Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas.

abstract：:IFN-alpha regulates tumor cell growth at least through induction of apoptosis. We have recently demonstrated that IFN-alpha causes apoptosis through upregulation of TNF-related apoptosis-inducing ligand (TRAIL) in Daudi B lymphoma and U266 myeloma cells. However, other cell lines such as Ramos and RPMI 8226 underwent ...

journal_title：Oncology reports

authors： Yanase N,Kanetaka Y,Mizuguchi J

更新日期：2007-10-01 00:00:00

abstract：:Erythropoietin (Epo) is a key regulator of erythroid cell proliferation, differentiation and apoptosis. In the form of the recombinant protein, it is widely used to treat various types of anemias, including that associated with cancer and with the myelosuppressive effects of chemotherapy, particularly platinum-based r...

journal_title：Oncology reports

authors： Kriška J,Solár P,Varinská L,Solárová Z,Kimáková P,Mojžiš J,Fedoročko P,Sytkowski AJ

更新日期：2013-09-01 00:00:00

abstract：:To explore the effect of NET-1 on the proliferation, migration and endocytosis in the hepatocellular carcinoma (HCC) cell line SMMC-7721, we constructed the pU6H1-NET-1-siRNA (NET-1siRNA) and pcDNA3.1/myc-NET-1 (myc-NET-1) vectors and transfected them into SMMC-7721 cells. The expression levels of NET-1 mRNA and prote...

journal_title：Oncology reports

authors： Wang GL,Chen L,Wei YZ,Zhou JM,Wu YY,Zhang YX,Qin J,Zhu YY

更新日期：2012-06-01 00:00:00

abstract：:DEK, a transcription factor, is involved in mRNA splicing, transcriptional control, cell division and differentiation. Recent studies suggest that DEK overexpression can promote tumorigenesis in a wide range of cancer cell types. However, little is known concerning the status of DEK in pancreatic ductal adenocarcinoma...

journal_title：Oncology reports

authors： Sun J,Bi F,Yang Y,Zhang Y,Jin A,Li J,Lin Z

更新日期：2017-02-01 00:00:00

abstract：:We performed methylation specific PCR to explore the mechanism of inactivation of tumor suppressor genes P15, P16, P53 and VHL in 48 oral SCC. The frequencies of aberrant methylation on the promoter of the P15, the P16, the P53 and the VHL genes were 0.27 (13/48), 0.42 (20/48), 0.04 (2/48) and none, respectively. Alto...

journal_title：Oncology reports

authors： Yeh KT,Chang JG,Lin TH,Wang YF,Tien N,Chang JY,Chen JC,Shih MC

更新日期：2003-05-01 00:00:00

abstract：:Few studies have examined apoptosis induced by low-voltage electric pulses (LVEPs). LVEP-induce changes in membrane potential that are below the membrane breakdown threshold and increase membrane permeability without electroporation (pore formation) through the transport of extracellular substances via phagocytosis. W...

journal_title：Oncology reports

authors： Matsuki N,Takeda M,Ishikawa T,Kinjo A,Hayasaka T,Imai Y,Yamaguchi T

更新日期：2010-05-01 00:00:00

abstract：:Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid pre...

journal_title：Oncology reports

authors： Lu L,Chen J,Li M,Tang L,Wu R,Jin L,Liang Z

更新日期：2018-04-01 00:00:00

abstract：:The ability to detect K-ras oncogene may provide additional information for the management of patients with non-small cell lung cancer (NSCLC). In the present study, we detected the K-ras oncogene in 76 patients with NSCLC by two methods: direct sequencing of K-ras in tumor tissues and membrane array detection of the ...

journal_title：Oncology reports

authors： Chong IW,Chang MY,Sheu CC,Wang CY,Hwang JJ,Huang MS,Lin SR

更新日期：2007-07-01 00:00:00

abstract：:MicroRNA-455 (miR-455) has been considered as a novel cancer-related miRNA and dysregulated expression frequently occurs in various human types of cancer. However, its clinical significance, its biological function and the underlying molecular signaling involved in hepatocellular carcinoma (HCC) remain to be elucidate...

journal_title：Oncology reports

authors： Qin L,Zhang Y,Lin J,Shentu Y,Xie X

更新日期：2016-12-01 00:00:00

abstract：:ABCG2 is a multidrug cellular transport protein that is associated with resistance to certain treatments in patients, particularly anticancer treatment. The tumor-protective properties of ABCG2 expression are reported to be a feature of a subset of stem cell-like tumor cells. While protection against chemotherapy has ...

journal_title：Oncology reports

authors： Zoernig I,Ziegelmeier C,Lahrmann B,Grabe N,Jäger D,Halama N

更新日期：2013-05-01 00:00:00

abstract：:Survivin, a member of the inhibitor-of-apoptosis family is an essential protein for regular mitosis and is involved in an anti-apoptotic pathway. In some studies, an association between survivin expression and radiosensitivity has been described for tumor cells, but the relationship between p53 and survivin regarding ...

journal_title：Oncology reports

authors： Kappler M,Taubert H,Bartel F,Blümke K,Panian M,Schmidt H,Dunst J,Bache M

更新日期：2005-01-01 00:00:00

abstract：:Mutations of the von Hippel-Lindau (VHL) tumor suppressor gene cause hereditary and sporadic renal cell carcinomas (RCCs). The best characterized function of VHL protein is suppression of the α subunit of hypoxia inducible factor (HIF). Additional VHL functions have been reported, including induction of senescence upo...

journal_title：Oncology reports

authors： Macher-Goeppinger S,Bermejo JL,Schirmacher P,Pahernik S,Hohenfellner M,Roth W

更新日期：2013-11-01 00:00:00

abstract：:Sirtuin 6 (SIRT6) is a member of the mammalian NAD+‑dependent deacetylase sirtuin family that acts to maintain genomic stability and to repress genes. SIRT6 has recently been reported to be a tumor suppressor that controls cancer metabolism, although this effect of SIRT6 is still in dispute. Moreover, the role of SIRT...

journal_title：Oncology reports

authors： Feng J,Yan PF,Zhao HY,Zhang FC,Zhao WH,Feng M

更新日期：2016-03-01 00:00:00

abstract：:B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) is directly involved in cell growth, proliferation and self-renewal of cancer stem cells (CSCs). The aim of the present study was to assess the role of Bmi1 in the maintenance of stemness properties and tumorigenicity of human bladder CSC-like side ...

journal_title：Oncology reports

authors： Zhu D,Wan X,Huang H,Chen X,Liang W,Zhao F,Lin T,Han J,Xie W

更新日期：2014-02-01 00:00:00

abstract：:hTERTC27, a 27-kDa hTERT C-terminal polypeptide has been demonstrated to cause hTERT-positive HeLa cell apoptosis and inhibits the growth of mouse melanoma. hTERTC27 has been associated with telomere dysfunction, regulation of gene-regulated apoptosis, the cell cycle and activation of natural killer (NK) cells, but it...

journal_title：Oncology reports

authors： Gong HX,He L,Li XP,Wang YD,Li Y,Huang JJ,Wang Z,Xie D,Kung HF,Peng Y

更新日期：2012-04-01 00:00:00

abstract：:Genetically modified tumour cells producing cytokines such as interleukin 12 (IL-12) are potent activators of the antitumour immune responses and represent a promising therapeutic modality when combined with chemotherapy. The objective of this study was to examine whether IL-12-producing cellular vaccines can augment ...

journal_title：Oncology reports

authors： Mikyšková R,Indrová M,Símová J,Bieblová J,Bubeník J,Reiniš M

更新日期：2011-06-01 00:00:00

abstract：:Tumour cell proliferation is an important biological prognostic parameter to be considered alongside clinical and histopathological parameters. It has been evaluated by immunohistochemistry using proliferative markers (PCNA, Ki67, etc.) and by flow cytometry considering DNA content, growth fraction (S + G2M) and S-pha...

journal_title：Oncology reports

authors： Tirelli G,Sidari L,Giacomarra V,Papanikolla L,Sasso F,Russolo M,Melato M

更新日期：2002-05-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) endows cancer cells with enhanced invasive and metastatic potential during cancer progression. Fractalkine, also known as chemokine (C-X3-C motif) ligand 1 (CX3CL1), the only member recognized so far that belongs to the CX3C chemokine subfamily, was reported to participate in...

journal_title：Oncology reports

authors： Tang J,Xiao L,Cui R,Li D,Zheng X,Zhu L,Sun H,Pan Y,Du Y,Yu X

更新日期：2016-02-01 00:00:00

abstract：:Regulated intramembrane proteolysis of epithelial cell adhesion molecule (EpCAM) results in shedding of the extracellular domain (EpEX) and release of the intra-cellular domain (EpICD) into the cytoplasm. Released EpICD associates with FHL2, β-catenin and Lef-1 to form a nuclear complex and triggers oncogenic signalin...

journal_title：Oncology reports

authors： Park SY,Bae JS,Cha EJ,Chu HH,Sohn JS,Moon WS

更新日期：2016-07-01 00:00:00

abstract：:Bee venom (BV) therapy is a type of alternative medical treatment used to treat various diseases in oriental medicine. The mechanisms underlying the effects of BV remain poorly understood. In the present study, we evaluated the antiviral effect of BV on cervical carcinoma cell lines (CaSki, HeLa, C33A and TC-1). BV tr...

journal_title：Oncology reports

authors： Kim YW,Chaturvedi PK,Chun SN,Lee YG,Ahn WS

更新日期：2015-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are novel tools for cancer therapy. Frizzled7 (FZD7) is an important co-receptor in the WNT signaling pathway. The WNT signaling pathway is aberrantly activated in Helicobacter pylori (H. pylori)‑infected gastric cancer cells. However, the role of FZD7 in H. pylori‑induced gastric tumorigenesis rema...

journal_title：Oncology reports

authors： Geng Y,Lu X,Wu X,Xue L,Wang X,Xu J

更新日期：2016-04-01 00:00:00

abstract：:Esophageal cancer (EC) has a globally increasing incidence with poor curative treatment options and survival rates. Crucial risk factors are exposure to toxins or carcinogens. Microsomal epoxide hydrolase (mEH) is a biotransformation enzyme essential for the detoxification of xenobiotics. Polymorphisms in exon 3 and e...

journal_title：Oncology reports

authors： Dura P,Bregitha CV,Te Morsche RH,Roelofs HM,Kristinsson JO,Wobbes T,Witteman BJ,Tan AC,Drenth JP,Peters WH

更新日期：2012-06-01 00:00:00

abstract：:Hypoxia promotes the invasive and metastatic potential of tumour cells. A recent study has shown that the activation of the chemokine receptor CXCR4 by lack of oxygen in breast cancer is HIF-1-dependent. We have previously demonstrated that CXCR4 signalling is involved in the establishment of lymph node metastasis in ...

journal_title：Oncology reports

authors： Ishikawa T,Nakashiro K,Klosek SK,Goda H,Hara S,Uchida D,Hamakawa H

更新日期：2009-03-01 00:00:00

abstract：:Cigarette smoke has been implicated as a major risk factor for esophageal squamous cell carcinoma (ESCC). Several lines of evidence have suggested that the promoting effect of cigarette smoking extract (CSE) on ESCC is mediated by upregulation of cyclooxygenase-2 (COX-2) expression. Yet, the underlying molecular and c...

journal_title：Oncology reports

authors： Gong J,Chu Y,Xu M,Huo J,Lv L

更新日期：2016-01-01 00:00:00

abstract：:Acute pancreatitis (AP) is an inflammatory disease with high morbidity and mortality rates. Pancreatic ductal cells are the most susceptible of all cell types that are exposed to the noxious stimuli of pancreatitis. Our previous studies demonstrated that emodin, a natural product extracted from Rheum palmatum L., prot...

journal_title：Oncology reports

authors： Zhang Q,Hu F,Guo F,Zhou Q,Xiang H,Shang D

更新日期：2019-08-08 00:00:00

abstract：:The role of vascular endothelial growth factor (VEGF) during peritoneal dissemination of ovarian carcinoma and the association with tumor microvessel density (MVD) and matrix metalloproteinase (MMP) activity was investigated. To this end, MVD, tumor tissue and ascitic fluid levels of VEGF, and MMP activity of ascitic ...

journal_title：Oncology reports

authors： Yabushita H,Shimazu M,Noguchi M,Kishida T,Narumiya H,Sawaguchi K,Noguchi M

更新日期：2003-01-01 00:00:00

abstract：:Extracellular matrix remodeling crucial to tumorigenesis involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs). MMP production is stimulated by multiple factors, including the extracellular matrix metallo-proteinase inducer EMMPRIN/CD147. Overexpression of EMMPRIN...

journal_title：Oncology reports

authors： Takahashi M,Suzuki S,Ishikawa K

更新日期：2012-01-01 00:00:00

abstract：:Activation of p53-independent pathways plays an important role in phytochemical-induced apoptosis and is considered to be a crucial factor in the invasion and metastasis of cancer. Previous studies have shown that combined effects of Stephania tetrandra with medicinal herbs exhibit beneficial effects in cancer patient...

journal_title：Oncology reports

authors： Yu VW,Ho WS

更新日期：2013-06-01 00:00:00

abstract：:Reactive oxygen species (ROS) can drive the de‑differentiation of tumor cells leading to the process of epithelial-to-mesenchymal transition (EMT) to enhance invasion and metastasis. The invasive and metastatic phenotype of malignant cells is often linked to loss of E-cadherin expression, a hallmark of EMT. Recent stu...

journal_title：Oncology reports

authors： Wang Y,Ma J,Shen H,Wang C,Sun Y,Howell SB,Lin X

更新日期：2014-11-01 00:00:00

abstract：:Osteosarcoma (OS) has an unfavorable prognosis and tends to metastasize to lung tissue. Although the CXCL12-CXCR4 axis appears to affect progression and metastasis in numerous tumors, its mechanism and downstream pathways in OS remain unclear. We used western blotting and flow cytometry to detect CXCR4 and CXCR7 expre...

journal_title：Oncology reports

authors： Liao YX,Fu ZZ,Zhou CH,Shan LC,Wang ZY,Yin F,Zheng LP,Hua YQ,Cai ZD

更新日期：2015-07-01 00:00:00