A novel immunotherapeutic modality with direct hemoperfusion targeting transforming growth factor-beta prolongs the survival of tumor-bearing rats.

abstract：:trans‑Resveratrol (Rsv) is a natural compound contained in red wine and grape skins that has various beneficial effects for organisms such as lengthening of their life span. Rsv induces expression of the human TP53 and HELB genes, which are involved in the regulation of DNA maintenance. In the present study, a lucifer...

journal_title：Oncology reports

authors： Uchiumi F,Katsuda C,Akui M,Kusaka M,Tanaka M,Asai M,Tanuma SI

更新日期：2020-07-01 00:00:00

abstract：:The challenging possibility of selectively inducing mitotic death in tumor cells by combining genotoxic agents with the inhibition of G2 checkpoints of the cell cycle is the subject of intensive investigation. We show that very low concentrations (3.5 and 5 nM) of okadaic acid induce mitotic death in two glioblastoma ...

journal_title：Oncology reports

authors： Castigli E,Sciaccaluga M,Schiavoni G,Brozzi F,Fabiani R,Gorello P,Gianfranceschi GL

更新日期：2006-02-01 00:00:00

abstract：:The gene Nm23, which encodes for a nucleoside diphosphate kinase, has been defined as a metastasis-suppressor gene because of the inverse correlation between its expression and the metastatic capacity of the tumor cells. For colorectal cancer, however, the findings are equivocal. The aim of our study was to assess, in...

journal_title：Oncology reports

authors： Dusonchet L,Corsale S,Migliavacca M,Calò V,Bazan V,Amato A,Cammareri P,Totaro MS,Agnese V,Cascio S,La Rocca G,Sisto PS,Dardanoni G,Valerio MR,Grassi N,Latteri S,Cajozzo M,Buscemi M,Castorina S,Morello V,Tomasino R

更新日期：2003-09-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is the predominant histologic subtype of esophageal cancer and is characterized by a high mortality rate and geographic differences in incidence. microRNAs (miRNAs) are small, non-coding RNAs that play important roles in the regulation of genes associated with cancer developme...

journal_title：Oncology reports

authors： Zhang N,Fu H,Song L,Ding Y,Wang X,Zhao C,Zhao Y,Jiao F,Zhao Y

更新日期：2014-10-01 00:00:00

abstract：:In this work we studied the effect of v-raf and different form RAF on up regulation of VEGF gene expression and angiogenesis. In the experiments the truncated forms of RAF1 gene were transfected into the cells of the established human urothelial line HCV-29, otherwise non-angiogenic. The plasmids coding for mitochondr...

journal_title：Oncology reports

authors： Malecki M,Seneta M,Miloszewska J,Trembacz H,Przybyszewska M,Janik P

更新日期：2004-01-01 00:00:00

abstract：:Ginsenoside is known to have potential cancer-preventive activities. The major active components in red ginseng consist of a variety of ginsenosides including Rg3, Rg5 and Rk1, each of which has different pharmacological activities. Among these, Rg3 has been reported to exert anticancer activities through inhibition o...

journal_title：Oncology reports

authors： Choi YJ,Lee HJ,Kang DW,Han IH,Choi BK,Cho WH

更新日期：2013-09-01 00:00:00

abstract：:Platinum compounds and vinorelbine (VNB) are active in the treatment of non-small cell lung cancer (NSCLC), but moderate toxicity has been reported. The aims of the present study were to assess activity and tolerability of low dose carboplatin (CBDCA): 4.5 AUC according to Calvert formula on day 1, combined with vinor...

journal_title：Oncology reports

authors： Bretti S,Manzin E,Celano A,Ritorto G,Loddo C,Berruti A

更新日期：2001-03-01 00:00:00

abstract：:Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...

journal_title：Oncology reports

authors： Lee YM,Bae MH,Lee OH,Moon EJ,Moon CK,Kim WH,Kim KW

更新日期：2004-10-01 00:00:00

abstract：:Loss of proliferative control and failure to undergo cellular differentiation are key events during carcinogenesis. We recently identified a new potential tumor suppressor gene named MTUS1 (mitochondrial tumor suppressor 1), down-regulated in undifferentiated tumor cell lines, inhibiting tumor cell proliferation after...

journal_title：Oncology reports

authors： Zuern C,Heimrich J,Kaufmann R,Richter KK,Settmacher U,Wanner C,Galle J,Seibold S

更新日期：2010-01-01 00:00:00

abstract：:Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal...

journal_title：Oncology reports

authors： Li S,Wang C,Yu X,Wu H,Hu J,Wang S,Ye Z

更新日期：2017-01-01 00:00:00

abstract：:Membrane-associated RING-CH (MARCH) belongs to the family of RING-CH type E3 ubiquitin ligases. MARCH1 ubiquitinates and downregulates MHC class II expression in APCs and targets major players of the immune system. However, the role of MARCH1 in ovarian cancer has not been elucidated. The present study investigated th...

journal_title：Oncology reports

authors： Meng Y,Hu J,Chen Y,Yu T,Hu L

更新日期：2016-11-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in tumor invasion, but their prognostic significance is still under discussion. We set out to analyze the epithelial and stromal expression of MMP-2, MMP-7, MMP-9, MT1-MMP, TIMP-1 and TIMP-2 in advanced epithelial ovarian cancers and to ...

journal_title：Oncology reports

authors： Brun JL,Cortez A,Lesieur B,Uzan S,Rouzier R,Daraï E

更新日期：2012-04-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-β superfamily, are multifunctional signaling molecules that have become of increasing interest in cancer research. Recent observations suggest that alterations in BMPs and BMP signaling are associated...

journal_title：Oncology reports

authors： Hashida Y,Nemoto Y,Imajoh M,Murakami M,Taniguchi A,Komatsu N,Yokoyama A,Daibata M

更新日期：2012-03-01 00:00:00

abstract：:The objective of this study was to examine how splenectomy affects the immune response, particularly T cells, in chemically-induced mammary tumors. Female rats were splenectomized and then exposed to 9,10-dimethyl-1,2-benz(a)anthracene (DMBA) to induce mammary tumors. Splenectomy significantly decreased the rate of tu...

journal_title：Oncology reports

authors： Kossoy G,Ben-Hur H,Lifschitz O,Zusman I

更新日期：2002-01-01 00:00:00

abstract：:DEK, a transcription factor, is involved in mRNA splicing, transcriptional control, cell division and differentiation. Recent studies suggest that DEK overexpression can promote tumorigenesis in a wide range of cancer cell types. However, little is known concerning the status of DEK in pancreatic ductal adenocarcinoma...

journal_title：Oncology reports

authors： Sun J,Bi F,Yang Y,Zhang Y,Jin A,Li J,Lin Z

更新日期：2017-02-01 00:00:00

abstract：:The majority of patients with hormone receptor-positive metastatic breast cancer die from disease progression despite different types of anti-hormonal treatments. Preclinical studies have indicated that resistance to anti-hormonal therapies may be the result of an activated NF-κB si...

journal_title：Oncology reports

authors： Trinh XB,Sas L,Van Laere SJ,Prové A,Deleu I,Rasschaert M,Van de Velde H,Vinken P,Vermeulen PB,Van Dam PA,Wojtasik A,De Mesmaeker P,Tjalma WA,Dirix LY

更新日期：2012-03-01 00:00:00

abstract：:Breast cancer is the most common type of cancer among women worldwide. Research using breast cancer cell lines derived from primary tumors may provide valuable additional knowledge regarding this type of cancer. Therefore, the aim of this study was to investigate the phenotypic prof...

journal_title：Oncology reports

authors： Corrêa NC,Kuasne H,Faria JA,Seixas CC,Santos IG,Abreu FB,Nonogaki S,Rocha RM,Aparecida Borges Silva G,Gobbi H,Rogatto SR,Goes AM,Gomes DA

更新日期：2013-04-01 00:00:00

abstract：:VBP-1 has been isolated as a novel protein binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. The fundamental function of the gene was examined in the nematode, Caenorhabditis elegans (C. elegans). The C. elegans VBP-1 gene was expressed in adults only in the gonads and was also expressed in early s...

journal_title：Oncology reports

authors： Ichimiya H,Hino O,Kohara Y,Ishii N

更新日期：2003-03-01 00:00:00

abstract：:The Houttuynia cordata Thunb (HCT) extract has been used as a traditional Chinese herb medicine and as well as an effective drug for treating allergic inflammation for thousands of years. In this study, we investigated the anti-cancer activity of HCT and its molecular mechanisms in the human colon adenocarcinoma cell ...

journal_title：Oncology reports

authors： Tang YJ,Yang JS,Lin CF,Shyu WC,Tsuzuki M,Lu CC,Chen YF,Lai KC

更新日期：2009-11-01 00:00:00

abstract：:Orotate phosphoribosyl transferase (OPRT) is the initial enzyme of 5-fluorouracil (5-FU) activation, in which 5-FU is converted to 5-fluorouridinemonophosphate. Dihydropyrimidine dehydrogenase (DPD) is a degrading enzyme that catabolizes 5-FU. In this study, we investigated the expression of these enzymes in normal pr...

journal_title：Oncology reports

authors： Tanaka T,Kawashima H,Matsumura K,Yamashita-Hosono T,Yoshimura R,Kuratsukuri K,Harimoto K,Nakatani T

更新日期：2009-01-01 00:00:00

abstract：:The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a predictor of prognosis and response to cytotoxic treatments. Its immunoexpression was assessed in 63 ...

journal_title：Oncology reports

authors： Jardim BV,Moschetta MG,Leonel C,Gelaleti GB,Regiani VR,Ferreira LC,Lopes JR,Zuccari DA

更新日期：2013-09-01 00:00:00

abstract：:Multicellular tumor spheroids have been used to examine aspects of combined modality treatment since they often recreate the in vivo tumor environment much more closely than other models. The radioenhancement by gemcitabine (dFdC) on human glioma spheroids derived from cell lines (CLS) and biopsy tissue, grown as orga...

journal_title：Oncology reports

authors： Fehlauer F,Muench M,Smid EJ,Slotman B,Richter E,Van der Valk P,Sminia P

更新日期：2006-01-01 00:00:00

abstract：:Investigations into extracellular vesicles (EVs) have significantly increased since their role in physiological and pathological processes has become more clearly understood. Furthermore, it has become increasingly clear that several subpopulations of EVs exist, such as exosomes (EXOs) and microvesicles (MVs). Various...

journal_title：Oncology reports

authors： Giusti I,Di Francesco M,Cantone L,D'Ascenzo S,Bollati V,Carta G,Dolo V

更新日期：2015-11-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations occur in a variety of human cancers, suggesting a possible role for mitochondrial respiratory functions in tumorigenesis. Recent studies have demonstrated that SDHD, a nuclear gene encoding one of the mitochondrial complex II subunits, acts as a tumor-suppressor for hereditary parag...

journal_title：Oncology reports

authors： Habano W,Sugai T,Nakamura S,Uesugi N,Higuchi T,Terashima M,Horiuchi S

更新日期：2003-09-01 00:00:00

abstract：:Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. However, few studies have defined functional roles and mechanis...

journal_title：Oncology reports

authors： Yan L,Wang Y,Wang ZZ,Rong YT,Chen LL,Li Q,Liu T,Chen YH,Li YD,Huang ZH,Peng J

更新日期：2016-01-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a process implicated in cancer progression in which the underlying cellular changes have been identified mainly using in vitro models. We determined the expression of some putative EMT biomarkers including E-cadherin, beta-catenin, zinc finger factor Snail (Snail), transfo...

journal_title：Oncology reports

authors： Logullo AF,Nonogaki S,Pasini FS,Osório CA,Soares FA,Brentani MM

更新日期：2010-02-01 00:00:00

abstract：:A phase I study of S-1 and biweekly docetaxel (DOC) combination therapy was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic parameters. Fourteen patients with advanced or recurrent gastric cancer were analyzed. The treatment consisted of S-1 [body surface area (BSA) <1.25 m2:80 mg/day, 1.25...

journal_title：Oncology reports

authors： Takahashi I,Emi Y,Kakeji Y,Tokunaga E,Ushiro S,Oki E,Watanabe M,Baba H,Maehara Y

更新日期：2006-04-01 00:00:00

abstract：:MicroRNAs (miRs) have emerged as prospective tools for human cancer therapy, including hepatocellular carcinoma (HCC) therapy. Previous studies have suggested that miR-381 functions as oncogenic or tumor-suppressive miRs in other cancer types. However, the role of miR-381 in HCC remains unknown. The present study inve...

journal_title：Oncology reports

authors： Zhang Q,Zhao S,Pang X,Chi B

更新日期：2016-03-01 00:00:00

abstract：:Recent research indicates that the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway may play an important role in chronic inflammation which promotes cancer progression, yet the mechanism is not clear. The present study aimed to investigate the role of the JAK/STAT3 pathway in the gr...

journal_title：Oncology reports

authors： Fang J,Chu L,Li C,Chen Y,Hu F,Zhang X,Zhao H,Liu Z,Xu Q

更新日期：2015-01-01 00:00:00

abstract：:Previous studies have demonstrated the tremendous tropism of mesenchymal stem cells (MSCs) for malignant gliomas, making these cells a potential vehicle for delivery of therapeutic genes to disseminated glioma cells. However, the mechanisms underlying the tropism of MSCs for gliomas remain poorly defined. It has been ...

journal_title：Oncology reports

authors： Xu F,Shi J,Yu B,Ni W,Wu X,Gu Z

更新日期：2010-06-01 00:00:00