Effect of the natural compound trans‑resveratrol on human MCM4 gene transcription.

abstract：:Cisplatin (CDDP)‑based combination chemotherapy is the standard for muscle‑invasive bladder cancer (MIBC). However, nearly all patients undergoing CDDP chemotherapy become refractory due to the development of CDDP resistance. Therefore, clarification of the mechanisms of CDDP resistance is urgently needed. The transcr...

journal_title：Oncology reports

authors： Sekino Y,Sakamoto N,Ishikawa A,Honma R,Shigematsu Y,Hayashi T,Sentani K,Oue N,Teishima J,Matsubara A,Yasui W

更新日期：2019-05-01 00:00:00

abstract：:Novel agents need to be developed to overcome the limitations of the current melanoma therapeutics. Atractylenolide I (AT-I) is a sesquiterpene compound isolated from atractylodis macrocephalae rhizoma. Previous findings demonstrated that AT-I exhibited cytotoxic action in melanoma cells. However, the molecular mechan...

journal_title：Oncology reports

authors： Ye Y,Chao XJ,Wu JF,Cheng BC,Su T,Fu XQ,Li T,Guo H,Tse AK,Kwan HY,Du J,Chou GX,Yu ZL

更新日期：2015-09-01 00:00:00

abstract：:Death-associated protein kinase (DAPK) plays an important role in apoptosis regulation and has been shown to maintain antitumor and metastasis suppressor properties. In the present study, we investigated whether DAPK overexpression may mediate vascular endothelial growth factor (VEGF)/hypoxia-inducible factor-1α (HIF-...

journal_title：Oncology reports

authors： Park ST,Kim BR,Park SH,Lee JH,Lee EJ,Lee SH,Rho SB

更新日期：2014-02-01 00:00:00

abstract：:The incidence of well‑differentiated thyroid cancer (WDTC) is rapidly increasing. Poor survival follows distant metastasis (DM) and recurrence. In the present study, we aimed to analyze the expression alterations in different stages of WDTC and the regulatory mechanism of DM and the recurrence of DM. A male patient di...

journal_title：Oncology reports

authors： Zhang YJ,Ma YS,Xia Q,Yu F,Lv ZW,Jia CY,Jiang XX,Zhang L,Shao YC,Xie WT,Lu GX,Yv XQ,Zhong P,Fu D,Wang XF

更新日期：2018-12-01 00:00:00

abstract：:Correlation between inhibition of cell motility and anti-invasive activity by the water extract of HangAmDan-B (HAD-B), a crude extract of eight Korean medicinal animals and plants, in NCI-H460 human non-small cell lung cancer (NSCLC) cells was investigated. Within the concentration...

journal_title：Oncology reports

authors： Choi YJ,Shin DY,Lee YW,Cho CK,Kim GY,Kim WJ,Yoo HS,Choi YH

更新日期：2011-12-01 00:00:00

abstract：:An arsenical compound, As2O3 has been reported to be effective for treating acute leukemia and induce apoptosis in many different tumor cell types. In this study we designed a novel arsenical compound, As4O6, and compared its ability to induce cell growth inhibition as well as gene expression profiles along with As2O3...

journal_title：Oncology reports

authors： Ahn WS,Bae SM,Lee KH,Kim YW,Lee JM,Namkoong SE,Lee IP,Kim CK,Seo JS,Sin JI,Kim YW

更新日期：2004-09-01 00:00:00

abstract：:The challenging possibility of selectively inducing mitotic death in tumor cells by combining genotoxic agents with the inhibition of G2 checkpoints of the cell cycle is the subject of intensive investigation. We show that very low concentrations (3.5 and 5 nM) of okadaic acid induce mitotic death in two glioblastoma ...

journal_title：Oncology reports

authors： Castigli E,Sciaccaluga M,Schiavoni G,Brozzi F,Fabiani R,Gorello P,Gianfranceschi GL

更新日期：2006-02-01 00:00:00

abstract：:The development and characterization of effective anticancer drugs against colorectal cancer (CRC) is of urgent need since it is the second most common cause of cancer death. The study was designed to evaluate the effects of two IGF-1R antagonists, MK-0646, a recombinant fully humanized monoclonal antibody and OSI-906...

journal_title：Oncology reports

authors： Leiphrakpam PD,Agarwal E,Mathiesen M,Haferbier KL,Brattain MG,Chowdhury S

更新日期：2014-01-01 00:00:00

abstract：:Apoptin, a small protein derived from chicken anemia virus, possesses the capacity to specifically kill tumor cells while leaving normal cells intact. Previous studies have indicated that the subcellular localization of apoptin appears to be crucial for this tumor-selective activity. Apoptin resides in the cytoplasm o...

journal_title：Oncology reports

authors： Peng C,Yang P,Cui Y,He M,Liang L,Di Y

更新日期：2013-06-01 00:00:00

abstract：:Combined chemotherapy with 5-fluorouracil and leucovorin (LV) has been widely used for the treatment of patients with colorectal cancer. Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), whic...

journal_title：Oncology reports

authors： Tsukioka S,Sakamoto E,Tsujimoto H,Nakagawa F,Saito H,Uchida J,Kiniwa M,Fukushima M

更新日期：2011-05-01 00:00:00

abstract：:Sulforaphane (SFN) was first isolated from broccoli sprout and it is present at high concentrations in plants belonging to the Cruciferae family. The chemotherapeutic and anti‑cancerogenic capacities of SFN have been demonstrated by inhibition of cancer cell proliferation in several cancer cell lines. The aim of the p...

journal_title：Oncology reports

authors： Żuryń A,Krajewski A,Klimaszewska-Wiśniewska A,Grzanka A,Grzanka D

更新日期：2019-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to play an important role in diverse biological processes and cancer progression. The objective of the present study was to investigate the role of miR-497 in ovarian cancer angiogenesis. We found that miR-497 expression was downregulated in human ovarian cancer tissues, and the low ...

journal_title：Oncology reports

authors： Wang W,Ren F,Wu Q,Jiang D,Li H,Shi H

更新日期：2014-11-01 00:00:00

abstract：:The aim of this study was to define the clinical implications of semi-quantitative telomerase activity in gynecological tumors by comparing the telomerase activity of cancerous lesion and the adjacent non-cancerous lesion. In 118 cases of gynecologic tumors, including 41 uterine cervical tumors, 43 uterine body tumors...

journal_title：Oncology reports

authors： Sakamoto M,Toyoizumi T,Kikuchi Y,Okamoto A,Nakayama H,Aoki D,Yamamoto K,Hata H,Sugishita T,Tenjin Y

更新日期：2000-09-01 00:00:00

abstract：:The estrogen receptor (ER) expression and HER2 amplification are important factors in determining the prognosis and therapy of breast cancer. Interactions between the two signaling pathways for example resulted in ERalpha-dependent regulation of HER2 expression in breast cancer cells. In this study, we investigated to...

journal_title：Oncology reports

authors： Lattrich C,Juhasz-Boess I,Ortmann O,Treeck O

更新日期：2008-03-01 00:00:00

abstract：:The objective of the present study was to explore the in vitro and in vivo anticancer effects of Platycodin D (PD), derived from Platycodin grandiflorum, on highly metastatic MDA-MB-231 breast cancer cells. Using the MTT assay, we found that PD inhibited MDA-MB-231 cell growth in a concentration-dependent manner, with...

journal_title：Oncology reports

authors： Kong Y,Lu ZL,Wang JJ,Zhou R,Guo J,Liu J,Sun HL,Wang H,Song W,Yang J,Xu HX

更新日期：2016-09-01 00:00:00

abstract：:Orotate phosphoribosyl transferase (OPRT) is the initial enzyme of 5-fluorouracil (5-FU) activation, in which 5-FU is converted to 5-fluorouridinemonophosphate. Dihydropyrimidine dehydrogenase (DPD) is a degrading enzyme that catabolizes 5-FU. In this study, we investigated the expression of these enzymes in normal pr...

journal_title：Oncology reports

authors： Tanaka T,Kawashima H,Matsumura K,Yamashita-Hosono T,Yoshimura R,Kuratsukuri K,Harimoto K,Nakatani T

更新日期：2009-01-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) plays a key role in the transformation of normal cells to cancerous cells. Although inhibitors of STAT3 have been shown to suppress the growth of multiple cancer types in vitro and in vivo, such agents are of particular interest for the prevention of breast ca...

journal_title：Oncology reports

authors： Shoemaker RH,Fox JT,Juliana MM,Moeinpour FL,Grubbs CJ

更新日期：2019-09-01 00:00:00

abstract：:Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend on different cellular mechanisms ...

journal_title：Oncology reports

authors： Zhou J,Hu Q,Zhang X,Zheng J,Xie B,Xu Z,Zhang W

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to explore the relationship between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKIs) and the expression of the cancer stem cell (CSC)‑related markers. Specimens of 72 cases of lung adenocarcinoma with significantly different therapeutic effects of the firs...

journal_title：Oncology reports

authors： Hu F,Li C,Zheng X,Zhang H,Shen Y,Zhou L,Yang X,Han B,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:Recently, gene fusions between the androgen responsive gene TMPRSS2 and members of the ETS-family of DNA-binding transcription factor genes were found in prostate cancer. Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression o...

journal_title：Oncology reports

authors： Winnes M,Lissbrant E,Damber JE,Stenman G

更新日期：2007-05-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) has a typical progressive course with transition from a chronic phase to a terminal blast crisis phase. However, the mechanisms that lead to disease progression remain unclear. Bone marrow mesenchymal stem cells (BMMSCs) play important roles in maintaining the bone marrow microenviro...

journal_title：Oncology reports

authors： Han Y,Wang Y,Xu Z,Li J,Yang J,Li Y,Shang Y,Luo J

更新日期：2013-08-01 00:00:00

abstract：:Cytochalasin B (CB) is a cell-permeable mycotoxin. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments, it inhibits cell movement and induces nuclear extrusion. In the present study, we investigated the anticancer activity of CB in HeLa human cervical carcinoma cells. CB showed sig...

journal_title：Oncology reports

authors： Hwang J,Yi M,Zhang X,Xu Y,Jung JH,Kim DK

更新日期：2013-10-01 00:00:00

abstract：:Metastasis is the major process responsible for the death in cancer patients. In the search for more effective antineoplasic drugs, many substances are under investigation, among them lapachol. This study aims to examine the molecular and morphological alterations caused by lapachol treatment, as well as its effects o...

journal_title：Oncology reports

authors： Balassiano IT,De Paulo SA,Henriques Silva N,Cabral MC,da Gloria da Costa Carvalho M

更新日期：2005-02-01 00:00:00

abstract：:The metabolism of arachidonic acid by either the cyclooxygenase or lipoxygenase (LOX) pathway is believed to play an important role in tumor promotion. We investigated the expression of 5- and 12-LOX in renal cell carcinoma (RCC), as well as the effects of their inhibitors on cell proliferation in 2 RCC cell lines (Ca...

journal_title：Oncology reports

authors： Matsuyama M,Yoshimura R,Mitsuhashi M,Tsuchida K,Takemoto Y,Kawahito Y,Sano H,Nakatani T

更新日期：2005-07-01 00:00:00

abstract：:The histogenesis of depressed adenoma of the colon has not been sufficiently investigated. Pericryptal myofibroblasts are stromal cells expressing smooth muscle actin, and are involved in the differentiation and multiplication of epithelial cells in the colonic epithelium. COX-2 has been reported to be involved in the...

journal_title：Oncology reports

authors： Harada K,Higaki S,Amano A,Hashimoto K,Hashimoto S,Gondo T,Sakaida I

更新日期：2007-06-01 00:00:00

abstract：:Mother-to-infant transmission of hepatitis B virus (HBV) can occur as an intrauterine, intrapartum or postpartum infection. In the present study, we induced a multifunctional viral regulator of HBV gene products, HBx, and its different fragments to overexpress in a tropho-blast cell line, HTR-8/SVneo. We then identifi...

journal_title：Oncology reports

authors： Cui H,Li QL,Chen J,Na Q,Liu CX

更新日期：2015-10-01 00:00:00

abstract：:Neuroblastoma is a tumor accounting for approximately 10% of all childhood malignancies and 50% of all childhood cancer-related deaths. MYCN gene copy number variation represents the most important prognostic factor in neuroblastoma. Prognostic significance of MYCN gene expression is more complicated and may depend on...

journal_title：Oncology reports

authors： Prochazka P,Hrabeta J,Vicha A,Cipro S,Stejskalova E,Musil Z,Vodicka P,Eckschlager T

更新日期：2013-06-01 00:00:00

abstract：:Zinc finger protein 307 (ZNF307) is a new Krüppel-associated box zinc-finger protein gene and a member of the zinc-finger family of transcriptional factors. Notably, the role of ZNF307 and its underlying mechanisms involved in hepatocarcinogenesis are poorly investigated. In the present study, we found that the expres...

journal_title：Oncology reports

authors： Liang Y,Li Q,Chen K,Ni W,Zhan Z,Ye F,Li Y,Fang Y,Zhang F,Chen L,Ding Y

更新日期：2017-10-01 00:00:00

abstract：:Irinotecan HCl (CPT-11) has frequently been used in chemotherapy or concurrent chemoradiotherapy for patients with advanced cervical cancer, although an effective protocol for chemoradiotherapy with CPT-11 has not yet been established. Using the radiosensitive human cervical squamous cell carcinoma cell line ME180 and...

journal_title：Oncology reports

authors： Tanaka T,Yukawa K,Umesaki N

更新日期：2005-11-01 00:00:00

abstract：:Osteosarcoma (OS) is a common primary malignancy in children and adolescents with relative high survival rate after chemotherapy. While the toxicity of chemotherapy and personalized different response to chemotherapy makes it difficult for the selection of therapeutics and improvement of diagnosis. In this study, we c...

journal_title：Oncology reports

authors： Zhang W,Han S,Sun K

更新日期：2017-02-01 00:00:00