role of miR-24-3p in the development of bladder cancer by regulating DEDD, a memb...

journal_title：Oncology reports

authors： Yu G,Jia Z,Dou Z

更新日期：2017-02-01 00:00:00

abstract：:This study assessed the prediction of gastric cancer recurrence based on detection of occult neoplastic cells (ONCs) in lymph nodes, and by using criteria that were developed to identify patients with a high risk of recurrence/metastasis. The subjects were 60 patients of stage II or III gastric cancer with lymph node ...

journal_title：Oncology reports

authors： Mukai M,Sato S,Komatsu N,Kimura T,Ninomiya H,Kawada M,Nakasaki H,Ogoshi K,Makuuchi H

更新日期：2004-07-01 00:00:00

abstract：:Immune responses are frequently depressed in patients with cancer. One of the reasons for a poor immune response is the presence of increased levels of immunosuppressive substances associated with tumor growth. Transforming growth factor-beta (TGF-beta), a representative immunosuppressive cytokine, plays various roles...

journal_title：Oncology reports

authors： Yamamoto Y,Ueda Y,Itoh T,Iwamoto A,Yamagishi H,Shimagaki M,Teramoto K

更新日期：2006-12-01 00:00:00

abstract：:MicroRNA (miRNA) is a type of endogenous non‑coding RNA implicated in various cellular processes. Studies have shown that miR-124 is involved in the malignant progression of cancer, but little is known concerning its potential role in breast cancer. Therefore, the purpose of this study was to conduct a functional anal...

journal_title：Oncology reports

authors： Du S,Li H,Sun X,Li D,Yang Y,Tao Z,Li Q,Liu K

更新日期：2016-12-01 00:00:00

abstract：:Gene therapy mediated by murine leukemia virus (MLV)-based replicating retrovirus vector (RRV) was previously proven to be highly effective in tumor cell killing, resulting in significant suppression of tumor growth in vivo. Recently, we developed a different form of RRV which is derived from another retrovirus, gibbo...

journal_title：Oncology reports

authors： Lu YC,Chen YJ,Yu YR,Lai YH,Cheng JC,Li YF,Shen CH,Tai CK

更新日期：2012-07-01 00:00:00

abstract：:No information is currently available regarding pancreatic cancer (PC) pattern of care in Italy. In the present study, a nationwide survey using a questionnaire was performed to enquire the local standards for PC diagnosis and radiotherapy treatment. Fifty-seven percent of 140 Italian centres completed questionnaire. ...

journal_title：Oncology reports

authors： Macchia G,Sainato A,Talamini R,Boz G,Bacigalupo A,Caravatta L,Fiore M,Friso ML,Fusco V,Lupattelli M,Mantello G,Mattiucci GC,Slim N,Sciacero P,Turri L,Valentini V,Morganti AG,Genovesi D

更新日期：2015-07-01 00:00:00

abstract：:Formation of cancer stem cells (CSCs) and increased cells proliferation are involved in tumorigenesis, tumour recurrence and therapy resistance and microRNA is essential for the development of the biological traits of CSCs and the increased cells proliferation. Studying molecular mechanism of tumorigenesis, tumour rec...

journal_title：Oncology reports

authors： Liu Y,Miao L,Ni R,Zhang H,Li L,Wang X,Li X,Wang J

更新日期：2016-12-01 00:00:00

abstract：:Histone deacetylase (HDAC) 4 is an emerging target in cancer therapeutics, but little is known about the function of HDAC4 in gynecologic malignancies. Therefore we investigated the mechanism of HDAC4 promoting the proliferation of epithelial ovarian cancer cells (OV). In this study, we observed that the proliferation...

journal_title：Oncology reports

authors： Shen YF,Wei AM,Kou Q,Zhu QY,Zhang L

更新日期：2016-02-01 00:00:00

abstract：:Using a series of potential biomarkers relevant to mechanisms of protein synthesis, we observed that estrogen receptor (ER)-positive breast tumor cells exist in two distinct yet interconvertible phenotypic states (of roughly equal proportion) which differ in the degree of differentiation and use of IRES-mediated trans...

journal_title：Oncology reports

authors： Vaklavas C,Zinn KR,Samuel SL,Meng Z,Grizzle WE,Choi H,Blume SW

更新日期：2018-06-01 00:00:00

abstract：:The present study was designed to retrospectively examine the efficacy of postoperative adjuvant chemotherapy in 107 patients with stage II primary colorectal cancer who underwent curative resection. The chemotherapy regimen was intravenous 5FU/LV in 30 patients (FL-IV group) and oral UFT/PSK in 77 patients (oral grou...

journal_title：Oncology reports

authors： Ito I,Mukai M,Ninomiya H,Kishima K,Tsuchiya K,Tajima T,Oida Y,Nakamura M,Makuuchi H

更新日期：2008-11-01 00:00:00

abstract：:EGFR, p27kip1 and Skp2, have been implicated in human cancer development. We have studied these molecules in a search for molecular markers that may have prognostic value in head and neck squamous cell carcinomas (HNSCC). Tissue samples of 62 patients were collected and immunohistochemical analysis was carried out for...

journal_title：Oncology reports

authors： Carracedo DG,Astudillo A,Rodrigo JP,Suarez C,Gonzalez MV

更新日期：2008-09-01 00:00:00

abstract：:Epidemiologic studies indicate the use of either statins or aspirin have beneficial effects in prostate cancer patients. The present study was undertaken to evaluate the effects and mechanisms of atorvastatin and aspirin alone or in combination in human prostate cancer cells cultured in vitro and grown as xenograft tu...

journal_title：Oncology reports

authors： He Y,Huang H,Farischon C,Li D,Du Z,Zhang K,Zheng X,Goodin S

更新日期：2017-02-01 00:00:00

abstract：:Iodine-125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. However, the radiobiological mechanism underlying brachytherapy remains unclear. Therefore, we investigated the influence of continuous and low-energy 125I irradiation on the cell cycle dist...

journal_title：Oncology reports

authors： Zhang WF,Jin WD,Li B,Wang MC,Li XG,Mao WY,Luo KY

更新日期：2014-08-01 00:00:00

abstract：:The mechanisms of drug resistance in cancer are not fully elucidated. To study the drug resistance of gastric cancer, we analyzed gene expression and DNA methylation profiles of 5-fluorouracil (5-FU)- and cisplatin (CDDP)-resistant gastric cancer cells and biopsy specimens. Drug-resistant gastric cancer cells were est...

journal_title：Oncology reports

authors： Maeda O,Ando T,Ohmiya N,Ishiguro K,Watanabe O,Miyahara R,Hibi Y,Nagai T,Yamada K,Goto H

更新日期：2014-04-01 00:00:00

abstract：:Pentoxifylline is commonly used in the treatment of peripheral vascular diseases. It improves microcirculatory flow and tissue perfusion. Moreover, pentoxifylline displays some immunomodulatory properties that presumably might affect the anticancer response. Therefore, the aim of the present study was to evaluate the ...

journal_title：Oncology reports

authors： Grzela T,Lazarczyk M,Niderla J,Golab J,Lazarczyk MA,Skopinski P

更新日期：2003-11-01 00:00:00

abstract：:Recent research indicates that the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway may play an important role in chronic inflammation which promotes cancer progression, yet the mechanism is not clear. The present study aimed to investigate the role of the JAK/STAT3 pathway in the gr...

journal_title：Oncology reports

authors： Fang J,Chu L,Li C,Chen Y,Hu F,Zhang X,Zhao H,Liu Z,Xu Q

更新日期：2015-01-01 00:00:00

abstract：:The incidence of malignant melanoma has increased greatly in recent decades presenting a high mortality rate despite intensive efforts in this area of research. Recent studies indicate that the chemokine receptor 4 (CXCR4) plays a critical role in cancer. Thus, it has been reported that CXCL12 binding to CXCR4 initiat...

journal_title：Oncology reports

authors： André ND,Silva VA,Watanabe MA,De Lucca FL

更新日期：2016-04-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an important role in maintaining immunological tolerance. However, this mechanism is one of the major obstacles to overcome when attempting to improve antitumor immunity. Protein-bound polysaccharide‑K (PSK) has been used clinically as an antitumor drug, and one of its antitumor mechani...

journal_title：Oncology reports

authors： Aoki R,Iijima H,Kato M,Uchida M,Wada T,Murata M,Ogawa K,Naritaka Y,Yoshimatsu K

更新日期：2014-01-01 00:00:00

abstract：:A phase II trial of vinorelbine and low dose prednisone in hormone-refractory metastatic prostate cancer was conducted in order to investigate its safety, efficacy and impact on quality of life. Vinorelbine was administered at the dose of 25 mg/m(2) i.v. weekly for 12 weeks and then biweekly, along with 10 mg of daily...

journal_title：Oncology reports

authors： Robles C,Furst AJ,Sriratana P,Lai S,Chua L,Donnelly E,Solomon J,Sundaram M,Feun L,Savaraj N

更新日期：2003-07-01 00:00:00

abstract：:Inhibitor of DNA-binding protein 1 (ID1) is commonly abnormally overexpressed in colorectal cancer (CRC); yet, the functional significance of ID1 in the growth and invasive properties of CRC cells remains largely unclear. The present study investigated the effects of ID1 downregulation on the cell growth and metastati...

journal_title：Oncology reports

authors： Lai X,Liao J,Lin W,Huang C,Li J,Lin J,Chen Q,Ye Y

更新日期：2014-07-01 00:00:00

abstract：:Cucurbitacin D (CuD), isolated from plants from the Cucurbitaceae family, is a potential antitumour agent since it inhibits proliferation, migration and metastasis of cancer cells. Despite CuD antitumour activity in cancer cells, the effects of CuD on gastric cancer cell lines remain unclear. The present study aimed t...

journal_title：Oncology reports

authors： Zhang YZ,Wang CF,Zhang LF

更新日期：2018-06-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) and its metabolite prostaglandin E2 (PGE2) can potentially affect most of the events in cancer development, including promotion of proliferation, resistance to apoptosis, angiogenesis, immune suppression and invasion. However, worldwide attention has predominantly centered on the cardiovascula...

journal_title：Oncology reports

authors： Li M,Tan SY,Wang XF

更新日期：2014-12-01 00:00:00