Abstract:
:Metastasis is the major process responsible for the death in cancer patients. In the search for more effective antineoplasic drugs, many substances are under investigation, among them lapachol. This study aims to examine the molecular and morphological alterations caused by lapachol treatment, as well as its effects on the intrinsic tissue invasive property of this cell line. HeLa cells were exposed to different concentrations of lapachol, and the resulting alterations on cellular protein profile, morphology and invasiveness property were studied. At 400 microg/ml, cellular viability remains unchanged, but lapachol induces alterations in the protein profile and inhibits the invasiveness of HeLa cells in CAM model. With these results, we can conclude that lapachol has a great potential of application in fighting metastasis.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Balassiano IT,De Paulo SA,Henriques Silva N,Cabral MC,da Gloria da Costa Carvalho Mkeywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
329-33issue
2eissn
1021-335Xissn
1791-2431journal_volume
13pub_type
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